Learning and Memory

Cellular Mechanisms

Zoran Đogaš

Learning objectives for the Seminar S22 (Learning and Memory):

•  To understand the concept of Brain Plasticity •  Habituation (behavior and synaptic mechanism) •  Sensitization (behavior and synaptic

mechanism) •  Trisynaptic pathway •  Long Term Potentiation in the Hippocampus •  Cellular mechanisms of LTP (NMDA / NO)

Post-tetanic potentiation

Monosynaptic reflex in cats Loyd, 1949.

Habituation and Sensitization

Animal model: Aplysia californica

Reflex behavior and cellular mechanisms

E. Kandel et al. Nobel prize

LTP in Hippocampus

Animal model: Rat slices

Long-Term Potentiation cellular mechanisms

NMDA / NO