immunogenetics m phil 30 12-14
TRANSCRIPT
Immunogenetics
Learning Objectives
• By the end of this lecture……….we all should be able:
– To appreciate the organization of immune system
– Understand the disorders related to immune system
– Explain the underlying mechanisms of immune disorders
Role of immune system and their applications
Innate and Adaptive imunity
Primary and Secondary Response
B and T Cells
Memory Cells
Macrophage development
Complement Proteins
Cytokines
Cytokines
Immunoglobulins
• Papaine splits the immunoglobulin molecule into three fragments.
– Two similar, each containing an antibody site capable of combining with a specific antigen antigen-binding fragment or Fab
– The Crystallizable fragment Fc
The immunoglobulin molecule is made up of four polypeptidechains:•Two light(L) 220 AA •Two heavy (H) 440 AAEach Fab fragment is composed of L chains linked to the amino-terminal portion of the H chains,Fc fragment is composed only of the carboxv-terminal portion of the H chain
Immunoglobulins
Immunoglobulins
A Closer look at structure
Genetics of antibody formationBasis of Diversity
Genetics of Antibody formationA closer look
Class switching
Antibody mediated diseases
Immune complex diseases
T Cell Mediated Diseases
HLA Associated DiseasesLocus of genes that encode for proteins on the surface of cells that are responsible for
regulation of the immune system in humans.
Deficiency Diseases
Thank you!