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John T. McDevitt 1 Rice University

JOHN T. MCDEVITT

Chair, Department Biomaterials New York University College of Dentistry

433 First Avenue, Room 820 New York, NY 10010-4086, USA

Email: [email protected] Phone: 212-998-9204; FAX: 212-995-4244

PROFESSIONAL APPOINTMENTS January 2015-present Chair, Department Biomaterials, New York University July 2009-present Brown-Weiss Professor of Bioengineering and Chemistry,

Rice University June 2010-present Founding Director, Gulf Coast Consortium Cluster: Early Disease

Detection (network of 100+ clinical researchers) July 2009-present Adjunct Professor of Chemistry & Biochemistry, UT Austin Sept. 2009-present Director, Oral Cancer Center (Grand Opportunities, NIDCR-NIH) Sept. 2008-June 2009 Adjunct Professor of Bioengineering and Chemistry, Rice U. Sept. 2006-present Director, Texas-Kentucky Salivary Diagnostics Consortium (NIH) Sept. 2005-present Adjunct Professor, University of Texas Medical Branch Sept. 2000-June 2009 Full Professor, University of Texas at Austin Inorganic, Analytical and Physical Chemistry Divisions Sept. 1995-Aug. 2000 Associate Professor, University of Texas at Austin Inorganic, Analytical and Physical Chemistry Divisions July 1989- Aug. 1995 Assistant Professor, University of Texas at Austin Inorganic, Analytical and Physical Chemistry Divisions EDUCATIONAL TRAINING INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY

California Polytechnic State Univ. B.S. 1982 Chemistry/Sensors Devices

Stanford University Ph.D. 1987 Physical/Materials Chemistry

University of North Carolina Post-doc 1987-89 Analytical/Materials

EXECUTIVE SUMMARY John T. McDevitt and his research team have pioneered the development of a universal platform sensor technology with capacity to digitize biological signatures for a broad range of essential health conditions. Following the successful development and clinical deployment of the programmable bio-nano-chip sensor system, the McDevitt laboratory is now focused on the study of human disease progression as well as wellness status monitoring using biological signatures extracted from these chip-based sensors. These lab-on-a-chip efforts are


distinguished by the high level of clinical validation achieved through involvement in 6 major clinical trials covering 10 clinical sites and over 5000 patients. These efforts encompassed basic research (185 publications), a broad base of Federal and Foundation support (exceeding $30M), strong intellectual property protection (145 patents and patent applications) and launching of three diagnostic companies (with > $42M in private funding). Recently, these efforts have resulted in one of the largest cytology database ever established for potentially malignant oral cancer lesions and have led to one of the largest cardiac biomarker studies ever completed. Over the past 15 years, McDevitt has led numerous large multisite international clinical studies involving the p-BNC technology, served as the Principal Investigator for U-01 Cooperative Research Programs (10+ years), Gates Award and Grand Opportunity efforts. SELECTED ACCOMPLISHMENTS, HONORS AND AWARDS • 2016 Wallace H. Coulter Lecturership Award, Highest Award from AACC • Nokia Sensing X Prize Finalist—Round 2 • Scientific Founder and Chief Scientific Officer for SensoDx, LLC. • Nokia Sensing X Prize Finalist—Round 1 • Outstanding New Faculty Member School of Engineering, Rice Alumni Association • Honored Alumnus Award, College of Science and Mathematics, California

Polytechnic State University • Stephen T. Sonis Visiting Professor Award, Brigham and Women’s Hospital • Popular Science Best of What's New Award in the Personal Health category • Scientific Founder for LabNow, Inc. (HIV immune test for resource poor settings) • Gates Award Grant Recipient (HIV monitoring for use in Africa) • Science Coalition Best Scientific Advances of the Year • Best Poster Award, Boston MRS meeting • Primary inventor of “Taste Chip Technology” • Presidential Young Investigator Award, U.T. Austin • Exxon Education Foundation Award, U.T. Austin • Grace Fellowship, Stanford University • Chemistry Dept. Research Award, California Polytechnic State University

UNIQUE EXPERTISE Leveraging strong foundations in nano science and engineering, microfabrication, microfluidics, biosensors, clinical chemistry and artificial intelligence, the McDevitt laboratory over the past 15 years has pioneered development of the programmable bio-nano-chip (p-BNC) sensor platform. This mini-detection ensemble with multiplexed and multi-class (cellular, genomic, proteomic) capabilities has been customized for cancer diagnostics, cardiovascular disease, saliva-based diagnostics, infectious diseases, drugs of abuse detection, and cell imaging systems including the development of ‘pathology on a chip’. Over the past 5 years, the McDevitt laboratory has secured in-depth experience with management and execution of international prospective clinical trials for the p-BNC that resulted in the collection of unique databases and defined first-in-kind disease-wellness signatures for oral cancer and cardiac disease progression. Machine


learning methods have been applied to extract accurate disease progression calculators which are now being validated clinically.


CLINICAL TRAIL SUMMARY

Study Sponsor Study Period

Disease Area

# of Participants

Number of Biomarkers

Development of a Lab-on-a-Chip System for Saliva-

Based Diagnostics

NIDCR- U-01

9/1/06 – 2/28/15

Cardiac Disease

1000 patients

17 proteins

Monitoring of Oral Cancer Patients Using Novel Lab-

on-a-Chip Ensembles

NIDCR-Grand

Opportunity

9/25/09 -

9/30/14

Oral Cancer

999 patients 7 cellular markers

Texas Cancer Diagnostics Pipeline Consortium: Oral

Cancer

CPRIT 9/1/10 - 2/28/16

Oral Cancer

2200 patients

7 cellular markers

Texas Cancer Diagnostics Pipeline Consortium:

Ovarian Cancer

CPRIT 9/1/10 - 2/28/16

Ovarian Cancer

1250 patients

4 proteins + >10 auto-antibodies

Texas Cancer Diagnostics Pipeline Consortium:

Prostate Cancer

CPRIT 9/1/10 - 2/28/16

Prostate Cancer

400 patients 3 proteins

Advanced Bio-nano-chips for Saliva Based Drug Test at Point of Arrest

UK: Home Office

9/1/09 - 3/31/13

Drugs of Abuse

240 participants

12 drugs or metabolites

SCIENTIFIC POSITIONS & ADVISORY BOARDS July 2014 – Present Board of Directors, Willis-Ekbom Disease Foundation May 2014– Present Founder and Chief Scientific Officer, SensoDx, LLC. January 2014 – Present Editorial Board Member, Advanced Health Care Technologies January 2013 – Present Editorial Board Member, Disease Markers, IOS Press, STM

Publishing House January 2013 Program Committee Member, Second Annual SLAS Conference

and Exhibition October 2012 – Present Member, Acute Kidney Injury Network March 2012 Ad Hoc NIDCR/NIH Study Section Member, Collaborative

Research on the Transition from Acute to Chronic Pain June 2012 NIH Special Emphasis / Scientific Review Group ZDE1 JR NIDCR June 2012 Working Group Member, NHLBI Onsite Tools and Technologies

for CV Research: Point-of-Care Working Group February 2012 – Present Editorial Board Member, International Journal of Biotechnology

& Biochemistry, Research India Publications January 2012 NIH Study Section Member, Bioengineering Models and

Technologies October 2011 NIH Special Emphasis / Scientific Review Group 2012 / 01

ZRG1 IMST-J


August 2011 NIH Special Emphasis / Scientific Review Group 2011 / 10 ZRG1 AARR-K (90) S

September 2011 - 2012 Protégé Member, (TAMEST) The Academy of Medicine, Engineering and Science of Texas

September 2011 - 2012 Faculty Representative, Rice 6D Initiative September 2011 - 2012 Bioengineering Representative, Provost Strategic Task Force September 2011-August 2012 Bioengineering Faculty Representative, Rice University

Corporate Foundation Committee September 2011-August 2012 Faculty Advisor, Rice’s Empowering Leadership Alliance September 2011 - 2012 Bioengineering Faculty Representative, Rice Center for

Engineering Leadership (RCEL) September 2011-August 2012 Member, Bioengineering Faculty Search Committee, Rice September 2011 - Present Member, Masters in Bioengineering Selection Committee, Rice August 2011 – August 2012 Research Committee Member, Rice University July 2011 – Present Editorial Board Member, International Journal of Molecular

Sciences June 2011 – June 2012 Executive Committee Member, Rice 360, Global Health Initiative November 2010-Present Editorial Board Member, Journal of Biosensors & Bioelectronics

Open Access, OMICS Publishing Group September 2010-2012 Mentor, Advance Triad Mentor Program, Rice University June 2010-June 2012 Editorial Board Member, Nano-Bio-Analysis, New World

Publishing International June 2010-2012 Study Section), NIH Instrumentation and Systems Development December 2009-Present Faculty Representative, Rice Institutional Safety Committee April 2009 NIST Panel on Chemical Science and Technology, Division on

Engineering and Physical Sciences, the National Academies. February 2009 Editorial Board Member, International Journal of Molecular

Sciences ‘Molecular Diagnostics’ section. September 2009 Advisory Board Member, Rice 360, Global Health Initiative. June 2007 NIH Study Session Member, NIH National Institute of Biomedical

Imaging and Bioengineering (NIBIB) panel to review Point-of-Care Technology Research Network (U54) applications.

September 2005 NIH Workshop Organizer, Improving Healthcare Accessibility Through Point-of-Care Technologies.

August 2005 NIH Study Session Member, Assays and Methods Development May 2005 – May 2010 Scientific Advisory Board Member, LabNow Corporation,

Austin, TX. January 2005 NIH Study Session Member, Assays and Methods Development July 2004 – July 2010 Chief Technologist, LabNow Corporation, Austin, TX. Technical

Advisor for sensor array applications. April 2001- Feb. 2003 Scientific Advisory Board, Constellation Technology

Corporation, Largo, FL. April 2000- June 2001 Chief Technology Consultant, Labnetics, Corp., Austin, TX.

Principal Technical Advisor for the multi-sensor array applications. December 2000 External Program Review Committee, Program in Materials

Science and Engineering at Louisiana State University. November 1995 Scientific Consultant, Westinghouse Bettis Atomic Power

Facility, West Muffin, PA. Technical Advisor for the development of superconductor applications.


1994-1998 Scientific Advisor. Acted as advisor to several companies including: Superconductive Components, Inc., Columbus, OH (development of superconductor targets); Quantum Magnetics, San Diego, CA (development of superconductor SQUID devices); Conductus, Inc., Sunnyvale, CA (development of superconductor devices); Microelectronics and Computer Consortium, Austin, TX (development of superconductor applications); 3M, Austin, (development of tape conductors).

CURRENT & RECENT RESEARCH SUPPORT Summary Over the past decade over $30M from Federal Funding and Foundation sources has been secured to support sensor-related work in the McDevitt Laboratory. Much of the current support is derived from major clinical trials that involve participation from 10 clinical sites and these efforts have resulted in the recruitment of over 5000 patients. Note that several of these active trials have been awarded increments and supplements with new award numbers. These individual increments are listed below as separate entries with the most recent increment listed first. 1. Title: “Texas Cancer Diagnostics Pipeline Consortium” Source of Support: Cancer Prevention & Research Institute of Texas Grant Number: RP140024 Total Award Amount: $3,912,225; Project Duration: 03/01/14 to 02/28/16 Principal Investigator: John T. McDevitt Scope: Continuation of the original CPRIT program with the goal to develop cost-effective cancer screening devices and diagnostic testing procedures through the adaptation of the bio-nano-chip platform with potential to move new cancer biomarker research into clinical practice. 2. Title: “Texas Cancer Diagnostics Pipeline Consortium” Source of Support: Cancer Prevention & Research Institute of Texas Grant Number: RP101382 Total Award Amount: $6,034,983; Project Duration: 08/01/10 to 02/28/14 Principal Investigator: John T. McDevitt Scope: With collaboration of experts in the fields of Gynecologic Oncology, Oral Medicine and Genitourinary Oncology the McDevitt group aims to develop cost-effective cancer screening devices and diagnostic testing procedures through the adaptation of the bio-nano-chip platform that will move new cancer biomarker research into clinical practice. 3. Title: “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics” Source of Support: National Institutes of Health; Supplement Award (U-01 Mechanism) Total Award Amount: $2,402,346; Project Duration: 08/30/12 to 02/28/15 Principal Investigator: John T. McDevitt Scope: Consistent with the most recent program data which suggests an increase of 300 patients is necessary to achieve the goal of adequate power for 7 marker panel with our current AMI rate, this supplement was granted to cover recruitment of 300 additional patients as well as the associated kits and salaries to cover the various biomarker measurements.


4. Title: “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics” Source of Support: National Institutes of Health; Administrative Supplement Award (U-01 Mechanism) Total Award Amount: $944,581; Project Duration: 09/23/11 to 02/28/12 Principal Investigator: John T. McDevitt Scope: This supplement was established to hire additional clinical coordinators to provide more coverage at study sites, thus increasing enrollment of subjects in the clinical trial being conducted at Baylor College of Medicine. The supplement also supported increase effort for current staff and additional supplies to accommodate an increase in the number of patients being enrolled for the current clinical trial. 5. Title: “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics” Source of Support: National Institutes of Health; Administrative Supplement Award (U-01 Mechanism) Total Award Amount: $1,060,432; Project Duration: 09/01/10 to 02/28/12 Principal Investigator: John T. McDevitt Scope: This Administrative Supplement focuses on optimizing the clinical study design by incorporating a few aspects which were not considered in the original proposal. These new program elements serve to create a higher impact effort that has the potential to have a significant impact on the treatment of US citizens for the number one cause of mortality, cardiac heart disease. 6. Title: “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics” Source of Support: National Institutes of Health; Administrative Supplement Award (U-01 Mechanism) Total Award Amount: $1,551,457; Project Duration: 09/01/09 to 08/31/11 Principal Investigator: John T. McDevitt Scope: This Administrative Supplement focuses specifically on the topic of biomarker validation which serves as the next critical step in the plans to complete the development of novel saliva-based diagostic aids. 7. Title: “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics” Source of Support: National Institutes of Health; Grant Number: 1U-01 DE017793-01 (U-01 Mechanism) Total Award Amount: $2,335,983; Project Duration: 09/01/06 to 07/31/10 Principal Investigator: John T. McDevitt Scope: The McDevitt group’s role for this joint program that spans 5 research groups is to develop new methods for measurement of saliva-based analytes using microfluidic devices. 8. Title: “Development of New Chip-Based Sensors for Monitoring of Oral Cancer” Source of Support: Renaissance Health Service Corporation (Delta Dental) Total Amount: $150,000 Project Duration: 5/1/13 to 6/30/14 Principal Investigator: John T. McDevitt Scope: The development of a minimally-invasive brush biopsy test for oral cancer diagnosis (no scalpel biopsy would be required) that when combined with a novel microchip can be performed in clinics or dentist’s offices with results that are available in a matter of minutes (within visit). These funds will be used to complete the validation phase of the ongoing clinical trial.


9. Project/Proposal Title: “Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles” Source of Support: National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering; Administrative Supplement Award Total Amount: $377,826 Project Duration: 8/01/12 to 9/30/13 Principal Investigator: John T. McDevitt Scope: This is the second Administrative Supplement that aims at completing the analysis of additional clinical samples expected from New York University. 10. Title: “Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles” Source of Support: National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering; Administrative Supplement Award Total Amount: $1,145,448 Project Duration: 8/01/11 to 7/31/12 Principal Investigator: John T. McDevitt Scope: This Administrative Supplement focuses on optimizing the study clinical design by adding two additional sites to this study, the University of Sheffield and New York University. 11. Title: “Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles” Source of Support: National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering Total Amount: $1,955,950 Project Duration: 9/25/09 to 8/31/11 Principal Investigator: John T. McDevitt Scope: The development of a minimally-invasive brush biopsy test for oral cancer diagnosis (no scalpel biopsy would be required) that when combined with a novel microchip can be performed in clinics or dentist’s offices with results that are available in a matter of minutes (within visit). 12. Title: “Texas Emerging Technology Fund (ETF): Pilot and Prospective Studies for the Development of the “Trauma Chip”: Use of Lab-on-a-Chip and Biomarkers of Trauma for the Diagnosis of Risk for Acute Renal Failure (ARF)” Source of Support: University of Texas Health Science Center - Houston Grant Number: PO #0000461732 Total Award Amount: $100,057; Project Duration: 08/04/11 to 08/31/15 Principal Investigator: John T. McDevitt Scope: The ultimate objective of this accelerated program is to investigate the potential of this lab-on-chip NBC technology to assess biomarker changes in urine composition of critically injured trauma patients as a tool for noninvasive identification of patients at risk for ARF. 13. Title: “A Bio-Nano-Chip for Salivary Anticonvulsant Drug Assay in Epilepsy Patients” Source of Support: John S. Dunn Research Foundation Total Amount: $98,463; Project Duration: 01/01/12 to 06/30/14 Principal Investigator: Giridhar P. Kalamangalam Scope: Through this program the bio-nano-chip will be adapted to a portable anticonvulsant assay system that utilizes patient salivary samples. The goal is to produce a device that that is suitable for frequent domiciliary use by patients themselves, so that potentially hazardous dips in antiepileptic drug concentrations are identified in advance and corrected by dosage adjustment. The program will target three commonly used AEDs: phenytoin, phenobarbital and levetiracetam. 14. Title: “Programmable Bio-Nano-Chips for Point of Care Diagnostics in Support of Flight”


Source of Support: Wyle Laboratories Inc. / NASA Grant Number: NAS 9-02078 Total Award Amount: $342,285; Project Duration: 09/06/12 to 04/30/14 Principal Investigator: John T. McDevitt Scope: Rather than relying on sample return and ground-based analysis, in-flight analysis will provide ‘point-of-care’ (POC) assessment of analytes of interest to the NASA biomedical research community. NASA has called for in-flight lab analysis technologies and specified a set of four high priority analytes targeted to demonstrate the technology, and an expanded set of high priority analytes targeted to assess extensibility of the technology for potential future solicitations. Within the scope is the requirement for the four research analytes to be measured concurrently (i.e. multiplexed test) and validated against a laboratory gold standard (i.e. ELISA, other comparable assay detection methods). 15. Title: “Integrated Omics Consortium” Source of Support: Baylor College of Medicine / Center for Advancement of Science in Space (CASIS) Grant Number: 101839713 Total Award Amount: $50,000; Project Duration: 05/07/13 to 05/07/2015 Principal Investigator: John T. McDevitt Scope: Through this program a Cardiac ScoreCard will be developed that functions with the companion p-BNC system to gather biomarker signatures from needle-stick quantities of blood and with this information quantifies the patient’s cardiovascular wellness status. The Cardiac ScoreCard will be used to quantify the user’s cardiovascular health from information embedded in biomarker signatures. SUBMITTED PROPOSALS 1. Title: “Programmable Bio-Nano-Chip Platform for Management of Oral Cancer on a Global Basis” UH2/UH3 Source of Support: National Institutes of Health/ National Institute of Dental and Craniofacial Research Total Amount: $3,997,245 Principal Investigator: John T. McDevitt Scope: The ultimate goal of this program is to adapt this now proven lab-based approach into scalable and modular instruments, cost-effective disposables and intuitive software modules that will be used for the screening of oral cancer in low and middle income countries. 2. Title: “Programmable Bio-Nano-Chip Technology Customized to Aid in the Diagnosis of Sports Related Concussion” Source of Support: NineSigma, Inc, National Football League (NFL) Total Award Amount: $1,499,723 Principal Investigator: John T. McDevitt Scope: This program will strive to develop portable new diagnostic solutions that can be used to assess in real time the potential injury that athletes may incur in events. 3. Title: “Lab on a chip method validation for cytome endpoint assessment in various cancers” Source of Support: National Institutes of Health


Total Award Amount: $1,203,316 Principal Investigator: John T. McDevitt Scope: Through this program we plan to transform the cytokinesis-blocked micronucleus assay (CBMN) for use as a cancer adjunctive screen to LDCT, and show that the method is amenable to the management of other malignancies including breast cancer and mammography. 4. Title: “Programmable Bio-Nano-Chip” Source of Support: X-Prize Foundation Total Amount: $120,000 Principal Investigator: John T. McDevitt Scope: The in development programmable bio-nano-chip (p-BNC) technology has matured to the point that is now serving as a tool for biomarker measurement and validation for a number of high impact clinical applications. The technology, if down-selected after an on-site demonstration, will also be subject to validation by the NASA selected analytical platforms to show feasibility for potential on-orbit demonstration aboard the ISS. 5. Title: “Evaluating Health Benefits Resulting from Reductions in Cocaine Use via a Customized Chip Based Cardiac Biomarker Profiling System” Source of Support: Baylor College of Medicine / National Institutes of Health Total Amount: $1,137,655 Principal Investigator: John T. McDevitt Scope: This study focuses on using the programmable Bio-Nano-Chip (p-BNC) technology and its enhanced analytical performance to elucidate cardiac biomarker profiles for the beneficial health outcomes associated with reduced levels of cocaine use. 6. Title: “Early Disease Detection through Distributed Diagnostic Devices (E5D)” Source of Support: National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering Total Amount: $8,352, 916 Principal Investigator: John T. McDevitt Scope: This Early Disease Detection through Distributed Diagnostic Devices (E5D) POCTRN will establish an infrastructure involving 5 core elements that will allow for testing of over 25 prototypes in 5 major healthcare environments, each tied to common theme of early disease detection. With oversight from the Gulf Coast Consortia, this E5D POCTRN will establish strategic partnerships to ensure standard operating procedures and testing protocols, clinical collaborations within the Texas Medical Center (world's largest medical complex), unmet clinical and user needs, market assessment and commercialization relationships, and move new POC technologies into widespread clinical practice. 7. Title: “Programmable Bio-Nano-Chip Technology for the Point-of-Care Assessment of Cardiac Toxicity in Breast Cancer Patients Receiving Treatment” Source of Support: John S. Dunn Research Foundation Total Amount: $100,000 Principal Investigator: John T. McDevitt Scope: This program targets the development of a portable and convenient test for promptly identifying cardiac problems in breast cancer patients that are receiving chemotherapy. Successful completion of this program will be a significant step toward the development of cost-


and diagnostically-effective technology that reduces the pain and suffering as well as helps increase the long-term survivability of breast cancer patients. 8. Title: “Lab on a Chip Cytokinesis-blocked MicroNucleus Cytome (LOC-CBMN) Assay Source of Support: Cancer Prevention & Research Institute of Texas Total Amount: $100,000 Principal Investigator: John T. McDevitt Scope: We propose to investigate the adaptation of the CBMN assay to a Lab-on-a-Chip (LOC) platform. We propose to adapt a LOC approach that has been demonstrated successfully with counting, identifying and differentiating cellular material through acquisition of both biomarker expression as well as cytomorphometric parameters. Here this method will be adapted to classify cells in the CBMN assay according to the number of nuclei using a fully automated image-processing algorithm measuring epi-fluorescence data. PAST RESEARCH SUPPORT Title: “Research in Chemistry and Biochemistry” Source of Support: LabNow Total Amount: $397,060; Project Duration: 02/07/05 to 02/07/08 Principal Investigator: John T. McDevitt Title: “Integrated Single Bead Chromatographic Separation and Detection for Metal Cation Detection” Source of Support: The Welch Foundation Total Amount: $150,000; Project Duration: 06/01/02 to 05/31/08 Principal Investigator: John T. McDevitt Title: “TI-3D grant” Source of Support: The Welch Foundation Total Amount: $50,000; Project Duration: 04/01/07 to 12/31/07 Principal Investigator: John T. McDevitt Title: “Saliva Analysis with an Array Sensor” Source of Support: National Institutes of Health Total Amount: $1,000,000 (McDevitt Portion); Project Duration: 01/01/03 to 12/31/07 Principal Investigator: Eric Anslyn Co-PI: John T. McDevitt Title: “Systems for Detecting Bioaerosols” Source of Support: US Army Research, Development and Engineering Command Total Amount: $750,000; Project Duration: 06/01/04 to 09/31/07 Principal Investigator: John T. McDevitt Title: “Development of Customized Chips for Early Detection of Emerging Infectious Diseases” Source of Support: Health Resources and Services Administration Total Amount: $396,000; Project Duration: 09/01/04 to 02/28/07 Principal Investigator: John T. McDevitt


Title: “Further Development of the UT Electronic Tongue” Source of Support: National Institutes of Health Total Amount: $355,000 (McDevitt Portion); Project Duration: 05/01/02 to 03/31/06 Principal Investigator: Eric Anslyn Co-PI: John T. McDevitt Title: “The Development of Multiplexed Arrays for the Assessment of Cardiac Risk Associated with the Use of Tobacco Products” Source of Support: Research Management Group Total Amount: $717,650; Project Duration: 09/01/02 to 08/31/05 Principal Investigator: John T. McDevitt Title: “Texas Consortium for the Development of Biological Sensors” Source of Support: Army Research Office, MURI Total Amount: $299,999 (McDevitt Portion); Project Duration: 05/01/02 to 04/30/05 Principal Investigator: A. Ellington; Co-PI: John T. McDevitt Title: “Center for the Design and Fabrication of Sensor Arrays” Source of Support: Beckman Foundation Technologies Initiative Total Amount: $312,500 (McDevitt Portion); Project Duration: 07/99 to 06/04 Principal Investigator: J. Shear; Co-PI: John T. McDevitt Title: “Micro-Array Based Neuropathology Studies” Source of Support: Texas Advanced Research Program Total Amount: $100,355; Project Duration: 01/01/02 to 12/31/04 Principal Investigator: John T. McDevitt Title: “Electronic Taste Chip, a Novel Method of Detection of Bioterrorism Agents” Source of Support: US Army Research, Development and Engineering Command, University of South Florida Collaboration Total Amount: $107,000 (McDevitt Portion); Project Duration: 10/01/02 to 09/31/04 Principal Investigator: John T. McDevitt (UT) Title: “Development of a Microarray for CTL Detection” Source of Support: National Institute of Health, Harvard Medical School – Massachusetts General Hospital Collaboration Total Amount: $110,000 (McDevitt Portion); Project Duration: 10/01/02 to 09/30/04 Principal Investigator: Bruce Walker, MD; Co-PI: John T. McDevitt Title: “Development of Smart Bio-triggers Detectors for Military Applications” Source of Support: Constellation Technology Corporation Subcontract award sponsored by Army SMDC Total Amount: $100,000 (McDevitt Portion); Project Duration: 06/01/02 to 12/31/03 Principal Investigator: John T. McDevitt (UT) Title: “A New Pathway for Multi-Disciplinary Graduate Education in Optical Molecular Bioengineering” Source of Support: National Science Foundation, IGERT (Integrative Graduate Education and Research Training Grant) Total Amount: $208,231 (McDevitt Portion); Project Duration: 10/01/98 to 09/30/03


Principal Investigator: R. Richards-Kortum; Co-PI: John T. McDevitt Title: “An Accelerated Program for the Development of Chip-based Bacteria and Spore Detectors” Source of Support: Siemens Corporation Total Amount: $226,500; Project Duration: 05/01/02 to 06/30/03 Principal Investigator: John T. McDevitt Title: “Development of Customized Chip-Based Detectors for Military Applications” Source of Support: Constellation Technology Corporation Subcontract award sponsored by Defense Threat Reduction Agency Total Amount: $250,000; Project Duration: 12/01/00 to 12/31/02 Principal Investigator: John T. McDevitt PUBLICATIONS: 2000 TO PRESENT (FROM 185 TOTAL) Below provided is a selected list of publications from the year 2000 to present. A comprehensive list of McDevitt group manuscripts may be found online at the following URL: http://mcdevitt.rice.edu/Publications/. About 5 years ago the McDevitt laboratory initiated the launching of a series of clinical trials that involved 3 years of patient recruitment and a couple of years of chip-based measurements. As is typical for trials of this type, the main findings can’t be communicated until all clinical results for all patients are recorded. In just the last few months, several of these trials have reached maturity and the first series of publications have been released. Some of these recent clinical trial findings are included in the below listings for the year 2014. 185. J.L. Ebersole, C. Campbell, John McDevitt, and C.S. Miller, “Serum and Salivary Analyte

Levels and Oral Health in Metabolic Syndrome,” Journal of Periodontal Research, 2014, to be submitted.

184. John T. McDevitt, “A Programmable Bio-Nano-Chip-based Point-of-Care Test for

Measurement of Free, Complexed and Total Prostate Specific Antigen,” Clinica Chimica Acta, 2014, Submitted.

183. McRae, M.P., Bozkurt, B., Ballantyne, C.M., Christodoulides, N., Simmons, G., Nambi,

V., Miller, C.S., Ebersole, J.L., & McDevitt, J.T., “Cardiac ScoreCard: A Diagnostic Multivariate Index Assay System for Predicting Multiple Cardiovascular Disease Progression Levels,” Expert Systems with Applications, 2014, Submitted.

182. S. Speight, T. Abram, P. Floriano, R. James, M. Thornhill, K.R. Alexander, N.

Vigneswaran, S. Redding, S. McGuff, C. Murdoch, J. Phelan, J.T. McDevitt, “Inter-observer Error in Dysplasia Grading: Towards an Enhanced Gold Standard for Clinical Pathology Trials,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2014, Submitted.


181. G.W. Simmons, M. McRae, N. Christodoulides, J. Hayes, R. Mehalso, P. V. Ruijven and J.T. McDevitt, “Programmable Bio-Nano-Chip System: An Ultra-Flexible Platform for Bioscience and Clinical Measurements,” MicroTas2014, 2014, Submitted.

180. Jie Chou, Eliona Kulla, Glennon Simmons, Rushi Patel, Pierre N. Floriano, Nicolaos Christodoulides, John T. McDevitt, “Enhancement of Performance in Bead-Based Microarrays: Effects of a Chip Geometry on Bioagent Capture,” Lab on a Chip, 2014, Submitted.

179. Basil H. Shadfan, Archana Simmons, Glennon W. Simmons, Andy Ho, Jorge Wong,

Karen H. Lu, Robert C. Bast Jr., John T. McDevitt, “A Multiplexable, microfluidic, platform for the rapid quantitation of a biomarker panel for early ovarian cancer detection at the Point of Care”, Cancer Prevention Research, 2014, Accepted.

178. C. S. Miller, J. D. Foley, P. N. Floriano, N. Christodoulides, J. L. Ebersole, C. L.

Campbell, A. L. Bailey, B. G. Rose, D. F. Kinane, M. J. Novak, J. T. McDevitt, X. Ding, R. J. Kryscio, "Utility of Salivary Biomarkers for Predicting Acute Myocardial Infarction", Journal of Dental Research, 2014, Submitted.

177. I.M. Thompson, J. Hernandez, R.J. Leach, S. Bock, J. Hoefler, Z. Feng, J. Kagan, N.

Christodoulides, A. Haque, J.T. McDevitt, T. Huang, D. Ankerst, “PSA and Prostate Cancer Early Detection: Targeting Detection of Consequential Prostate Cancers”, 2013, Submitted.

176. L. P. Grazett, D. Paltoo, J. T. McDevitt, S. Sia, P. Barrett, F. Apple, P. Gurbel, R.

Weissleder, H. Leeds, E. Iturriaga, A. Rao, B. Adhikari, P. Desvigne-Nickens, Z. Galis, P. Libby, "Onsite Tools and Technologies for Clinical Cardiovascular Research and Point-of-Care: National Heart, Lung, and Blood Institute (NHLBI) Working Group", Journal of the American College of Cardiology, 2013, Submitted.

175. A. Raamanathan, G. W. Simmons, N. Christodoulides, P. N. Floriano, W. B. Furmaga, S.

P. Redding, K. H. Lu, R. C. Bast, J. T. McDevitt, "Programmable Bio-Nano-Chip Systems for Serum Ca125 Quantification: Towards Ovarian Cancer Diagnostics at the Point-of-Care", Cancer Prevention Research, 2012, 5, 706. DOI: 10.1158/1940-6207.CAPR-11-0508.

174. J. T. McDevitt, "Bio-Nano-Chip Devices May Open up New Oral Diagnostics

Opportunities", International Journal of Experimental Dental Science, 2012, 2, iv. 173. A. R. Kerr, M. H. Thornhill, K. D'Apice, C. Murdoch, P. Speight, S. Hegarty, S. W.

Redding, N. Vigneswaran, N. Christodoulides, P. N. Floriano, J. T. McDevitt, "Non-Invasive Lab-on-a-Chip Characterization of Potentially Malignant Oral Disorders", Oral Diseases, 2012, 18, 4.

172. J. D. Foley, J. D. Sneed, S. R. Steinhubl, J. R. Kolasa, J. L. Ebersole, Y. Lin, R. J.

Kryscio, J. T. McDevitt, C. L. Campbell, C. S. Miller, "Oral Fluids That Detect Cardiovascular Disease Biomarkers", Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2012, 2, 2017-14. DOI: 10.1016/j.oooo.2012.05.024.


171. J. D. Foley, J. D. Sneed, S. R. Steinhubl, J. R. Kolasa, J. L. Ebersole, Y. Lin, R. J.

Kryscio, J. T. McDevitt, C. L. Campbell, C. S. Miller, "Salivary Biomarker Associated with Myocardial Necrosis: Results from an Alcohol Septal Ablation Model", The Journal of the American Dental Association, 2012, 114, 616-623. DOI: 10.1016/j.oooo.2012.05.024.

170. N. Christodoulides, P. N. Floriano, X. Sanchez, L. Li, K. Hocquard, A. Patton, R.

Muldoon, C. S. Miller, J. L. Ebersole, S. Redding, C. Yeh, W. Furmaga, B. Bozkurt, C. Ballantyne, J. T. McDevitt, "Programmable Bio-Nano-Chip Technology for the Diagnosis of Cardiovascular Disease at the Point-of-Care", Methodist DeBakey Cardiovascular Journal, 2012, 8, 6.

169. N. Christodoulides, P. N. Floriano, J. T. McDevitt, "Innovative Programmable Bio-Nano-

Chip (p-BNC) Technology: Bridging the Gap between Biomarker Discovery and Clinical Implementation", IEEE Transactions on Biomedical Engineering, 2012, Submitted.

168. J. Chou, J. Wong, N. Christodoulides, P. N. Floriano, G. W. Simmons, X. Sanchez, J. T.

McDevitt, "Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare", Sensors, 2012, 12, 15467-15499. DOI:10.3390/s121115467.

167. J. Chou, L. Li, N. Christodoulides, P. N. Floriano, J. T. McDevitt, "Effects of Sample

Delivery on Analyte Capture in Porous Bead Sensors", Lab on a Chip, 2012, 12, 5249-5256. DOI: 10.1039/c2lc40752c.

166. J. Chou, A. Lennart, J. Wong, M. F. Ali, P. N. Floriano, N. Christodoulides, J. T.

McDevitt, "Modeling Analyte Transport and Capture in Porous Bead Sensors", Analytical Chemistry, 2012, 84, 2569 - 2575. DOI: 10/1021/ac2022822.

165. J. Chou, N. Du, T. Ou, P. N. Floriano, N. Christodoulides, J. T. McDevitt, "Hot Embossed Polyethylene through-Hole Chips for Bead-Based Microfluidic Devices", Biosensors and Bioelectronics, 2012, 12, 662-8. DOI: 10.1016/j.bios.2012.09.056. 164. A. Raamanathan, N. Christodoulides, G. Simmons, P. N. Floriano, W. Furmaga, S.

Redding, K. H. Lu, R. C. Bast, and J. T. McDevitt, "Bio-Nano-Chip Immunosensor for Serum CA125 Quantification: Towards Ovarian Cancer Diagnostics at the Point-of-Care", Lab on a Chip, 2011, Submitted.

163. J. T. McDevitt, S. E. Weigum, P. N. Floriano, N. Christodoulides, S. Redding, C. Yeh, H.

S. McGuff, SPIE Newsroom, March 28th, 2011. DOI: 10.1117/2.1201102.003547. 162. J. V. Jokerst, J. Chou, J. P. Camp, J. Wong, A. Lennart, A. Pollard, P. N. Floriano, N.

Christodoulides, G. Simmons, Y. Zhou, M. Ali, J. T. McDevitt, "Location of Biomarkers and Reagents within Agarose Beads of a Programmable Nano-Bio-Chip", Small, 2011, 7, 613-624. DOI: 10.1002/smll.201002089.

161. W. V. Giannobile, J. T. McDevitt, R. S. Niedbala, D. Malamud, "Translation and Clinical

Applications of Salivary Diagnostics", Advances in Dental Research, 2011, 23, 375-380. DOI: 10.1177/0022034511420434.


160. E. Fu, P. Yager, P. N. Floriano, N. Christodoulides, J. T. McDevitt, "Perspective on Diagnostics for Global Health", IEEE Pulse, 2011, 2, 40-50. DOI: 10.1109/MPUL.2011.942766.

159. N. Du, J. Chou, E. Kulla, P. N. Floriano, N. Christodoulides, J. T. McDevitt, "A

Disposable Bio-Nano-Chip Using Agarose Beads for High Performance Immunoassays", Biosensors & Bioelectronics, 2011, 28, 251-256. DOI: 10.1016/j.bios.2011.07.027.

158 N. Christodoulides, P. N. Floriano, J. T. McDevitt, "Programmable Bio-Nano-Chip

Systems: Tools for Affordable Healthcare", Texas CEO Magazine, 2011, July / August 2011, 42-46.

157. M. F. Ali, J. Chou, P. N. Floriano, N. Christodoulides, J. T. McDevitt, "Modular Nucleic

Acid Sensors: Incorporation of Molecular Beacon Probes within the Programmable Bio-Nano-Chip System", Biosensors and Bioelectronics, 2011, Submitted.

156. C. Yeh, N. Christodoulides, P. N. Floriano, C. S. Miller, J. L. Ebersole, S. E. Weigum, J.

T. McDevitt, S. Redding, "Current Development of Saliva/Oral Fluid-Based Diagnostics", Texas Dental Journal, 2010, 651-661.

155. J. Wong, M. F. Ali, J. T. McDevitt, "Multifunctional and Multicompartment Bead

Ensembles for Integrated Lab-on-a-Chip Sensor Applications", Journal of the American Chemical Society, 2010, submitted.

154. S. E. Weigum, P. N. Floriano, S. W. Redding, C. K. Yeh, S. D. Westbrook, H. S. McGuff,

A. Lin, F. R. Miller, F. Villarreal, S. D. Rowan, N. Vigneswaran, M. D. Williams, J. T. McDevitt, "Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology", Cancer Prevention Research, 2010, 3, 518-528. DOI: 10.1158/1940-6207.capr-09-0139.

153. C. S. Miller, J. D. Foley, A. L. Bailey, C. L. Campell, R. L. Humphries, N. Christodoulides,

P. N. Floriano, G. Simmons, B. Bhagwandin, J. W. Jacobson, S. W. Redding, J. L. Ebersole, J. T. McDevitt, "Current Developments in Salivary Diagnostics", Biomarkers in Medicine, 2010, 4, 171-189. DOI: 10.2217/bmm.09.68.

152. J. V. Jokerst, J. T. McDevitt, "Programmable Nano-Bio-Chips: Multifunctional Clinical

Tools for Use at the Point-of-Care", Nanomedicine, 2010, 5, 143-155. DOI: 10.2217/nnm.09.94.

151. J. V. Jokerst, J. W. Jacobson, B. D. Bhagwandin, P. N. Floriano, N. Christodoulides, J.

T. McDevitt, "Programmable Nano-Bio-Chip Sensors: Analytical Meets Clinical", Analytical Chemistry, 2010, 82, 1571-1579. DOI: 10.1021/ac901743u.

150. J. V. Jokerst, J. P. Camp, J. Wong, L. A., A. Pollard, P. N. Floriano, N. C.

Christodoulides, G. W. Simmons, J. Zhou, M. F. Ali, J. T. McDevitt, "Nano-Scale Control of Sensing Elements in Programmable Nano-Bio-Chips", Small, 2011, X, 1–12.

149. M. F. Ali, J. T. McDevitt, "Molecular Beacon Encoded Beads in Tandem with an

Integrated Fluidics System", Nucleic Acids Research, 2010, Submitted.


148. S. E. Weigum, S. W. Redding, C. Yeh, H. S. McGuff, N. Vigneswaran, J. T. McDevitt, "Lab-on-a-Chip Sensor for Analysis of Cellular Biomarkers in Oral Exfoliative Cytology: A New Diagnostic Tool for Early Detection of Oral Cancer", Oral Oncology, 2009, 111-111. DOI: 10.1016/j.oos.2009.06.251.

147. J. V. Jokerst, A. Raamanathan, N. Christodoulides, P. N. Floriano, A. A. Pollard, G. W.

Simmons, J. Wong, C. Gage, W. B. Furmaga, S. W. Redding, J. T. McDevitt, "Nano-Bio-Chips for High Performance Multiplexed Protein Detection: Determinations of Cancer Biomarkers in Serum and Saliva Using Quantum Dot Bioconjugate Labels", Biosensors & Bioelectronics, 2009, 24, 3622-3629. DOI: 10.1016/j.bios.2009.05.026.

146. J. V. Jokerst, B. Bhagwandin, J. W. Jacobson, J. T. McDevitt, "Clinical Applications of a

Programmable Nano-Bio-Chip", Lab on a Chip, 2009, 24-27. 145. P. N. Floriano, N. Christodoulides, C. S. Miller, J. L. Ebersole, J. Spertus, B. G. Rose, D.

F. Kinane, M. J. Novak, S. Steinhubl, S. Acosta, S. Mohanty, P. Dharshan, C. K. Yeh, S. Redding, W. Furmaga, J. T. McDevitt, "Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study", Clinical Chemistry, 2009, 55, 1530-1538. DOI: 10.1373/clinchem.2008.117713.

144. P. J. Melfi, S. Camiolo, J. T. Lee, M. F. Ali, J. T. McDevitt, V. M. Lynch, J. L. Sessler,

"Immobilization of a Hexaphyrin(1.0.1.0.0.0) Derivative onto a Tentagel-Amino Resin and Its Use in Uranyl Cation Detection", Dalton Transactions, 2008, 1538-1540. DOI: 10.1039/b718627d.

143. E. Kousvelari, J. T. McDevitt, D. Malamud, D. Wong, D. Walt, "Saliva-Based Diagnostic

Technologies: Highlights of the Nidcr's Program", Saliva Diagnostics, 2008. 142. J. V. Jokerst, P. N. Floriano, N. Christodoulides, G. W. Simmons, J. T. McDevitt,

"Integration of Semiconductor Quantum Dots into Nano-Bio-Chip Systems for Enumeration of Cd4+T Cell Counts at the Point-of-Need", Lab on a Chip, 2008, 8, 2079-2090. DOI: 10.1039/b817116e.

141. A. T. Wright, N. Y. Edwards, E. V. Anslyn, J. T. McDevitt, "The Discriminatory Power of

Differential Receptor Arrays Is Improved by Prescreening - a Demonstration in the Analysis of Tachykinins and Similar Peptides", Angewandte Chemie-International Edition, 2007, 46, 8212-8215. DOI: 10.1002/anie.200701236.

140. S. E. Weigum, P. N. Floriano, N. Christodoulides, J. T. McDevitt, "Cell-Based Sensor for

Analysis of Egfr Biomarker Expression in Oral Cancer", Lab on a Chip, 2007, 7, 995-1003. DOI: 10.1039/b703918b.

139. S. B. Schougaard, N. Reitzel, T. Bjornholm, K. Kjaer, T. R. Jensen, O. E. Shmakova, R.

Colorado, T. R. Lee, J. H. Choi, J. T. Markert, D. Derro, A. de Lozanne, J. T. McDevitt, "Direct Imaging by Atomic Force Microscopy of Surface-Localized Self-Assembled Monolayers on a Cuprate Superconductor and Surface X-Ray Scattering Analysis of Analogous Monolayers on the Surface of Water", Thin Solid Films, 2007, 515, 8424-8429. DOI: 10.1016/j.tsf.007.04.034.


138. C. P. Price, L. J. Kricka, P. G. Biondich, J. Bishop, S. Boppart, P. F. Brennan, E. Brewer, M. Carroll, G. L. Cote, M. Dailey, M. I. Descour, R. T. Domeier, P. D'Orazio, K. Ehmann, R. O. Esenaliev, S. R. Feinglass, M. Follen, H. Francis, R. M. Gardner, A. Heller, J. Hickner, C. Krause, I. Lauks, C. Macaulay, J. T. McDevitt, B. Palcic, A. Pinkos, D. S. Prough, D. S. Puskin, J. Ralston, R. L. Rardin, R. Richards-Kortum, J. Starren, K. E. Thomemius, T. Tkaczyk, A. Watson, T. C. Wright, "Improving Healthcare Accessibility through Point-of-Care Technologies", Clinical Chemistry, 2007, 53, 1665-1675. DOI: 10.1373/clinchem.2006.084707.

137. P. N. Floriano, S. Acosta, N. Christodoulides, S. E. Weigum, J. T. McDevitt, "Microchip-

Based Enumeration of Human White Blood Cells", Microchip-Based Assay Systems, Methods and Applications, Methods in Molecular Biology (Humana Press), 2007, 385, 53-64. DOI: 10.1007/978-1-59745-426-1.

136. N. Y. Edwards, T. W. Sager, J. T. McDevitt, E. V. Anslyn, "Boronic Acid Based Peptidic

Receptors for Pattern-Based Saccharide Sensing in Neutral Aqueous Media, an Application in Real-Life Samples", Journal of the American Chemical Society, 2007, 129, 13575-13583. DOI: 10.1021/ja073939u.

135. N. Christodoulides, P. N. Floriano, C. S. Miller, J. L. Ebersole, S. Mohanty, P. Dharshan,

M. Griffin, A. Lennart, K. L. M. Ballard, C. P. King, M. C. Langub, R. J. Kryscio, M. V. Thomas, J. T. McDevitt, "Lab-on-a-Chip Methods for Point-of-Care Measurements of Salivary Biomarkers of Periodontitis", Oral-Based Diagnostics, 2007, 1098, 411-428. DOI: 10.1196/annals.1384.035.

134. N. Christodoulides, P. Dharshan, J. Wong, P. N. Floriano, D. Neikirk, J. T. McDevitt, "A

Microchip-Based Assay for Interleukin-6", Microchip-Based Assay Systems, Methods and Applications, Methods in Molecular Biology (Humana Press), 2007, 385, 131-144. DOI: 10.1007/978-1-59745-426-1_10.

133. S. F. Li, D. Y. Fozdar, M. F. Ali, H. Li, D. B. Shao, D. M. Vykoukal, J. Vykoukal, P. N.

Floriano, M. Olsen, J. T. McDevitt, P. R. C. Gascoyne, S. C. Chen, "A Continuous-Flow Polymerase Chain Reaction Microchip with Regional Velocity Control", Journal of Microelectromechanical Systems, 2006, 15, 223-236. DOI: 10.1109/ jmems.2005.859083.

132. A. T. Wright, M. J. Griffin, Z. L. Zhong, S. C. McCleskey, E. V. Anslyn, J. T. McDevitt,

"Differential Receptors Create Patterns That Distinguish Various Proteins", Angewandte Chemie-International Edition, 2005, 44, 6375-6378. DOI: 10.1002/anie.200501137.

131. A. T. Wright, E. V. Anslyn, J. T. McDevitt, "A Differential Array of Metalated Synthetic

Receptors for the Analysis of Tripeptide Mixtures", Journal of the American Chemical Society, 2005, 127, 17405-17411. DOI: 10.1021/ja055696g.

130. Y. S. Sohn, A. Goodey, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk, "A

Microbead Array Chemical Sensor Using Capillary-Based Sample Introduction: Toward the Development of An "Electronic Tongue"", Biosensors & Bioelectronics, 2005, 21, 303-312. DOI: 10.1016/j.bios.2004.08.050.


129. W. R. Rodriguez, N. Christodoulides, P. N. Floriano, S. Graham, S. Mohanty, M. Dixon, M. Hsiang, T. Peter, S. Zavahir, I. Thior, D. Romanovicz, B. Bernard, A. P. Goodey, B. D. Walker, J. T. McDevitt, "A Microchip CD4 Counting Method for Hiv Monitoring in Resource-Poor Settings", PLOS Medicine, 2005, 2, 663-672. DOI: e18210.1371/journal.pmed.0020182.

128. A. C. Pavel, D. K. Romanovicz, M. J. Yacaman, J. T. McDevitt, "Preparation of Polymer-

Covered Metal Nanorods and Metal Microcrystals by Intrinsic Two-Dimensional Crystalline Lattice Templating", Journal of Materials Research, 2005, 20, 3034-3046. DOI: 10.1557/jmr.2005.0377.

127. S. F. Li, P. N. Floriano, N. Christodoulides, D. Y. Fozdar, D. B. Shao, M. F. Ali, P.

Dharshan, S. Mohanty, D. Neikirk, J. T. McDevitt, S. C. Chen, "Disposable Polydimethylsiloxane/Silicon Hybrid Chips for Protein Detection", Biosensors & Bioelectronics, 2005, 21, 574-580. DOI: 10.1016/j.bios.2004.12.010.

126. S. Kim, I. S. Chang, J. T. McDevitt, "Self-Assembled Monolayer Cleaning Methods:

Towards Fabrication of Clean High-Temperature Superconductor Nanostructures", Applied Physics Letters, 2005, 86. DOI: 15410410.1063/1.1899753.

125. P. N. Floriano, N. Christodoulides, D. Romanovicz, B. Bernard, G. W. Simmons, M.

Cavell, J. T. McDevitt, "Membrane-Based on-Line Optical Analysis System for Rapid Detection of Bacteria and Spores", Biosensors & Bioelectronics, 2005, 20, 2079-2088. DOI: 10.1016/j.bios.2004.08.046.

124. N. Christodoulides, S. Mohanty, C. S. Miller, M. C. Langub, P. N. Floriano, P. Dharshan,

M. F. Ali, B. Bernard, D. Romanovicz, E. Anslyn, P. C. Fox, J. T. McDevitt, "Application of Microchip Assay System for the Measurement of C-Reactive Protein in Human Saliva", Lab on a Chip, 2005, 5, 261-269. DOI: 10.1039/b414194f.

123. N. Christodoulides, P. N. Floriano, S. A. Acosta, K. L. M. Ballard, S. E. Weigum, S.

Mohanty, P. Dharshan, D. Romanovicz, J. T. McDevitt, "Toward the Development of a Lab-on-a-Chip Dual-Function Leukocyte and C-Reactive Protein Analysis Method for the Assessment of Inflammation and Cardiac Risk", Clinical Chemistry, 2005, 51, 2391-2395. DOI: 10.1373/clinchem.2005.054882.

122. Y. S. Sohn, A. Goodey, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk, "A

Micromachined Fluidic Structure for Capillary-Based Sample Introduction into a Microbead Array Chemical Sensor", Sensor Letters, 2004, 2, 69-72. 10.1166/sl.2004.027

121. S. B. Schougaard, M. F. Ali, J. T. McDevitt, "Evidence for High Stability against Water

Corrosion of NdBa2Cu3O7 +/-Delta Relative to YBa2Cu3O7-Delta and EuBa2Cu3O7-Delta", Applied Physics Letters, 2004, 84, 1144-1146. DOI: 10.1063/1.1641529.

120. W. R. Rodriguez, N. Christodoulides, P. N. Floriano, S. Graham, S. Mohanty, M. Dixon,

M. Hsiang, T. Peter, S. Zavahir, I. Thior, D. Romanovicz, B. Bernard, A. P. Goodey, B. D. Walker, J. T. McDevitt, "A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings: Featured in Monitoring Treatment: At What Cost", Science, 2004, 304.


119. S. Li, D. Fozdar, S. Chen, P. N. Floriano, N. Christodoulides, M. F. Ali, P. Darshan, J. T.

McDevitt, "Disposable Polydimethylsiloxane/Silicon Hybrid Chips for Protein Detection", American Institute of Physics, IMECE, 2004, 1-5.

118. R. Kirby, E. J. Cho, B. Gehrke, T. Bayer, Y. S. Park, D. P. Neikirk, J. T. McDevitt, A. D.

Ellington, "Aptamer-Based Sensor Arrays for the Detection and Quantitation of Proteins", Analytical Chemistry, 2004, 76, 4066-4075. DOI: 10.1021/ac049858n.

117. S. L. Wiskur, P. N. Floriano, E. V. Anslyn, J. T. McDevitt, "A Multicomponent Sensing

Ensemble in Solution: Differentiation between Structurally Similar Analytes", Angewandte Chemie-International Edition, 2003, 42, 2070-2072. DOI: 10.1002/anie.200351058.

116. S. C. McCleskey, M. J. Griffin, S. E. Schneider, J. T. McDevitt, E. V. Anslyn, "Differential

Receptors Create Patterns Diagnostic for ATP and GTP", Journal of the American Chemical Society, 2003, 125, 1114-1115. DOI: 10.1021/ja021230b.

115. S. C. McCleskey, P. N. Floriano, S. L. Wiskur, E. V. Anslyn, J. T. McDevitt, "Citrate and

Calcium Determination in Flavored Vodkas Using Artificial Neural Networks", Tetrahedron, 2003, 59, 10089-10092. DOI: 10.1016/j.tet.2003.10.021.

114. A. P. Goodey, J. T. McDevitt, "Multishell Microspheres with Integrated Chromatographic

and Detection Layers for Use in Array Sensors", Journal of the American Chemical Society, 2003, 125, 2870-2871. DOI: 10.1021/ja029696h.

113. M. F. Ali, R. Kirby, A. P. Goodey, M. D. Rodriguez, A. D. Ellington, D. P. Neikirk, J. T.

McDevitt, "DNA Hybridization and Discrimination of Single-Nucleotide Mismatches Using Chip-Based Microbead Arrays", Analytical Chemistry, 2003, 75, 4732-4739. DOI: 10.1021/ac034106z.

112. S. L. Wiskur, A. Metzger, J. J. Lavigne, S. E. Schneider, E. V. Anslyn, J. T. McDevitt, D.

Neikirk, J. B. Shear, "Mimicking the Mammalian Sense of Taste through Single-Component and Multicomponent Analyte Sensors", Chemistry of Taste: Mechanisms, Behaviors, and Mimics, 2002, 825, 276-288. DOI: 10.1021/bk-2002-0825.ch021.

111. G. Roy, J. T. McDevitt, "In Vitro Taste Sensors: Technology and Applications", Chemistry

of Taste: Mechanisms, Behaviors, and Mimics, 2002, 825, 262-275. DOI: 10.1021/bk-2002-0825.ch020.

110. N. Christodoulides, M. Tran, P. N. Floriano, M. Rodriguez, A. Goodey, M. Ali, D. Neikirk,

J. T. McDevitt, "A Microchip-Based Multianalyte Assay System for the Assessment of Cardiac Risk", Analytical Chemistry, 2002, 74, 3030-3036. DOI: 10.1021/ac011150a.

109. Y. S. Sohn, A. P. Goodey, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk,

"Development of Micromachined Fluidic Structure for a Biological and Chemical Sensor Array", Kluwer Academic Publisher, 2001, 177-178.


108. A. Goodey, J. J. Lavigne, S. M. Savoy, M. D. Rodriguez, T. Curey, A. Tsao, G. Simmons, J. Wright, S. J. Yoo, Y. Sohn, E. V. Anslyn, J. B. Shear, D. P. Neikirk, J. T. McDevitt, "Development of Multianalyte Sensor Arrays Composed of Chemically Derivatized Polymeric Microspheres Localized in Micromachined Cavities", Journal of the American Chemical Society, 2001, 123, 2559-2570. DOI: 10.1021/ja0033411.

107. T. E. Curey, A. Goodey, A. Tsao, J. Lavigne, Y. Sohn, J. T. McDevitt, E. V. Anslyn, D.

Neikirk, J. B. Shear, "Characterization of Multicomponent Monosaccharide Solutions Using an Enzyme-Based Sensor Array", Analytical Biochemistry, 2001, 293, 178-184. DOI: 10.1006/abio.2001.5114.

106. H. Q. Yin, J. S. Zhou, R. Dass, J. P. Zhou, J. T. McDevitt, J. B. Goodenough, "Grain-

Boundary Room-Temperature Low-Field Magnetoresistance in Sr2FeMoO6 Films", Journal of Applied Physics, 2000, 87, 6761-6763. DOI: 10.1063/1.372833.

105. Y. S. Sohn, A. Tsao, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk, "Liquid Flow

through an Array-Based Chemical Sensing System", SPIE International Society for Optical Engineering, 2000, 4177, 212-219.

104. N. Reitzel, D. R. Greve, K. Kjaer, P. B. Hows, M. Jayaraman, S. Savoy, R. D.

McCullough, J. T. McDevitt, T. Bjornholm, "Self-Assembly of Conjugated Polymers at the Air/Water Interface. Structure and Properties of Langmuir and Langmuir-Blodgett Films of Amphiphilic Regioregular Polythiophenes", Journal of the American Chemical Society, 2000, 122, 5788-5800. DOI: 10.1021/ja9924501.

SELECTED INVITED PRESENTATIONS: 2005 TO PRESENT (FROM 250 TOTAL) 250. “Cardiac ScoreCard: A Step Past the Framingham Risk Score”, X Prize Facility in Los

Angeles, CA, November 5, 2014 (Nokia Sensing XChallenge Finalist Presentation). 249. “Programmable Bio-Nano-Chip Sensors: A Commercial Platform to Digitize Biology”,

Commercialization of Micro-nano Systems Conference (COMS) and nanoUtah Conference, Salt Lake City, October 15, 2014 (Plenary Lecture).

248. “The Programmable Bio-Nano-Chip System: A Platform to Digitize Biology,”

Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX, September 24, 2014.

247. “Programmable Bio-Nano-Chips Customized for Cardiac and Cancer Diagnostic

Applications,” International Society for Optics and Photonics, Rice University, Houston, TX, May 19-20, 2014.

246. “Programmable Bio-Nano-Chip System for Saliva Diagnostics”, Sensing Technologies

for Global Health, Military Medicine, and Environmental Monitoring IV, Baltimore, MD, May 5, 2014.


245. "Programmable Bio-Nano-Chips Customized for Affordable Healthcare and Wellness Applications”, Global Health Innovation Conference, Yale University, New Haven, CT, April 12-13, 2014.

244. “mHealth, the Wireless Future of Cardiovascular Medicine: a Transdisciplinary

Perspective”, Clinical and Translational Science Institute, University of California, Los Angeles, March 06, 2014.

243. “Programmable Bio-Nano-Chips Customized Major Diseases,” Texas Life Sciences,

Rice University BioScience Research Collaborative, Houston, TX, February 20, 2014. 242. “Point of Care Analysis of Prostate and Ovarian Cancer”, NCI-NIBIB Point of Care

Technologies for Cancer Conference, NIH Campus, Bethesda, MD, January 8, 2014. 241. “Bio-Nano-Chip Technologies for Point of Care Testing of Drugs and Metabolites”,

Plenary Speaker, 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Grand America Hotel, Salt Lake City, UT, September 23, 2013.

240. Faculty Mentor and Session Leader for the Summer of 2013 Institute on Mobile

Technology Research to Enhance Health, University of California, Los Angeles, August 26-30, 2013.

239. “Programmable Bio-Nano-Chip Systems for Serum CA125 Quantification”, 7th Annual

Enabling Point-of-Care Diagnostics Conference, Hyatt Regency Washington on Capitol Hill, Washington, D.C., August 20-21, 2013.

238. “Programmable Bio-Nano-Chips as a Platform to Facilitate Toxicology Studies”,

Advanced Models of Imaging-based Screening Conference, BioScience Research Collaborative, Houston, TX, May 13-14, 2013.

237. “Programmable Bio-Nano-Chip Sensors Customized for Cardiac Applications”, Baylor

College of Medicine Cardiovascular Research Institute, McMillian Auditorium at Baylor College of Medicine, Houston, TX May 1, 2013.

236. “Update on a Lab-on-a-Chip System for Saliva Diagnostics: Link to Oral Cancer”, SPIE

Defense, Security, and Sensing Symposium 2013, Baltimore Convention Center, Baltimore, Maryland, April 29- May 1, 2013.

235. “Update on Cell Based Assessment of Oral Cancer”, American Academy of Oral

Medicine Meeting, Hyatt Regency, San Antonio, TX, April 26, 2013. 234. “Programmable Bio-Nano-Chip Sensors Case Sector #1: Cellular Processing Units”,

Class - Bioprocess Engineering/Cell Biology for Engineer, Instructor – Kimberly Anderson, Ph.D., University of Kentucky, April 8, 2013.

233. “The Story Behind the Programmable Bio-Nano-Chip”, 8th Annual CCTS Spring

Conference, Lexington Convention Center, Lexington, KY, April 8, 2013.


232. “The Programmable Bio-Nano-Chip: A Fully Automated Platform that Bridges from Biomarker Discovery to Clinical Application”, Session Chair – Advances in Near Patient Testing Devices, 2nd Annual SLAS Conference and Exhibition: SLAS 2013, Gaylord Palms Resort and Convention Center, Orlando, FL, January 12-16, 2013.

231. “The Programmable Bio-Nano-Chip: Next Generation Tools for Global Health

Applications”, IEEE EMBS Micro and Nanotechnology in Medicine Conference, Westin Maui Resort, Hawaii, December 2-6, 2012.

230. “Lab-on-a-Chip Sensors Technologies”, Keynote Speaker, 11th Annual Transatlantic

Science Week, Rice University – BRC, Houston, TX, November 15, 2012. 229. “Programmable Bio-Nano-Chip Sensors: Bridging the Gaps in Healthcare”, Plenary

Lecture, ASME 2012 International Mechanical Engineering Congress & Exposition, Hilton Americas, Houston, TX, November 12, 2012.

228. “The Texas Cancer Diagnostics Pipeline”, CPRIT Innovations In Cancer Prevention and

Research Conference, Renaissance Hotel, Austin, TX October 24, 2012. 227. “Bio-Nano-Chip Technology for Biomarker Assessment in Heart Failure”, 16th Annual

Scientific Meeting of the Heart Failure Society of America, Washington State Convention and Trade Center, Seattle, WA, September 12, 2012.

226. “The Programmable Bio-Nano-Chip System: Analytical meets Clinical”, BioMedical

Technology Club, Rotary House International, Houston, TX, September 4, 2012. 225. “Building the Cancer Diagnostics Pipeline One Biomarker at a Time”, Biomarker World

Congress, Loews Philadelphia Hotel, Philadelphia, PA, May 22, 2012. 224. “Building the Biomarker Highway”, 28th Southern Biomedical Engineering Conference,

MD Anderson, Mid Campus 1 Building (1MC), 3rd Floor Conference Center, Houston, TX, May 4-6, 2012.

223. “Building the Biomarker Highway”, Center for Computational and Integrative Biomedical

Research (CIBR) Short Talk Series, CIBR M423, Houston, TX, February 22, 2012. 222. “The Programmable Bio-Nano-Chip: A Fully Automated Platform that Bridges from

Biomarker Discovery to Clinical Application”, First Annual SLAS Conference and Exhibition, San Diego Convention Center, San Diego, CA, February 6, 2012.

221. “Building the Biomarker Highway: A Pathway to Affordable Healthcare”, Rice

Engineering Alumni Fall Meeting & Faculty Lecture, Saint Arnold Brewery, Houston, TX, December 6, 2011.

220. CPRIT Foundation - Breakthrough Roundtable Meeting and Dinner (Panel Member),

Austin Convention Center, Austin, TX, November 14, 2011.


219. “Scientific Discoveries Improving Healthcare”, International Year of Chemistry Lecture Series – Panel Discussion, Houston Museum of Natural Science, Houston, TX, November 1, 2011.

218. “Building the Texas Cancer Diagnostics Pipeline One Biomarker at a Time”, American

Association For Cancer Research Conference - Frontiers in Cancer Prevention Research, Boston Convention and Exhibition Center, Boston, MA, October 23, 2011.

217. “Building the Biomarker Highway: A Pathway to Affordable Healthcare”, Keck Seminar,

Bioscience Research Collaborative, Rice University, Houston, TX, October 21, 2011. 216. “Building the Biomarker Highway: Advanced Diagnostics Based on Programmable Bio-

Nano-Chip Sensors”, Lab-on-a-Chip World Congress 2011, South San Francisco Conference Center, South San Francisco, CA, September 30, 2011.

215. “Clinical Trial in Applied Diagnostics” (Panel Discussion) American Academy of

Microbiology Colloquium – Moving Forward in the Diagnosis of Infectious Diseases in Resource Limited Countries: Diagnostic Technology Advances, “Les Pensieres” Foundation Merieux Conference Center, Veyrier du Lac, France, September 13, 2011.

214. “Programmable Bio-Nan-Chip Sensors: New Tools for Global Health Applications”, ITI

Symposium – Nanotechnology: Point of Care Diagnostics Imaging and Therapeutics, Quadrus Conference Center, Stanford, CA, August 13, 2011.

213. “AIDS Related Technology Applications” NIH Special Emphasis Panel (Panel Member),

Video Assisted Meeting Teleconference. 212. “Medical Microdevices: New Tools for Bioscience and Clinical Research” Keynote

Speaker - 10th International Summer School on Biocomplexity from Gene to System, Istanbul, Turkey, July 4, 2011.

211. “Building the Biomarker Highway: A Summary of Programmable Bio-Nano-Chip Clinical

Trials” ” Keynote Speaker - 10th International Summer School on Biocomplexity from Gene to System, Istanbul, Turkey, July 4, 2011.

210. “Next Generation Diagnostic Devices Based on Bio-Nano-Chip Sensors: A Step Toward

More Affordable Healthcare”, 2011 Stephen T. Sonis Visiting Professor, Brigham and Women’s Hospital, Division of Oral Medicine and Dentistry, Boston, MA, May 18, 2011.

209. “Programmable Bio-Nano-Chip Sensors: From Illness to Wellness Using Data Driven

Medicine”. Rice Alliance – Austin Chapter, AT&T Conference Center, Austin, TX, May 10, 2011.

208. “Tools for Affordable Healthcare: Programmable Bio-Nano-Chip Sensors”, TEDxRiceU

Event: Impact, Community, McMurty Auditorium, Rice University, Houston, TX, April 2, 2011.


207. “Bio-Nano-Chip Technologies for HIV Management and Prevention”, The Foundation of AIDS Research Capitol Hill Briefing, Hart Senate Office Building, Washington, D.C., March 9, 2011.

206. “A Point-of-Care Test to Assess CD4 Counts in the Developing World”, Global Health

Care: New Technologies, Annual Meeting of the American Association for the Advancement of Science, Washington, D.C., February 17-21, 2011.

205. “Tumor, Biology, Diseases and Diagnostics”, 8th Gordon Research Conference On

Salivary Glands and Exocrine Biology, National Institute of Health, Galveston, TX, February 6-11, 2011.

204. “Building the Texas Cancer Diagnostics Pipeline One Bio-Nano-Chip at a Time”, Cancer

Prevention Grand Rounds Seminar Series, MD Anderson Cancer Center, Houston, TX, January 28, 2011.

203. “2010 Symposium of the Henry Wheeler Center for Emerging and Neglected Diseases

(CEND)”, Keynote Speaker, University of California, Berkley, December 9-10, 2010. 202. “Materials Considerations for Programmable Bio-Nano-Chip Sensor Systems”, 2010

Materials Research Society Fall Meeting, Sheraton Hotel, Boston Massachusetts, November 30, 2010.

201. “Cancer Biomarkers Bio-nano-chip Platform”, 21st Early Detection Research Network

Steering Committee Meeting, Hyatt Regency DFW, Dallas-Ft. Worth, Texas November 15, 2010.

200. “Case Studies of Salivary Diagnostics for Systemic Diseases”, American Association for

Dental Research 3rd Fall Focused Symposium: “Salivary Diagnostics: Scientific & Clinical Frontiers”, Water View Conference Center, Arlington, VA, November 13, 2010.

199. “Building the Texas Cancer Diagnostics Pipeline”, Texas Life Science Conference,

Oncology Innovations Colloquium, Hilton Americas, Houston, TX, November, 10, 2010. 198. “Next Generation Diagnostic Devices Based on Bio-Nano-Chip Sensors: A Step Toward

More Affordable Healthcare?” Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases Seminar Series, The University of Texas Health Science Center – Houston, October 8, 2010.

197. “Programmable Bio-Nano-Chip Sensor Systems: From Humanitarian to Clinical

Applications”, St. Luke’s Lakeside Hospital, Science Café Series, The Woodlands, TX, September 14, 2010.

196. “Programmable Bio-Nano-Chip Sensor Systems: from Humanitarian to Clinical

Applications” The US-Turkey Advanced Study Institute on Global Healthcare Challenges, Antayla, Turkey, July 16, 2010.

195. “Next Generation Medical Devices Based on Bio-Nano-Chips” Challenges & Solutions in

Medicine, MD Anderson Cancer Center, Houston, TX, July 8, 2010.


194. “Big Think Symposium” (invited meeting participant), National Institute of Health, Natcher

Conference Center, NIH Campus, Bethesda, MD, May 6 & 7, 2010. 193. “Starting Your Own Company” (panel discussion member), Applying the Fruits of Your

Research: A Symposium on Intellectual Property, Technology Transfer, and Entrepreneurship, Loyola University of Chicago, IL, April 20, 2010.

192. "Frontiers in Pathogen Detection: From Nanosensors to Systems", SPIE Photonics West,

San Francisco, CA, January 23, 2010. 191. “HIV Immune Function Testing in Resource Poor Settings”, Transitioning Global Health

Technologies from Labs to LDCs, Rice University, Nov. 6, 2009. 190. “Next Generation Diagnostic Devices Based on Bio-nano-chip Sensor Systems, MD

Anderson Cancer Center, Nov. 2, 2009. 189. “Next Generation Diagnostic Devices Based on Bio-nano-chip Sensor Systems”,

Walgreens Corporate Center, Wellesley College, Wellesley, MA, Oct. 13, 2009. 188. “Next Generation Diagnostic Devices Based on Bio-nano-chip Sensor Systems”,

Walgreens Corporate Center, Chicago, IL, Sept. 17 1, 2009. 187. “Cardiovascular Diseases and Salivary Diagnosis”, American Academy of Oral Medicine

2009 Annual Meeting, Miami, FL, May 1, 2009. 186. AADR Meeting, “Integrated Bio-nano-chip Sensor Systems for Human Salivary Proteins”,

Miami, FL, April 4, 2009. 185. “Veterinary Applications for Bio-nano-chips, Michael DeBakey Institute, TAMU, College

Station, TX, February 20, 2009. 185. “Next Generation Diagnostic Devices Based on Bio-nano-chip Sensor Systems,” Baylor

College of Medicine, Houston, TX, February 12, 2009. 184. “Next Generation Diagnostic Devices Based on Bio-nano-chip Sensor Systems,”

University of Texas Health Science Center-Houston, Houston, TX, January 16, 2009. 183. “Saliva Diagnostics Using Lab-on-a-Chip Technologies,” Program Review, National

Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, December 18, 2008.

182. “Cardiac Applications for Integrated Bio-nano-chip Sensor Systems”, Indo-US Workshop

on Low-Cost Diagnostic and Therapeutic Technologies sponsored by the National Institutes of Health, Hyderabad, India, November 19, 2008.

181. “Integrated Bio-nano-chip Sensor Systems: From Bioterrorism to Humanitarian

Applications,” Bioengineering Applications to Address Global Health conference, co-


sponsored by the Pratt School of Engineering and the Duke Global Health Institute, Duke University in Durham, NC, November 6, 2008.

180. “Integrated Bio-nano-chip Sensor Systems,” 5th International Congress of Nano-Bio &

Clean Tech, San Francisco, CA, October 29, 2008. 179. “Integrated Bio-nano-chip Sensor Systems: From Bioterrorism to Humanitarian

Applications,” BioMonterrey 08, Monterrey, Mexico, October 15, 2008. 178. “Integrated Bio-nano-chip Sensor Systems: From Bioterrorism to Humanitarian

Applications,” Southwest Regional Meeting American Chemical Society Meeting, Little Rock, AR, October 3, 2008.

177. “Next Generation Saliva Diagnostics Based on Bio-nano-chip Sensor Systems,” Delaware

State Dental Society, Delaware Academy of Medicine, Frank M. Hoopes Memorial Lecture, Ammon Center at the Stanton Campus of Christiana Care, Newark, NJ, Wednesday, October 1, 2008.

176. “Lab-on-a-Chip Sensor for Veterinary Applications”, Veterinary Medical Teaching

Hospital, Texas A&M University, College Station, TX, August 28, 2008. 175. “Lab-on-a-Chip Sensor Technologies”, BioMedical Users Group, 2nd BioMedical Users

Group (BMUG), Sematech, Austin, TX, July 24,, 2008. 174. “Overview of Microchip Sensors: New Applications for Lab-on-a-Chip Systems,”

Chemistry Department Seminar Series, Rice University, Houston, TX, May 1, 2008. 173. “Integrated Bio-nano-chip Sensor Systems: From Bio-terrorism to Humanitarian

Applications”, Santa Clara University, Santa Clara, CA, April 11, 2008. 172. “Next Generation Cardiac Diagnostics Bio-nano-chip Sensors for Oral Fluid Testing”,

The American Association for Dental Research 37th Annual Meeting, Dallas, TX, April 3, 2008.

171. “Integrated Bio-nano-chip Sensor Systems: From Bio-terrorism to Humanitarian

Applications”, SPIE Meeting, Biological Countermeasures Session, Orlando, FL, March 16-20, 2008.

170. “Integrated Bio-nano-chip Sensor Systems: From Bio-terrorism to Humanitarian

Applications”, Houston Society for Engineering in Medicine and Biology - Keynote lecture for the Micro-Nano sessions, Houston, TX, February 7, 2008.

169. “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics,” New York

University, New York City, NY, December 10, 2007. 168. “Integrated lab-on-a-chip devices for oral fluid analysis”, University of Texas Health

Science Center at San Antonio, San Antonio, TX, October 9, 2007.


167. “Development of a Lab-on-a-Chip System for Saliva Based Diagnostics,” Tufts University, Boston, MA, July 23, 2007.

166. “Electronic Taste Chip Sensors for Rapid Detection of Chemical and Biological Targets:

Development of Customized Lab-on-a-Chip Systems for Analysis of Complex Fluids,” Chemistry Department Seminar Series, April 20, 2007, Rice University, Houston, TX.

165. “CD4 HIV Immune Function Measurements Using Point-of-Care Bio-nano-chip Sensor

Systems”, Beyond Traditional Borders, Integrated Technology Solutions to Advance Global Health symposium, April 18, 2007, Baker Institute for Public Policy, Rice University, Houston, TX.

164. “Integrated Lab-on-a-Chip Devices as Nano-Bio Sensor Systems,” Rice University,

Biomedical Engineering Seminar Series, February 22, 2007. 163. “Integrated Lab-on-a-Chip Devices for Complex Fluid and BioFilm Analysis”, Biofilm-

Material Interactions: New Tools, Technologies, and Opportunities, Fall Materials Research Society Meeting, Boston, MA, November 29, 2006.

162. “Integrated Lab-on-a-Chip devices for Complex Fluid Analysis,” The Knowledge

Foundation’s Ninth International Conference Detection Technologies 2006: New Developments in Identification of Microorganisms & Chemicals, November 9 - 10, 2006, San Diego, CA.

161. “Integrated lab-on-a-chip devices for oral fluid analysis”, New York Academy of Sciences

Conference on Oral-Based Diagnostics, October 13, 2006. Emerald Pointe Resort, Lake Lanier Islands, Georgia.

160. “Integrated lab-on-a-chip devices for complex fluid analysis,” 232nd ACS National

Meeting, San Francisco, CA, September 10-14, 2006. 159. “Integrated Lab-on-a-Chip Devices as Nano-Bio Sensor Systems,” International

Congress of Nanobiotechnology and Nanomedicine, San Francisco, CA (NanoBio 2006), held on June 19-21, 2006.

158. “Overview of Microchip Sensors: New Applications for Lab-on-a-Chip Systems”

NIBIB/NSF POCT Workshop, April 10-12, 2006, Washington, DC. 157. “Saliva Diagnostics Using Lab-on-a-Chip Technologies,” NIH Program Review,

University of California at Los Angeles, Los Angeles, CA, December 15, 2005. 156. “Towards the Development of a Lab-on-a-Chip Dual Function White Blood Cell and C-

Reactive Protein Analysis Method for the Assessment of Inflammation and Cardiac Risk,” Phillip Morris External Research Program Symposium: Advances in Biomarkers and Screening Models for Tobacco Related Diseases, Washington, DC, December 5, 2005.

155. “HIV Monitoring Devices for Use in Resource-Poor Settings,” Women in Natural Sciences

meeting, University of Texas, Austin, TX, November 11, 2005.


154. “Overview of Microchip Sensors: New Applications for Lab-on-a-Chip Systems,” LabNow

Scientific Advisory Board Meeting, Austin, TX, November 9, 2005. 153. “Microchip Sensors: From Bioterrorism to Humanitarian Applications,” Innovative

Biosensor Technologies and Methods Session, SPIE Meeting, Boston, MA, October 25, 2005.

152. “Microscope Sensors for In Vitro Diagnostics Applications,” Abbott Scientific

Headquarters, Chicago, IL, September 27, 2005. 151. “Nano to Global Diagnostics Program: Development of Microchip-Based Sensors for

Detection and Diagnosis of Emerging Infectious Diseases,” Analytical Chemistry Gordon Conference, Roscoff, France, June 16, 2005.

150. “Synergies Between Humanitarian and BioDefense Applications,” San Antonio-Austin

Life Sciences Association BioDefense Summit IV, San Antonio, TX, April 29, 2005. 149. “Electronic Taste Chip Sensors for Rapid Detection of Chemical and Biological Targets:

Development of Customized Lab-on-a-Chip Arrays for Clinical Chemistry Applications,” 37th Annual Oak Ridge Conference, American Association for Clinical Chemistry National Meeting, Baltimore, Maryland, April 15, 2005.

SELECTED PATENT APPLICATIONS AND INVENTION DISCLOSURES: 2000 TO PRESENT (FROM >145 TOTAL) A comprehensive list of McDevitt group patents and patent applications may be found online at the following URL: http://mcdevitt.rice.edu/Patents/. 145. John T. McDevitt, Nicolaos Christodoulides, and Giridhar Kalamangalam, “Bio-Nano-

Chips for Anticonvulsant Drug Salivary Assay”, Provisional Patent # 61/893,588, Date: 10/22/2013.

144. John T. McDevitt, Ahmed Haque, Michael McRae, and Glennon Simmons, “Integrated

Instruments for the Analysis of Biomarker Concentrations using the Programmable Bio-Nano-Chips”, Provisional Patent # 14/319,497, Date: 6/30/2014.

143. John T. McDevitt, Tim Abram, “Microfluidic 3D-tumor Dosing and Imaging Platform”,

Provisional Patent # 14/299908, Date: 6/9/2014. 142. John T. McDevitt, Pierre N. Floriano, “Oral Cancer Risk Scoring”, Provisional Patent #

14/261670, Date: 4/25/14. 141. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Tim Abram,

“Multisample Bio-Nano Chip Platform”, Provisional Patent, #14/258770, Date: 4/22/2014.


140. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, and Glennon Simmons “Bio-Nano-Chips for On-Site Drug Testing” SG Publication # SG194892; Publication Date: 12-30-2013.

139. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, and Glennon Simmons

“Bio-Nano-Chips for On-Site Drug Testing” WO Publication # WO2012154306; Publication Date: 11-15-2012.

138. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, and Glennon Simmons

“Bio-Nano-Chips for On-Site Drug Testing” CA Publication # CA2836061; Publication Date: 11-15-2012.

137. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Martin Thornhill, Spencer

Redding, Nadarajah Vigneswaran, Craig Murdoch, and Paul Speight “Oral Cancer Point of Care Diagnostics”, US Publication # US2013295580; Publication Date: 11-07-2013.

136. John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Martin Thornhill, Spencer

Redding, Nadarajah Vigneswaran, Craig Murdoch, and Paul Speight “Oral Cancer Point of Care Diagnostics”, WO Publication # WO2012065117; Publication Date: 05-18-2012.

135. John T. McDevitt, Pierre N. Floriano, Nicolaos Christodoullides, and Glennon Simmons

“Biomarker Signatures for Wellness Testing”, US Publication # US2013130933; Publication Date: 05-25-2013.

134. John T. McDevitt, Pierre N. Floriano, Nicolaos Christodoullides, and Glennon Simmons

“Biomarker Signatures for Wellness Testing”, WO Publication # WO2012021714; Publication Date: 02-12-2012.

133. John T. McDevitt, Craig S. Miller, Jeffrey L. Ebersole, Nicolaos Christodoulides, and

Pierre N. Floriano “Methods and Compositions for Diagnosis of Acute Myocardial Infarction”, US Publication # US2012208715; Publication Date: 08-16-2012.


Pierre N. Floriano “Methods and Compositions for Diagnosis of Acute Myocardial Infarction”, WO Publication # EP2467720; Publication Date: 06-27-2012.


Pierre N. Floriano “Methods and Compositions for Diagnosis of Acute Myocardial Infarction”, WO Publication # WO2011022628; Publication Date: 02-24-2011.

130. John T. McDevitt, Nicolaos Christodoulides, Pierre Floriano, and Ian Thompson,

“Prostate Cancer Point of Care Diagnostics”, US Publication # US2013274136; Publication Date: 10-17-2013.

129. John T. McDevitt, Nicolaos Christodoulides, Pierre Floriano, and Ian Thompson,

“Prostate Cancer Point of Care Diagnostics”, WO Publication # WO2012065025; Publication Date: 07-19-2012.


128. John T. McDevitt, Nicolaos Christodoulides, Pierre Floriano, and Ian Thompson, “Prostate Cancer Point of Care Diagnostics”, US Publication # US20100412994P; Publication Date: 05-18-2012.

127. John T. McDevitt, Nicolaos Christodoulides, Jeff Ebersole, Craig S. Miller, and Pierre

Floriano, “Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics”, EP Publication # EP2147115; Publication Date: 01-27-2010.


Floriano, “Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics”, US Publication # US2008300798; Publication Date: 12-04-2008.


Floriano, “Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics”, WO Publication # WO2008131039; Publication Date: 10-30-2008.


Floriano, “Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics”, CA Publication # CA2697357; Publication Date: 10-30-2008.

123. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, and Nick J.

Christodoulides, “Method and system for the analysis of saliva using a sensor array”, US Patent # 7651868; Date Issued: 01-26-2010.


Christodoulides, “Method and system for the analysis of saliva using a sensor array”, EP Publication # EP1695082; Date Issued: 08-30-2006.


Christodoulides, “Method and system for the analysis of saliva using a sensor array”, AU Publication # AU2004300168; Date Issued: 06-30-2005.


Christodoulides, “Method and system for the analysis of saliva using a sensor array”, CA Publication # CA2549190; Date Issued: 06-30-2005.


Christodoulides, “Method and system for the analysis of saliva using a sensor array”, WO Publication # WO2005059551; Date Issued: 06-30-2005.

118. Bruce Walker, William Rodriguez, John T. McDevitt, and Nick J. Christodoulides. “A

microchip-based system for HIV diagnostics” DE Publication # DE602004024285; Date Issued: 01-07-2010.

117. Bruce Walker, William Rodriguez, John T. McDevitt, and Nick J. Christodoulides. “A

microchip-based system for HIV diagnostics” AT Publication # AT449962; Date Issued: 12-15-2009.


116. A microchip-based system for HIV diagnostics. “A microchip-based system for HIV diagnostics” EP Patent # EP1590669; Date Issued: 11-25-2009.

115. John T. McDevitt, Bruce D. Walker, William R. Rodriguez, Nick J. Christodoulides, and

Pierre Floriano, “A microchip-based system for HIV diagnostics”, US Publication # US2006234209; Publication Date: 10-19-2006.


Pierre Floriano, “A microchip-based system for HIV diagnostics”, JP Publication # JP2006516743; Publication Date: 07-06-2006.


Pierre Floriano, “A microchip-based system for HIV diagnostics”, BRP Publication # BRP10407299; Publication Date: 02-07-2006.


Pierre Floriano, “A microchip-based system for HIV diagnostics”, AU Publication # AU2004212464; Publication Date: 08-26-2004.


Pierre Floriano, “A microchip-based system for HIV diagnostics”, CA Publication # CA2515348; Publication Date: 08-26-2004.

110. Bruce D. Walker, William R. Rodriguez, and John T. McDevitt, “A microchip-based

system for HIV diagnostics”, WO Publication # WO2004072097; Publication Date: 08-26-2004.

109. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Fluid based analysis of multiple analytes by a sensor array”, US Publication # US2009258791; Publication Date: 10-15-2009.

108. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Fluid based

analysis of multiple analytes by a sensor array”, US Patent # US6908770; Publication Date: 02-17-2009.

107. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Fluid based

analysis of multiple analytes by a sensor array”, US Patent # US7491552; Publication Date: 06-21-2005.

106. John T. McDevitt, Pierre Floriano, and Nick J. Christodoulides, “Capture and detection

of microbes by membrane methods”, EP Publication # EP2107120; Publication Date: 10-07-2009.

105. John T. McDevitt, Pierre Floriano, and Nick J. Christodoulides, “Capture and detection

of microbes by membrane methods”, IN Patent # IN231681; Publication Date: 03-07-2009.


104. John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, BRP Publication # BRPI0501090; Publication Date: 10-03-2006.

103. John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk,

Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, ZA Patent # ZA200500889; Publication Date: 07-26-2006.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, US Publication # US2006079000; Publication Date: 04-13-2006.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, US Publication # US2006073585; Publication Date: 04-06-2006.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, JP Publication # JP2005533502; Publication Date: 11-10-2005.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, EP Publication # EP1546367; Publication Date: 06-29-2005.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, AU Publication # AU2003256742; Publication Date: 02-09-2004.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, CA Publication # CA2494727; Publication Date: 01-29-2004.


Eric Anslyn, and Jason Shear, “Capture and detection of microbes by membrane methods”, WO Publication # WO2004009840; Publication Date: 01-29-2004.

95. John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas, and

Patrick E. Rogers, “Methods and compositions related to determination and use of white blood cell counts”, US Publication # US2009215072; Publication Date: 08-27-2009.


Patrick E. Rogers, “Methods and compositions related to determination and use of white blood cell counts”, EP Publication # EP1910824; Publication Date: 04-16-2008.


Patrick E. Rogers, “Methods and compositions related to determination and use of white blood cell counts”, WO Publication # WO2007053186; Publication Date: 05-10-2007.


92. John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas, and Patrick E. Rogers, “Methods and compositions related to determination and use of white blood cell counts”, AU Publication # AU2006309284; Publication Date: 05-10-2007.


Patrick E. Rogers, “Methods and compositions related to determination and use of white blood cell counts”, CA Publication # CA2610793; Publication Date: 05-10-2007.

90. Eric V. Anslyn, John T. McDevitt, Jason B. Shear, Dean P. Neikirk, Aaron T. Wright, and

Zhenlin Zhong, “System and method of analyte detection using differential receptors”, US Publication # US2009215646; Publication Date: 08-27-2009.

89. Eric V. Anslyn, John T. McDevitt, Jason B. Shear, Dean P. Neikirk, Aaron T. Wright, and

Zhenlin Zhong, “System and method of analyte detection using differential receptors”, WO Publication # WO2007005666; Publication Date: 01-11-2007.

88. John T. McDevitt, Nicolaos J. Christodoulides, Glennon W. Simmons, Karri Ballard, and

Pierre N. Floriano, “Systems and methods including self-contained cartridges with detection systems and fluid delivery systems”, ZA Publication # ZA200800413; Publication Date: 07-29-2009.


Pierre N. Floriano, “Systems and methods including self-contained cartridges with detection systems and fluid delivery systems”, EP Publication # EP1899450; Publication Date: 03-19-2008.


Pierre N. Floriano, “Systems and methods including self-contained cartridges with detection systems and fluid delivery systems”, CA Publication # CA2613078; Publication Date: 01-04-2007.


Pierre N. Floriano, “Systems and methods including self-contained cartridges with detection systems and fluid delivery systems”, WO Publication # WO2007002480; Publication Date: 01-01-2007.


Pierre N. Floriano, “Systems and methods including self-contained cartridges with detection systems and fluid delivery systems”, AU Publication # AU2006261953; Publication Date: 01-04-2007.

83. Dean P. Neikirk, Eric V. Anslyn, Nicolaos Christodoulides, Jason B. Shear, and John T.

McDevitt, “Method and system for the detection of cardiac risk factors”, AU Publication # AU2009202457; Publication Date: 07-16-2009.


McDevitt, “Method and system for the detection of cardiac risk factors”, AU Patent # AU2003228711; Publication Date: 07-16-2009.


81. Dean P. Neikirk, Eric V. Anslyn, Nicolaos Christodoulides, Jason B. Shear, and John T. McDevitt, “Method and system for the detection of cardiac risk factors”, US Publication # US2004029259; Publication Date: 02-12-2004.


McDevitt, “Method and system for the detection of cardiac risk”, EP Publication # EP1502097; Publication Date: 02-02-2005.


McDevitt, “Method and system for the detection of cardiac risk”, CA Publication # CA2523626; Publication Date: 11-06-2003.


McDevitt, “Method and system for the detection of cardiac risk”, WO Publication # WO03090605; Publication Date: 11-06-2003.

77. Pierre N. Floriano, Nicolaos Christodoulides, Karri Ballard, and John T. McDevitt,

“Detecting multiple types of leukocytes”, EP Publication # EP2027249; Publication Date: 02-25-2009.


“Detecting multiple types of leukocytes”, US Publication # US2008050830; Publication Date: 02-28-2008.


“Detecting multiple types of leukocytes”, WO Publication # WO2007134191; Publication Date: 11-22-2007.


“Detecting multiple types of leukocytes”, CA Publication # CA2651872; Publication Date: 11-22-2007.

73. Shannon Weigum, Pierre N. Floriano, Nicolaos Christodoulides, and John T. McDevitt,

“Detecting tumor biomarker in oral cancer”, EP Publication # EP2021491; Publication Date: 02-11-2009.


“Detecting tumor biomarker in oral cancer”, US Publication # US2008038738; Publication Date: 02-14-2008.


“Detecting tumor biomarker in oral cancer”, WO Publication # WO2007134189; Publication Date: 11-22-2007.

70. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, US Publication # US2008219891; Publication Date: 09-11-2008. 69. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, EP Patent # EP1255980; Publication Date: 06-30-2008.


68. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, US Patent # US7316899; Publication Date: 01-08-2008. 67. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, AU Publication # AU3320001; Publication Date: 08-07-2001. 66. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, WO Publication # WO0155702; Publication Date: 08-02-2001. 65. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Portable sensor

array system”, CA Publication # CA2401782; Publication Date: 08-02-2001. 64. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “System for

transferring fluid samples through a sensor array”, AT Publication # AT403145; Publication Date: 08-15-2008.

63. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, and Young-Soo

Sohn, “System for transferring fluid samples through a sensor array”, AU Publication # AU3801101; Publication Date: 08-07-2001.

62. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, and Young-Soo

Sohn, “System for transferring fluid samples through a sensor array”, WO Publication # WO0155704; Publication Date: 08-02-2001.

61. Nicolaos Christodoulides, Pierre N. Floriano, Karri Ballard, and John T. McDevitt,

“Detecting human or animal immunoglobin-E”, US Publication # US2008176253; Publication Date: 07-24-2008.

60. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, and Damon V.

Borich, “A method and apparatus for the delivery of samples to a chemical sensor array”, DE Publication # DE60031988; Publication Date: 06-14-2007.


Borich, “A method and apparatus for the delivery of samples to a chemical sensor array”, AT Publication # AT346287; Publication Date: 12-15-2006.


Borich, “A method and apparatus for the delivery of samples to a chemical sensor array”, EP Patent # EP1204859; Publication Date: 11-22-2006.


Borich, “Method and apparatus for the delivery of samples to a chemical sensor array”, US Patent # US7022517; Publication Date: 04-04-2006.

56. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Method and

apparatus for the delivery of samples to a chemical sensor array”, AU Patent # AU773679; Publication Date: 06-03-2004.


55. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Method and apparatus for the delivery of samples to a chemical sensor array”, US Patent # 6713298; Publication Date: 03-30-2004.


Borich, “Method and apparatus for the delivery of samples to a chemical sensor array”, WO Publication # WO0106239; Publication Date: 01-25-2001.


Borich, “Method and apparatus for the delivery of samples to a chemical sensor array”, CA Publication # CA2379130; Publication Date: 01-25-2001.

52. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J.

Christodoulides, Karri L. Michael-Ballard, Pierre Floriano, and Bruce Bernard, “System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements”, EP Publication # EP1735618; Publication Date: 12-27-2006.

51. John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean

P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems”, US Publication # US2006257992; Publication Date: 11-16-2006.


P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems”, WO Publication # WO2005085796; Publication Date: 09-15-2005.




P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems”, CA Publication # CA2557549; Publication Date: 09-09-2005.



46. John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard, and

Bruce Bernard, “Particle on membrane assay system”, EP Publication # EP1723420; Publication Date: 11-22-2006.


45. John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard, and Bruce Bernard, “Particle on membrane assay system”, CA Publication # CA2557563; Publication Date: 09-15-2005.


Bruce Bernard, “Particle on membrane assay system”, WO Publication # WO2005085854; Publication Date: 09-15-2005.


Bruce Bernard, “Particle on membrane assay system”, US Publication # US2005191620; Publication Date: 09-01-2005.


P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements”, US Publication # US2006257941; Publication Date: 11-16-2006.


P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements”, US Publication # US2006257991; Publication Date: 11-16-2006.

40. John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean P. Neikirk, Eric V. Anslyn, and Jason B. Shear, “Integration of fluids and reagents into self-contained cartridges containing sensor elements”, US Publication # US2006257993; Publication Date: 11-16-2006.


Bruce Bernard, “Membrane assay system including preloaded particles”, US Publication # WO2006257854; Publication Date: 11-16-2006.


Bruce Bernard, “Membrane assay system including preloaded particles”, US Publication # WO2005090983; Publication Date: 09-29-2005.

37. John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear, and Dean P., “Multi-

shell microspheres with integrated chromatographic and detection layers for use in array sensors”, US Publication # US2006228256; Publication Date: 10-12-2006.


shell microspheres with integrated chromatographic and detection layers for use in array sensors”, ZA Publication # ZA200506560; Publication Date: 05-31-2006.


shell microspheres with integrated chromatographic and detection layers for use in array sensors”, EP Publication # EP1590659; Publication Date: 11-02-2005.


34. John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear, and Dean P., “Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors”, CA Publication # CA2515305; Publication Date: 08-26-2004.


shell microspheres with integrated chromatographic and detection layers for use in array sensors”, WO Publication # WO2004072613; Publication Date: 08-26-2004.

32. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “System and

method for the analysis of bodily fluids”, US Publication # US2005136548; Publication Date: 06-23-2005.


method for the analysis of bodily fluids”, US Publication # 2004053322; Publication Date: 03-18-2004.


method for the analysis of bodily fluids”, AU Publication # AU3659701; Publication Date: 08-07-2001.


method for the analysis of bodily fluids”, WO Publication # WO0155701; Publication Date: 08-02-2001.

28. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Byunghwa Park, and

Yoon Sok Park, “Method and apparatus for the confinement of materials in a micromachined chemical sensor array”, JP Publication # JP2004529323; Publication Date: 09-24-2004.


Yoon Sok Park, “Method and apparatus for the confinement of materials in a micromachined chemical sensor array”, EP Publication # EP1373874; Publication Date: 01-02-2004.


Yoon Sok Park, “Method and apparatus for the confinement of materials in a micromachined chemical sensor array”, WO Publication # WO02061392; Publication Date: 12-27-2002.


Yoon Sok Park, “Method and apparatus for the confinement of materials in a micromachined chemical sensor array”, US Publication # US2002197622; Publication Date: 12-26-2002.


Yoon Sok Park, “Method and apparatus for the confinement of materials in a micromachined chemical sensor array”, CA Publication # CA2437558; Publication Date: 08-08-2002.


23. Eric V. Anslyn, Jason B. Shear, John T. McDevitt, and Dean P. Neikirk, “Sensor arrays for the measurement and identification of multiple analytes in solutions”, AU Publication # AU770949; Publication Date: 03-11-2004.

22. Eric V. Anslyn, Jason B. Shear, John T. McDevitt, and Dean P. Neikirk, “Sensor arrays

for the measurement and identification of multiple analytes in solutions”, EP Publication # EP1097369; Publication Date: 05-09-2001.


for the measurement and identification of multiple analytes in solutions”, AU Publication # AU5316599; Publication Date: 02-07-2000.


for the measurement and identification of multiple analytes in solutions”, WO Publication # WO0004372; Publication Date: 01-27-2000.


for the measurement and identification of multiple analytes in solutions”, CA Publication # CA2337155; Publication Date: 01-27-2000.

18. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Detection

system based on an analyte reactive particle”, US Patent # US6602702; Date Issued: 08-05-2003.


system based on an analyte reactive particle”, AU Publication # AU1325201; Date Issued: 02-05-2001.


system based on an analyte reactive particle”, WO Publication # WO0106253; Date Issued: 01-25-2001.

15. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Method of

preparing a sensor array”, US Patent # US6649403; Date Issued: 11-18-2003. 14. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Method of

preparing a sensor array”, AU Publication # AU3470901; Date Issued: 08-07-2001. 13. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “Method of

preparing a sensor array”, WO Publication # WO0155703; Date Issued: 08-02-2001. 12. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “General

signaling protocols for chemical receptors in immobilized matrices”, AU Publication # AU1429701; Publication Date: 07-08-2003.

11. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “General

signaling protocols for chemical receptors in immobilized matrices”, US Patent # US6589779; Publication Date: 02-05-2001.


10. John T. McDevitt, Eric V. Anslyn, Jason B. Shear, and Dean P. Neikirk, “General signaling protocols for chemical receptors in immobilized matrices”, WO Publication # WO0106244; Publication Date: 01-25-2001.


system for collecting and transmitting chemical information”, US Publication # US2003064422; Publication Date: 04-03-2003.


system for collecting and transmitting chemical information”, AU Publication # AU4719501; Publication Date: 08-07-2001.


system for collecting and transmitting chemical information”, WO Publication # WO0155952; Publication Date: 01-31-2001.

6. Eric V. Anslyn, Jason B. Shear, John T. McDevitt, and Dean P. Neikirk, “Magnetic-based

placement and retention of sensor elements in a sensor array”, AU Publication # AU2002330841; Publication Date: 01-02-2003.


placement and retention of sensor elements in a sensor array”, WO Publication # WO02103371; Publication Date: 12-27-2002.


placement and retention of sensor elements in a sensor array”, US Publication # US2002160363; Publication Date: 10-31-2002.

3. Ji Ping Zhou, John T. McDevitt, and John B. Goodenough, “Jc in high magnetic field of

bi-layer and multi-layer structures for high temperature superconductive materials”, US Patent # US6221812; Date Issued: 04-24-2001.

2. Eric V. Anslyn, Sherry L. Acanfora-Florin, Damon Borich, James W. Douglas, John T.

McDevitt, John A. McMorris III, Gregory A. Mullins, Dean B. Neikirk, Mike J. Otworth, John S. Scott, and Jason B. Shear, “Method and system for remotely collecting and evaluating chemical/biochemical information”, AU Publication # AU4990500; Publication Date: 11-21-2000.

1. Eric V. Anslyn, Sherry L. Acanfora-Florin, Damon Borich, James W. Douglas, John T.

McDevitt, John A. McMorris III, Gregory A. Mullins, Dean B. Neikirk, Mike J. Otworth, John S. Scott, and Jason B. Shear, “Method and system for remotely collecting and evaluating chemical/biochemical information”, WO Publication # WO0068670; Publication Date: 11-16-2000.

MENTORING SUMMARY Over the past decade, typical group size has been in the range of 15 to 30 co-workers spanning levels of senior research scientists, post docs, graduate students, technicians, undergraduate


students and selected high school students. Over 25 Ph.D. and Master level dissertation projects have been completed under Dr. McDevitt’s supervision and he has served on over 125 dissertation committees. Former co-workers have been placed well in prominent academic positions, national laboratories, medical schools and corporate positions. Several former students from Dr. McDevitt’s lab have established their own companies. TEACHING Taught interdisciplinary courses including numerous bioengineering and chemistry courses at levels spanning from freshman chemistry with 300+ students to special topics graduate courses involving 10 or less students. Developed a number of popular specialized training courses designed to a hybrid lab-lecture experience where students learn to devise, fabricate and test their own medical device. Created new ‘BioMEMS and Medical Microdevice’ course requiring students to use course content to develop their own ‘virtual company’. Multiple new start-up ventures resulted from these courses.

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