inhibitors, agonists, screening librariesupdate.medchemexpress.com/pdf/mce_brochure.pdf · 2017. 4....
TRANSCRIPT
www.MedChemExpress.com
MedChem Express
Inhibitors, Agonists, Screening Libraries
Inhibitors
Inhibitor Cocktails
Compound Screening Libraries
Disease Related Products
Vitamin D Related Products
Natural Products
Antibody-Drug Conjugate Related Products
ImmunologyTargetedInhibitors
CancerTargetedInhibitors
Antibody-Drug Conjugates
CellSignaling Pathways
GPCR/G Protein
Epigenetics
Cell Cycle/DNA Damage
MAPK/ERK Pathway
Autophagy
Protein Tyrosine Kinase
PI3K/Akt/mTOR
NF-κBStem Cells/Wnt
TGF-beta/Smad
Compound Screening Libraries
Publications Citing Use of MCE Products
Contents About Us
About Us
Inhibitors
Screening Libraries
2
2
3
5
6
7
8
Inhibitor Cocktails
Overview of MCE
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years of experience in the life science industry. MCE will be a competent and trustworthy partner for your research and scientific projects.
Quality
We offer: • Structurally and synthetically diverse biologically active compounds • Flexible order volume ranging from milligrams to kilograms scale • On-time delivery of productsWe are a client-centric company and are always looking to hearing from you about how our products and services might better assist you.
Services
Experience
Our chemists are highly experienced in molecular synthesis and the preparation of large quantities of structurally diverse and synthetically challenging molecules. We work with clients that have widely different needs and we have been very successful in meeting such needs.
Natural Products
Antibody-Drug ConjugateRelated Products
Disease Related Products
Vitamin D Related Products
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Product quality is the key to our success and we take pride in offering only the highest-grade products. Product identity, quality, purity and activity are assured by our robust quality control and assurance polices, programs and procedures. We perform thorough analytical testing - including HNMR, LC-MS and HPLC - stability testing and activity assays on our products and the results from these tests are available to clients.
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Target Name Cat. No.
A
0-9
Cat. No.Target Name
Clozapine
Galanthamine5-Iodotubercidin
NameTarget Cat. No.
Inhibitors, Agonists, Screening Libraries
F
I
G
H
J
Istradefylline
MirabegronVilanterolGSK2141795MK 2206LDK378LDN193189Enzalutamide
PD 123319AVE 0991
CHIR-090RadezolidTedizolidTriptolideKU-60019AZ20VE-822Alisertib
B
R428
ABT-199ABT-737NavitoclaxWEHI-539DasatinibPonatinib(+)-JQ-1
C
BI 2536GSK 525762AGSK1324726AI-BET151OTX-015AVL-292CGI-1746PCI-32765
5-HT Receptor
Adenosine KinaseAChE
Adenosine Receptor
Adrenergic Receptor
Akt
ALK
Androgen ReceptorAngiotensin Receptor
Antibacterial
Apoptosis InducerATMATR
Aurora KinaseAxl
Bcl-2 Family
Bcr-Abl
BET Bromodomain
BTK
Caspase
CDK
Lorcaserin HY-17366
HY-76299HY-15424HY-10888HY-10889HY-14773HY-14300AHY-15965HY-10358HY-15656HY-12071AHY-70002HY-15778HY-10259AHY-15460HY-14800HY-14855HY-32735HY-12061HY-15557HY-13902HY-10971HY-15150
HY-15531HY-50907HY-10087HY-15607AHY-10181HY-12047HY-13030HY-50698HY-13032HY-13960HY-13235HY-15743HY-18012HY-11999HY-10997
HY-16658
HY-16297
HY-15777
HY-12293
HY-50767
HY-10008
HY-15368
Preladenant
CCR HY-50674
CFTR
CGRP Receptor
Ivacaftor
MK-0974
Ki20227c-Fms
HY-13017
HY-32709
HY-10408
Chk
CK2c-Met/HGFRCMVCXCR
Cytochrome P450
MK-3207AZD-7762LY2603618SCH900776CX-4945TivantinibLetermovirPlerixafor ReparixinSCH 527123SCH 546738Abiraterone CobicistatOrteronelTalarozole
HY-10302HY-10992HY-14720HY-15532HY-50855HY-50686HY-15233HY-50912HY-15251HY-10198HY-10017HY-75054HY-10493HY-10505HY-14531
GSK-923295 HY-10299CENP-E
E
DDeubiquitinase ML-323
SJB3-019A
Dynamin Mdivi-1CX-5461
HY-17543HY-80012
HY-15886HY-13323DNA/RNA Synthesis
EZH2
Afatinib
3-Deazaneplanocin A
HY-10261
HY-12186
Endothelin Receptor
EGFR
ERK
EPZ-6438GSK126
HY-13803HY-13470
F
Factor Xa 5-R-Rivaroxaban HY-76948
FAK PF-562271 HY-10459PND-1186
FGFR BIBF 1120LY2874455
HY-50904HY-13304
NVP-BGJ398 HY-13311
ApixabanRivaroxaban
HY-50667HY-50903
Ponatinib HY-12047
FLT3 AST 487 HY-15002
Pacritinib
Ponatinib
HY-16379
HY-12047
LCL161IDO-IN-2
IRAK inhibitor 4
Oseltamivir HY-13318Cilengitide HY-16141
HY-15518HY-15683
MLN120B HY-15473
HY-13278
CYT387
CC-930
SP600125
HY-10962
HY-15495
HY-12041
AZD-1480 HY-10193
BMS-509744 HY-11092
IAPIDO
IRAK
Influenza VirusIntegrin
IKK
JNK
JAK
Itk
Asunaprevir
Romidepsin
HCV
HDAC
HedgehogHIFHIV
HMTase
Riociguat HY-14779
HY-14434
HY-15149
GPR40 TAK-875
Cinaciguat
HY-10480GSK-3 CHIR-99021 HY-10182
HY-14181Guanylate Cyclase
Gap Junction Protein
GlyT1
Tonabersat
Bitopertin
HY-15204
Glucagon Receptor MK 0893 HY-50663HY-10809
GPCR19 INT-777 HY-15677
FXR GW 4064 HY-50108
Ganetespib HY-15205
VismodegibFG-4592BMS-626529
3-Deazaneplanocin A
HY-10440HY-13426HY-15440
HY-12186
HSP
BoceprevirLedipasvirPSI-7977R-1479SimeprevirTelaprevir
HY-10237HY-15602HY-15005HY-10444HY-10241HY-10235
TasquinimodVorinostat
HY-10528HY-10221
Dolutegravir
Tipranavir
HY-13238
HY-15148
AZ505EPZ-5676EPZ-6438GSK126
HY-15226HY-15593HY-13803HY-13470
INCB 024360 HY-15689
Baricitinib HY-15315
Pacritinib
Ruxolitinib
HY-16379
HY-50856
AZD-9291CO-1686Erlotinib Atrasentan MacitentanSitaxsentan XMD8-92
HY-15772HY-15729HY-12008HY-15403AHY-14184HY-11103HY-14443
HY-13917
C
Z-VAD-FMK
LEE011
LY2857785
Palbociclib
SNS-032
LY2835219
INCB3344
InhibitorsOver 6000 selective inhibitors and agonists targetingmore than 300 key proteins.
www.MedChemExpress.com
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Name Cat. No.Target
R
Senicapoc HY-50694Potassiun Channel
S
W
γ
CalcitriolMaxacalcitolBIBF 1120CabozantinibPonatinibRegorafenibSU5416Vandetanib
HY-10002HY-32339
ICG-001 HY-14428
HY-50904HY-13016HY-12047HY-10331HY-10374HY-10260
VEGFR
Wnt
DAPTLY-411575PF-3084014
HY-13027HY-50752HY-15185
γ-secretase
V
Calcipotriol HY-10001
LenalidomideNecrostatin 2
Daun02Doxorubicin INNO-206
HY-A0003HY-14622HY-13061HY-15142HY-16261
TNF-alpha
Topoisomerase
VD/VDR
T
DasatinibSaracatinib
HY-10181HY-10234
Src
BAY 61-3606
LY2109761LY2157299SD-208GS-9620TAK-242
HY-14985
HY-12075HY-13226HY-13227HY-15601HY-11109
Syk
TGF-β Receptor
TLR
Raf
Ras
SCDsFRP-1SGKSGLTSIKs
Smo
RSV
DabrafenibLGX818MLN 2480Vemurafenib
HY-14660HY-15605HY-15246HY-12057
Salirasib HY-14754
ROCK SLx-2119Y-27632
HY-15307HY-10583
HY-50709WAY 316606EMD638683CanagliflozinHG-9-91-01
LDE225
TMC353121
A939572HY-10858HY-15193HY-10451HY-15776
HY-16582
HY-11097
ONO-AE3-208 HY-50901BortezomibCarfilzomibMG-132
HY-10227HY-10455HY-13259
Prostaglandin ReceptorProteasome
AZD1208 HY-15604PKC412 HY-10230
BI 2536 HY-50698
PimPKC
PLK
P
GSK2606414 HY-18072PERK
Darapladib HY-10521Phospholipase
BYL-719CAL-101GDC-0032
HY-15244HY-13026HY-13898
PI3K
OTSSP167 HY-15512AMELKMMADMonomethyl auristatin E
HY-15581HY-15162
Microtubule/Tubulin
VcMMAEAZD2014EverolimusTorin 2WYE-125132
HY-15575HY-15247HY-10218HY-13002HY-10044
mTOR
K
L
M
Name Cat. No.Target
ST 2825 HY-50937MyD88
N
O
P
Istaroxime
AP1903AP20187SBE-β-CDSobetiromeTacrolimusTeriflunomideTH-302
HY-15718A
HY-16046HY-13992HY-17031HY-14823HY-13756HY-15405HY-10535
SEA0400 HY-15515Na+/Ca2+ ExchangerNa+/K+ ATPase
EVP-6124 HY-15430AnAChRMLN4924 HY-70062NAEFK866 HY-50876Nampt
Others
SB 203580 HY-10256p38 MAPK
PF-3758309 HY-13007p21-activated Kinases
Suvorexant HY-10807OX Receptor
BMN-673MK-4827
HY-16106HY-10619
PARP
Olaparib HY-10162
Bay 60-7550PF-04447943
HY-14992HY-15441
BIBF 1120 HY-50904
PDE
PDGFR
SCH772984SelumetinibTrametinibU0126
HY-50846HY-50706HY-10999HY-12031
CobimetinibGDC-0623
MEK
MI-773Nutlin-3aRG7112RG7388
MDM2/p53
HY-13064HY-15610
HY-17493HY-10029HY-10959HY-15676
AM095AM966
BardoxoloneKeap1-Nrf2
LPL Receptor
UmeclidiniummAChR
HY-16039HY-15277
HY-13324
HY-12100
ElacridarTariquidarZosuquidar
HY-50879HY-10550HY-50671
P-glycoprotein
PI3K GDC-0941GSK2636771IPI-145
HY-50094HY-15245HY-17044
Akt
AMPK
MAPKIKKα
p53
TSC2
TSC1
mTORC1
ULK1 Complex
Ras
Insulin
Insulin Receptor
PI3K
PDK-1
mTOR
GβL Raptor
Autophagy
Inhibitor Cocktails
Customer Reviews
Components
Components
Components
Components
5
Price Comparison
Price Comparison
Price Comparison
Price Comparison
Inhibitors, Agonists, Screening Libraries
Protect Your ProteinsMore Efficiently!
Phosphatase Inhibitor Cocktail I (100× in DMSO)
Cat. No.: HY-K0021
Phosphatase Inhibitor Cocktail I effectively inhibits alkaline phosphatases and serine/ threonine protein phosphatases such as PP1 and PP2A.
Bcl-2
GAPDH
Time
Brand
0 h RT, 6 h
Control MCE Roche Sigma
Bcl-2
GAPDH
Control MCE Roche Sigma
Time
Brand
0 h RT, 12 h
MCE Protease Inhibitor Cocktail provides Bcl-2 protection in thyroid cancer cell line 8505C, and is most effective after 6-12 hours incubation at room temperature.
$0 $200 $400 $600
MCE $35 $250Roche $64 $438
Pierce $483 $68 Sigma $510 $71.8
1 mL × 10 (100× Conc.)1 mL (100× Conc.)Size:
Ingredient
AEBSFAprotininBestatin
Target
Serine proteasesSerine proteasesAminopeptidases
Ingredient
E-64LeupeptinPepstatin A
Target
Cysteine proteasesSerine and cysteine proteasesAspartic proteases
Merck (Calbiochem) $650$83
1 mL × 10 (100× Conc.)Size:
$0 $400 $800 $1,200
$440Merck (Calbiochem)$1,260 Roche$315MCE
Protease Inhibitor Cocktail (EDTA-Free)
Cat. No.: HY-K0010 (100× in DMSO)
Protease inhibitor cocktail is used in mammalian cell lysates or tissue extracts to increase protein stability.
Pre-dissolved in DMSO
1 mL1 mL × 101 mL × 501 mL × 100
Cat. No.: HY-K0011 (mini-Tablet)
One mini-Tablet can be added to 10 mL extraction medium directly.
Price
$120$200
mini-Tablet
25 pcs50 pcs
Price
$45$315$1330$1990
Pre-dissolved in DMSO
1 mL1 mL × 101 mL × 501 mL × 100
1 mL × 10 (100× Conc.)Size:
Ingredient
(-)-p-Bromotetramisole oxalateCantharidinMicrocystin LR, Microcystis aeruginosa
100× Conc.
2.5 mM500 μM500 nM
Target
Alkaline phosphatasesSer/Thr phosphatasesPP1 and PP2A
Phosphatase Inhibitor Cocktail III (100× in DMSO)
Cat. No.: HY-K0023
Phosphatase Inhibitor Cocktail III effectively inhibits serine/threonine and alkaline phosphatases.
1 mL × 10 (100× Conc.)Size:
$0 $400 $800 $1,200
Sigma $485
Roche $1,260 MCE $265
Merck (Calbiochem) $544
Abcam $650
Ingredient
Sodium fluorideSodium orthovanadateSodium tartrate dihydrateSodium molybdate Imidazole
100× Conc.
100 mM100 mM400 mM115 mM200 mM
Target
Acid phosphatasesAlkaline phosphatases, PTPs, ATPasesAcid phosphatasesAcid and phosphoprotein phosphatasesAlkaline phosphatases
Ingredient
(-)-p-Bromolevamisole oxalateCantharidinCalyculin A
100× Conc.
2.5 mM500 µM1 µM
Target
Alkaline phosphatasesProtein phosphatase 2A (PP2A)Protein phosphatases 1 and 2A (PP1 and PP2A)
Sigma $672
Roche $1,260 MCE $395
Merck (Calbiochem) $935
Abcam $950
$0 $400 $800 $1,200
Phosphatase Inhibitor Cocktail II (100× in ddH2O)
Cat. No.: HY-K0022
Phosphatase Inhibitor Cocktail II effectively inhibits acid and alkaline phosphatases as well as protein tyrosine phosphatases (PTPs).
Price
$55$395$1840$2765
Pre-dissolved in DMSO
1 mL1 mL × 101 mL × 501 mL × 100
Price
$38$265$1106$1660
Pre-dissolved in ddH2O
1 mL1 mL × 101 mL × 501 mL × 100
Price
$35$250$1000$1500
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MassachusettsInstitute ofTechnology
Tsinghua University
University of CaliforniaSan Francisco
Cancer
Endocrinology
Metabolic Disease
Inflammation/Immunology
Cardiovascular Disease
Infection
Neurological Disease
7
(24R)-MC 976
(24S)-24,25-Dihydroxyvitamin D3
(24S)-MC 976
Secalciferol Seocalcitol TacalcitolFalecalcitriol
Impurity B of Calcitriol Impurity C of Alfacalcidol Impurity C of Calcitriol Impurity of Calcipotriol
Lexacalcitol
Calcitriol Derivatives Cholecalciferol Doxercalciferol Doxercalciferol-D3 Eldecalcitol Ercalcidiol
Calcifediol Calcifediol-D6 Calcipotriol Calcitetrol Calcitriol Calcitriol D6
25-Hydroxy VD2-D6
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
Alfacalcidol
Alfacalcidol-D6
1alpha, 25-Dihydroxy VD2-D6
24, 25-Dihydroxy VD2 24, 25-Dihydroxy VD3 24R-Calcipotriol
1alpha-Hydroxy VD4
Inhibitors, Agonists, Screening Libraries
25,26-Dihydroxyvitamin D3
VD2-D3 VD3-D6 Vitamin D4
Maxacalcitol Maxacalcitol-D6 MC 1046 MC 976 Paricalcitol Paricalcitol-D6
1alpha, 24, 25-Trihydroxy VD2
Disease Related Products
Vitamin D Related Products
Enzalutamide MG-132 MLN4924 BIBF 1120 GSK126 SCH772984
Everolimus (+)-JQ-1 Cilengitide Trametinib Olaparib
Dasatinib AZD-9291 PCI-32765 Z-VAD-FMK GSK 525762A BMN-673
Selumetinib Y-27632 OTX-015 OTSSP167 Vemurafenib Afatinib
Bortezomib LY294002 Cobimetinib U0126 GDC-0032
Palbociclib
Monomethyl auristatin E
Forskolin INT-777 Ivacaftor Ibutamoren Ulipristal
TAK-875 MK-8245 Lorcaserin CHIR-99021 GW 4064 Ipragliflozin
TAK-242 SB 203580 ST 2825 Reparixin Calcipotriol HG-9-91-01
RN486 MCC950 Teriflunomide
CC-930 Resiquimod Umeclidinium BMS-509744 Ki20227 Vilanterol
Ruxolitinib Talarozole Baricitinib AM966 Tacrolimus GS-9620
PTC124 Rosiglitazone
Sobetirome Ranirestat Dapagliflozin LCQ-908 Odanacatib Pioglitazone
Canagliflozin Maxacalcitol LX-4211 EMD638683 Lesinurad Alfacalcidol
Mifepristone Silodosin TAK-438 DHEA Etonogestrel Cabergoline
Tanaproget MSI-1436 Dienogest Pasireotide
VX-809
SEA0400 Riociguat Apixaban Rivaroxaban Istaroxime AVE 0991
Simeprevir Dolutegravir PSI-7977 Telaprevir Asunaprevir Boceprevir
DAPT Suvorexant Clozapine PF-04447943 Tonabersat PF-3084014
EVP-6124 LY-411575 Istradefylline MK-3207 Bay 60-7550 Galanthamine
BMS-927711 Opicapone Lu AE58054 Cebranopadol Pitolisant Brexpiprazole
Brivaracetam Vortioxetine LX1606 SKF-82958
Ledipasvir Letermovir Cobicistat BMS-626529 Rilpivirine Elvitegravir
Entecavir Ritonavir Emtricitabine Ribavirin Tenofovir Lamivudine
Adefovir dipivoxil Efavirenz Lopinavir
Macitentan Bosentan Cinaciguat Darapladib 5-R-Rivaroxaban PD 123319
Vernakalant Sitaxsentan AHU-377 Mibefradil
Dabigatran etexilate
NS-30420-HETE
Tel: +4686500910Fax: +4686531025E-mail: [email protected]: Bergkällavägen 37 lokal 24 192 79 Sollentuna Sweden
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Tel: 609-228-6898Fax: 609-228-5909 E-mail: [email protected]: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
ADC Cytotoxins Mitomycin C
Methotrexate
Auristatin F
PF-06380101 10-Deacetyl-7-xylosyl paclitaxel Monomethyl auristatin E
Daunorubicin Tubulysin A PNU-159682 MMAF Taltobulin
D8-MMAE Campathecin Dolastatin 10 Doxorubicin Auristatin E
Paclitaxel Triptolide Daun02 MMAD Ansamitocin P-3
Saccharides and Glycosides
Phenylpropanoids
Flavonoids
Terpenoids and Glycosides
Quinones
Xylitol
Psoralen
Icariin
Isoliquiritigenin
Ginsenoside Rb1
Steroids Polyphyllin I
Alkaloids Aconitine
Acids and Aldehydes Homovanillic acid γ-aminobutyric acid
Phenols Curcumin Apocynin Salidroside Gastrodin Polydatin Rosmarinic acid
Lappaconitine
Vindoline 10-Hydroxycamptothecine
Rhynchophylline Neferine Nitidine chloride Dinorargemonine Dendrobine
Theobromine Piperine Matrine Peimine Epiberberine
Stigmasterol β-Sitosterol Progesterone Bufalin
Ginsenoside Rg1
Ginsenoside Rg2
Notoginsenoside R1 Neoandrographolide
Ginsenoside Rh1 Ginsenoside Rh3 Ginsenoside Ro Ginkgolide B Ginsenoside C-K
Cucurbitacin E Astragaloside IV Norcantharidin Ginsenoside F2 Ginsenoside Rf
Atractylenolide I Atractylenolide II Atractylenolide III Pulchinenoside A Anemoside B4
Ginsenoside Rb2 Ginsenoside Rb3 Ginsenoside Rc Ginsenoside Rd Ginsenoside Re
Astragaloside Sanggenone C (-)-Epicatechin gallate Calycosin-7-O-β-D-glucoside
Schisandrin C
Arbutin Aloin B
Troxerutin Puerarin Luteolin Catechin Strychnine
Aloe emodin
Schisandrin A Schisandrol B Schisantherin A Schisantherin B Schisantherin E
Psoralidin Sauchinone Schisandrin Schisanhenol Schisandrin B
L-Rhamnose Manninotriose
8
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Cucurbitacin B
Antibody-Drug Conjugates VcMMAE
DOXO-EMCH
INNO-206 Vc-MMAD Mc-MMAD Mc-MMAE Cys-mcMMAD
ADC Linkers Val-cit-PAB-OH
6-Maleimidohexanoic acid N-hydroxysuccinimide ester
Fmoc-Val-Cit-PAB Fmoc-Val-Cit-PAB-PNP Mc-Val-Cit-PABC-PNP (Ac)Phe-Lys(Alloc)-PABC-PNP
Natural Products
Antibody-Drug ConjugateRelated Products