LAMPIRAN PROBIT EMBRIO

Uji Normalitas

One-Sample Kolmogorov-Smirnov Test

Jam24Jam48Jam72Jam96

N15151515

Normal Parametersa,bMean39,333342,333347,000067,6667

Std. Deviation17,5119017,5119023,4368521,70144

Most Extreme DifferencesAbsolute,119,114,166,182

Positive,119,106,166,149

Negative-,094-,114-,100-,182

Kolmogorov-Smirnov Z,460,440,645,703

Asymp. Sig. (2-tailed),984,990,800,706

a. Test distribution is Normal.

b. Calculated from data.

Probit Analysis

Data Information

N of Cases

Valid60

RejectedOut of Rangea0

Missing0

Number of Responses > Number of Subjects0

Control Group0

Dosis438 mg12

578 mg12

763 mg12

1007 mg12

1328 mg12

a. Cases rejected because of out of range group values.

Convergence Information

Number of IterationsOptimal Solution Found

PROBIT15Yes

Parameter Estimates

ParameterEstimateStd. ErrorZSig.95% Confidence Interval

Lower BoundUpper Bound

PROBITaJam,011,00116,701,000,010,012

Interceptb438 mg-1,367,058-23,648,000-1,425-1,310

578 mg-1,002,055-18,316,000-1,056-,947

763 mg-,715,054-13,348,000-,768-,661

1007 mg-,372,053-7,019,000-,425-,319

1328 mg,103,0541,911,056,049,157

a. PROBIT model: PROBIT(p) = Intercept + BX

b. Corresponds to the grouping variable Dosis.

Chi-Square Tests

Chi-SquaredfbSig.

PROBITPearson Goodness-of-Fit Test246,18254,000a

Parallelism Test30,3234,000

a. Since the significance level is less than ,150, a heterogeneity factor is used in the calculation of confidence limits.

b. Statistics based on individual cases differ from statistics based on aggregated cases.

Cell Counts and Residuals

NumberDosisJamNumber of SubjectsObserved ResponsesExpected ResponsesResidualProbability

PROBIT1124,0001001513,4101,590,134

2148,0001001519,850-4,850,199

3172,0001001527,869-12,869,279

4196,0001004037,2032,797,372

5124,0001001513,4101,590,134

6148,0001002519,8505,150,199

7172,0001002527,869-2,869,279

8196,0001005537,20317,797,372

9124,0001001513,4101,590,134

10148,0001002019,850,150,199

11172,0001002027,869-7,869,279

12196,0001003537,203-2,203,372

13224,0001002522,9212,079,229

14248,0001002531,519-6,519,315

15272,0001002541,256-16,256,413

16296,0001004051,567-11,567,516

17224,0001004022,92117,079,229

18248,0001004031,5198,481,315

19272,0001004041,256-1,256,413

20296,0001005551,5673,433,516

21224,0001003022,9217,079,229

22248,0001003031,519-1,519,315

23272,0001003041,256-11,256,413

24296,0001006051,5678,433,516

25324,0001003532,4752,525,325

26348,0001004042,300-2,300,423

27372,0001004052,632-12,632,526

28396,0001005562,789-7,789,628

29324,0001005032,47517,525,325

30348,0001005042,3007,700,423

31372,0001005552,6322,368,526

32396,0001006562,7892,211,628

33324,0001003532,4752,525,325

34348,0001004042,300-2,300,423

35372,0001004052,632-12,632,526

36396,0001006562,7892,211,628

37424,0001004545,549-,549,455

38448,0001005555,900-,900,559

39472,0001005565,862-10,862,659

40496,0001009074,82315,177,748

41424,0001005545,5499,451,455

42448,0001005555,900-,900,559

43472,0001005565,862-10,862,659

44496,0001009074,82315,177,748

45424,0001004545,549-,549,455

46448,0001004555,900-10,900,559

47472,0001005565,862-10,862,659

48496,0001008074,8235,177,748

49524,0001005564,191-9,191,642

50548,0001006073,362-13,362,734

51572,0001009581,16713,833,812

52596,00010010087,37512,625,874

53524,0001007564,19110,809,642

54548,0001008073,3626,638,734

55572,0001008581,1673,833,812

56596,0001009587,3757,625,874

57524,0001005564,191-9,191,642

58548,0001005573,362-18,362,734

59572,0001007081,167-11,167,812

60596,0001009087,3752,625,874

Confidence Limits

DosisProbability95% Confidence Limits for Jam

EstimateLower BoundUpper Bound

PROBITa438 mg,010-88,429-144,073-54,221

,020-63,290-110,829-33,651

,030-47,340-89,848-20,488

,040-35,341-74,145-10,507

,050-25,581-61,438-2,321

,060-17,274-50,6814,704

,070-9,990-41,30310,919

,080-3,468-32,95816,534

,0902,463-25,41721,690

,1007,923-18,52426,485

,15030,5289,35746,993

,20048,49430,43664,372

,25063,90747,47580,327

,30077,74961,86295,570

,35090,57574,472110,415

,400102,74585,904125,036

,450114,52196,581139,566

,500126,109106,809154,145

,550137,698116,830168,931

,600149,473126,853184,114

,650161,644137,087199,934

,700174,470147,766216,711

,750188,312159,199234,907

,800203,725171,846255,254

,850221,691186,504279,054

,900244,296204,855309,092

,910249,756209,275316,360

,920255,687214,073324,259

,930262,209219,343332,950

,940269,493225,223342,661

,950277,800231,923353,744

,960287,560239,787366,773

,970299,559249,444382,800

,980315,509262,267404,121

,990340,648282,449437,754

578 mg,010-122,162-187,718-82,432

,020-97,022-154,254-62,081

,030-81,072-133,079-49,113

,040-69,074-117,189-39,319

,050-59,314-104,295-31,321

,060-51,006-93,347-24,486

,070-43,722-83,771-18,469

,080-37,201-75,221-13,059

,090-31,269-67,466-8,117

,100-25,809-60,348-3,547

,150-3,204-31,16315,657

,20014,762-8,45831,410

,25030,17510,45645,490

,30044,01626,78758,789

,35056,84241,19671,835

,40069,01354,13784,948

,45080,78865,98798,304

,50092,37777,088112,010

,550103,96687,747126,158

,600115,74198,235140,877

,650127,912108,810156,355

,700140,738119,745172,876

,750154,579131,372190,879

,800169,992144,169211,075

,850187,958158,945234,757

,900210,563177,392264,699

,910216,023181,830271,949

,920221,955186,644279,832

,930228,476191,931288,506

,940235,760197,827298,202

,950244,068204,543309,269

,960253,828212,422322,282

,970265,826222,096338,293

,980281,776234,935359,597

,990306,916255,135393,212

763 mg,010-148,628-222,510-104,109

,020-123,489-188,959-83,846

,030-107,539-167,709-70,953

,040-95,540-151,748-61,230

,050-85,780-138,783-53,301

,060-77,473-127,765-46,537

,070-70,189-118,118-40,592

,080-63,667-109,493-35,255

,090-57,735-101,662-30,390

,100-52,276-94,464-25,900

,150-29,671-64,817-7,159

,200-11,705-41,5067,989

,2503,708-21,79321,270

,30017,550-4,43133,537

,35030,37611,23845,324

,40042,54725,59057,025

,45054,32238,86968,952

,50065,91151,27681,353

,55077,49963,02594,411

,60089,27574,368108,275

,650101,44585,589123,106

,700114,27297,006139,146

,750128,113108,993156,788

,800143,526122,063176,711

,850161,492137,052200,181

,900184,097155,669229,953

,910189,557160,137237,172

,920195,488164,981245,025

,930202,010170,297253,670

,940209,294176,222263,337

,950217,601182,966274,376

,960227,361190,874287,360

,970239,360200,577303,342

,980255,310213,448324,615

,990280,450233,685358,192

1007 mg,010-180,228-264,078-129,877

,020-155,089-230,475-109,666

,030-139,139-209,180-96,817

,040-127,140-193,177-87,136

,050-117,380-180,172-79,248

,060-109,073-169,113-72,524

,070-101,789-159,425-66,620

,080-95,267-150,759-61,325

,090-89,336-142,884-56,503

,100-83,876-135,643-52,058

,150-61,271-105,745-33,566

,200-43,305-82,117-18,736

,250-27,892-61,986-5,873

,300-14,051-44,0695,839

,350-1,224-27,65916,885

,40010,946-12,32927,609

,45022,7222,19238,294

,50034,31016,08049,213

,55045,89929,45260,648

,60057,67442,41172,896

,65069,84555,09486,266

,70082,67167,728101,088

,75096,51380,673117,773

,800111,92694,473136,966

,850129,892110,017159,880

,900152,497129,064189,222

,910157,957133,607196,366

,920163,888138,524204,147

,930170,410143,910212,721

,940177,694149,904222,320

,950186,001156,716233,290

,960195,761164,692246,207

,970207,760174,464262,119

,980223,710187,409283,318

,990248,849207,734316,808

1328 mg,010-224,067-321,944-165,397

,020-198,928-288,313-145,214

,030-182,978-266,994-132,390

,040-170,979-250,967-122,732

,050-161,219-237,939-114,867

,060-152,912-226,857-108,166

,070-145,628-217,146-102,286

,080-139,106-208,456-97,015

,090-133,175-200,556-92,217

,100-127,715-193,289-87,797

,150-105,110-163,251-69,446

,200-87,144-139,451-54,788

,250-71,731-119,102-42,143

,300-57,889-100,903-30,713

,350-45,063-84,121-20,039

,400-32,893-68,293-9,813

,450-21,117-53,098,198

,500-9,529-38,29410,201

,5502,060-23,68820,401

,60013,835-9,11631,036

,65026,0065,56742,407

,70038,83220,50454,926

,75052,67435,87069,189

,80068,08751,97886,075

,85086,05369,518106,993

,900108,65890,176134,724

,910114,11894,998141,590

,920120,049100,181149,104

,930126,571105,822157,424

,940133,855112,061166,777

,950142,162119,111177,509

,960151,922127,321190,192

,970163,921137,327205,871

,980179,871150,514226,827

,990205,010171,114260,041

a. A heterogeneity factor is used.

Relative Median Potency Estimates

(I) Dosis(J) Dosis95% Confidence Limits

EstimateLower BoundUpper Bound

PROBIT1233,73211,75060,811

360,19936,38193,020

491,79963,716133,639

5135,63899,704191,951

21-33,732-60,811-11,750

326,4665,73051,110

458,06734,99689,797

5101,90672,143146,950

32-26,466-51,110-5,730

1-60,199-93,020-36,381

431,60010,69757,257

575,43949,611112,643

42-58,067-89,797-34,996

1-91,799-133,639-63,716

3-31,600-57,257-10,697

543,83921,14273,158

52-101,906-146,950-72,143

1-135,638-191,951-99,704

3-75,439-112,643-49,611

4-43,839-73,158-21,142

Uji NormalitasOne-Sample Kolmogorov-Smirnov Test

Dosis438mgDosis578mgDosis763mgDosis1007mgDosis1328mg

N1212121212

Normal Parametersa,bMean24,583336,666747,500060,416776,2500

Std. Deviation12,6954411,5470110,7661116,5774117,07271

Most Extreme DifferencesAbsolute,237,220,257,378,163

Positive,237,220,257,378,163

Negative-,225-,156-,123-,176-,123

Kolmogorov-Smirnov Z,821,761,8901,310,564

Asymp. Sig. (2-tailed),511,608,406,065,908

a. Test distribution is Normal.

b. Calculated from data.

Probit Analysis

Data Information

N of Cases

Valid60

RejectedOut of Rangea0

Missing0

Number of Responses > Number of Subjects0

Control Group0

Waktu24 jam15

48 jam15

72 jam15

96 jam15

a. Cases rejected because of out of range group values.

Convergence Information

Number of IterationsOptimal Solution Found

PROBIT13Yes

Parameter Estimates

ParameterEstimateStd. ErrorZSig.95% Confidence Interval

Lower BoundUpper Bound

PROBITaDosis,002,00028,188,000,001,002

Interceptb24 jam-1,620,059-27,374,000-1,679-1,560

48 jam-1,532,059-26,171,000-1,591-1,474

72 jam-1,397,058-24,186,000-1,455-1,339

96 jam-,788,055-14,206,000-,844-,733

a. PROBIT model: PROBIT(p) = Intercept + BX

b. Corresponds to the grouping variable Waktu.

Chi-Square Tests

Chi-SquaredfbSig.

PROBITPearson Goodness-of-Fit Test195,85955,000a

Parallelism Test32,9653,000

a. Since the significance level is less than ,150, a heterogeneity factor is used in the calculation of confidence limits.

b. Statistics based on individual cases differ from statistics based on aggregated cases.

Cell Counts and Residuals

NumberWaktuDosisNumber of SubjectsObserved ResponsesExpected ResponsesResidualProbability

PROBIT11438,0001001517,979-2,979,180

21578,0001002524,468,532,245

31763,0001003534,670,330,347

411007,0001004549,903-4,903,499

511328,0001005569,604-14,604,696

61438,0001001517,979-2,979,180

71578,0001004024,46815,532,245

81763,0001005034,67015,330,347

911007,0001005549,9035,097,499

1011328,0001007569,6045,396,696

111438,0001001517,979-2,979,180

121578,0001003024,4685,532,245

131763,0001003534,670,330,347

1411007,0001004549,903-4,903,499

1511328,0001005569,604-14,604,696

162438,0001001520,357-5,357,204

172578,0001002527,288-2,288,273

182763,0001004037,9402,060,379

1921007,0001005553,3781,622,534

2021328,0001006072,583-12,583,726

212438,0001002520,3574,643,204

222578,0001004027,28812,712,273

232763,0001005037,94012,060,379

2421007,0001005553,3781,622,534

2521328,0001008072,5837,417,726

262438,0001002020,357-,357,204

272578,0001003027,2882,712,273

282763,0001004037,9402,060,379

2921007,0001004553,378-8,378,534

3021328,0001005572,583-17,583,726

313438,0001001524,397-9,397,244

323578,0001002531,962-6,962,320

333763,0001004043,185-3,185,432

3431007,0001005558,713-3,713,587

3531328,0001009576,90318,097,769

363438,0001002524,397,603,244

373578,0001004031,9628,038,320

383763,0001005543,18511,815,432

3931007,0001005558,713-3,713,587

4031328,0001008576,9038,097,769

413438,0001002024,397-4,397,244

423578,0001003031,962-1,962,320

433763,0001004043,185-3,185,432

4431007,0001005558,713-3,713,587

4531328,0001007076,903-6,903,769

464438,0001004046,624-6,624,466

474578,0001004055,571-15,571,556

484763,0001005566,901-11,901,669

4941007,0001009079,64510,355,796

5041328,00010010091,0618,939,911

514438,0001005546,6248,376,466

524578,0001005555,571-,571,556

534763,0001006566,901-1,901,669

5441007,0001009079,64510,355,796

5541328,0001009591,0613,939,911

564438,0001003546,624-11,624,466

574578,0001006055,5714,429,556

584763,0001006566,901-1,901,669

5941007,0001008079,645,355,796

6041328,0001009091,061-1,061,911

Confidence Limits

WaktuProbability95% Confidence Limits for Dosis

EstimateLower BoundUpper Bound

PROBITa24 jam,010-440,149-657,543-269,965

,020-270,397-463,896-117,884

,030-162,694-341,376-21,051

,040-81,674-249,43552,019

,050-15,770-174,821111,629

,06040,325-111,455162,509

,07089,509-56,019207,244

,080133,547-6,494247,409

,090173,59838,447284,039

,100210,46579,721317,851

,150363,105249,436459,011

,200484,418382,572572,948

,250588,494495,134672,354

,300681,958594,597763,244

,350768,566685,172849,060

,400850,748769,575932,034

,450930,260849,7661013,783

,5001008,512927,3121095,609

,5501086,7641003,5951178,698

,6001166,2761079,9591264,274

,6501248,4581157,8431353,767

,7001335,0661238,9651449,036

,7501428,5301325,6161552,738

,8001532,6061421,2441669,077

,8501653,9191531,8331805,562

,9001806,5591669,9881978,282

,9101843,4261703,2282020,128

,9201883,4771739,2912065,636

,9301927,5151778,8922115,726

,9401976,6991823,0612171,728

,9502032,7941873,3672235,667

,9602098,6981932,3882310,870

,9702179,7182004,8392403,430

,9802287,4212100,9942526,628

,9902457,1732252,2552721,096

48 jam,010-494,456-717,927-319,819

,020-324,703-524,106-167,912

,030-217,001-401,443-71,222

,040-135,980-309,3721,718

,050-70,076-234,63361,203

,060-13,982-171,147111,962

,07035,202-115,592156,578

,08079,240-65,947196,625

,090119,292-20,888233,136

,100156,15920,506266,828

,150308,798190,845407,365

,200430,112324,663520,620

,250534,188437,969619,282

,300627,651538,228709,375

,350714,259629,633794,361

,400796,441714,869876,502

,450875,953795,866957,445

,500954,205874,1641038,519

,5501032,457951,1281120,927

,6001111,9691028,0921205,903

,6501194,1521106,4951294,877

,7001280,7591188,0621389,701

,7501374,2231275,0921493,024

,8001478,2991371,0431609,040

,8501599,6121481,9101745,247

,9001752,2521620,3101917,722

,9101789,1191653,5961959,522

,9201829,1701689,7052004,984

,9301873,2081729,3512055,029

,9401922,3921773,5662110,985

,9501978,4871823,9182174,878

,9602044,3911882,9862250,034

,9702125,4111955,4862342,545

,9802233,1142051,6952465,690

,9902402,8662203,0202660,093

72 jam,010-578,759-811,736-397,003

,020-409,007-617,744-245,267

,030-301,304-494,936-148,721

,040-220,284-402,730-75,916

,050-154,380-327,863-16,559

,060-98,285-264,24934,073

,070-49,101-208,56878,563

,080-5,063-158,797118,483

,09034,988-113,609154,866

,10071,855-72,086188,428

,150224,49598,946328,272

,200345,808233,547440,743

,250449,884347,743538,515

,300543,348448,999627,612

,350629,955541,493711,509

,400712,138627,884792,495

,450791,650710,062872,257

,500869,902789,526952,165

,550948,154867,6011033,463

,6001027,666945,5911117,412

,6501109,8481024,9201205,460

,7001196,4561107,3071299,464

,7501289,9191195,0581402,066

,8001393,9951291,6421517,449

,8501515,3091403,0681653,097

,9001667,9481541,9761825,064

,9101704,8161575,3611866,766

,9201744,8671611,5671912,130

,9301788,9051651,3111962,077

,9401838,0891695,6242017,934

,9501894,1831746,0782081,726

,9601960,0871805,2512156,777

,9702041,1081877,8632249,176

,9802148,8101974,1962372,196

,9902318,5632125,6752566,446

96 jam,010-957,901-1237,021-741,307

,020-788,148-1042,491-590,109

,030-680,446-919,235-494,011

,040-599,425-826,619-421,616

,050-533,521-751,360-362,651

,060-477,427-687,365-312,401

,070-428,243-631,305-268,290

,080-384,205-581,156-228,747

,090-344,153-535,589-192,744

,100-307,286-493,681-159,566

,150-154,647-320,624-21,748

,200-33,333-183,73788,438

,25070,743-66,915183,584

,300164,20637,370269,652

,350250,814133,345350,068

,400332,996223,690427,100

,450412,508310,287502,443

,500490,760394,584577,517

,550569,012477,817653,657

,600648,524561,164732,249

,650730,707645,900814,890

,700817,314733,593903,588

,750910,778826,4141001,120

,8001014,854927,7381111,764

,8501136,1671043,5331243,043

,9001288,8071186,4771410,974

,9101325,6741220,6401451,897

,9201365,7251257,6221496,486

,9301409,7631298,1401545,658

,9401458,9471343,2331600,737

,9501515,0421394,4771663,738

,9601580,9461454,4651737,974

,9701661,9661527,9361829,513

,9801769,6691625,2151951,588

,9901939,4211777,8422144,689

a. A heterogeneity factor is used.

Relative Median Potency Estimates

(I) Waktu(J) Waktu95% Confidence Limits

EstimateLower BoundUpper Bound

PROBIT1254,307-59,296170,267

3138,61024,694258,679

4517,752384,663673,486

21-54,307-170,26759,296

384,303-28,964201,367

4463,445334,483612,695

32-84,303-201,36728,964

1-138,610-258,679-24,694

4379,142255,194519,582

42-463,445-612,695-334,483

1-517,752-673,486-384,663

3-379,142-519,582-255,194