cellular models for human disease

8/11/2019 Cellular Models for Human Disease

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Using cellularmodels to

study humandisease

Conrad Schools of Science

March 20, 2013

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Diane Wuest

4th Year PhD Student

Chemical & Biomolecular EngineeringDept.

Kelvin ee a!oratory

Be"ore #rad School$o B.S. Chemical & Biomolecular

Engineering "rom Cornello %ored ' years at a !iotechnology

company

(ntroduction

Used

cells tostudycancerdrugs

Used large-scale cell

experients!in

"ioreactors#to a$e

Using cellsto a$e aodel ofthe "rain

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BrainDisease is

)ard toStudy*

+he !rain is the most comple, organ o"the human !ody*

Detailed research is liited!ecause itis hardto investigate the !rain o" a li%inghuan "eing

o Unlie simpler organs- the !rain cannot!e removed and repaired outside o"the !ody

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BrainDisease is

)ard toStudy*

ong history o" !rain e,aminationo starting in the European enaissance

during the /011s 2.explains the Latin

names

Scientists have learned more a!out the!rain in the last 15 years than in allprevious centuries

o development o" sophisticated iagingtechni&ues

3any uestions a!out the !rain are

unans5eredo disease understandingo possi!le treatments

Degenerative diseases o"adult li"e 6Alzheimersdisease7

8eurogenetic diseases6Huntingtons

disease)

3eta!olic diseasesGauchers disease

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Cellular3odels

6aa :in

vitro7Can )elpesearch

*So +e need to study the ((( to a$e "raindrugs

Scientists can gro+ and study "rain cells in thela"oratoryto study the BBB

= in vitro experiental approach

o ;


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Cellular3odels

6aa :in

vitro7Can )elpesearch

Can compare in vitro conditions to in vivo6animal models7 studies

o then hope"ully dra5 conclusions "or humans

.

+esting a drug onhumans is limited!y$

/. Patient num!ers=. )aving enough

sample volume'. Ethical

considerations4. 3oney

Screening ne5 drugsis e>cient & cost?e


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Biotechnology &

Engineering in

@ction*

In vitro models are an e,ample o"(C45678$

In vitro models are an e,ample o"575/57$

he use of "iological systes to a$euseful products

issues, Cells Model Syste

Designing, ipro%ing, and anufacturinga product that can "e used for any

applications

Use

athe

atic

sand

econoic

s

6arge-scale9roduction

Coprehensi%e

9ro"leSol%ing

Sol%e a coplex pro"le "y

siplifying :copartentali;ing

cellular models for human disease

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