gominer: (zeeberg et al., genome biology, march 2003) for tour of gominer: advance using forward...
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GoMiner: (Zeeberg et al., Genome Biology, March 2003)
For Tour of GoMiner:
Advance using forward arrow
GoMiner: (Zeeberg et al., Genome Biology, March 2003)
GoMiner is a tool for biological interpretation of 'omic' data –
including data from gene expression microarrays. Omic
experiments often generate lists of dozens or hundreds of genes that differ in expression between
samples, raising the question, “What the h-ll does it all mean
biologically?”
To answer that question, GoMiner leverages the Gene Ontology (GO) to classify the genes into biologically coherent categories
and assess those categories statistically.
For biological interpretation of a microarray experiment, the user enters the list of genes on the
array and has the option of flagging them as up-regulated, down-regulated, or neither with
respect to some index standard.
This animation presents a tour of the highlights of GoMiner’s
functionality and user interface.
GoMiner: (Zeeberg et al., Genome Biology, March 2003)
An Unchanged Gene
An Overexpressed Gene
An Underexpressed Gene
Total Genes in Category
Fisher’s Exact p-Value for All Changed Genes in
CategoryRelative Enrichment ofUnderexpressed Genes In
Category
Relative Enrichment of AllChanged Genes in
Category
Relative Enrichment ofOverexpressed Genes In
Category
GoMiner: (Zeeberg et al., Genome Biology, March 2003)
GoMiner: (Zeeberg et al., Genome Biology, March 2003)
NCBI-StructuresEntrez Genome @ LocusLink
PubMedGeneCards
MedMiner
BioCarta @ CGAP
Click on a gene to linkOut to Major Molecular
Biology Databases
Results can also be exported for further
analysis with other tools
GoMiner has an additional visualization based on a Directed Acyclic Graph (DAG) view of your
experiment results and GO
Categories with a depletion of changed
genes
Mouse over a category to see the genes that have
been assigned there
The relationships between the GO categories
Categories with an enrichment of changed
genes
Visit http://dicover.nci.nih.gov/gominer to download and start using GoMiner