Leong PP, PhD

12/6/2014 1

Hypersensitivity

To describe pathophysiology and clinical outcome of the following clinical examples

Type I atopic dermatitis

Type II erythroblastoma fetalis

Type III systemic lupus erythematous

Type IV contact dermatitis

Autoimmunity

To describe the pathophysiology and clinical outcome of Grave disease and Hashimoto thyroiditis

Immunodeficiency

To understand the use of traditional chinese medicine (TCM) approach for immunodeficiency

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Pruritus dermatitis (red, flare up & extremely itchy)

Common in individual with history of hay fever or asthma

Associated with IgE antibody

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Immune mediated skin rash (swelling, erythema, vesiculation) at the site of contact with a chemicals Poison ivy

Nickel metal in costume jewelry

Dyes, perfume and etc

Mediated by sensitized Th1 cells

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Rh system antigen D

Two Rh blood type Rh positive

Dominant

More common in population

Rh negative

Incompatible haemolysis

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First pregnancy baby safe Rh ve mother acquires anti-Rh antibodies

Second pregnancy and onwards (baby is Rh +ve) Haemolytic disease of newborn brain damage,

mental retardted and even death

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Production of antibodies against a multitude of self-antigen including DNA (single and double stranded), nucleolar RNA, histones, RBCs, platelets. The disease is caused by the direct activity of the auto-antibodies and also by deposition of soluble antibody-antigen complexes which deposit along the walls of small blood vessels inflammtion & cell damage

Graves Disease Hashimoto thryoiditis

Hyperfunction of thyroid gland

Bulging eye, nervousness, enlarged thyroid, fast heart beat

Hypofunction of thyroid gland

Fatigue, enlarged thyroid, slow heart beat

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Auto-antibody

against TSH

receptor

Self-reactive

CTL

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Healthy == well functioning immune system

Immunodeficiency Immune system is suppressed by certain factors

e.g. nutrition, lifestyle and etc

Vulnerable to disease, infection, allergy and even cancer

Chinese Medicine Textbooks (since thousand years ago) Natural herbs

Dietary therapy

Acupuncture

Tai Chi

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http://www.tcmpage.com/hpimmunedef.html

Food with immune stimulation properties Shiitake mushroom

Lentinan anti-viral, immune stimulant

Garlic, sesame seed, yogurt, fruits & vegetables

Micro-nutrient Beta carotene, zinc and vitamin A, E and C

Low fat diet

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http://www.tcmpage.com/hpimmunedef.html

Astragalus (Huang Qi) Strong immune enhancing effect increased

number & activity of WBC

Showed to restore function of immune cells in cancer patient

Ginseng Widely used

Protects the liver, stimulates immune system, prevents radiation damage to nerve cells; has antioxidant effects, prevents cancer

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http://www.tcmpage.com/hpimmunedef.html

Chi Spleen Tonic (Bu Zhong Yi Qi Tang)

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Astragalus (Huang Qi)

Licorice (Gan Cao)

Agelica (Dang Gui)

Ginseng (Ren Shen)

Tangerine Peel (Chen Pi)

Cimicifuga (Sheng Ma)

Buplerum (Chai Hu)

Atractylodes (Bai Zhu)

http://www.tcmpage.com/hpimmunedef.html

Immunenergy Formula - Shi Quan Da Bu Tang Used to treat immune deficiency & fatigue

Often used for post-cancer management

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Angelica (Dang Gui)

Cnidium (Chuan Qiong)

Peony (Bai Shao)

Rehmannia (Shu Di Huang)

Ginseng (Ren Shen)

Atractylodes (Bai Zhu)

Poria (Fu Ling)

Licorice (Gan Cao)

Astragalus (Huang Qi)

Cinnamon (Rou Gui)

http://www.tcmpage.com/hpimmunedef.html

Regulation of immune system

Potential to treat wide range of health problems including immunodeficiency

Effects Increase the T cell count

Increase number of phagocytes

Increase WBC count and mobility

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http://www.tcmpage.com/hpimmunedef.html

Traditional Chinese martial art may help to boost immune system in elderly people

Showed to mount a stronger immune response to vaccine

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Miranda Hitti, Tai Chi May Boost Immune System, Journal of the American Geriatrics Society

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