Creating a new industryScientific Wellness

Determinants of Health in U.S.

60%

30%

10%

Genetics

Behavior & environment Health Care

Steven Schroeder et al. New England J Medicine, 2007

For every person in the US that the 10 highest grossing drugs do help (orange), they fail to improve the conditions of between 3 - 24 people (blue).

1) ABILIFY Schizophrenia

2) NEXIUM Heartburn

3) HUMIRA Arthritis

4) CRESTOR High cholesterol

5) CYMBALTA Depression

6) ADVAIR DISKUS Asthma

7) ENBREL Psoriasis

9) COPAXONE Multiple Sclerosis

8) REMICADE Crohn’s Disease

10) NEULASTA Neutropenia

Schork, Nicholas. Time for one-person trials. Nature. Vol 520. April 2015

Imprecision Medicine

Creating a new industryThe Innovators

6

Lee Hood, MD, PhDWorld renowned scientist, entrepreneur

2014: Creating a new industryTest the Concept – ISBInnovation meets execution

Millions of data points from each individual

Genome(1x)

Lab TestsBlood, saliva

(2x)

Gut Microbiome(1x)

Lifestyle / Quantified Self(Ongoing)

Genome(1x)

Lab TestsBlood, saliva (2x)

Gut Microbiome

(1x)

Lifestyle / Quantified

Self(Ongoing)

DISCOVERYData Integration & Correlations

2014 – Test the Concept

Build and test prototype to:

• Identify transitions

• Test efficacy of coaching

• Establish scientifically validated metrics for wellness

pic

What does wellness mean to you? Travel with my wife

Boost race performance

Avoid what dad died from

Play with my grandkids

Gain strength

I want to feel more confident

Enjoy the moment

Pursue my start-up dream

Lab work

Tracking

Genome

Microbiome

Coach

Dashboard

Community

ActionableRecs

2014 testWhat did we learn?

11

Nutritional Deficiencies

~90%

Transitions Identified (107 individuals)

Chronic Disease Risks

~70%Uncommon Diseases

~5%

BiomarkersMicrobiome

Quantified Self

GeneticsBiomarkers

Microbiome Quantified Self

Genetics BiomarkersMicrobiome

Quantified Self

Genetics

Improvements in labs with behavioral coaching

Cardiovascular Diabetes Inflammation Nutrition50%

55%

60%

65%

70%

75%

80%

85%

90%

95%

100%

Baseline3 months6 months

% ch

ange

in o

ut-o

f-ra

nge

mea

sure

men

ts

Improved by 33%

Improved by 6%

Improved by 12%

Improved by 21%

*29 participant on Statins

Personalized Coaching: OPTIMIZE WELLNESS

MeganAlicia Clayton

2015: Launching a new industry

Scientific Wellness

Innovation, execution and evangelism

Successful Company Launch July 2015

Arivale Business Model

Participant Engagement

• Individuals• Employers

Research Portal IP

Three Elements

1 2 3

Global Leaders Form Scientific Advisory Board

Frances Arnold, PhDCalifornia Institute of Technology

George Church, PhDHarvard Medical School

Jim Heath, PhDCalifornia Institute of Technology

Ed Lazowska, PhDUniversity of Washington

Larry Smarr, PhDUniversity of California, San Diego

Ralph Snyderman, MDDuke University

Bonnie Spring, PhDNorthwestern University

Lee Hood, MD, PhDInstitute for Systems Biology (chair)

Eric Topol, MDScripps Research Institute (uncompensated)

Gil Omenn, MD, PhDUniversity of Michigan

PartnersResearch Partnership• Founded by Leroy Hood, MD, PhD• Expertise in integrating and

modeling systems data• 135 scientists • 4th most impactful scientific

papers globally (SCImago, 2014)

Microbiome Sequencing• Pioneer in translating microbiome

science into novel therapeutics• Microbiome to Medicine initiative• Inflammatory Bowel Disease and

metabolic syndrome research

Metabolomics• Industry’s most comprehensive

metabolomics platform• Developed novel clinical

diagnostic tests for insulin resistance and impaired glucose tolerance

• More than 500 publications

Whole Genome Sequencing• 25 out of 32 FDA approved drugs

in 2014• 21 R&D Sites worldwide• World’s largest chemistry

organization• 100 drugs currently in

Phase I, II, or III

Genome Analysis Partnership• Developed by deCODE genetics• More than 350 publications• 40M validated variants from

350,000 whole genomes• 30X more data than the 1000

Genomes Project

Clinical Assays• World leaders in clinical assays• Serves 85% of physicians and

hospitals in the U.S• Operates thousands of patient

service centers

Proteomics• Innovators in cost-effective ELISA

panels for cardiovascular and inflammatory protein markers

• Partnered with Arivale and ISB for Hundred Person Wellness Project

2016: Launching a new industryScale the BusinessSales, Operations and ongoing innovation

Dashboard brings data to life

Goal: Increase the percent of pioneers who achieve their goals by tracking healthy habits and providing on-demand coaching

Arivale App: FROM BIOLOGICAL TO BEHAVIORAL TRACKING

From “Coach & Me” to “My Community & Me”

Mobile Experience Desktop Experience

Pioneer Engagement

Engaged Pioneers have completed a coaching call or assay in the past 60 days or have an upcoming call scheduled.

Assay Completion %

Blood Draw 1 98%

Blood Draw 2 89%

Blood Draw 3 93%

Other Assays (saliva, fitbit, microbiome) 80%

Total 90%

Arivale Age in Months

Percentage Engaged

1 100%2 100%3 100%4 95%5 95%6 93%7 94%8 93%9 87%

10 94%11 85%

Total 93%

26

Pioneer Satisfaction

Likely to recommend to a friend Satisfied with coaching experience Satisifed with overall experience70%

75%

80%

85%

90%

95%

100%

77%

83%

89%

85%

89%

93%

86%

91%

93%

72%

89%

82%

94%

90%

94%

79%

91%

84%

Pioneer Satisfaction 90-day

Jul 90-day Nov 90-day Jan 90-day Apr 90-day Sabey 90-day Intuit 90-day

Pioneer Attitudinal ResultsStatement

% of Pioneers @ baseline*

% of Pioneers @ Month 6+

% Change

“Overall, I feel my health is on the right track.” 62% 85% 23%

“I feel empowered to do the things I love in life.” 79% 84% 5%

“I feel rundown and don't have much energy.” 24% 9% -15%

“I feel like I've lost control of my life.” 7% 3% -4%

“Lately, I'm unable to concentrate, I lose focus.” 20% 9% -11%

“I'm satisfied with the way I'm living my life.” 58% 77% 19%

“I know how to live a healthy life.” 77% 95% 18%

• Percent who said they “Agree” or “Strongly Agree” with the statement.

Steve’s Success StoryMeasurementA1C

Insulin

Total Cholesterol

LDL-C

HDL-C

Triglycerides

CRP

Vitamin D

1st Blood Draw l 6.5

l 26

l 246

l 137

l 36

l 363

l 5.9

l 27

2nd Blood Draw l 5.9

l 12

l 197

l 115

l 49

l 165

l 3.2

l 37

Genes of Note• APOC3• PPARG• IL-6• AGT• TCF7L2• VDR (2 variants)

“My dad’s 97, I want to make it to 100. I think I have the genes, I know I have the right attitude, and now, with Arivale, I’ve got the plan.”

- Steve

Cindy’s Success StoryMeasurementInsulin

Vitamin D

LDL-C

LDL-P

Triglycerides

IL-8

Glutathione

1st Blood Draw l 16

l 36

l 114

l 1162

l 125

l 52.8

l 654

2nd Blood Draw l 13

l 47

l 91

l 1091

l 105

l 8.6

l 735

Genes of Note• APOC3• PPARG• VDR• GSTP1• IL-6• Lactose Intolerance

“I am down 12 pounds in 4 months and this is the best I’ve ever felt in my life”

- Cindy

The next chapterProvidence Health – Five PillarsEnterprise Program Expansion – Real World Evidence and ROIResearch Portal

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