janeway’s immunobiology seventh edition janeway’s immunobiology seventh edition chapter 10...
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Janeway’s Immunobiology
Seventh Edition
Janeway’s Immunobiology
Seventh Edition
Chapter 10Dynamics of Adaptive Immunity
Chapter 10Dynamics of Adaptive Immunity
Steffen Thiel
ca.1 uge
DC CD4 T cell
TH1TH2TH17Treg
Inhibition af andre CD4 T celler
Parasit infektion
TH1 response
TH2 response
Nye adhesionsmolekyler
Nye muligheder
Effect T
Effect T
TNF-
VCAM/ICAM
Effect T
Macrophag
Movie – lymphocyte migration
Ingen IL-12
Ingen egne T celler- men IL-12
IL-12 holder gang i TH1 celler
Memory
Memory T-cells
Hvordan ser overfladen af enmemory T cell ud
Ingen CD4 T cells Ingen memory
Godt CD8 T celle respons
Published online 26 September 2007 | Nature 449, 390 (2007)HIV vaccine failure prompts Merck to halt trial
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The Thai-trial – publiceret oktober 2009:
Hvad pressen og producenterne skrev:
"Although the level of protection was modest, we think the study is a major scientific advance,“ said Colonel Jerome Kim, HIV vaccines product manager for the U.S. Army.
The controversial $105 million trial, the largest and most expensive AIDS vaccine study ever conducted, took 6 years and involved more than 16,000 volunteers at eight sites in Thailand
Rent faktisk:
51 vaccinated people had become infected within 3 years of receiving their last shot,as compared with 74 people in the placebo group.
Immunity. 2010 Oct 29;33(4):542-54.Induction of immunity to human immunodeficiency virus type-1 by vaccination.McElrath MJ, Haynes BF.A recent vaccine regimen has shown modest efficacy against HIV-1 acquisition.
