Lymph SystemThymus oPrimary lymphoid organ (no nodule) oCapsulated oDark cortex around outside Education of thermocytes; kills thermocytes with self-antigens Epithelial reticular cells (light pink colored; looks like a starfish) form a net to hold thermocytes in the cortex oLighter colored medulla oStary-night appearance due to macrophages oEpithelial reticular cells also around the blood thymus barrier Want to keep blood out of the thymus because macrophages will remove the T cells that recognize any foreign antigens ThymicMedullaoHassall’s Corpuscles 3 rd type of reticular cell Involuting thymus oGains adipose with age Secondary lymphoid tissue oLook for Encapsulated: lymphoid nodes; spleen Unencapsulated: MALT All have nodular and diffuse regions oDiffuse region: T cells oNodular area: B cells oGerminal center: proliferation of B cells, especially during infection Tonsils: 3 types: lingual, palatine, pharyngeal; look at epithelial layer to distinguish oOral cavity: lingual and palatine Stratified squamous non-ketatinizin g oBack of throat: pharyngeal Pseudostratified (repiratory tract) oIdentifying tonsil features Nodules Crypts (looks like empty spaces in the tissue) No capsule Lymphocytes in the oral cavity sample the outside world oTranscytosis: cell at top takes a sample and pass antigens it from cell to cell oMigration to the surface: lymphocytes can move up and infiltrate Peyer’s patchoIlium of intestine oIdentifying features: Villi