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TRANSCRIPT
Antons Mozalevskis
WHO Regional Office for Europe
Hepatitis C in the WHO
European Region
Drug-related infectious disease (DRID) annual exper t meeting15–16 June 2015, EMCDDA – Lisbon
• Estimated number of people living with infection1:
– Hepatitis C - 14 million
– Over 60% infected live in eastern European and central Asian countries (EECA)
• Estimated number of deaths due to viral hepatitis2:
– 84 000 deaths due to Hep C annually
– Absolute majority due to sequelae (cirrhosis, HCC)
Burden of viral hepatitis C in the
WHO European Region
1 V.D. Hope et al. Epidemiol. Infect (2013) 1-172 Global Disease Burden Estimate
Hepatitis C among “most affected population groups”
in the WHO European Region, 2012
44%
4%
11%
2%
0%
10%
20%
30%
40%
50%
People whoinject drugs
Men who havesex with men
Sex workers Generalpopulation
Hepatitis C
V.D. Hope et al. Epidemiol. Infect (2013) 1-17
Geographical/epidemiological division of the
WHO European Region
Estimated Anti-HCV and HCV-RNA prevalence
in general population (WHO-EURO)
1 Gower E. Et al. Global epidemiology and genotype distribution of the hepatitis C virus. J Hepatology 2014; 61 (suppl 1)
Anti-HCV prevalence
HCV-RNA prevalence
Viraemic rate
2013 population (millions)
Anti-HCV infected (millions)
HCV-RNA infected (millions)
Central Europe 1.3% 1.0% 80% 119 1.5 1.2
Eastern Europe 3.3% 2.3% 69% 207 6.8 4.7
Western Europe 0.9% 0.6% 70% 425 3.7 2.6
Estimated Anti-HCV prevalence in general adult
population (WHO-EURO, 20121)
1 V.D. Hope et al. Epidemiol. Infect (2013) 1-17
Estimated Anti-HCV prevalence in people who
inject drugs (WHO-EURO, 20121)
1 V.D. Hope et al. Epidemiol. Infect (2013) 1-17
Objectives:
• to provide a standardised, timely and completepicture of the epidemiology of important infectious diseases;
• to allow sharing of data at the subnational level to identify specific geographic areas of risk and risk groups by age and gender;
Content:
• WHO/Europe infectious disease data set, compiled from reports submitted by Member States
WHO-EURO Centralised information
system for infectious disease (CISID)
• National focal point reporting on the yearly bases (March – May)
• Data sent in Excel (Section 1 & 3) or Word (Section 2) format
Section 1 – vaccine preventable diseases
Section 2 – sexually transmitted infections
Section 3 – other infections including viral hepatitis
• Data entered by the information management team or by relevant programme staff
CISID data from Joint Reporting Form (JRF)
CISID data from JRF
Hepatitis C - Number of cases
JRF data on hepatitis C from 2014
(as of 11.06.14)
• Out of 53 WHO-EURO Member States – reports from 40 MS
• Andorra – zero cases
• France, Germany, San Marino and Spain – no data on hepatitis C
• Reported cases of viral hepatitis from 35 MS
– 20 EU/EEA Member States
– 15 non-EU/EEA Member States
n=93 737
Reported HCV cases (n=93 737)
WHO-EURO, 2014
[CATEGORY
NAME][PERCEN
TAGE]
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NAME][PERCEN
TAGE]
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NAME][PERCEN
TAGE]
Reported HCV cases (n=93 737)
WHO-EURO, 2014
[CATEGORY
NAME][PERCEN
TAGE][CATEGO
RY NAME]
[PERCENTAGE]
[CATEGORY
NAME][PERCEN
TAGE]
Reported HCV cases outside EU/EEA (n=72 456)
Reporting non EU/EEA countries PWID unknown total
Albania 0 44
Armenia 169 51
Azerbaijan 1 688 709
Belarus 2789
Bosnia and Herzegovina 0 120 121
Georgia 0 2647 2647
Kazakhstan 175 2076 3157
Montenegro 0 15 15
Republic of Moldova 2 798 826
Russian Federation 59690 59690
Serbia 213 335 577
Switzerland 390 1220 1675
Tajikistan 0 71 71
The former Yugoslav Republic of Macedonia 0 82 82
Turkmenistan 2
Total 781 67911 72456
Hepatitis C data in the WHO European Region
«Space for imrovement» – I
• ECDC enhanced viral hepatitis surveillance
– Standartised case definitions (gradually adopted by EU/EEA
Member States)
– Data completness is poor but improving
– Case reporting should be complemented by serosurveys
and data on chronic hepatitis disease sequelae
Hepatitis C data in the WHO European Region
«Space for imrovement» – II
• WHO-EURO «Joint Reporting Form»
– Case definition harmonisation (ECDC case definition?)
– Ways to get rid of double reporting (ECDC and WHO-EURO)
– Data verification and analysis
Hepatitis C data in the WHO European Region
«Space for imrovement» – III
• Linking with EMCDDA DRID data?
• Updated review of published seroprevalence study data?
• Enhancing the network of the national viral hepatitis focal
points
WHO Regional Office for Europe
• Contact:
– Antons Mozalevskis, WHO-EURO focal point for
viral hepatitis: [email protected]
– Martin Donoghoe, WHO-EURO regional advisor
on HIV/AIDS & hepatitis: [email protected]
Thank you