guidline ebola_thailand 2014

8/12/2019 Guidline Ebola_Thailand 2014

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Ebola2557

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11. 22. 43. Ebola 54. 135. 176. Ebola 307. 338. 379. 41 43

Ebola 43 Ebola 47 - Ebola 50 52

56

1 2557 Hes Company Limited ISBN 978-616-11-2134-1


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Ebola 2557 1

Ebola .. 2557 Ebola Ebola

11 2557


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Ebola 25572

(Ebola) 23 .. 2557 (Guinea) Ebola 218 141 191 115 115 72 63 Ebola 26 16 16 Ebola 6 Conakry ( 58 24 ), Guekedou ( 127 91 ), Macenta ( 22 16 ),Kissidougou ( 6 5 ), Dabola ( 4 4 ) Djingaraye( 1 1 ) 22 2557 Medecins SansFrontieres (MSF) Control and Prevention, US.CDC) (Lib Ebola 3 Guinea Liberia

Liberia 13 .. 2557 Ebola Liberia 24 .. 2557 Ebola 35 6 2 27 6 .. 2557 27

1


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Ebola 2557 3

(Sierra Leone) 3 (Viral hemorrhagic fever, VHF) VHF 98 10 (Lassa virus) 88 Ebola Lassa virus ( 24 .. 2557) Guinea Liber Sierra Leone [1, 2]


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Ebola 25574

2


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Ebola 2557 5

Ebola

3.1 Ebola 1 [3]

European Centre for Disease Prevention and ( 7 ) 2 (secondary transmission) Ebola .. 2543

Ebola

1 Ebola

(

) Ebola

3


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Ebola 2557 7

Ebola

Ebola

Ebola 21 1

Ebola

Ebola


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Ebola 25578

3.3

/ / (

) )

/

:


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Ebola 2557 9

3.4 Ebola 1: Ebola

Ebola

1 21

2: Ebola


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Ebola 255710

3: Ebola

(IATA) 1 Ebola 3 :

Ebola ( 27 .. 2557 );

;

2 3 Ebola 3


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Ebola 2557 11

Ebola 1

3 1 [4]

1 Ebola

21 ( 2) [4]


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Ebola 255712

2 Ebola

21

:- +/- 1 - Index case- - Index case

EbolaMarburg

Lassa


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Ebola 2557 13

(Hemorrhagic fever) Ebola Marburg Ebola Marburg [5]

4.1

Ebola Ebola

21

Ebola

21 ( ( )

)

21

Ebola Ebola

(Case definition for surveillanc4


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Ebola 255714

4.2 (Routine surveillance) (Suspected case)

Ebola ( 27 .. 2557 )

(Confirmed case) IgM (Polymerase chain reaction, PCR) (viral isolation)

1. 2. 3. / 4.


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Ebola 2557 15

4.3

4.3.1

(Suspected case)

Ebola Ebola

Ebola 3


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Ebola 255716

Ebola

Ebola

4.3.2 (Probable case)

( )

(Laboratory confirmed case) RNA viru reverse transcriptase-polymerase chain reaction (RT-P Ebola

(Non-case) RNA **


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Ebola 255718

4

4.3.2

4.3.1

/

1

24

24

/ /


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Ebola 2557 19

1: Ebola

............/................./...............1. ........................................................................................................................... ......................................

..................... .................................................................................................................... ............................................................................................................................. .................................................... / ( )..................................................... .............................................................. ........................................................................................................... ................................................................................ ......................................................... ................................................................ [ ] [ ] [ ] [ ]

2. [ ] [ ] [ ] [ ] .......................................................................[ ] ..... ..... [ ] ............ [ ]

post-mortem skin biopsy.......................................................................... : [ ] [ ] [ ] [ ] [ ] ............................................ .................................................. ............................... ..............................................................................................................


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Ebola 255720

1

2

3 4

5

6

7

8

9

1 0

1 1 1 2 1 3 1 4

A

/

.....................................

B


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Ebola 2557 21

3. 21 Ebola

[ ] ...................... [ ] ................. [ ] ............... .................................................................................................. ...................................................................................... ................................................................................................ ......................................................................................

Ebola [ ] .......................... [ ] ................. [ ] ......................... .................................................................................................. ................................................................................................ ........................................................................................

............................................... .................................................

Ebola [ ] .......................... [ ] ................. [ ] ......................... .................................................................................................. ................................................................................................ ........................................................................................ ...................................................................... ..............................................

( ( ) )[ ] .......................... [ ] ................. [ ] ......................... ..................................................................................................... ........................................................................................................... ......................................................................................

( ).................................................................................................................................................................... / ........................................................................................ ........................................................................................................................

4. 1 ..................................................................... ................................ .................................................................................................................... 2 ..................................................................... ................................ ....................................................................................................................

5. ...................................................................................................................................................................................................................................................................................................................................................................................................


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Ebola 255722

5.2

2 1 21 38.5 2: Ebola [7] 3: Ebola [6] 2 21 42 ) 24


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Ebola 2557 23

2: Ebola

1 ....................................................................... .................................. ...................................... [ ] [ ] ......... // .....................

( ) ................................................................................................................ ( ) ........................................................................................................... ()........................................()...................................... ..........................................

2 [ ] 3[ ] 4[ ] 5[ ] 6

............................................................................................................ 3 [ ] [ ] [ ] [ ] [ ] [ ] [ ] .......................................1. [ ] [ ] [ ] PPE [ ] [ ] [ ] PPE [ ] [ ] [ ] [ ] 2. [ ] [ ] [ ] PPE [ ] [ ] [ ] PPE [ ] [ ] ........................ fit test [ ] [ ]

[ ] [ ] 3.

[ ] ................ [ ] [ ]


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Ebola 255724

4. [ ] .................................. [ ] [ ] 5. [ ] [ ] [ ] ............................................................................................................................................................................................................................................................................

...................................................................................................................................... ............................................................................................................ ........................................................ ................................................ 1- 5 = / 1 2 PPE = / 1 2 PPE 3-4-5 =

4 [ ] / / [ ] [ ] [ ] [ ] [ ] ........................................1. [ ] [ ] [ ]

( 5) 2. [ ] [ ] [ ] 3. [ ] [ ] [ ] 4. [ ] [ ] [ ] 5. [ ] [ ] [ ] 6. [ ] [ ] [ ] 7. [ ] [ ] [ ] 8. [ ] [ ] [ ] 9. [ ] [ ] [ ] 10. 8 9 [ ] [ ] [ ]


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Ebola 2557 25

PPE [ ] [ ] ........................ fit test [ ] [ ] [ ] [ ]

..................................................................................................................................................................................................................................................................

................................................................................................................................. ....................................................................................................... ...................................................... ............................................ 1 = / 2, 4, 5 7 8 = / 3 6 8, 9 10 = /

5 [ ] [ ] / [ ] / [ ] ........................ ................................................. ................................................. .......................................................... ................................................. [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] / / [ ] 1. [ ] [ ] [ ] 2. ? [ ] [ ] [ ]


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Ebola 255726

.................................................................................................................................................................................................................................................................................................................................................................................................................. ............................................................................................................

...................................................... .................................................. = / 1 2 =

6 1.

[ ] [ ] [ ] 2. [ ] [ ] [ ] .................................................................................................................................................................................................................................................................................................................................................................................................................. ............................................................................................................ ...................................................... .................................................. = / 1 2 =


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Ebola 2557 27

7 1. [ ] [ ] [ ] 2. [ ] [ ] [ ] 3. [ ] [ ] [ ]

8 Check list: / /

1. [ ] [ ] [ ] 2. [ ] [ ] [ ] 3. [ ] [ ] [ ]

................................................................. .................................................... ......... : 21 - = ......... [ ] [ ] ...................................................................................................................................................................................................................................................................................................................................................................................... ................................................................................................ ....................................................


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Ebola 255728

3: Ebola

:...................................................................... ............................................................... / 21 1.

.............................................................................................. [ ] [ ] ...................................................................... ....................................................... ..................................................................................................................................2. 1 2 3 4 5 6 7-

- - - - - - - - /- - -


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Ebola 2557 29

1 2 3 4 5 6 7- - - -

- - - - - -

3.

..................................................................................................................................................................................................................................................................

.................................................................................................................................

.................................................................................................................................

................................................................................................ ....................................................


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Ebola 255730

6.1

Ebola Ebola Ebola Ebola (Zaire) (Gabon)

2-21

1-2: 39 C (bradycardia) 2 (diarrhea rouge)

3-6: (soft palate) (dehydration)

5-7: 15 ( (popular tomaculopapular) 24

8-16: ( ) (severe dehydratio 12 (coma)

Ebola6


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Ebola 2557 31

12 14-16 (orchitis) hepatitis) transverse myelitis uveitis [6]

6.2 Shigellosis

Ebola (Toxemia) /

(Typhoid)

(lymphadenopathy) (re

(Malaria)

, (Leptospirosis), fever), (Typhus) / mononucleosis

(early stages of infection)


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Ebola 255732

Lassa fever (Pharyngitis)

(Yellow fever) Flaviviridae

(seroinvestigation) [6]

: Ebola (person-to-person transmission) Ebola (Endemic areas)


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Ebola 2557 33

7.1

Ebola

ELISA IgG IgM antigen Ebola Ebola

US-CDC (WHO) Ebola P4 [6]

7.2 7.2.1

3 1. (acute phase) 7

2. (convalescent phase)

14 paired serum 7-20 acute blood clot (Vacutainer type)

7


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Ebola 255734

(Viral isolation) 4 C P4

3. /

7.2.2

Ebola code3.6.6.4 Dangerous Goods (IATA) [6]

( 5 6)


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Ebola 2557 35

5 Ebola

EBOLA

Sampletransport container EBOLA - / -

- /

-

EBOLA PCR ELISA for IgG Antibody

EBOLA US-CDC :

3

EBOLA

3


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Ebola 255736

6 Ebola US-CDC

EBOLA US-CDC : 3

1. BSL-3 () Deep freezer

US-CDC2. US-CDC3. IATA

US-CDC


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8.1

Ebola

[6]

8.2

8


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Ebola 255738

stethosco

()


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Ebola 2557 39

1)

(Bleach) 1:10 1:100 10

2)

3) sterilization

autoclave stream sterilizer 20

/ negative pressure

7 21


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Ebola 255740

60 C 1

21

8.3

[6]


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Ebola 2557 41

9.1

- Ebola - - -

- Ebola- -

-

-

- -

9.2 /

- -

9


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Ebola 255742

- -

9.3

- - - - - - -

9.4

3 Emerging and Other Communicable Dis [6]


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Ebola 2557 43

Ebola

1. Ebola

Ebola ( ) .. 2519 Ebo - -

50

2. Ebola (lipid-enveloped)

(RNA) Filoviridae IgG ELISA (convalescent) P4 4 (Zaire) (Sudan) (Ivory Coast) (Gabon)

5 (Reston) (Macacafascicularis)


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Ebola 255744

(Accidental host)

3. 2-21 ( 5-12 )

(maculopapular rash)

50- 90

Ebola ( )


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Ebola 2557 45

Ebola ( Ebola ) Ebola

4. /

3-17


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Ebola 255746

Ebola Ebola Reston

5.

(supportive) hyper-immune sera [6]


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Ebola 2557 47

Ebola

.. 2504 - 2505 (Ethiopia) Ebola Ebola (Yellow fever)

.. 2515 (Zaire) E

.. 2519 - (Sudan) 284 150 ( 52) -

318 280 ( 88) Ebola

.. 2520

.. 2522 34 22 ( 64)

.. 2532 - 2533 Reston (Virginia) (USA) Ebola Reston (Macacafascicularis)

.. 2535 (Italy) Ebola Reston (Macacafascicularis)


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Ebola 255748

.. 2537 12 1

.. 2538

315 244 ( 77) .. 2539 - 37 21 ( 57) (Texas) USA Ebola Reston

2539 2540 61 45 ( 78) 1 (South Afri Ebola 1 [6]

.. 2540 - 2556 Ebola

.. 2557 24 - 25 Guinea Ebola 4 86 59 68.5 LiberiaSierra Leone Pasteur Institute Ebola Zaire


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Ebola 2557 49

Guinea CDC U Guin 20 Guinea Ebola 208 136 112 Ebola 25 18 24 16 24 21 Liberia

34 11 Ebola Zaire ( 97) Guinea Liberia 23 2557 Liberia The International Red C(IRC), Pentecostal Mission Unlimited (PMU)-Liberia Sa Pasteur CDC 7 Guinea 3 Liberia [1, 2]


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Ebola 255750

- Ebola

Ebola Ebola

Ebola

Ebola

2-21

9


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Ebola 2557 51

Eb

Ebola

Ebola Ebola Ebola

Ebola [8]


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Ebola 255752

Ebola

21

Ebola 1) Ebola

2)

(IATA)

1) Ebola

/ Ebola


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Ebola 2557 53

( )

Ebola

2)

Ebola

Ebola


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Ebola 255754

Ebola (IATA)

Ebola

Environment Protection Agency (EPA) 1%

30


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Ebola 2557 55

(compressed air)

( )

Ebola

Ebola

/

( )

(

) [9]


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Ebola 255756

1. World Health Organization, Regional Office for Africa. Ebola virus diseApril 2014).[] 25 2557. [ 5 2557.]http://www.afro.whoclusters-a-programmes/dpc/epidemic-a-pandemic-alert-and-response/odisease-west-africa-25-april-2014.html

2. Centers for Disease Control and Preventions.2014: Ebola HemorrhagicLiberia. [ ] 2 2557. [ 11 2557.] http://www.cdc.gov/vresources/outbreaks.html

3. European Centre for Disease Prevention and Control.Outbreak of Ebola v2014. Stockholm: ECDC; 2014.

4. European Centre for Disease Prevention and Control.Risk assessment guon aircraft. 2nd ed. Stockholm: ECDC; 2010.

5. World Health Organization and Centers for Disease Control and PreventiIntegrated Disease Surveillance and Response in the African Region, BraAtlanta, USA,: 1-398.

6. World Health Organization (1997). WHO recommended Guidelines fResponse: Ebola Haemorrhagic Fever (EHF).Geneva, Switzerland.: 1-307. Health Protection Surveillance Centre (2012).The Management of Vira

Dublin, Ireland: 1-1178. World Health Organization, Regional Office for Africa. Frequently A

disease.[ ]. [ 5 2557.]http://www.afro.who.int/en/clustersepidemic-a-pandemic-alert-and-response/epr-highlights/3648-frequently-afever.html

9. Centers for Disease Control and Preventions.Interim Guidance about EboCrews, Cargo and Cleaning Personnel, and Personnel Interacting with A].[ 5 2557.] http://www.cdc.gov/vhf/abroad/airline-worker


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