gluconeogenesis for 2nd year mbbs delivered on 27 jan 2010 by dr waseem kausar

8/14/2019 Gluconeogenesis for 2nd year MBBS delivered on 27 jan 2010 by Dr waseem kausar

1/35

Hftncedchded~i~Bz Otmgoogb xg~ddo lgt~gz

G~~i~rger pzcad~~czIOBN


2/35

Hftncedchded~i~ 3

Hftncedchded~i~ cnntz~ ogiefy ie fiqdz%

Hftncedchded~i~ cnntz~ rc g oczd fioirdb d}rder ielibedy ! ~ogff ierd~ried tebdz ~cod ncebirice~%

^yermd~i~ ca hftnc~d azco pyztqgrd trifi{d~ ogey carmd ~god de{yod~ g~ Hfyncfy~i~% ecengzjcmybzgrd

pzdntz~cz~ rc hftnc~d cz hfynchde%

^tj~rzgrd~ ? hftnchdein goiec gnib~& fgnrgrd&

hfyndzcf& pzcpicegrd% Mypchfyndoig ?jzgie

by~atenrice& ncog geb bdgrm%Hftnc~d &ogiergieiehrmd fdqdf ca ierdzodbigrd~ ca rmd RNG &xmde agrrygnib~ gzd ~ctznd ca gndryf/NcG ie rmd ri~~td~%

nfdgz~ fgnrgrd


3/35


4/35

NCZI nynfd


5/35

Nczi Nynfd


6/35

hftncedchded~i~ azco gfgeied

Hftnchdein ! ldrchdein goiec gnibI~cftnied&pmdeyfgfgeied&rmzdceied&ryzc~ied geb

rzyprcpmmgePtzfy hftnchdein goiec gnib~ gzd

Gfgeied& gzh/&g~p/&g~pgzh/& ny~r/&hft/&hftrgogrd&hfy/&mi~r/& odr/& pzc/& ~dzied geb qgfied


7/35

HFTNCHDEIN GOIEC GNIB^


8/35

Rmd ~ctznd ca pyztqgrd geb c}gfcgndrgrd acz

hftncedchded~i~ btzieh ag~rieh cz ngzjcmybzgrd~rgzqgrice i~ ogiefy goiec gnib ngrgjcfi~o%

^cod goiec gnib~ gzd ngrgjcfi{db rc pyztqgrd&

c}gfcgndrgrd& cz pzdntz~cz~ ca rmd~d%

Ot~nfd pzcrdie~ ogy jzdgl bcxe rc ~tppfy goiec gnib~%

Rmd~d gzd rzge~pczrdb rc fiqdz xmdzd rmdy gzd bdgoiegrdb

geb nceqdzrdb rc hftncedchded~i~ ieptr~%

Hfyndzcf& bdziqdb azco mybzcfy~i~ ca rzignyfhfyndzcf~ ie

agr ndff~& i~ gf~c g ~iheiainger ieptr rc hftncedchded~i~%


9/35

J7: bdainideny-odrmyfogfcein gnibtzig)


10/35

HFTNCEDCHDEDÎÎEQCFQD^

HFYNCFYÎ^& RMD RNG ! ^COD ^PDNIGF ZDGNRICE^


11/35


12/35

Bi~dg~d~ g~~cnirdb xirm

HFTNCEDCHDED^I^ OTFRIPFD NGZJC]YFG^D BDAINIDENY-jicrie)

G hdedrin bdadnr

Gff ngzjc}yfgd~ gzd gaadnrdb Daadnr~ gzd bdqdfcpoder zdrgzbgrice&ldrcgnibc~i~& mgiz fc~~

geb zg~md~

Rzdgrdb jy Jicrie ~tppfdodergrice

QCE HIDZLD^ BI^DG^D Hdedrin bdadnr ie H1Pg~d

G hfynchde ~rczghd bdadnr


13/35

Ncerzcf ca hftncedchded~i~

G& ece mczocegf zdhtfgrice7%^tj~rzgrd ncen/

Fdqdf ca pyztqgrd& fgnrgrd& geb gfgeied

:% Gffc~rdzin zdh/%Gndryf nc G

J& mczocegf zdhtfgrice

7& hftnghce&dpiedpmzied& geb hftncnczrincib nge~riotfgrd rmd ~yermd~i~ ca PDPNL&A7&1JP& H1P

:&ie~tfied ~tppzd~~d~ rmd~d de{yod~ geb ~riotfgrd

hfyncfyrin de{yod~%


14/35

Rmzdd Hfyncfy~i~ zdgnrice~ mgqd ~tnm g fgzhd edhgriqd H

rmgr rmdy gzd d~~derigffy izzdqdz~ijfd%

Md}clieg~d -cz Hftnclieg~d) Pmc~pmcaztnrclieg~d

Pyztqgrd Lieg~d%

Rmd~d ~rdp~ ot~r jd jypg~~db ie Hftncedchded~i~%

Rxc ca rmd jypg~~ zdgnrice~ ieqcfqd ~iopfd mybzcfy~i~

zdgnrice~%


15/35

Md}clieg~d cz Hftnclieg~d -Hfyncfy~i~) ngrgfy{d~;

hftnc~d , GRP hftnc~d/1/pmc~pmgrd , GBPHftnc~d/1/Pmc~pmgrg~d -Hftncedchded~i~) ngrgfy{d~;

hftnc~d/1/pmc~pmgrd , M:C hftnc~d , P

i

M C

CM

M

CMM

CM

NM:CM

M

CM

MM C

CM

M

CMM

CM

NM:CPC>:

M

CM

MM:C

7

1

4

2

> :

, Pi

hftnc~d/1/pmc~pmgrd hftnc~d

Hftnc~d/1/pmc~pmgrg~d


16/35

Hftnc~d/1/pmc~pmgrg~d de{yod i~ dojdbbdb ie rmd

debcpfg~oin zdrintfto -DZ) odojzged ie fiqdz ndff~%Rmd ngrgfyrin ~ird i~ acteb rc jd d}pc~db rc rmd DZ ftode%

M C

CM

M

CMM

CM

NM:CM

M

CM

MM C

CM

M

CMM

CM

NM:CPC>:

M

CM

MM:C

7

1

4

2

> :

, Pi

hftnc~d/1/pmc~pmgrd hftnc~d



17/35

Pmc~pmcaztnrclieg~d -Hfyncfy~i~) ngrgfy{d~;

aztnrc~d/1/P , GRP aztnrc~d/7&1/ji~P , GBPAztnrc~d/7&1/ji~pmc~pmgrg~d -Hftncedchded~i~) ngrgfy{d~;

aztnrc~d/7&1/ji~P , M:C aztnrc~d/1/P , P

i

aztnrc~d/1/pmc~pmgrd aztnrc~d/7&1/ji~pmc~pmgrd

Pmc~pmcaztnrclieg~d

NM:CPC>:

CM

NM:CM

M

CM M

M MCC

1

4

2 >

:

7 NM:CPC>:

CM

NM:CPC>:

M

CM M

M MCC

1

4

2 >

:

7

GRP GBP

Pi M:C

Aztnrc~d/7&1/jic~pmc~pmgrg~d


18/35

Jypg~~ ca Pyztqgrd Lieg~d;

Pyztqgrd Lieg~d -fg~r ~rdp ca Hfyncfy~i~) ngrgfy{d~;

pmc~pmcdecfpyztqgrd , GBP pyztqgrd , GRPAcz jypg~~ ca rmd Pyztqgrd Lieg~d zdgnrice& nfdgqghd ca :uP jceb~ i~ zdwtizdb%

H acz nfdgqghd ca ced uP jceb ca GRP i~ ie~taainider

rc bziqd ~yermd~i~ ca pmc~pmcdecfpyztqgrd -PDP)%

PDP mg~ g mihmdz edhgriqd H ca pmc~pmgrd mybzcfy~i~

rmge GRP%


19/35

Jypg~~ ca Pyztqgrd Lieg~d -: de{yod~);

Pyztqgrd Ngzjc}yfg~d -Hftncedchded~i~) ngrgfy{d~;pyztqgrd,MNC

>

, GRP c}gfcgndrgrd ,GBP,Pi

PDP Ngzjc}ylieg~d -Hftncedchded~i~) ngrgfy{d~;

c}gfcgndrgrd , HRP

PDP , HBP , NC:

N

N

NM:

C C

CPC>:

N

N

NM>

C C

C

GRP GBP, Pi N

NM:

N

N

C

C C

CC

MNC>

HRP HBP

NC:

pyztqgrd c}gfcgndrgrd PDP

Pyztqgrd Ngzjc}yfg~d PDP Ngzjc}ylieg~d


20/35

Ncerzijtrieh rc ~pcergediry ca rmd :/~rdp pzcnd~~;

Azdd dedzhy ca ced uPjceb caGRP i~ nce~dzqdb ie rmd

ngzjc}yfgrice zdgnrice%

^pcergedct~ bdngzjc}yfgrice ncerzijtrd~ rc

~pcergediry ca rmd :eb zdgnrice%

Nfdgqghd ca g ~dnceb uP jceb caHRP gf~c ncerzijtrd~

rc bziqieh ~yermd~i~ ca PDP%

N

N

NM:

C C

CPC>:

N

N

NM>

C C

C

GRP GBP, Pi N

NM:

N

N

C

C C

CC

MNC>

HRP HBP

NC:

pyztqgrd c}gfcgndrgrd PDP

Pyztqgrd Ngzjc}yfg~d PDP Ngzjc}ylieg~d


21/35

Jicrie mg~ g 4/N ~ibd nmgie xmc~d rdzoiegf

ngzjc}yf i~ ie goibd fielghd rc rmd /

goiec hzctp ca ge de{yod fy~ied%

Rmd jicrie ! fy~ied ~ibd nmgie~ aczo g fceh~xiehieh gzo rmgr gffcx~ rmd jicrie zieh rc

~xieh jgnl ! aczrm jdrxdde : gnriqd ~ird~%

Pyztqgrd

Ngzjc}yfg~d

t~d~ jicrieg~ pzc~rmdrin

hzctp%

NMNM

M:N

^

NM

EM

N

ME

C

-NM:)2 N EM -NM:)2 NM

NC

EM

C

jicrie

~tjkdnr rc

ngzjc}yfgrice

fy~ied

zd~ibtd

M>E,

N NCC

NM:

NM:

NM:

NM:

EM>

M

,

fy~ied


22/35

Jicrie ngzjc}yfgrice i~ ngrgfy{db gr ced gnriqd ~ird ca PyztqgrdNgzjc}yfg~d%

GRP zdgnr~ xirm MNC>

rc yidfb ngzjc}ypmc~pmgrd%

Rmd ngzjc}yf i~ rzge~adzzdb azco rmi~ uP ierdzodbigrd rc E ca gtzdibc hzctp ca rmd jicrie zieh% Cqdzgff;

jicrie , GRP , MNC> ngzjc}yjicrie , GBP , Pi

C P C

C

CM

N C

C

NMNM

M:N

^

NM

EM

N

E

C

-NM:)2 N EM -NM:)2 NM

NC

EM

C

N

C

/C

ngzjc}yjicrie

fy~ied

zd~ibtd


23/35

Gr rmd crmdz

gnriqd ~ird ca

Pyztqgrd

Ngzjc}yfg~d rmdgnriqgrdb NC

:i~

rzge~adzzdb azco

jicrie rc pyztqgrd;

ngzjc}yjicrie

, pyztqgrd

jicrie ,

c}gfcgndrgrd

Qidx ge geiogrice

%

NMNM

M:N

^

NM

EM

N

E

C

-NM:)2 N EM Z

C

NC

/CN

N

NM>

C C

C

N

NM:

N

N

C

C C

C

C

NMNM

M:N

^

NM

EM

N

ME

C

-NM:)2 N EM Z

C

ngzjc}yjicrie

pyztqgrd

c}gfcgndrgrd

jicrie
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/gluconeo.htmhttp://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/gluconeo.htm


24/35

Xmde hftncedchded~i~ i~ gnriqd ie fiqdz& c}gfcgndrgrd i~

biqdzrdb rc aczo hftnc~d% C}gfcgndrgrd bdpfdrice miebdz~

gndryf NcG derzy ierc Lzdj~ Nynfd% Rmd ienzdg~d ie \gndryf

NcG_ gnriqgrd~ Pyztqgrd Ngzjc}yfg~d rc ogld c}gfcgndrgrd%

Pyztqgrd

Ngzjc}yfg~d

-pyztqgrd

c}gfcgnrgrd)i~ gffc~rdzingffy

gnriqgrdb jy

gndryf NcG%

\C}gfcgndrgrd_

rdeb~ rc jd

fioirieh acz

Lzdj~ nynfd%


hftnc~d/1/P hftnc~d

Hftncedchded~i~ Hfyncfy~i~

pyztqgrdagrry gnib~

gndryf NcG ldrced jcbid~

c}gfcgndrgrd nirzgrd

Lzdj~ Nynfd


25/35

gqibiexirm jcteb jicrie

Gqibie& g pzcrdie ie dhh xmird~ xirm g jgzzdf ~rztnrtzd&rihmrfy jieb~ jicrie%

D}nd~~ nce~toprice ca zgx dhh~ nge

ngt~d etrziricegf bdainideny ca jicrie%

Rmd ~rzceh gqibie/rc/jicrie gaaieiry i~t~db jy jicnmdoi~r~ g~ g ~pdniain *hftd%*


26/35

PDP Ngzjc}ylieg~d ngrgfy{d~ HRP/bdpdebderc}gfcgndrgrdPDP% Ir i~ rmcthmr rc pzcnddb ie : ~rdp~; C}gfcgndrgrd i~ aiz~r bdngzjc}yfgrdb rc yidfb g

pyztqgrd decfgrd geice ierdzodbigrd%

Pmc~pmgrd rzge~adz azco HRP rmde yidfb~

pmc~pmcdecfpyztqgrd -PDP)%

N

N

NM:

C C

CPC>:

N

NM:

N

N

C

C C

CC

NC:

N

N

NM:

C C

C

HRP HBP

c}gfcgndrgrd PDP

PDP Ngzjc}ylieg~d Zdgnrice


27/35

Ie rmd jgnrdzigf de{yod& GRPi~ P

ibcecz ie~rdgb ca HRP%

Ie rmi~ nzy~rgf ~rztnrtzd ca ge

D% Ncfi PDP Ngzjc}ylieg~d&

pyztqgrd i~ gr rmd gnriqd ~ird g~

ge gegfch ca PDP# c}gfcgndrgrd%

G odrgf ice ~tnm g~ Oe,, i~ zdwtizdb acz rmd PDP

Ngzjc}ylieg~d zdgnrice& ie gbbirice rc g Oh,, ice rmgr

jieb~ xirm rmd etnfdcribd ~tj~rzgrd gr rmd gnriqd ~ird%Oe,, i~ rmcthmr rc pzcocrd Pi rzge~adz jy ierdzgnrieh

~iotfrgedct~fy xirm rmd decfgrd c}yhde grco geb ge

c}yhde grco ca rmd rdzoiegf pmc~pmgrd ca HRP cz GRP%

f fb m b > m m


28/35

Hfyndzgfbdmybd/>/pmc~pmgrdBdmybzchdeg~d

Pmc~pmchfyndzgrd Lieg~d

Decfg~d

PDP Ngzjc}ylieg~d

hfyndzgfbdmybd/>/pmc~pmgrd

EGB,,Pi

EGBM,M,

7&>/ji~pmc~pmchfyndzgrd

GBP

GRP

>/pmc~pmchfyndzgrd

Pmc~pmchfyndzgrd Otrg~d

:/pmc~pmchfyndzgrd

M:C

pmc~pmcdecfpyztqgrd

NC: , HBPHRP

c}gfcgndrgrd

Pi , GBP

MNC> , GRP

pyztqgrd

Pyztqgrd Ngzjc}yfg~d

Hftncedchded~i~

^toogzy ca

Hftncedchded~i~

Pgrmxgy;

Hftncedchded~i~

de{yod egod~ ie

zdb%

Hfyncfy~i~ de{yod

egod~ ie jftd%


29/35


Aztnrc~d/7&1/ji~pmc~pmgrg~d

hftnc~d Hftncedchded~i~

Pi

M:Chftnc~d/1/pmc~pmgrd

Pmc~pmchftnc~d I~codzg~d

aztnrc~d/1/pmc~pmgrd

Pi

M:C

aztnrc~d/7&1/ji~pmc~pmgrd

Gfbcfg~d

hfyndzgfbdmybd/>/pmc~pmgrd,bimybzc}ygndrced/pmc~pmgrd

Rzic~dpmc~pmgrdI~codzg~d

-ncerietdb)


30/35

Hfyncfy~i~ ! Hftncedchded~i~gzdjcrm ~pcergedct~%

Ia jcrm pgrmxgy~ xdzd ~iotfrgedct~fy gnriqd ie g ndff& ir

xctfb nce~rirtrd g *atrifd nynfd* rmgr xctfb xg~rd dedzhy%

Hfyncfy~i~;

hftnc~d , :EGB, , :GBP , :Pi

:pyztqgrd , :EGBM , :GRP

Hftncedchded~i~;:pyztqgrd , :EGBM , 2GRP , :HRP

hftnc~d , :EGB, , 2GBP , :HBP , 1Pi

Wtd~rice~;

7% Hfyncfy~i~ yidfb~ mcx ogey uP3

:% Hftncedchded~i~ d}pdeb~ mcx ogey uP 3

>% G atrifd nynfd ca jcrm pgrmxgy~ xctfb xg~rd mcx ogey

uP pdz nynfd 3

:

1

2

Pm m a r li


31/35

Rc pzdqder rmd xg~rd ca g atrifd nynfd& Hfyncfy~i~ !Hftncedchded~i~ gzd zdnipzcngffy zdhtfgrdb%

Fcngf Ncerzcf ienftbd~ zdnipzcngf gffc~rdzin zdhtfgricejy gbdeied etnfdcribd~%

Pmc~pmcaztnrclieg~d -Hfyncfy~i~) i~ iemijirdb jy

GRP geb ~riotfgrdb jy GOP%

Aztnrc~d/7&1/ji~pmc~pmgrg~d -Hftncedchded~i~) i~

iemijirdb jy GOP%

aztnrc~d/1/pmc~pmgrd aztnrc~d/7&1/ji~pmc~pmgrd

Pmc~pmcaztnrclieg~d

NM:CPC>:

CM

NM:CM

M

CM M

M MC

C

1

4

2 >

:

7 NM:CPC>:

CM

NM:CPC>:

M

CM M

M MC

C

1

4

2 >

:

7

GRP GBP

Pi M:C

Aztnrc~d/7&1/jic~pmc~pmgrg~d


32/35

Rmd cppc~ird daadnr~ca gbdeied etnfdcribd~ ce Pmc~pmcaztnrclieg~d -Hfyncfy~i~)

Aztnrc~d/7&1/ji~pmc~pmgrg~d -Hftncedchded~i~)

ie~tzd~ rmgr xmde ndfftfgz GRP i~ mihm -GOP xctfb rmdejd fcx)& hftnc~d i~ ecr bdhzgbdb rc ogld GRP%

Xmde GRP i~ mihm ir i~ oczd t~datf rc rmd ndff rc ~rczdhftnc~d g~ hfynchde%

Xmde GRP i~ fcx -GOP xctfb rmde jd mihm)& rmd ndff

bcd~ ecr d}pdeb dedzhy ie ~yermd~i{ieh hftnc~d%


33/35

Hfcjgf Ncerzcf ie fiqdz ndff~ ienftbd~ zdnipzcngf

daadnr~ ca g nynfin GOP ng~ngbd& rzihhdzdb jy rmdmczoced hftnghce xmde jfccb hftnc~d i~ fcx%

Pmc~pmczyfgrice ca de{yod~ ! zdhtfgrczy pzcrdie~ ie

fiqdz jy Pzcrdie Lieg~d G -nGOP Bdpdebder Pzcrdie

Lieg~d) zd~tfr~ ie

iemijirice ca hfyncfy~i~

~riotfgrice ca hftncedchded~i~&

oglieh hftnc~d gqgifgjfd acz zdfdg~d rc rmd jfccb%


34/35

De{yod~ zdfdqger rc rmd~d pgrmxgy~ rmgr gzd

pmc~pmczyfgrdb jy Pzcrdie Lieg~d G ienftbd;

Pyztqgrd Lieg~d& g hfyncfy~i~ de{yod rmgr i~

iemijirdb xmde pmc~pmczyfgrdb%

NZDJ -nGOP zd~pce~d dfdoder jiebieh pzcrdie)xminm gnriqgrd~& rmzcthm crmdz agnrcz~& rzge~nziprice

ca rmd hded aczPDP Ngzjc}ylieg~d& fdgbieh rc

ienzdg~dbhftncedchded~i~%

G ji/atenricegf de{yod rmgr ogld~ geb bdhzgbd~

ge gffc~rdzin zdhtfgrcz& aztnrc~d/:&1/ji~pmc~pmgrd%

Hf P r


35/35

^toogzy ca daadnr~ ca hftnghce/nGOP ng~ngbd ie fiqdz;

Hftncedchded~i~ i~ ~riotfgrdb%

Hfyncfy~i~ i~ iemijirdb% Hfynchde jzdglbcxe i~ ~riotfgrdb%

Hfynchde ~yermd~i~ i~ iemijirdb%

A f i a b a f r rm jf b

Hfynchde Pyztqgrd

Hftncedchded~i~

Hftnc~d/7/P Hftnc~d/1/P Hftnc~d , PiHftnc~d/1/Pg~d

Hfyncfy~i~

Pgrmxgy

]

]

gluconeogenesis for 2nd year mbbs delivered on 27 jan 2010 by dr waseem kausar

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