FLOREtina 2015 International Congress

Florence (Italy)10-13 December 2015

www.floretina.it

Organizers: Stanislao Rizzo - Florence (Italy)

Carl Claes - Antwerpen (Belgium) José García-Arumí - Barcelona (Spain)

Kourous A. Rezaei - Chicago (USA) Ramin Tadayoni - Paris (France)

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Dear Friends and Colleagues, We are delighted to welcome you to Florence for the 1st edition of FLOREtina meeting on 10-13 December 2015. The main topics include both medical and surgical retina diseases. Innovations in imaging, diagnostic techniques and different treatment approaches will be the focus of the discussion. Scientific program comprises plenary sessions with debates and panel discussions, delegates from all over the world will be involved in the meeting with televoting system. On Friday and Saturday morning, during live surgery from University Hospital of Florence, the surgeons will show new surgical techniques, new machines as well as how to operate them to achieve the best results both in routine and complicated retina surgery cases. We are hoping for a truly international meeting without a local connotation. On the other hand Florence, which is considered the birthplace of the Renaissance, the cradle of artists, scientists and inventors, represents an ideal framework for an all over the world knowledge sharing. Looking forward to welcoming you to Florence, Stanislao Rizzo Carl Claes José García-Arumí Kourous A. Rezaei Ramin Tadayoni

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ORGANIZERS Stanislao Rizzo - Florence (Italy) Carl Claes - Antwerpen (Belgium) José García-Arumí - Barcelona (Spain) Kourous A. Rezaei - Chicago (USA) Ramin Tadayoni - Paris (France)

PROGRAM COMMITTEE Fernando Arévalo, USA Remzi Avci, Turkey Francesco Bandello, Italy Martín Charles, Argentina Francesco Faraldi, Italy André Gomes, Brazil Virgilio Morales-Canton, Mexico Manish Nagpal, India Yuichiro Ogura, Japan Ehab El Rayes, Egypt Gianni Virgili, Italy Young-Hee Yoon, South Korea

SURGEONS Involved in Live Surgery Pierre-Olivier Barale, France Francesco Boscia, Italy Antonio Jr. Capone, USA Steve Charles, USA David Chow, USA Carl Claes, Belgium Michele Coppola, Italy José García-Arumí, Spain Carlos Mateo, Spain Cesare Mariotti, Italy Virgilio Morales-Canton, Mexico Marco Mura, Saudi Arabia Kourous Rezaei, USA Stanislao Rizzo, Italy Tommaso Rossi, Italy Ramin Tadayoni, France

SCIENTIFIC SECRETARIAT Andrea Giorni, Italy Alfonso Savastano, Italy Tomaso Caporossi, Italy Francesco Barca, Italy

INTERNATIONAL SPEAKERS Carl C. Awh, USA Pierre-Olivier Barale, France Susan Bressler, USA Antonio Jr. Capone, USA Steve Charles, USA David Chow, USA Borja Corcostegui, Spain Lyndon Da Cruz, UK Donald J. D’Amico, USA Pravin U. Dugel, USA Claus Eckardt, Germany Marta S. Figueroa, Spain Thomas Friberg, USA Stratos V. Gotzaridis, Greece Giuseppe Guarnaccia, Switzerland Tarek Hassan, USA Heinrich Heimann, UK Allen C. Ho, USA Suber Huang, USA Mark Humayun, USA Antonia Joussen, Germany Kazuaki Kadonosono, Japan Jean Francois Korobelnik, France Baruch Kuppermann, USA Anat Loewenstein, Israel Robert MacLaren, UK Stephanie Magazzeni, France Carlos Mateo, Spain Joseph Moisseiev, Israel Marco Mura, Saudi Arabia Fanny Nerinckx, Belgium Kirk Packo, USA Michel Paques, France Fanis Pavlidis, Germany Gisbert Richard, Germany Gabor B. Scharioth, Germany Stephen G. Schwartz, USA Steven D. Schwartz, USA Paulo Stanga, UK Patricia Udaondo, Spain George Williams, USA Thomas Wolfensberger, Switzerland David Wong, China Marco Zarbin, USA Sandrine Zweifel, Switzerland

NATIONAL SPEAKERS Paolo Arpa, Italy Claudio Azzolini, Italy Maurizio Battaglia Parodi, Italy Giorgio Beltrame, Italy Francesco Boscia, Italy Paolo Carpineto, Italy Michele Coppola, Italy Stefano De Cillà, Italy Pier Luigi Esposti, Italy Bruno Falcomatà, Italy Luigi Fontana, Italy Cesare Forlini, Italy Fabrizio Giansanti, Italy Alfonso Giovannini, Italy Paolo Lanzetta, Italy Guido Lesnoni, Italy Cesare Mariotti, Italy Cinzia Mazzini, Italy Ugo Menchini, Italy Rita Mencucci, Italy Francesco Saverio Mennini, Italy Andrea Mercanti, Italy Edoardo Midena, Italy Piergiorgio Neri, Italy Claudio Panico, Italy Mariacristina Parravano, Italy Fabio Patelli, Italy Alfredo Pece, Italy Grazia Pertile, Italy Vittorio Picardo, Italy Stefano Piermarocchi, Italy Giuseppe Querques, Italy Guido Ripandelli, Italy Mario Romano, Italy Tommaso Rossi, Italy Andrea Sodi, Italy Federico Solignani, Italy Giovanni Staurenghi, Italy Gian Marco Tosi, Italy Lorenzo Vannozzi, Italy Monica Varano, Italy Marco Vecchi, Italy Silvio Zuccarini, Italy

COMMITTEES & FACULTY UNDER THE PATRONAGE OF:

FLORETINA SUPPORTS:

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PROGRAM OVERVIEW: AUDITORIUM ROOM VERDE ROOM LIMONAIA ROOM ONICE ROOM 9 ROOM 4 ROOM 5 ROOM 6

Thu

rsd

ay 1

0 14.30 - 15.30 ? ? ?

BAUSCH + LOMB NSAID treatment in the

prevention of CME: clinical evidences

ZEISS

Rescan Advanced Wetlab

15.30 - 17.00 DIABETIC MACULAR EDEMA OCULAR TRAUMA COURSE

17.00 - 17.30 COFFEE BREAK

17.30 - 18.30 DIABETIC RETINOPATHY ESASO

The Future Is Small

ZEISS Rescan Advanced Wetlab

19.30 - 21.00 OPENING CEREMONY

Frid

ay 1

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08.00 - 12.00 LIVE SURGERY ZEISS

Rescan Advanced Wetlab 12.00 - 13.00 WORLD SURGICAL RETINA

13.00 - 14.00

LUNCH

ALLERGAN Management of DME: the Patient

in Focus

ALCON Instrument Size, Cutting Speed

and Beyond in Vitreoretinal Surgery

DORC Rethinking Complex Retina

GEUDER Tamponades: New Generation of

Silicone Oils and Wash-out Liquids

SOOFT Preservative-free Intravitreal

Triamcinolone: Up to Date

SIFI New therapies for chronic diabetic macular edema

ZEISS Rescan Advanced Wetlab 14.00 - 15.30

IMAGING AND DIAGNOSTIC TECHNIQUES

15.30 - 16.45 AMD1

16.45 - 17.00 ITALIAN MASTERS OF RETINA AWARDS

17.00 - 17.30

COFFEE BREAK

LASER PHOTOCOAGULATION IN RETINAL DISEASES: NEW

PERSPECTIVE FOR AN OLD TREATMENT

ALCON Minimizing Macular Edema Risk

in Cataract Surgery

ALFA INTES Dyes in Vitreoretinal Surgery

OPTIKON The R-evolution keeps going

C.I.O. Scharioth Macula Lens - SML: a

New Hope for Patients with Macular Degeneration

MEDONE Suprachoroidal Surgery: Buckling

and Beyond ZEISS Rescan Advanced Wetlab

17.30 - 18.30 AMD2

Satu

rday

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08.00 - 12.00 LIVE SURGERY

12.00 - 13.00 RETINAWS

13.00 - 14.00

LUNCH

NOVARTIS Changing the Burden of

Maculopaties: Ten Years of Experience with Anti-VEGFs

ZEISS New Horizon in OCT

BAUSCH + LOMB B+L Vitreoretinal Approach: New

Trends

SECOND SIGHT Restoring Hope Through Vision - ARGUS II Bionic Eye, 8 Years of

Experience and 150 Patients Worldwide

ALCON Journey in VMT from Pivotal

Studies to Real-Life Data

ADAPTIVE OPTICS IN RETINAL DISORDERS

It is Time to Exchange Expertise and Experience in DME

14.00 - 15.00 VITREOMACULAR TRACTION AND

MACULAR HOLE

15.00 - 16.30 MACHINES / INNOVATION / NEW-TECH

16.30 - 16.50 COFFEE BREAK

16.50 - 18.30 RETINAL DETACHMENT AND PVR

COURSE

Sun

day

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3 08.30 - 10.00 PAPERS SESSION VIDEOS SESSION

10.00 - 11.00 MYOPIC MACULOPATHY

MAIN SESSION (15.30-17.00)

SPONSORED COURSES (14.30-15.30)

PRELIMINARY PROGRAM

ROOM ONICE NSAID treatment in the prevention of CME: 14.30-15.30 clinical evidences Moderators: Rita Mencucci, Gianni Virgili Penetration and persistence of NSAIDs in ocular tissues after topical instillation: profile of an ideal NSAID Piergiorgio Neri Anti-inflammatory therapy for prevention of post -surgical CME: the missing link Luigi Fontana Additive effect of Bromfenac over intravitreal injection of anti-VEGF drugs alone in reducing retinal thickness in neovascular AMD Maurizio Battaglia Parodi Real life experience with Bromfenac: review of clinical cases Federico Solignani Questions to experts

ROOM 6 Rescan Advanced Wet Lab From 14.30 Introduction Ramin Tadayoni WET LAB

AUDITORIUM DIABETIC MACULAR EDEMA 15.30-17.00 Chairs: Anat Loewenstein, Sandrine Zweifel Moderators: Suber Huang, Gian Marco Tosi Dynamic functionality and static changes of retinal vessels in eyes with diabetic macular edema Giuseppe Querques Relationship between gain in BCVA and changes in OCT retinal thickness in randomized clinical trials of anti-VEGF therapy for DME Marco Zarbin A Comparison of Anti-VEGF agents in the management of Diabetic Macular Edema Susan Bressler DME treatment: established evidence Pravin Dugel Dexamethasone implant for diabetic macular edema: do pivotal trials hold the promise? Paolo Lanzetta Direct comparison of intravitreal ranibizumab and dexamethasone implant for the treatment of diabetic macular edema in matched eyes of the same patients Tarek Hassan Tailored treatment for DME Edoardo Midena Vitrectomy for Diabetic Macular Edema Works Fernando Arévalo DISCUSSION CASE PRESENTATIONS: Claudio Panico, Sandrine Zweifel

ROOM VERDE OCULAR TRAUMA - COURSE 16.00-17.00 Chair: Carl Claes Treatment of Suprachoroidal Haemorrhage Cesare Forlini Traumatic IOL subluxation repair Stratos V. Gotzaridis 25G in trauma Marco Mura Approach to eyes with NLP Marco Zarbin Surgical techniques Carl Claes

COFFEE BREAK (17.00-17.30)

THURSDAY DECEMBER 10 THURSDAY DECEMBER 10

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PARTICIPANTS REGISTRATION (From 12.30)

MAIN SESSION (08.00-13.00) MAIN SESSION (17.30-18.30)

AUDITORIUM DIABETIC RETINOPATHY 17.30-18.30 Chair: Susan Bressler Moderators: Francesco Faraldi, Paolo Carpineto Early neuroretinal degenerative signs in Diabetic Retinopathy Paolo Carpineto Multimodal investigation of the early pathologic retinal changes in patients with type 1 diabetes mellitus Monica Varano The role of anti-VEGF agents in the management of Proliferative Diabetic Retinopathy Susan Bressler Laser therapy for retinal disease. Does it still make sense? Thomas Friberg 27 G Bimanual surgery for proliferative diabetic retinal detachment Martin Charles Complex PDR cases André Gomes DISCUSSION

AUDITORIUM WORLD SURGICAL RETINA: global issues and controversies 12.00-13.00 Chairs: Kourous Rezaei, Ramin Tadayoni Panel: Kazauki Kadonoso, Kirk Packo, Manish Nagpal, Andre Gomes Telemedicine paradigm for Universal Newborn Screening and surveillance of ROP Antonio Jr. Capone Endophthalmitis prophylaxis - differences between US and EU Stephen G. Schwartz VITREOUS FLOATERS TREATMENT PROS:Pravin U. Dugel CONS: Joseph Moisseiev DISCUSSION

OPENING CEREMONY (19.30-21.00)

THURSDAY DECEMBER 10

10

FRIDAY DECEMBER 11

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AUDITORIUM LIVE SURGERY 08.00-12.00 Moderators from OR: Kourous Rezaei, David Wong Moderators from Auditorium: Donald J. D’Amico, Fabio Patelli MACULAR SURGERY: Presentations from the auditorium OCT-angiography in vitreo-macular interface pathologies Paolo Carpineto Macular pucker surgery Cesare Mariotti ERM surgery and the reasons to limited functional recovery in otherwise successfully operated eyes André Gomes ILM peeling for diabetic macular edema Donald J. D’Amico The importance of filters and dyes in the macular surgery Michele Coppola

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ROOM ONICE The Future is Small 17.30-18.30 Chairs: Borja Corcostegui, Francesco Bandello, Giuseppe Guarnaccia Coordinators: Bruno Falcomatà, Maurizio Battaglia Parodi New mininvasive vitreous cutters and the cutters of the future Donald J. D’Amico The Current State of Portable Vitrectors Tarek Hassan 27 G vitrectomy techniques Carl Claes The fluidics and the exact pressure control during mininvasive vitrectomy Tommaso Rossi The thermoinfusion used as a surgical tools Mario Romano Mininvasive vitrectomy in paediatric diseases Antonio Jr. Capone Vitrectomy and Pharmacology: new and future pharmacological agents for better results José Garcia-Arumí DISCUSSION

PRELIMINARY PROGRAM

FRIDAY DECEMBER 11

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FRIDAY DECEMBER 11

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ROOM 6 Rescan Advanced Wet Lab Full Day Introduction Ramin Tadayoni WET LAB

ROOM LIMONAIA Instrument size, cutting speed and beyond in Vitreoretinal Surgery 13.00-14.00 Moderator: Steve Charles Speakers: Steve Charles, Carl Claes, Marco Mura, Kirk Packo 13.00-13.05 Introduction – Opening remarks Steve Charles 13.05-13.15 The Physics Behind Small Gauge Vitreoretinal Surgery Steve Charles 13.15-13.55 Benefits of 27 Gauge in Simple and Complex Vitreoretinal Surgeries: Video Presentations and Panel Discussions Carl Claes, Marco Mura, Kirk Packo 13.55-14.00 Closing Remarks Steve Charles

ROOM VERDE Management of DME: The Patient in Focus 13.00-14.00 Chair: Edoardo Midena Inflammation in ME Edoardo Midena How to decide - whom to treat with what? Anat Loewenstein Outcomes in Clinical Practice Patricia Udaondo Why steroids? Mariacristina Parravano

ROOM ONICE Rethinking Complex Retina 13.00-14.00 Francesco Boscia, Fanny Nerinckx, Fanis Pavlidis, Fernando Arevalo Moderator: Francesco Boscia Why innovation is critical to retina surgery Francesco Boscia Confronting challenging cases Fanny Nerinckx EVA: First experiences of a new surgical system Marco Vecchi TDC: Two Dimensional Cutter for next generation vitrectomy Fanis Pavlidis 27g - is it a real option for complex cases? Fernando Arevalo

ROOM 9 Tamponades: New Generation of Silicone Oils and Wash-out Liquids 13.00-14.00 Chair: David Wong Introduction David Wong Silicone oils with high molecular weight additives: design concept, laboratory based evidence and results of RCT David Wong The choice of silicone oil in real practice: how to select the best option Mario Romano Experience with F4H5 Antonia Joussen Heavy Silicone Oils History, new generation with increased stability, a review Tomaso Caporossi DISCUSSION

ROOM 4 Preservative-free intravitreal triamcinolone: up to date 13.00-14.00 Chair: Alfonso Giovannini Moderator: Teresio Avitabile Intravitreal triamcinolone: from clinical trial to clinical practice Guido Lesnoni Our experience with intravitreal preservative-free triamcinolone in diabetic macular edema Paolo Carpineto My way with intravitreal preservative-free triamcinolone acetonide Cesare Forlini Intravitreal preservative-free triamcinolone acetonide as therapy of non-responder ocular phlogosis Piergiorgio Neri Pharmacogenetics as a tool in intravitreal therapy planning Stefano Piermarocchi Efficacy of a new intravitreal triamcinolone formulation in patients with diabetic macular edema low-responders to anti-VEGF: clinical and pharmacogenetic aspects Claudio Panico

LUNCH AND SPONSORED LUNCH SYMPOSIA (13.00-14.00)

PRELIMINARY PROGRAM

FRIDAY DECEMBER 11

14

FRIDAY DECEMBER 11

15

MAIN SESSION (14.00-16.45)

AUDITORIUM IMAGING AND DIAGNOSTIC TECHNIQUES: Innovations for clinical practice and research 14.00-15.30 Chairs: Edoardo Midena, Steven D. Schwartz Moderators: Claudio Azzolini, Lyndon Da Cruz Retina imaging: what is new? Giovanni Staurenghi En Face OCT Mario Romano Angio-OCT Edoardo Midena OCT angiography on diabetic retinopathy Yuichi Ogura OCT in ocular tumors Cinzia Mazzini Adaptive Optics and photoreceptor imaging Steven D. Schwartz How new imaging methods can aid in the differential diagnosis of intraocular tumours Heinrich Heimann Chorioretinal Biopsy in the diagnosis and management of complex retinal disease Lyndon Da Cruz Diagnostic and prognostic biopsies of intraocular tumours - improving techniques and treatment Heinrich Heimann DISCUSSION CASE PRESENTATIONS Giovanni Staurenghi

AUDITORIUM AMD 1 15.30-16.45 Chairs: Ugo Menchini, Marco Zarbin Moderator: Gianni Virgili Diagnosis and monitoring of AMD, including novel technologies for early detection Anat Loewenstein Genetic Testing for AMD: Indications and Controversies Carl C. Awh Angio OCT in macular degeneration Alfredo Pece Anti-VEGF therapy: where did we come from and where are we going to? Sandrine Zweifel Aflibercept in the treatment of wet-AMD: from pivotal trials to real-life including switching Paolo Lanzetta

Fibrosis and Treatment Resistance in Exudative AMD: The Significance of PDGF/VEGF Crosstalk Pravin Dugel Management of AMD-related CNV with Pegaptanib Maurizio Battaglia Parodi DISCUSSION Current treatment, future outcomes and bilateral treatment: debate on AMD evidences Discussants: Francesco Boscia, Paolo Lanzetta, Anat Loewenstein, Marco Zarbin

COFFEE BREAK AND SPONSORED COFFEE BREAKS (17.00-17.30)

AUDITORIUM ITALIAN MASTERS OF RETINAL DISEASES AWARDS 16.45-17.00 Rosario Brancato, Vito De Molfetta, Alessandro Schirru, Mario Stirpe

ROOM VERDE Laser photocoagulation in retinal diseases: new perspective for an old treatment 17.00-17.30 Moderator: Anat Loewenstein The role of laser treatment for DME in anti-VEGF era Francesco Boscia Photostimulation with yellow micropulsed diode laser for macular diseases Pier Luigi Esposti Subthreshold retinal photocoagulation Paolo Lanzetta Laser treatment in vascular retina diseases Baruch Kuppermann

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ROOM ONICE Dyes in vitreo-retinal surgery 17.00-17.30 Lutein in chromovitrectomy: biocompatibility and efficacy Mario Romano Coloring the ILM and ERM with dyes based Lutein, trypan blue and Brilliant blue: clinical experiences Michele Coppola Clinical trials on the evaluation of the safety profile of Doubledyne: preliminary Tomaso Caporossi

PRELIMINARY PROGRAM

ROOM 9 The R-evolution keeps going 17.00-17.30 Tommaso Rossi

FRIDAY DECEMBER 11

16

SATURDAY DECEMBER 12

17

MAIN SESSION (17.30-18.30)

AUDITORIUM AMD 2 17.30-18.30 Chairs: Teresio Avitabile, Thomas Friberg New perspectives on macular degeneration Thomas Friberg Effect of Chromogranin A-derived Vasostatin-1 on Laser-Induced Choroidal Neovascularization in the Mouse Francesco Bandello Management of submacular hemorrhage with pars plana vitrectomy and subretinal TPA injection Remzi Avci RPE transplantation in macular disease Lyndon Da Cruz Autologous choroidal transplantation: what have we learned in 10 years? Grazia Pertile Cell and gene Therapy for Age Related Macular Degeneration Allen C. Ho DISCUSSION

MAIN SESSION (08.00-13.00)

AUDITORIUM RETINAWS 12.00-13.00 Chairs: Kourous Rezaei

Panel: Ehab El Rayes, Remzi Avci, Marco Mura, Claus Eckardt, Allen C. Ho, Martin Charles, Virgilio Morales-Canton, Kirk Packo

LUNCH AND SPONSORED LUNCH SYMPOSIA (13.00-14.00)

AUDITORIUM LIVE SURGERY 08.00-12.00 Moderators from OR: Donald J. D’Amico, Heinrich Heimann Moderators from Auditorium: Fabio Patelli, David Wong RETINAL PROSTHESIS: Presentations from the auditorium The Argus II Retinal Prosthesis J. Fernando Arevalo Eye-on-a-chip David Wong Electronic retinal implants - the subretinal approach Robert MacLaren

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ROOM 5 Suprachoroidal Surgery Techniques 17.00-17.30 Treatment of peripheral detachments and retinal breaks using suprachoroidal buckling

Patient selection, indications for use and treatment risks Choosing the incision site Creating the sclerotomy to access the suprachoroidal space Creating the buckle

Treatment of myopic macular detachments

Patient selection and treatment risks Insertion of the Flexible Illuminated Cannula Placement of the buckle

Future ideas for suprachoridal Surgery

Delivery of therapeutic agents and implants into the suprachoroidal space Possible treatments for uveitis, CRVO and other diseases of the retina

Ehab El Rayes

ROOM 4 Scharioth Macula Lens - SML - New Hope for Patients with Advanced Maculopathy 17.00-17.30 AMD and treatment options today SML concept and technology Patient selection Pre and Post-op examinations Surgery Gabor B. Scharioth Questions and Answers

ROOM VERDE Changing the burden of maculopaties: 13.00-14.00 ten years of experience with Anti-VEGFs The Pharmacoeconomist perspective Francesco Saverio Mennini The Physician perspective Francesco Boscia Treatment appropriateness: actual scenario and future developments Claudio Azzolini

ROOM LIMONAIA ZEISS AngioPlex™ OCT Angiography: the next generation of vascular imaging 13.00-14.00 Welcome, topic and speakers introduction Jean Francois Korobelnik

ZEISS AngioPlex OCT Angiography presentation Stephanie Magazzeni Clinical Cases, interactive mode

Jean Francois Korobelnik, Francesco Bandello

DISCUSSION

PRELIMINARY PROGRAM

SATURDAY DECEMBER 12 SATURDAY DECEMBER 12

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MAIN SESSION (14.00-15.00)

AUDITORIUM VITREOMACULAR TRACTION AND MACULAR HOLE 14.00-15.00 Chairs: Ramin Tadayoni, Guido Lesnoni Moderators: Paolo Arpa, Thomas Wolfensberger Structural and vascular intraretinal changes: new classification of vitreo-macular traction Mario Romano Correct case selection in macular hole surgery André Gomes Ocriplasmin in the real world in 2015 and beyond Stephen G. Schwartz Autologous ILM Transplant for refractory macular hole not closed after previous ILM peel (Case series) Thomas Wolfensberger Face down in macular hole is it still needed Ehab El Rayes Vitreoretinal interface abnormalities in retinal dystrophies Andrea Sodi DISCUSSION CASE PRESENTATIONS George Williams

ROOM 5 ADAPTIVE OPTICS IN RETINAL DISORDERS 13.00-14.00 Moderator: Andrea Sodi Ocular Vascular Imaging with Adaptive Optics Michel Paques Photoreceptors exploration with Adaptive Optics Mariacristina Parravano

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ROOM 9 Restoring hope through vision - ARGUS II Bionic Eye 13.00-14.00 8 years of experience and 150 patients worldwide Chair: Thomas Wolfensberger Bioengineering Argus II Mark Humayun Argus II retinal implant: reaching artificial vision via surgical approach, experience in Italy Fabio Patelli Argus II implant in dry AMD Paulo Stanga Safety, reliability and benefit of the Argus II device Suber Huang

ROOM 4 Journey in VMT from pivotal studies to real-life data 13.00-14.00 Moderator: Ramin Tadayoni General introduction Ramin Tadayoni VMT epidemiology, ocriplasmin clinical profile and the importance of Optimizing Early Detection and Diagnosis Giovanni Staurenghi Italian real life clinical cases and key learnings Francesco Barca Journey in VMT from pivotal studies to real word data David Chow DISCUSSION

ROOM 6 It is time to exchange expertise and experience in DME 13.00-14.00 Speakers: Susan Bressler, Edoardo Midena

ROOM ONICE B+L Vitreoretinal approach: new trends 13.00-14.00 Moderator: Paolo Lanzetta 25 gauge procedure on a Macular Hole Stefano De Cillà Surgery Plan Strategy on Diabetic Patient Michele Coppola The advantages of a combined procedure with Stellaris Andrea Mercanti Which is the correct IOL for a patient at vitreoretinal surgery procedure risk?: the opinion of an anterior Surgeon Vittorio Picardo

PRELIMINARY PROGRAM

SATURDAY DECEMBER 12 SATURDAY DECEMBER 12

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AUDITORIUM MACHINES/INNOVATION/NEW-TECH 15.00-16.30 Chairs: Claus Eckardt, Mark Humayun Moderators: David Chow, Pravin U. Dugel, Gisbert Richard New Instrumentation David Chow Running towards a bionic man Mark Humayun Why Heads-up surgery? Claus Eckardt Retinal prosthesis in Dry-AMD Paulo Stanga Multimodal Digitally Assisted Vitrectomy Surgery: The Next Revolution? Pravin U. Dugel Hydraulic Resistance and vitreous chunk lenght: the quest for ideal cut-rate Tommaso Rossi 27G Vitrectomy and new vitreoretinal surgical techniques Pravin U. Dugel Surgical Innovation: Does it benefit the treatment of complex cases? Mario Romano Improving fluid and air stability with MIVS Martin Charles Working under air during Vitrectomy. Why and When Carlos Mateo Permanent keratoprosthesis with new approaches with small gauge and medium term perfluorochemical tamponades Donald J. D’Amico DISCUSSION

MAIN SESSION (15.00-16.30)

COFFEE BREAK 16.30-16.50

MAIN SESSION (16.50-18.30)

AUDITORIUM PVR - COURSE 17.45-18.30 Chair: José Garcia-Arumì, Panel: Donald J. D’Amico, Borja Corcóstegui, Kirk Packo, Ramin Tadayoni PVR from concept to surgical progress Ramin Tadayoni Scleral buckle and vitrectomy in PVR Borja Corcóstegui How to manage PVR in trauma cases José Garcia-Arumì The role of relaxing retinotomy in PVR Donald J. D’Amico Endotamponades in PVR Kirk Packo DISCUSSION

AUDITORIUM RETINAL DETACHMENT 16.50-17.45 Chairs: Carl Claes, José García-Arumí Moderators: Giorgio Beltrame, Guido Ripandelli Scleral buckling is the procedure of choice for rhegmatogenous RD in young patients Joseph Moisseiev Chandelier based buckling surgery Manish Nagpal 27G and RD (Is it feasible?) Carl Claes A Rescue Therapy For Persistent Optic Disc Pit Maculopathy In Previously Vitrectomized Eyes Marta S. Figueroa A safer way to remove proliferative membranes in retinal detachment: PFCL and staining José García-Arumí DISCUSSION

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PRELIMINARY PROGRAM

SUNDAY DECEMBER 13

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AUDITORIUM PAPERS AND VIDEOS SESSION 09.00-10.00 Best Presentation Award “Luigi Barca”

BREAKFAST WITH EXPERTS (08.30-09.00)

END OF THE MEETING

Small tables of discussion with retina experts

MAIN SESSION (09.00-11.00)

AUDITORIUM MYOPIC MACULOPATHY 10.00-11.00 Chairs: Francesco Boscia, Carlos Mateo Moderator: Silvio Zuccarini Myopic maculopathy imaging Alfredo Pece Anti-VEGF as soon as possible for how long? Young-Hee Yoon Macular hole surgery in high myopia: comparing techniques Grazia Pertile VITRECTOMY VS SCLERAL BUCKLING - DEBATE Minimally invasive vitrectomy for myopic foveoschis Francesco Boscia Long-term outcomes of 23g vitrectomy with ILM peeling and gas tamponade for myopic traction maculopathy Marta S. Figueroa “AMB” macular buckle in retinal detachment and macular hole in high myopia Cesare Forlini Myopic Macular Hole. Is it still a challenge? Carlos Mateo Suprachoroidal buckles in myopic macular hole Ehab El Rayes DISCUSSION

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PRELIMINARY PROGRAM

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EXHIBITION FLOORPLAN

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EXHIBITORS LIST

ABBOTT MEDICAL OPTICS A, B

BAUSCH + LOMB 3, 4

AKTIVE C2

ALCON 11, 12

ALFA INTES + ALFA INSTRUMENTS + KEMIN E

ALLERGAN 19

BAYER 2

CALDERARO MEDICAL SERVICE + NEW TECH + NIDEK 1, 17, 18

CIO ITALIA P

CSO 16

DORC 5, 6

E. JANACH F

E.SA.MED N

ESASO Desk 1

ESPANSIONE Group + HAAG STREIT SURGICAL 13

FARMAPLUS ITALIA Desk 3

FARMEZ 15

FARMIGEA S

GEUDER + C&B MEDICAL + FLUORON I

INSIGHT INSTRUMENTS C3

LEICA C

MEDICAL BOOKS Desk 5

MEDONE C4

MS MEDICAL SERVICE + TOPCON 10

NICOX O

NOVARTIS H, M

OCULUS 20

OFF ITALIA R

OPTIKON Desk 4

ORBIS Desk 2

SECOND SIGHT D

SIFI Group T

SOOFT / OO Group G

SYNERGETICS 7

THEA 14

VISUFARMA C1

VITREQ L

VOLK OPTICAL C5

ZEISS 8, 9

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GENERAL INFORMATION:

CLOAKROOM A cloakroom is available for participants in the basement floor close to the Exhibition and the Auditorium. SPEAKERS READY ROOM If you are speaking at the meeting, plan time to visit the Speakers Ready Room to review your presentation. This space will have an audio-visual tech on site. The Speaker Ready Room will be located on the Lowest Level of the Palazzo Dei Congressi building, known as the PASSI PERDUTI (Basement – Lowest Level) at the Firenze Fiera Congress & Exhibition Center. This space is open during the following hours for speakers use: Thursday 10: 12.30 – 18.30 Friday 11: 07.30 – 18.30 Saturday 12: 07.30 – 18.30 Sunday 13: 08.00 – 11.30 PowerPoint projection is available in all meeting rooms. For technical reason speakers are not allowed to make presentations with laptop in the meeting rooms, but must load their presentation in the Speakers Ready Room. E.C.M. (ITALIAN ATTENDEES ONLY) Per il Congresso FLOREtina 2015 non è previsto l’accreditamento residenziale. Per garantire la possibilità di acquisire i crediti formativi, sarà incluso nella quota d’iscrizione un programma di formazione a distanza (FAD) rivolto ai medici. La piattaforma FAD sarà disponibile a partire dal 1 febbraio 2016 fino al 31 Gennaio 2017 all’indirizzo www.floretinafad.it. Ai fini dell’ottenimento dei crediti ECM è necessario: • Collegarsi al sito ed inserire i propri dati personali e il proprio

indirizzo email usando l’apposito form di registrazione; • Validare la propria utenza attraverso un apposito link ricevuto

all’indirizzo email fornito; • Completare il percorso formativo e compilare tutti i

questionari. L’attestazione dei crediti è subordinata al superamento del questionario di valutazione dell’apprendimento con una percentuale uguale o superiore al 75% di risposte esatte (numero massimo di 5 tentativi a scalare).

L’attestato ECM, qualora ne ricorrano le condizioni, sarà scaricabile dall’apposita sezione “crediti ECM” del sito. Si precisa che per coloro completeranno e supereranno il percorso formativo nel 2016, l’anno di riferimento per i crediti sarà il 2016; altrimenti i crediti avranno validità per l’anno 2017.

MOBILE PHONES AND PHOTOGRAPHY Please do not forget to turn your mobile phones to silent mode during sessions Participants are kindly requested to refrain from taking pictures during sessions. NON-SMOKING POLICY The FLOREtina Congress is a Non-Smoking event. Delegates are reminded that smoking in enclosed spaces is illegal in Italy.

LIABILITY AND INSURANCE The Congress Secretariat and Organisers cannot accept liability for personal accidents or loss of or damage to private property of participants. Participants are advised to take out their own personal travel and health insurance for their trip.

SAFETY AND SECURITY Please do not leave bags or suitcases unattended at any time, whether inside or outside the session halls. Hotels strongly recommend that you use their safety deposit boxes for your valuables.

FIRST AID Should you require first aid assistance, please contact the registration desk or any uniformed member of the meeting staff.

CITY INFORMATION Visit www.firenzeturismo.it/en/for information on Florence.

CURRENCY Euro (EUR) All major credit cards (Visa, MasterCard, American Express) are accepted in most of the restaurants, shops etc.

CONGRESS VENUE Palazzo dei Congressi Piazza Adua, 1 - 50100 Florence (Italy) www.firenzefiera.it WEBSITE The official website is www.floretina.it. LANGUAGE English is the official language. Simultaneous translations English/Italiano will be provided during main sessions. REGISTRATION DESK HOURS The Registration Desk will be opened as follows: Thursday 10: 12.30 – 19.00 Friday 11: 07.30 – 19.00 Saturday 12: 07.30 – 19.00 Sunday 13: 08.00 – 11.30 EXHIBITION OPENING HOURS The Exhibition will be opened as follows Thursday 10: 14.00 – 18.30 Friday 11: 08.00 – 18.30 Saturday 12: 08.00 –18.30 Sunday 13: 08.00 – 12.00 CONGRESS NAME BADGE Upon registration you will receive your name badge. You are kindly requested to wear your badge during all sessions and events. CERTIFICATES OF ATTENDANCE Certificates of attendance are available from the registration desks. INTERNET ACCESSS WiFi Internet access WiFi is available for congress participants throughout the public areas. In order to log in please use the following user name and password: Username: floretina2015 Password: floretina2015

FLOREtina 2015 APP Install the FLOREtina 2015 interactive mobile App to your smartphone and portable devices to access all the Congress information you could need during and after the Congress: • See the overview of sessions, speakers and exhibitors • Create your own program for the event, including

bookmarking the sessions you wish to attend • Vote during Live Surgery sessions • Receive real-time updates Download the FLOREtina App

now to enhance your congress experience! Download available on iTunes and Google Play stores. BREAKS Lunch and refreshment breaks are included in the delegate fee and will be available as follows: Thursday 10: Refreshment break 17.00 – 17.30, Exhibition Area Friday 11 and Saturday 12: Refreshment station 09.00 – 12:00, Exhibition Area Lunch* 17.00 – 17.30, Exhibition Area + Lunch Symposia Rooms Refreshment break 16.30 – 16.50, Exhibition Area Sunday 13: Farewell breakfast 08.30 – 09.00, Exhibition Area *Tickets to collect the lunch box are in your congress badge. SOCIAL EVENTS Opening Ceremony The Opening Ceremony will be held in the wonderful Salone dei 500 of Palazzo Vecchio. Thursday 10, 19.30 – 21.00. All registered delegates and exhibition visitors are welcome to attend.

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ACKNOWLEDGEMENTS: GENERAL INFORMATION:

AKTIVE ALFA INSTRUMENTS ALFA INTES ANGELINI SPA BIOFTA-BIODUE SPA C.M.S. CALDERARO MEDICAL SERVICE CB MEDICAL C.I.O. CSO SRL E. JANACH

ESPANSIONE GROUP FARMAPLUS ITALIA SRL FARMEZ SRL FLUORON GMBH GEUDER AG INSIGHT INSTRUMENTS LEICA MICROSYSTEMS M.S. MEDICAL SERVICE SRL MEDONE MEDICAL BOOKS

MEDESA SRL NEW TECH SPA NICOX FARMA SRL NIDEK MEDICAL SRL OFF ITALIA SRL STELOR MEDICA SRL SYNERGETICS ITALIA TOPCON ITALIA VISUFARMA VITREQ

DIAMOND

PLATINUM

GOLD

SILVER

BRONZE

ELECTRICITY The electric current supplied is 220 V. Round, two-pin plug points are available, as elsewhere in Europe. In case you have any devices from the USA or UK, please remember to bring a transformer/adapter. LOCAL HOUR GMT + 1 hour BANKING Most Florence banks open between 08:30 and 13:30 and 14:45 to 15:45 Monday to Friday. They are closed on weekends and public holidays and most of them have a cash dispenser and a currency exchange service. TRANSPORTATION • From the main train station: Firenze S. Maria Novella is a

“main” station located right inside the city centre, in Piazza della Stazione, and a primary hub in Firenze’s public transport system. It hosts over 400 trains per day and is a major intersection point for many bus and taxi lines.

• From the airport: A bus connection (Linea-Volainbus) is operating from the airport to the city centre (Firenze S. Maria Novella station) every 20-25 minutes.

• Taxis: Taxis in Florence can be ordered by phone: +39 055 4242 +39 055 4390 or found at the official taxi stands. You cannot stop a taxi on the road.

• Bus: Florence has a comprehensive network of local bus routes. Most of them stop at the main railway station and therefore near to the convention venue. Bus tickets can be purchased at most coffee bars and kiosks. Fare is €1,20 multiple trips, valid up to 60 minutes.

• Car parking: There are several paying parking areas around the Congress Centre.

USEFUL TELEPHONE NUMBERS IN FLORENCE • Medical emergency: 118 • Fire emergency: 115 • Police: 113

• Florence airport – information: 055 3061300 • Florence airport – lost luggage: 055 3061302 • For international calls from Italy: 00 + country code +

number • For international calls to Italy: +39 + city code + number

24hour Pharmacies: Santa Maria Novella Station Via Calzaiuoli, 7 r Piazza San Giovanni, 20

CONGRESS CARD We have the pleasure to offer to FLOREtina 2015 delegates a special Congress Card downloadable for free, valid for the whole stay in Florence during the congress. It provides special offers and discounted fees at museums, historical sites, shops, restaurants, wellness centers, golf clubs, bike rental stands, car rental agencies, sightseeing tours, taxis, and airport transfer with private driver. The Congress Card is not nominal and can be used by the participants as well as by anyone accompanying them. A further bonus is that it is also valid a few days prior to and after the congress date. Click on www.floretina2015.it/congress-card to discover the Congress Card and activate it!

ORGANIZING SECRETARIAT:

AIM Group International - Florence Office Viale G. Mazzini, 70 - 50132 Florence, Italy Ph.+39 055 233881 - Fax. +39 055 3906908 info@floretina.it - www.floretina.it