impaired renal outcome in former elbw cases at young...
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Erasmus MC Rotterdam, the Netherlands
KU Leuven, Belgium
[email protected] [email protected]
Impaired Renal Outcome In Former ELBW Cases At Young Adolescent Age Is Common, But Not Associated With Perinatal Steroids
preterm term born, but growth restricted eg kidney donor, risk to end up on dialysis ? BW < 2.5 kg
Star et al. Curr Rev Pediatr 2018
Raaijmakers et al. Blood Pressure 2015
Cystatin C and eGFR
Characteristic Cases Controls
P N Estimate N Estimate
Renal length (cm) 84 8.73 79 9.01 0.004
Parenchymal thickness (cm) 84 1.06 79 1.09 0.089
eGFR cystatin C (mL/min/1.73 m2) 59 97.2 59 108.7 <0.001
UVNa/average renal length (mmol/cm) 67 11.93 65 11.85 0.93
PRA (ng/mL/h) 56 1.21 71 1.75 0.001
Raaijmakers et al. Hypertension 2017
George et al. Pediatr Nephrol 2011; Raaijmakers et al. Arch Dis Child online
Raaijmakers et al. Arch Dis Child online
indicators of cardiovascular risk are much more common in former ELBW cases
(pre)hypertension, 30 and 20 %
eGFR, CKD stage 2, 25 % at 11 years
risk factor assessment in our cohort was negative
next steps ?
microvasculature/microcirculation (retina)
pooling of data with other ELBW cohorts in search of risk factors
pooling of data with other cohorts (healthy aging, NEVA-HT study)
pooled data in 157 ELBW cases and 123 term controls at 11 years risk factors in ELBW cases, eGFR and kidney size (ultrasound) gestational age birth weight disease severity pre- and postnatal steoids
Erasmus MC Rotterdam, the Netherlands
KU Leuven, Belgium
[email protected] [email protected]
impaired renal outcome in former ELBW cases at young adolescent age is common, but not associated with perinatal steroids