NEW 9 NEW 9TH EDITIONEDITIONTH

PRAISE FOR PREVIOUS EDITIONS“…this is an excellent overview of immunology placed in a biological context….both the style of writing and the use of figures mean that complicated concepts are put across very well indeed…”--Immunology News

“This is one of the best basic immunology textbooks available. Materials are well organized and clearly presented. It is a must-have….The chapters are well ordered and the language is clear and succinct. Ample, well-designed diagrams and tables illustrate complex ideas.”--Doody Reviews

“This is the only immunology text I would need, as all the important topics are given detailed coverage; the diagrams, tables, and videos rapidly get across important concepts in an easily understood way.”--Oxford Medical School Gazette

A CLINICAL COMPANIONSEVENTH EDITION

RAIF GEHA AND LUIGI NOTARANGELO, BOTH AT HARVARD MEDICAL SCHOOL

Case Studies in Immunology, Seventh Edition is intended for medical students and undergraduate and graduate students in immunology. It presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms of that specific disorder. The cases themselves demonstrate how immunological problems are deconstructed in the clinic and each one is followed by a concise summary of the clinical finding and questions which can serve as discussion points.

The book includes a total of 55 cases and can be used as either a stand-alone text, review aid, or as a companion to Janeway’s Immunobiology, Ninth Edition and The Immune System, Fourth Edition.

Six new cases have been added to this edition: �DOCK8 deficiency �Activated PI3K delta syndrome �Increased susceptibility to candida infections �LRBA deficiency �T cell signaling defects �Channelopathies

March 2016358 pages • 255 illustrationsPaperback • 978-0-8153-4512-1 • £41

To view a list of all the cases and a sample case, please visit www.garlandscience.com/product/isbn/9780815345121

Fig. 33.1 Innate immune mechanisms establish a state of inflammation at sites of infection.

2-4 Park SquareMilton ParkAbingdonOxfordshireOX14 4RN

NINTH EDITION

KENNETH MURPHY AND CASEY WEAVER

Janeway’s Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, students will appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists will value its comprehensive scope and depth. Janeway’s Immunobiology presents immunology from a consistent point of view throughout—that of the host’s interaction with an environment full of microbes and pathogens. The Ninth Edition has been thoroughly revised bringing the content up-to-date with significant developments in the field, especially on the topic of innate immunity, and improving the presentation of topics across chapters for better continuity.

Also new to the Ninth Edition is a Question Bank available to adopting instructors, and the Garland Science Learning System which allows instructors to assign online tutorials with assessments on

specific immunology topics and review the performance of the entire class, as well as individual students, via the instructor dashboard.

Fig. 3.22 cGAS is a cytosolic sensor of DNA that signals through STING to activate type I interferon production.

May 2016900 pages • 624 illustrationsPaperback • 978-0-8153-4551-0 • £53

TABLE OF CONTENTSPart I: An Introduction to Immunobiology and Innate ImmunityChapter 1: Basic Concepts in ImmunologyChapter 2: Innate Immunity: The First Lines of DefenseChapter 3: The Induced Responses of Innate Immunity

Part II: The Recognition of AntigenChapter 4: Antigen Recognition by B-cell and T-cell ReceptorsChapter 5: The Generation of Lymphocyte Antigen Receptors Chapter 6: Antigen Presentation to T Lymphocytes

Part III: The Development of Mature Lymphocyte Receptor RepertoiresChapter 7: Lymphocyte Receptor Signaling

Chapter 8: The Development of B and T Lymphocytes

Part IV: The Adaptive Immune ResponseChapter 9: T Cell-Mediated Immunity Chapter 10: The Humoral Immune ResponseChapter 11: Integrated Dynamics of Innate and Adaptive Immunity Chapter 12: The Mucosal Immune System

Part V: The Immune System in Health and DiseaseChapter 13: Failures of Host Defense MechanismsChapter 14: Allergy and Allergic DiseasesChapter 15: Autoimmunity and TransplantationChapter 16: Manipulation of the Immune ResponseTo download a detailed table of contents and a sample chapter, please visit www.garlandscience.com/product/isbn/9780815345510

NEW IN THE NINTH EDITION� Now organized around the concept of modular immune responses, combining innate and

adaptive immunity into effector modules and explaining the integration of the innate and adaptive immune response.

� Updated with the latest developments on innate lymphoid cells and innate sensing mechanisms, including cycling GMP-SMP synthase (cGAS) and activation of the STING pathway.

� Incorporates the new mechanisms of class switch recombination involving RNA guides for AID.

Fig. 3.6 Neutrophil extracellular traps (NETs) can trap bacteria and fungi.

� Includes an expanded, updated coverage of CD4 T cell subsets, including an in-depth handling of follicular helper T cells and their role in B cell class switching and affinity maturation.

� Improved coverage of chemokine networks and their role in coordinating immunity.

� Includes new content on cytoskeletal reorganization and integrin activation in antigen receptor signaling and expanded coverage on Akt and mTOR signaling.

� Revised and updated sections on mechanisms of immune evasion by pathogens and HIV/AIDS.

LEARNING SYSTEMThe Garland Science Learning System is our new online homework platform designed to improve and track student performance. It allows instructors to select homework assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard.

The user-friendly system provides a convenient way to gauge student progress, and tailor classroom discussion, activities, and lectures to areas that require specific remediation. The features and assignments include:

Instructor Dashboard displays data on student performance, such as responses to individual questions and length of time spent to complete assignments.

Tutorials explain essential or difficult concepts and are integrated with a variety of questions that assess student engagement and mastery of the material.

ONLINE RESOURCESFOR INSTRUCTORSQuestion Bank written by Leslie Berg (University of Massachusetts Medical School) provides a comprehensive collection of questions that require the student to reflect upon and synthesize concepts in each chapter and can be used by instructors for the creation of exams. Animations and Videos There are over 40 narrated movies based on figures in the book and videos selected from visually compelling experiments.The Art of Immunobiology The figures and tables from the book are available as individual JPEGs or preloaded into PowerPoint® presentations.Lecture Outlines The section headings, concept headings, and figures from the text have been integrated into PowerPoint presentations.

FOR STUDENTSAnimations and VideosOnline Searchable GlossaryInteractive Flashcards

� Updated and more detailed consideration of mechanisms of immune-mediated disease.

� Expanded coverage of cancer immunotherapy, including chimeric antigen receptor T cell (CAR T cell) therapy.

� Comprehensive update to Appendix I: The Immunologist’s Toolbox, with the addition of many new techniques, including mass spectrometry, in vivo administration of antibodies, RNAi, and the CRISPR/Cas9 system.

� Illustration program has been thoroughly updated with over 100 new figures and improved with newer and better images of protein structures and micrographs.

� Completely updated end-of-chapter questions in a variety of types that review each chapter’s concepts.