human disease dhealth/s/diseases_and_conditions/a
TRANSCRIPT
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HUMAN DISEASE
http://www.ncbi.nlm.nih.gov/pubmedhealth/s/
diseases_and_conditions/a/
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MEDICAL BIOTECHNOLOGY
• Seeks to – Understand human health and disease– Use biotechnologies to prevent, diagnose,
treat/cure disease and its recurrence
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HUMAN DISEASE
• Acute– Structural such as gallstones– Infectious such as pneumonia
• Chronic– stable (stays the same)– Progressive, gets worse and sometimes negatively
affects other areas of the body – Some do both in different people
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HUMAN DISEASE
• Genetic – Down’s syndrome• Behavioral – smoking causes lung cancer
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HUMAN DISEASE: Classified by impacted organ, tissue or cellular system
• Cardiovascular• Pulmonary• Renal• Gastrointestinal• Liver and biliary system• Hematologic• Metabolic• Endocrine
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HUMAN DISEASE: Classified by impacted organ, tissue or cellular system
• Women’s and Men’s health• oncologic• Bone and bone mineral metabolism• Musculoskeletal and connective tissue• Neurologic• Infectious• Aging• Substance abuse
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http://www.ivy-rose.co.uk/Revise/AnatomyPhysiology/index.php
http://www.nccpa.net/ExamsContentBPOrgans.aspx
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CASE STUDY HEPATITIS C VIRUS• Infection of the liver leading to inflammation• Some(15%) people recover from infection; most
become chronic carriers• Most infections are asymptomatic for about 20 years• Complicated disease process that progresses but not
in all patients• Immune response and genome (HLA) impact
outcome• Liver cancer• Liver failure
NORMAL FIBROTIC CIRRHOTIC
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CASE STUDY – DOWN SYNDROME
• Genetic defect – 3 copies of chromosome 21 occurs early in embryo development; = error in cell division
• Identified prenatally• Causes problems with the way the body and
brain develop• Most common chromosomal defect
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CASE STUDY – DOWN SYNDROME
• Mild to severe in terms of physical appearance as well as mental and social development
• low muscle tone, small stature, an upward slant to the eyes, and a single deep crease across the center of the palm
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CASE STUDY - BEHAVIORAL
• Lung cancer because of smoking• Liver disease because of alcohol abuse
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CASE STUDY – MYASTHENIA GRAVIS
• Acquired autoimmune disorder that lessens transmission across neuromuscular junctions weakening muscle responses– Autoantibodies to acetylcholine receptor
(AChR )block binding of Ach• Weakens voluntary skeletal or ocular muscles• Loss of facial expression, muscle fatigue,
droopy eyelids• Female to male ration = 6:4
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