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RegisteredName: Hunter'sDakota

CallName: Dakota

RegistrationID: SR92827704

Microchip: 956000005644165

Breed: EnglishSpringerSpaniel

Gender: Male

Owner: DonHunter

Country: UnitedStates

Testingdate: 2018/6/11

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Hunter'sDakota,EnglishSpringerSpaniel

Testresults-Knowndisordersinthebreed

Disorder Type ModeofInheritance Result

AcralMutilationSyndrome,(AMS) NeurologicalDisorders

AutosomalRecessive Clear

Cone-RodDystrophy,(cord1-PRA/crd4) OcularDisorders AutosomalRecessive(IncompletePenetrance)

Clear

DegenerativeMyelopathy,(DM) NeurologicalDisorders

AutosomalRecessive(IncompletePenetrance)

Clear

HereditaryPhosphofructokinase(PFK)Deficiency BloodDisorders AutosomalRecessive Clear

QTSyndrome CardiacDisorders

AutosomalDominant Clear

X-LinkedTremors;mutationoriginallyfoundinEnglishSpringerSpaniel

NeurologicalDisorders

X-linkedRecessive Clear

JonasDonner,PhD,HeadofResearchandDevelopmentatGenoscoperLaboratories

OnbehalfofGenoscoperLaboratories,


Laboratories


CallName: Dakota


Microchip: 956000005644165


Gender: Male

Owner: DonHunter



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Testresults-Traits-page1

CoatTypeTrait Genotype Description

CoatLength l/l Thedogisgeneticallylong-haired.

Furnishings/ImproperCoatinPortugueseWaterDogs(markertest)

GG/CC Thedogisnotgeneticallylikelytoexpressfurnishings.

KRT71c.451C>T(p.Arg151Trp) C/C Thedogdoesnotcarryanycopiesofthetestedallelecausingcurlycoat.Thedogmostlikelyhasnon-curlyhair.

SGK3 I/I ThedogdoesnotcarrythetestedhairlessnessalleleoftheAmericanHairlessTerrier.




Laboratories


CallName: Dakota


Microchip: 956000005644165


Gender: Male

Owner: DonHunter



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CoatColorTrait Genotype Description

ColorLocusE-Extensions E/E ThedogislikelytoexpressthecoatcolordefinedbytheKandAloci.

ColorLocusB-Brown b/b Thedogislikelytohavebrowncoat.

ColorLocusK-DominantBlack KB/ky||kbr/ky||kbr/kbr

Thedogisgeneticallydominantblackorbrindle.

ColorLocusA-Agouti at/at Thedoghasgeneticallytanpointsorsaddletanpattern.

ColorLocusS-Piebaldorextremewhitespotting

sp/sp Thedogislikelytohavepiebaldspottingortobeextremewhite.

ColorLocusH-Harlequin h/h Thedogdoesn'thaveharlequinpattern.

Albinism(caL-allele) C/C Thisdogdoesnotcarrythetestedmutationforalbinism.

Merle(Mallele) m/m Thisdogisgeneticallynon-merleanddoesnotcarryaSILVgeneSINEinsertion.

SaddleTan(RALYgenedupl.) dup/dup ThedogmayhavetanpointsifithastanpointgenotypeattheAlocus.




Laboratories


CallName: Dakota


Microchip: 956000005644165


Gender: Male

Owner: DonHunter



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MorphologyTrait Genotype Description

BMP3c.1344C>A(p.Phe448Leu)

C/C Thedogdoesnotcarrythetestedalleletypicallyassociatedwithshortenedhead(brachycephaly).Thedogismorelikelytohaveanelongatedhead(dolichocephaly).

Tc.189C>G(p.Ile63Met)

C/C Thedogdoesnotcarrythetestedbobtail-causinggeneticvariant.Thedogismostlikelylong-tailed.

chr10:11072007 C/C Thedogcarriestwocopiesofanalleletypicallyassociatedwithfloppyears.Thedogismorelikelytohavefloppythanprickedears.




Laboratories


CallName: Dakota


Microchip: 956000005644165


Gender: Male

Owner: DonHunter



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BodySizeTrait Genotype Description

IGF1(chr15:41221438) G/G Thedogishomozygousfortheancestralalleletypicallyassociatedwithlargebodymass.

IGF1Rc.611G>A(p.Arg204His)

G/G Thedogcarriestwoancestralallelestypicallyfoundinlarger-sizedbreeds.

FGF4insertion D/D Thedogishomozygousfortheancientallele.Thedogislikelytohavelegsofnormallength.

STC2(chr4:39182836) T/T Thedoghastwocopiesoftheancestralalleleassociatedwithlargerbodysize.

Bodysize,GHR1genevariantE191K

G/G Thedoghastwocopiesoftheancestralalleleassociatedwithlargerbodysize.

GHR2(p.Pro177Leu) C/C Thedoghastwocopiesoftheancestralalleleassociatedwithlargerbodysize.

HMGA2 G/G Thedoghastwocopiesoftheancestralalleleassociatedwithlargerbodysize.




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Testresults-Additionaldisordersfoundinotherbreeds-page1

BloodDisorders-page1Disorder ModeofInheritance Result

BleedingdisorderduetoP2RY12defect AutosomalRecessive Clear

CanineCyclicNeutropenia,CyclicHematopoiesis,GreyCollieSyndrome,(CN)


CanineLeukocyteAdhesionDeficiency(CLAD),typeIII AutosomalRecessive Clear

CanineScottSyndrome,(CSS) AutosomalRecessive Clear

FactorIXDeficiencyorHemophiliaB;mutationGly379Glu X-linkedRecessive Clear

FactorIXDeficiencyorHemophiliaB;mutationoriginallyfoundinAiredaleTerrier


FactorIXDeficiencyorHemophiliaB;mutationoriginallyfoundinLhasaApso


FactorVIIDeficiency AutosomalRecessive Clear

FactorVIIIDeficiencyorHemophiliaA;mutationoriginallyfoundinBoxer X-linkedRecessive Clear

FactorVIIIDeficiencyorHemophiliaA;mutationoriginallyfoundinGermanShepherdDog


FactorVIIIDeficiencyorHemophiliaA;mutationoriginallyfoundinHavanese


FactorVIIIDeficiencyorHemophiliaA;mutationoriginallyfoundinOldEnglishSheepdog


FactorVIIIDeficiencyorHemophiliaA;p.Cys548TyrmutationoriginallyfoundinGermanShepherd


FactorXIDeficiency AutosomalDominant(IncompletePenetrance)

Clear

GlanzmannThrombastheniaTypeI,(GT);mutationoriginallyfoundinPyreneanMountainDog


GlanzmannThrombastheniaTypeI,(GT);mutationoriginallyfoundinmixedbreeddogs


HereditaryElliptocytosis Clear

Macrothrombocytopenia;disease-linkedvariantoriginallyfoundinNorfolkandCairnTerrier


May-HegglinAnomaly(MHA) AutosomalDominant Clear

PrekallikreinDeficiency AutosomalRecessive Clear

PyruvateKinaseDeficiency;mutationoriginallyfoundinBeagle AutosomalRecessive Clear


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BloodDisorders-page2Disorder ModeofInheritance Result

PyruvateKinaseDeficiency;mutationoriginallyfoundinPug AutosomalRecessive Clear

PyruvateKinaseDeficiency;mutationoriginallyfoundinWestHighlandWhiteTerrier


TrappedNeutrophilSyndrome,(TNS) AutosomalRecessive Clear

VonWillebrand'sDisease(vWD)Type1 AutosomalRecessive Clear

VonWillebrand'sDisease(vWD)Type3;mutationoriginallyfoundinKooikerhondje


VonWillebrand'sDisease(vWD)Type3;mutationoriginallyfoundinScottishTerrier


VonWillebrand'sDisease(vWD)Type3;mutationoriginallyfoundinShetlandSheepdog



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OcularDisorders-page1Disorder ModeofInheritance Result

CanineMultifocalRetinopathy1,(CMR1);mutationoriginallyfoundinMastiff-relatedbreeds


CanineMultifocalRetinopathy2,(CMR2);mutationoriginallyfoundinCotondeTulear


CanineMultifocalRetinopathy3,(CMR3);mutationoriginallyfoundinLapponianHerder


CollieEyeAnomaly,(CEA) AutosomalRecessive Clear

ConeDegeneration,(CD)orAchromatopsia;mutationoriginallyfoundinAlaskanMalamute


ConeDegeneration,(CD)orAchromatopsia;mutationoriginallyfoundinGermanShepherdDog


ConeDegeneration,(CD)orAchromatopsia;mutationoriginallyfoundinGermanShorthairedPointer


Cone-RodDystrophy1,(crd1);mutationoriginallyfoundinAmericanStaffordshireTerrier


Cone-RodDystrophy2,(crd2);mutationoriginallyfoundinAmericanPitBullTerrier


Cone-RodDystrophy,StandardWirehairedDachshund,(crdSWD) AutosomalRecessive Clear

CongenitalEyeDisease;mutationoriginallyfoundinIrishSoft-CoatedWheatenTerrier


DominantProgressiveRetinalAtrophy,(DPRA) AutosomalDominant Clear

GeneralizedProgressiveRetinalAtrophy AutosomalRecessive Clear

GoldenRetrieverProgressiveRetinalAtrophy1,(GR_PRA1) AutosomalRecessive Clear

PrimaryHereditaryCataract,(PHC);mutationoriginallyfoundinAustralianShepherd

AutosomalDominant(IncompletePenetrance)

Clear

PrimaryLensLuxation,(PLL) AutosomalRecessive Clear

PrimaryOpenAngleGlaucoma,(POAG);mutationoriginallyfoundinBassetFauvedeBretagne


PrimaryOpenAngleGlaucoma,(POAG);mutationoriginallyfoundinBeagle


PrimaryOpenAngleGlaucoma,(POAG);mutationoriginallyfoundinNorwegianElkhound


PrimaryOpenAngleGlaucoma,(POAG);mutationoriginallyfoundinPetitBassetGriffonVendeen


Primarylensluxation(PLL)andglaucoma;mutationoriginallyfoundinSharPei



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OcularDisorders-page2Disorder ModeofInheritance Result

ProgressiveRetinalAtrophyTypeIII,(PRAtypeIII);mutationoriginallyfoundinTibetanSpanielandTibetanTerrier


ProgressiveRetinalAtrophy,(CNGA1-PRA);mutationoriginallyfoundinShetlandSheepdog


ProgressiveRetinalAtrophy,(PAP1_PRA);mutationoriginallyfoundinPapillonandPhalene


ProgressiveRetinalAtrophy,(PRA);mutationoriginallyfoundinBasenji AutosomalRecessive Clear

ProgressiveRetinalAtrophy,(PRA);mutationoriginallyfoundinSwedishVallhund


ProgressiveRod-ConeDegeneration(PRCD) AutosomalRecessive Clear

Rod-ConeDysplasia1,(rcd1);mutationoriginallyfoundinIrishSetter AutosomalRecessive Clear

Rod-ConeDysplasia1a,(rdc1a);mutationoriginallyfoundinSloughi AutosomalRecessive Clear

Rod-ConeDysplasia3,(rcd3) AutosomalRecessive Clear

X-LinkedProgressiveRetinalAtrophy2,(XLPRA2) X-linkedRecessive Clear

CardiacDisordersDisorder ModeofInheritance Result

DilatedCardiomyopathy,(DCM);mutationoriginallyfoundinSchnauzer AutosomalRecessive Clear

EndocrineDisordersDisorder ModeofInheritance Result

CongenitalHypothyroidism;mutationoriginallyfoundinTenterfieldTerrier AutosomalRecessive Clear

CongenitalHypothyroidism;mutationoriginallyfoundinToyFoxandRatTerrier



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ImmunologicalDisordersDisorder ModeofInheritance Result

AutosomalRecessiveSevereCombinedImmunodeficiency,(ARSCID) AutosomalRecessive Clear

Complement3(C3)Deficiency AutosomalRecessive Clear

MyeloperoxidaseDeficiency AutosomalRecessive Clear

SevereCombinedImmunodeficiencyinFrisianWaterDogs,(SCID) AutosomalRecessive Clear

X-LinkedSevereCombinedImmunodeficiency(XSCID);mutationoriginallyfoundinBassetHound


X-LinkedSevereCombinedImmunodeficiency(XSCID);mutationoriginallyfoundinCardiganWelshCorgi



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RenalDisordersDisorder ModeofInheritance Result

CystinuriaTypeI-A;mutationoriginallyfoundinNewfoundlandDog AutosomalRecessive Clear

CystinuriaTypeII-A;mutationoriginallyfoundinAustralianCattleDog AutosomalDominant Clear

FanconiSyndrome AutosomalRecessive Clear

Hyperuricosuria,(HUU) AutosomalRecessive Clear

PolycysticKidneyDiseaseinBullTerriers,(BTPKD) AutosomalDominant Clear

PrimaryHyperoxaluria,(PH);mutationoriginallyfoundinCotondeTulear AutosomalRecessive Clear

ProteinLosingNephropathy,(PLN);NPHS1genevariant Clear

RenalCystadenocarcinomaandNodularDermatofibrosis,(RCND) AutosomalDominant Clear

X-LinkedHereditaryNephropathy,(XLHN) X-linkedRecessive Clear

X-LinkedHereditaryNephropathy,(XLHN);mutationoriginallyfoundinNavasotaDog


Xanthinuria,Type1a;mutationoriginallyfoundinmixedbreeddogs AutosomalRecessive Clear

Xanthinuria,Type2a;mutationoriginallyfoundinToyManchesterTerrier AutosomalRecessive Clear

Xanthinuria,Type2b;mutationoriginallyfoundinCavalierKingCharlesSpanielandEnglishCockerSpaniel



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MetabolicDisordersDisorder ModeofInheritance Result

GlycogenStorageDiseaseTypeIIorPompe'sDisease,(GSDII) AutosomalRecessive Clear

GlycogenStorageDiseaseTypeIIIa,(GSDIIIa) AutosomalRecessive Clear

GlycogenStorageDiseaseTypeIa,(GSDIa) AutosomalRecessive Clear

HypocatalasiaorAcatalasemia AutosomalRecessive Clear

IntestinalCobalaminMalabsorptionorImerslund-GräsbeckSyndrome,(IGS);mutationoriginallyfoundinBeagle


IntestinalCobalaminMalabsorptionorImerslund-GräsbeckSyndrome,(IGS);mutationoriginallyfoundinBorderCollie


MucopolysaccharidosisTypeIIIA,(MPSIIIA);mutationoriginallyfoundinDachshund


MucopolysaccharidosisTypeVII,(MPSVII);mutationoriginallyfoundinBrazilianTerrier


MucopolysaccharidosisTypeVII,(MPSVII);mutationoriginallyfoundinGermanShepherd


PyruvateDehydrogenasePhosphatase1(PDP1)Deficiency AutosomalRecessive Clear


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MuscularDisordersDisorder ModeofInheritance Result

CavalierKingCharlesSpanielMuscularDystrophy,(CKCS-MD) X-linkedRecessive Clear

CentronuclearMyopathy,(CNM);mutationoriginallyfoundinGreatDane AutosomalRecessive Clear

CentronuclearMyopathy,(CNM);mutationoriginallyfoundinLabradorRetriever


DuchenneorDystrophinMuscularDystrophy,(DMD);mutationoriginallyfoundinGoldenRetriever


DuchenneorDystrophinMuscularDystrophy,(DMD);mutationoriginallyfoundinNorfolkTerrier


MuscularDystrophy,Ullrich-type;mutationoriginallyfoundinLandseer AutosomalRecessive Clear

MuscularHypertrophy(DoubleMuscling) AutosomalRecessive Clear

MyotoniaCongenita;mutationoriginallyfoundinAustralianCattleDog AutosomalRecessive Clear

MyotubularMyopathy;mutationoriginallyfoundinRottweiler X-linkedRecessive Clear

NemalineMyopathy;mutationoriginallyfoundinAmericanBulldog AutosomalRecessive Clear

X-LinkedMyotubularMyopathy X-linkedRecessive Clear


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NeurologicalDisorders-page1Disorder ModeofInheritance Result

AlaskanHuskyEncephalopathy,(AHE) AutosomalRecessive Clear

AlexanderDisease(AxD);mutationoriginallyfoundinLabradorRetriever AutosomalDominant Clear

Bandera'sNeonatalAtaxia,(BNAt) AutosomalRecessive Clear

BenignFamilialJuvenileEpilepsyorRemittingFocalEpilepsy AutosomalRecessive Clear

CerebellarCorticalDegeneration,(CCD);mutationoriginallyfoundinVizsla


CerebralDysfunction;mutationoriginallyfoundinFriesianStabyhoun AutosomalRecessive Clear

Dandy-Walker-LikeMalformation(DWLM);mutationoriginallyfoundinEurasier


Early-OnsetProgressivePolyneuropathy;mutationoriginallyfoundinAlaskanMalamute


FetalOnsetNeuroaxonalDystrophy,(FNAD) AutosomalRecessive Clear

HereditaryAtaxiaorCerebellarAtaxia;mutationoriginallyfoundinOldEnglishSheepdogandGordonSetter


HyperekplexiaorStartleDisease AutosomalRecessive Clear

Hypomyelination;mutationoriginallyfoundinWeimaraner AutosomalRecessive Clear

JuvenileMyoclonicEpilepsy,(JME);mutationoriginallyfoundinRhodesianRidgeback


Juvenileencephalopathy;mutationoriginallyfoundinParsonRussellTerrier


L-2-Hydroxyglutaricaciduria,(L2HGA);mutationoriginallyfoundinStaffordshireBullTerrier


L-2-Hydroxyglutaricaciduria,(L2HGA);mutationoriginallyfoundinWestHighlandWhiteTerrier


LagottoStorageDisease,(LSD) AutosomalRecessive Clear

NeonatalCerebellarCorticalDegenerationorCerebellarAbiotrophy,(NCCD)


NeonatalEncephalopathywithSeizures,(NEWS) AutosomalRecessive Clear

NeuroaxonalDystrophy(NAD);mutationoriginallyfoundinSpanishWaterDog


NeuronalCeroidLipofuscinosis1,(NCL1);mutationoriginallyfoundinDachshund



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NeurologicalDisorders-page2Disorder ModeofInheritance Result

NeuronalCeroidLipofuscinosis10,(NCL10);mutationoriginallyfoundinAmericanBulldog


NeuronalCeroidLipofuscinosis8,(NCL8);mutationoriginallyfoundinAlpineDachsbracke


NeuronalCeroidLipofuscinosis8,(NCL8);mutationoriginallyfoundinAustralianShepherd


NeuronalCeroidLipofuscinosis8,(NCL8);mutationoriginallyfoundinEnglishSetter


NeuronalCeroidLipofuscinosis,(NCL7);mutationoriginallyfoundinChineseCrestedDogandChihuahua


Polyneuropathywithocularabnormalitiesandneuronalvacuolation,(POANV);mutationoriginallyfoundinBlackRussianTerrier


ProgressiveEarly-OnsetCerebellarAtaxia;mutationoriginallyfoundinFinnishHound


SensoryNeuropathy;mutationoriginallyfoundinBorderCollie AutosomalRecessive Clear

SpinalDysraphism AutosomalRecessive Clear

SpinocerebellarAtaxiawithMyokymiaand/orSeizures(SCA) AutosomalRecessive Clear

SpinocerebellarAtaxia/Late-OnsetAtaxia(SCA,LOA) AutosomalRecessive Clear

Spongydegenerationwithcerebellarataxia,(SDCA1);mutationoriginallyfoundinBelgianShepherdDog



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NeuromuscularDisordersDisorder ModeofInheritance Result

CongenitalMyasthenicSyndrome(CMS);mutationoriginallyfoundinLabradorRetriever


CongenitalMyasthenicSyndrome,(CMS);mutationoriginallyfoundinJackRussellTerrier


CongenitalMyasthenicSyndrome,(CMS);mutationoriginallyfoundinOldDanishPointingDog


EpisodicFalling,(EF) AutosomalRecessive Clear

Exercise-InducedCollapse,(EIC) AutosomalRecessive(IncompletePenetrance)

Clear

GM2Gangliosidosis,mutationoriginallyfoundinJapaneseChin AutosomalRecessive Clear

GM2Gangliosidosis;mutationoriginallyfoundinToyPoodle AutosomalRecessive Clear

GloboidCellLeukodystrophyorKrabbeDisease,(GLD);mutationoriginallyfoundinIrishSetter


GloboidCellLeukodystrophyorKrabbeDisease,(GLD);mutationoriginallyfoundinTerriers


ParoxysmalDyskinesia,(PxD);mutationoriginallyfoundinIrishSoftCoatedWheatenTerrier



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SkeletalDisordersDisorder ModeofInheritance Result

Chondrodysplasia;mutationoriginallyfoundinNorwegianElkhoundandKarelianBearDog


CleftPalate;CleftLipandPalatewithSyndactyly;ADAMTS20genemutationoriginallyfoundinNovaScotiaDuckTollingRetriever


CleftPalate;DLX6genemutationoriginallyfoundinNovaScotiaDuckTollingRetriever


CraniomandibularOsteopathy,(CMO);mutationassociatedwithterrierbreeds

AutosomalDominant(IncompletePenetrance)

Clear

HereditaryVitaminD-ResistantRickets,(HVDRR) AutosomalRecessive Clear

Osteochondrodysplasia;mutationoriginallyfoundinMiniaturePoodle AutosomalRecessive Clear

Osteochondromatosis;mutationoriginallyfoundinAmericanStaffordshireTerrier

AutosomalDominant Clear

OsteogenesisImperfecta,(OI);mutationoriginallyfoundinBeagle AutosomalDominant Clear

OsteogenesisImperfecta,(OI);mutationoriginallyfoundinDachshund AutosomalRecessive Clear

SkeletalDisease;mutationoriginallyfoundinKarelianBearDog AutosomalRecessive Clear

SkeletalDysplasia2,(SD2) AutosomalRecessive Clear

SpondylocostalDysostosis AutosomalRecessive Clear

VandenEnde-GuptaSyndrome,(VDEGS) AutosomalRecessive Clear


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DermalDisordersDisorder ModeofInheritance Result

DystrophicEpidermolysisBullosa;mutationoriginallyfoundinCentralAsianOvcharka


DystrophicEpidermolysisBullosa;mutationoriginallyfoundinGoldenRetriever


EpidermolyticHyperkeratosis AutosomalRecessive Clear

FocalNon-EpidermolyticPalmoplantarKeratoderma,(FNEPPK);mutationoriginallyfoundinDoguedeBordeaux


HereditaryFootpadHyperkeratosis,(HFH) AutosomalRecessive Clear

Ichthyosis;mutationoriginallyfoundinAmericanBulldog AutosomalRecessive Clear

Ichthyosis;mutationoriginallyfoundinGreatDane AutosomalRecessive Clear

LamellarIchthyosis,(LI) AutosomalRecessive Clear

LigneousMembranitis AutosomalRecessive Clear

Musladin-Luekesyndrome,(MLS) AutosomalRecessive Clear

X-LinkedEctodermalDysplasia,(XHED) X-linkedRecessive Clear

PharmacogeneticsDisorder ModeofInheritance Result

Multi-DrugResistance1,(MDR1)orIvermectinSensitivity AutosomalDominant Clear


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OtherDisordersDisorder ModeofInheritance Result

AcuteRespiratoryDistressSyndrome,(ARDS);mutationoriginallyfoundinDalmatian


AmelogenesisImperfecta,(AI) AutosomalRecessive Clear

CongenitalKeratoconjunctivitisSiccaandIchthyosiformDermatosis,(CKCSID)


DentalHypomineralization;mutationoriginallyfoundinBorderCollie AutosomalRecessive Clear

Narcolepsy;mutationoriginallyfoundinDachshund AutosomalRecessive Clear

Narcolepsy;mutationoriginallyfoundinLabradorRetriever AutosomalRecessive Clear

PersistentMüllerianDuctSyndrome,(PMDS);mutationoriginallyfoundinMiniatureSchnauzer


PrimaryCiliaryDyskinesia,(PCD) AutosomalRecessive Clear


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APPENDIXExplanationoftheresultsofthetesteddisorders

Autosomalrecessiveinheritance(ARI)

Clear-Adogcarriesnocopiesofthetestedmutationandhasnoorreducedlikelihoodofdevelopingandpassingonthedisease/condition.Carrier-Adogcarriesonecopyofthetestedmutation.Carrierstypicallyhaveanormal,healthyappearancebutpassonthemutationtoapproximately50%oftheiroffspring.Atrisk-Adogcarriestwocopiesofthetestedmutationandisathighorincreasedriskofdevelopingthedisease/condition.

Autosomaldominantinheritance(ADI)

Clear-Adogcarriesnocopiesofthetestedmutationandhasnoorreducedlikelihoodofdevelopingandpassingonthedisease/condition.Atrisk-Adogcarriesoneortwocopiesofthetestedmutationandisathighorincreasedriskofdevelopingthedisease/condition.

X-linkedrecessiveinheritance(X-linked)

Clear-Adogcarriesnocopiesofthetestedmutationandhasnoorreducedlikelihoodofdevelopingandpassingonthedisease/condition.Carrier-Femalecarrierstypicallyhaveanormal,healthyappearancebutcarryonecopyofthetestedmutationononeoftheirXchromosomes.AsmalesonlyhaveoneXchromosome,therearenomalecarriers.Atrisk-Femaledogsatriskcarrytwomutatedcopiesofthetestedmutation.MalescarryonecopyofthetestedmutationontheirsingleXchromosome.Dogsatriskareathighorincreasedriskofdevelopingthedisease/condition.

Pleasenotethatthedescriptionsabovearegeneralizedbasedontypicallyobservedinheritancepatterns.Whenobtaininga'carrier'or'atrisk'testresult,alwaysrefertothecorrespondingonlinetestdocumentationformoredetailedinformationontheconditionandanyexceptions.


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OPTIMALSELECTION™DNATESTTERMSANDCONDITIONS

OptimalSelection™GeneticBreedingAnalysisisaproprietaryprocessdesignedandintendedtobeusedonpurebreddogssolelyto1)Helpquantifythegeneticcompatibilityofpotentialbreedingpairsand2)ToidentifyspecificallelesorDNAmutationsthatareassociatedwithcertaininheriteddiseasesortraits.Nootherpurposeisauthorizedorpermitted.Itisnotintendedtodiagnosediseasesorpredictbehaviorinanyparticulardog.

Uponreceiptofyourdog’sDNAsample,WisdomHealthwillanalyzeyourdog’sDNAtodeterminechromosomalsimilaritiesanddifferencesinthegeneticprofileofapotentialsireanddamandprovideamatchanalysis.Yourdog’sDNAwillalsobeanalyzedforthepresenceofspecificallelesthatareassociatedwithinheritedconditionsidentifiedasoccurringinyourdog’sbreed.WisdomHealth'stestingproceduresaredesignedtoprovidereliableandaccurateresults,butarenotguaranteed.Bysubmittingyourdog’ssample(s)forOptimalSelection™analysisitisunderstoodthatyouagreethatthesample(s),analysis,resultsandrelatedinformationmaybeusedconfidentiallybyMarsinconjunctionwithothersamplestoincreasetheunderstandingofthebreed’sgeneticstructure,aswellasforinternal,researchanddevelopment,orstatisticalpurposesandmaybesharedwiththirdpartiesforthesepurposes.

SamplesmaybedisposedoforstoredatWisdomHealth’soptionandwillnotbereturned.PleaseviewthefullMarsPrivacyPolicyhere:http://www.mars.com/global/policies/privacy/pp-english.aspxItisalsounderstoodthatfuturereleasesoftheOptimalSelection™testmayrefineresultsasmoreinformationisobtainedregardingthebreedstructureand/orifnewgeneticmarkersareincluded.OptimalSelection™geneticassessmentsforindividualdogsandpotentialmateswillbeavailableonlinetotheperson(s)whoregisteredthesample.Adog’sresults,photoandotherinformationmaybesharedbytheownerwithotherindividualswhomtheychooseortransferredtoanewownerifthedogchangesownership.Thecontentofsuchonlineservices1)maybealteredduetochanges,additions,orremovalsofadog’sinformationintheOptimalSelection™databaseorduetochangesintechnicalorotherdesignofsuchservicesand2)includesinformationaboutthirdpartiesandotherWisdomHealthclients’dogs,whichWisdomHealthisnotresponsibleorliablefor.WisdomHealthhasrighttoterminateaccesstoonlineservicesoneyearfromthepurchasedate,unlessalongerperiodhasbeenagreedupon.

YouagreetoWisdomHealthinstructionsrelatedtoorderingprocess,payment,samplingandsampledelivery.Youalsocertifythattheanimaldescribedinyourorderisthesameanimalwhosesampleissubmittedforanalysis,andthatallinformationisaccurate.YouwarrantthatyouareentitledtoobtainandsupplysamplestoWisdomHealth.Intheunlikelyeventthatitisnotpossibletoprovideananalysis(forexampleduetoaninsufficientDNAsample)orthatanerrorintheanalysisoccurs,liabilitybyWisdomHealthorrelatedcompaniesandindividualsisdisclaimedanddamagesinanyeventarelimitedtothepaymentactuallyreceivedbyWisdomHealthforthespecifiedanalysisatissue.WisdomHealth’sstudyofthecomplexitiesofthecaninegenomeisongoingwiththegoalofcontinuingtoprovidethemostadvancedandcompleteanalysispossible.

WisdomHealthreservestherighttouseanythirdpartyofitschoicetoundertakethetesting,analysisorlaboratoryservicesfortheanalysis.

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