glycolysis for 2nd yearmbbs 07 jan 2010 (dr. waseem kausar)

Upload: imdcbiochem

Post on 30-May-2018

212 views

Category:

Documents


0 download

TRANSCRIPT

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    1/61

    M@VFGN_BV@RJ LJR@FGDO]LM@VFGN_BV@RJ LJR@FGDO]LBv q`}jjl e`z}`v+Bv q`}jjl e`z}`v+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    2/61

    Okrvgbzmrogk rg Ljr`fgdo}lOkrvgbzmrogk rg Ljr`fgdo}l

    Mglsdj~ }zf}r`kmj} `vj fvgejkbgqk igv jkjvay$ vjpzovjb ljr`fgdorj}$}rvzmrzv`d mglsgkjkr}$ jrm+

    Mjdd} lz}r }ykrnj}oxj kjq mglsdj~}zf}r`kmj}+

    Rngz}`kb} gi }zmn vj`mrogk} `vjgmmzvvoka }olzdr`kjgz}dy ok `

    }okadj mjdd+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    3/61

    ((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((

    Bjiokorogk}8Bjiokorogk}8

    M`r`fgdo}lM`r`fgdo}l< rnj fvj`ebgqk gi

    mglsdj~ }zf}r`kmj}+@k`fgdo}l@k`fgdo}l < rnj }ykrnj}o} gi

    mglsdj~ }zf}r`kmj} ivgl }olsdjvgkj}+(((((((((((((((((((((((((((((((((((((((((((((((((((((((((((

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    4/61

    Ajkjv`d S`rnq`y} gi Ljr`fgdo}lAjkjv`d S`rnq`y} gi Ljr`fgdo}l

    ,, M`r`fgdo}l ,,

    0, Fvj`ebgqk gi l`mvglgdjmzdj} rgfzodboka fdgme} ,, ajkjv`ddy nybvgdyrom

    svgrjok sgdy}`mmn`vobj dosob kzmdjom `mob}

    `lokg adzmg}j$ adymjvgd vofg}j$

    `mob} grnjv }za`v} i`rry `mob} f`}j}$sng}sn`rj

    ,, kg z}j`fdj jkjvay yojdb njvj,

    gkdy fzodboka fdgme} gfr`okjb

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    5/61

    6, Fvj`ebgqk gi lgkgljv} rgmgllgk okrjvljbo`rj}

    `lokg adzmg}j$ adymjvgd$`mob} grnjv }za`v} i`rry `mob}

    syvz`rjKN2% `mjryd Mg@

    morvom `mob mymdjJR]'G~ Sng}@RS MG6G~ob`roj svgmj}}j},, svgbzmj @RS )

    K@BN igv jkjvay

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    6/61

    =,Fvj`ebgqk gi okrjvljbo`rj} rg MG6

    `kb jdjmrvgk} o} `mmglsdo}njb

    rnvgzan ` mjkrv`d g~ob`roj s`rnq`y8

    rnj Morvom @mob MymdjMorvom @mob Mymdj gvRM@RM@ gv rnj

    Evjf} MymdjEvjf} Mymdj+

    Rno} mymdj dj`b} rg rnj svgbzmrogk

    gi @RS fy svgmj}}j} m`ddjb jdjmrvgkrv`k}sgvr `kb g~ob`rojsng}sngvyd`rogk+

    (((((((((((((((((((((((((((((((((((((((((((((((((((((((((((

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    7/61

    svgrjok} sgdy}`mmn`vobj} dosob}svgrjok} sgdy}`mmn`vobj} dosob}`lokg adzmg}j$ adymjvgd`mob} grnjv }za`v} i`rry `mob}

    KN2

    % syvz`rj

    `mjryd Mg@ Okrjvljbo`rj}Okrjvljbo`rj}

    morvom `mob mymdj MG6

    ,,@k`fgdo}l@k`fgdo}l,,

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    8/61

    ,, ]glj Ajkjv`d Svokmosdj}]glj Ajkjv`d Svokmosdj} ,,

    Svgmj}}j} gi ljr`fgdo}l `vj noandymgkrvgddjb8

    @k`fgdo}l `kb m`r`fgdo}l `vj kgr

    kjmj}}`vody f`d`kmjb , gkj gv rnj

    grnjv l`y svjbglok`rj ok mjvr`ok

    mjdd} gv `r boiijvjkr rolj} bjsjkboka

    gk mjdd kjjb}

    Rnj s`rnq`y rg }ykrnj}oxj `

    mglsdj~ }zf}r`kmj o} kgr }olsdy rnj

    vjjv}j gi rnj bjav`b`roj s`rnq`y+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    9/61

    Lgbj} gi MgkrvgdLgbj} gi Mgkrvgd

    0, Djjd gi jkjvayDjjd gi jkjvay, oi dgq$ `k`fgdo}lo} zkdoejdy gv olsg}}ofdj

    6, Djjd gi }zf}rv`rj}Djjd gi }zf}rv`rj}

    =, Djjd gi jkxylj mgi`mrgv}Djjd gi jkxylj mgi`mrgv},dosgom `mob$ rno`lokj$ K@B%$ jrm+

    2, sNsN , `iijmr} ogkox`rogk }r`rj}$ o+j+$

    ` lgdjmzdj l`y fj vj`mroj gkdy oi ok.zk/svgrgk`rjb }r`rj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    10/61

    :, Jkxylj}Jkxylj},,`/ pz`krory, vjsvj}}ogk gv okbzmrogk

    gij~svj}}ogk gi okigvl`rogk ok BK@f/ `mroory, l`y n`j ok`mroj gv dj}}`mroj }r`rj}$ `ddg}rjvom jkxylj} n`j

    %% gv ,, jiijmrgv}$ ijjbf`me mgkrvgd,fzodb,zs gi svgbzmr oknofor} jkxylj9, Mgls`vrljkr`dox`rogkMgls`vrljkr`dox`rogk , ]glj

    jkxylj} `kb }zf}rv`rj} vj}rvomrjbrg mjvr`ok gva`kjddj} }g `} rg l`ejrnj }zf}rv`rj `kb jkxylj ``od`fdj

    rgajrnjv ok voanr sd`mj+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    11/61

    1, Ngvlgkj mgkrvgdNgvlgkj mgkrvgd, Mjvr`ok mjdd}`vj r`vajrjb fy ngvlgkj}$ qnomnokbovjmrdy vjazd`rj mjddzd`vs`rnq`y}+

    Bjiokorogk8Bjiokorogk8 Ngvlgkj} `vj }l`ddvjazd`rgvy lgdjmzdj} }ykrnj}oxjbjd}jqnjvj `kb bjdojvjb rg r`vajrmjdd}+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    12/61

    M`vfgnybv`rj Ljr`fgdo}l GjvojqM`vfgnybv`rj Ljr`fgdo}l Gjvojq adymgajk

    sjkrg}j ADZMG]J grnjv}za`v}

    syvz`rj

    d`mr`rj `mjryd Mg@ JrGN

    RM@ mymdj @RS

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    13/61

    Adymgdy}o}

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    14/61

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    15/61

    AD_MGD_]O]AD_MGD_]O] Adzmg}j @RS nj~geok`}j @BS

    Adzmg}j 9,sng}sn`rjsng}sngadzmg,o}gljv`}j

    Ivzmrg}j 9,sng}sn`rj @RSsng}sngivzmrgeok`}j @BS Ivzmrg}j 0$9,fo}sng}sn`rj

    `dbgd`}j

    rvog}j sng}sn`rj o}gljv`}jBonybvg~y`mjrgkj Adymjv`dbjnybj

    sng}sn`rj =,sng}sn`rj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    16/61

    Adymjv`dbjnybj =,sng}sn`rjadymjv`dbjnybj K@B% % So=,sng}sn`rj K@BN % N%

    bjnybvgajk`}j 0$=,Fo}sng}sngadymjv`rj @BSsng}sngadymjv`rj eok`}j @RS

    =,Sng}sngadymjv`rjsng}sngadymjvglzr`}j 6,Sng}sngadymjv`rjjkgd`}j N6G

    Sng}sngjkgdsyvz`rj @BSsyvz`rj eok`}j @RS

    Syvz`rj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    17/61

    Adymgdy}o}Adymgdy}o}Qn`r o} adymgdy}o}7

    Rjk }rjs ljr`fgdom s`rnq`y rgmgkjvr adzmg}j okrg rqg lgdjmzdj}gi syvz`rj `kb rqg lgdjmzdj}

    j`mn gi K@BN `kb @RS+ @dd m`vfgnybv`rj} rg fj m`r`fgdoxjblz}r jkrjv rnj adymgdyrom s`rnq`y+

    , Adymgdy}o} o} mjkrv`d ok ajkjv`rokafgrn jkjvay `kb ljr`fgdomokrjvljbo`voj}+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    18/61

    OLSGVR@KMJ GI AD_MGD_]O]

    ]orj < myrgsd`}l gi @DD RNJ MJDD]

    lj`k} < }qjjr }sdorrokagkdy }gzvmj gi jkjvay gi VFM}

    Adzmg}j jkrvy okrg rnj mjdd} fy

    0< K`% okbjsjkbjkr i`modor`rjb

    6< K`% bjsjkbjkr

    svgobj m`vfgk }ejdjrgk igv kgk j}}jkro`d `lokg `mob} `kbadymjvgd s`vr gi i`r+

    Vjjv}ofdj vj`mrogk igv adzmgkjgajkj}o}

    MJVR@OK BO]J@]J]

    njlgdyrom bo}j`}j < SE bjiomojkmyI`roazj }ykbvglj < SIE bjiomojkmy

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    19/61

    ,Syvz`rjSyvz`rj m`k fj izvrnjv svgmj}}jb8

    `/ `k`jvgfom`ddy rg d`mr`rjd`mr`rj ok lz}mdj`kb ok mjvr`ok lomvg,gva`ko}l} gv

    f/ `k`jvgfom`ddy rg jrn`kgdjrn`kgd.ijvljkr`rogk/ gv

    m/ `jvgfom`ddy rg MG6 `kb N6G o` rnj

    morvom `mob mymdj+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    20/61

    ,, @dmgngd ijvljkr`rogk `kb`k`jvgfom adymgdy}o} .d`mr`rj/ `vj

    kgrjiiomojkr jkjvay svgobjv} }okmj rno}adymgdyrom s`rnq`y yojdb} dorrdj @RS+

    ,, @jvgfom svgmj}}oka gi syvz`rjrnvgzan rnj morvom `mob mymdj`kb vj}sov`rogk aoj} ` lgvj

    mglsdjrj g~ob`rogk `kb ` lzmnnoanjv @RS yojdb+, Adymgdy}o} svgobj} syvz`rj$

    ` svjmzv}gv igv vj}sov`rogk$ rnj

    Ad d o nAd d o n r r

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    21/61

    Adymgdy}o} n`} rqg }r`aj}+Adymgdy}o} n`} rqg }r`aj}+

    @+ @k jkjvay okj}rljkr sn`}j+Vj`mrogk}$ 0,:+ Adzmg}j rg rqgadymjv`dbjnybj =,sng}sn`rj

    lgdjmzdj}+ Rqg @RS} `vj okj}rjb+F+ @k jkjvay s`ygiisn`}j+Vj`mrogk} 9,03+ rqg adymjv`dbjnybj

    =,sng}sn`rj lgdjmzdj} rg rqgsyvz`rj sdz} igzv @RS lgdjmzdj}+,, @ kjr girqg @RS lgdjmzdj} gjv`dd

    sdz} rqg K@BN+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    22/61

    Sn`}j O+ Jkjvay Okj}rljkr+Sn`}j O+ Jkjvay Okj}rljkr+

    0, Adzmg}j o} sng}sngvyd`rjb+ Adzmg}jjkrjv} ` mjdd rnvgzan ` }sjmoiomadzmg}j rv`k}sgvr svgmj}}+ Or o}

    pzomedy sng}sngvyd`rjb `r rnjj~sjk}j gi `k @RS+ Rnj okj}rljkr gi`k @RS njvj o} m`ddjb svoloka+

    Jkxylj} < nj~geok`}jnj~geok`}j gvadzmgeok`}jadzmgeok`}j

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    23/61

    @RS @BS

    adzmg}j adzmg}j 9,sng}sn`rj

    Ag! < ,09+1 eH'lgdj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    24/61

    Vj`mrogk8Vj`mrogk8

    iov}r jkjvay okj}rljkr noandy j~jvagkom$ A< ,09+1eH'lgdj$ .j}}jkro`ddy ovvjjv}ofdj/

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    25/61

    Nj~geok`}jNj~geok`}j igzkb ok `dd mjdd} gi jjvy

    gva`ko}l dgq }sjmoiomory igvlgkg}`mmn`vobj} .}olsdj }za`v}/

    o+j+$ grnjv lgkg}`mmn`vobj} m`k fjsng}sngvyd`rjb fy nj~geok`}j+ vjd`rojdy noan `iiokory igv adzmg}j$

    EL< 3+0 lL

    oknoforjb fy or} svgbzmr$ adzmg}j

    9,sng}sn`rj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    26/61

    Adzmgeok`}jAdzmgeok`}j

    igzkb ok dojv noan EL .{03lL/ igv adzmg}j

    kgr oknoforjb fy adzmg}j,9,sng}sn`rj lg}r jiijmroj qnjk adzmg}j djjdok fdggb o} noan$ o+j+$ voanr `irjv lj`d+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    27/61

    6, O}gljvox`rogk gi adzmg}j 9,sng}sn`rj

    Jkxylj < sng}sngadzmgo}gljv`}jsng}sngadzmgo}gljv`}j

    adzmg}j 9,sng}sn`rj ivzmrg}j 9,sngsn`rj

    `dbg}j rg ejrg}j o}gljvox`rogk

    vjjv}ofdj$ A

    < 0+1 eH'lgdj

    = ] b n n d ro

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    28/61

    =, ]jmgkb sng}sngvyd`rogkJkxylj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    29/61

    2, Mdj``aj rg rqg rvog}jsng}sn`rj}

    Jkxylj eH'lgdj$ bvojk fy

    NM

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    30/61

    ,, ljmn`ko}l8 ejrg `r M6 giI,0$9,fo} S mgkbjk}j} qorn ,`lokj

    gi dy} `r `mroj }orj gi jkxylj.]mnoii f`}j okrjvljbo`rj/$ `oboka okm`vfgk,m`vfgk fgkb mdj``aj+

    N NNM,GS N ,N6G NM,GS

    M

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    31/61

    :, O}gljvox`rogk gi bonybvg~y`mjrgkjsng}sn`rj

    Jkxylj < rvog}j,sng}sn`rj o}gljv`}jrvog}j,sng}sn`rj o}gljv`}j

    N6M,GN

    M

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    32/61

    `ddgq} okrjvmgkjv}ogk gi rqg rvog}jng}sn`rj svgbzmr} gi `dbgd`}j mdj``a

    gkdy adymjv`dbjnybj sng}sn`rj m`kj z}jb izvrnjv ok adymgdy}o}+`dbg}j,ejrg}j o}gljvox`rogk }olod`v

    g sng}sngadzmgo}gljv`}j v~k`ddgq} bonybvg~y`mjrgkj sng}sn`rjg fj ljr`fgdoxjb `}

    dymjv`dbjnybj =,sng}sn`rjvjjv}ofdj$ A< %1+: eH'lgdj+no} o} olsgvr`kr ok adzmgkjgajkj}o}

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    33/61

    (((((((((((((((((((((((((((((((((((((((((((((((((

    Jkb gi Iov}r Sn`}j8

    , Svgbzmrogk gi rqg adymjv`dbjnybj=,sng}sn`rj lgdjmzdj} ivgl gkjadzmg}j lgdjmzdj qorn rnj

    j~sjkborzvj gi rqg @RS}+, Rnjvjigvj8 rnj jkjvay yojdb} gi rnjigddgqoka }rjs} `vj lzdrosdjb fy rqg+

    ((((((((((((((((((((((((((((((((((((((((((((((((((

    ]jmgkb Sn`}j8]jmgkb Sn`}j8

    9 G~ob`rogk gi adymjv`dbjnybj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    34/61

    9, G~ob`rogk gi adymjv`dbjnybj=,sng}sn`rj

    Jkxylj< adymjv`dbjnybj,=,sng}sn`rjbjnybvgajk`}j

    %

    ,`bborogk gi sng}sn`rj$ g~ob`rogk$svgbzmrogk gi K@BN$ igvl`rogk gi

    noan jkjvay mglsgzkb

    adymjv`dbjnybj =,sng}sn`rj 0$= fo}sng}sngadymjv`rj

    GGSG

    G K@B K@BN G

    GSGN M

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    35/61

    , Iov}r noan jkjvay mglsgzkbajkjv`rjb < fjaokkoka gi s`ygii+

    , svgbzmr o} `k `mydsng}sn`rj$ `iz}jbm`vfg~ydom,sng}sngvom `mob

    `knybv`rj$ qnomn n`} ` jvy noanivjj jkjvay gi nybvgdy}o}+, vjjv}ofdj v~k$ A < %9+= eH'lgdj

    fjm`z}j rno} iz}jb avgzs vjr`ok}}glj gi rnj jkjvay svgbzmjb fy rnjg~ob`rogk gi rnj `dbjnybj rg rnj

    m`vfg~ydom `mob+

    o b o

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    36/61

    ,, vj`mrogk svgbzmj} olsgvr`krvjbzmoka mglsgzkb K@BN

    < komgrok`lobj `bjkokj bokzmdjgrobj$vjbzmjb igvl+ N

    UMgvj K@B% o}

    vjmymdjb `kb kgrz}jb zs okljr`fgdo}l+\

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    37/61

    Ljmn`ko}l gi A=S Bjnybvgajk`}jLjmn`ko}l gi A=S Bjnybvgajk`}j

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    38/61

    1, Rv`k}ijv gi sng}sn`rj rg l`ej @RSJkxylj < sng}sngadymjv`rj

    eok`}j

    , iov}r }zf}rv`rj djjd sng}sngvyd`rogk$yojdboka @RS

    , 6 0$= fo} SA yojdb 6 @RS}$ rnz} }g i`v@RS yojdb < @RS okszr

    , noan ivjj jkjvay yojdb$ A+>eH'lgdj bvoj} }jjv`d gi rnj svjogz}

    G

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    39/61

    >, Sng}sn`rj }noir }jrzsJkxylj< sng}sngadymjv`rj lzr`}j

    , }noir} sng}sn`rj ivgl sg}orogk = rg 6, vjjv}ofdj$ A < % 2+9 eH'lgdj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    40/61

    , ljmn`ko}l okgdj} sng}sngvyd`rjbjkxylj okrjvljbo`rj qorn rnjigvl`rogk gi 6$= fo}sng}sngadymjv`rj

    ? Ajkjv`rogk gi }jmgkb jvy noan

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    41/61

    ?, Ajkjv`rogk gi }jmgkb jvy noanjkjvay mglsgzkb fy ` bjnybv`rogk

    Jkxylj < jkgd`}j

    ,, dorrdj jkjvay mn`kaj ok rno}vj`mrogk$

    A

    < %0+1 eH'lgdj fjm`z}j rnj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    42/61

    , rnj jkjvay o} dgmejb okrg rnj noanjkjvay zki`gv`fdj jkgd

    mgkioazv`rogk fy sng}sngvom `mob j}rjv

    , zsgk d`rjv nybvgdy}o} gi sng}sn`rj8

    N noan jkjvay dgq jkjvaynoan jkjvay dgq jkjvayG G

    ,M

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    43/61

    03, Iok`d ajkjv`rogk gi @RSJkxylj < syvz`rj eok`}j

    SG N @BS @RS G,GGM,M

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    44/61

    , v~k o} }g j~jvagkom fjm`z}j rnj jkgdok SJS o} rv`k}igvljb rg ` ejrg ok

    syvz`rj+, bvoj} }jjv`d svjogz} vj`mrogk}+, syvz`rj o} rnj svol`vy svgbzmr

    gi adymgdy}o}, syvz`rj eok`}j o} ` noandyvjazd`rjb jkxylj+

    F ee o

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    45/61

    FggeejjsokaFggeejjsoka8, 6 @RS} ivgl j`mn adymjv`dbjnybj

    =,sng}sn`rj < rgr`d gi 2 sjv gvoaok`dadzmg}j ok }jmgkb sn`}j+

    , 6 lgdjmzdj} gi K@BN `d}g svgbzmjb+

    , 6 @RS} qjvj okj}rjb ok rnj iov}r

    sn`}j gi adymgdy}o}+

    Adymgdy}o}8 Okj}r 6 @RS 2 @RS

    kjr 6 @RS `kb 6 K@BN

    ] i J V d ro no]zll`vy gi Jkjvay Vjd`rogk}nos}

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    46/61

    ]zll`vy gi Jkjvay Vjd`rogk}nos}]zll`vy gi Jkjvay Vjd`rogk}nos}igv Adymgdy}o}igv Adymgdy}o}

    Okszr < 6 @RS0+ adzmg}j % @RS adzmg}j,9,S6+ ivzmrg}j,9,S % @RS ivzmrg}j 0$9fo}sng}sn`rj

    Gzrszr < 2 @RS % 6 K@BN0+ 6 adymjv`dbjnybj =,S % 6 So % 6 K@B%

    6 .0$= fo}sng}sngadymjv`rj/ % 6 K@BN6+ 6 .0$= fo}sng}sngadymjv`rj/ % 6 @BS6 .=,S,adymjv`rj/ % 6 @RS=+ 6 SJS % 6 @BS 6 syvz`rj % 6 @RS

    Kjr < 6 @RS `kb 6 K@BN

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    47/61

    Jkjvay _ojdb Ivgl Adymgdy}o}Jkjvay _ojdb Ivgl Adymgdy}o}

    dzmg}j 9 MG6 < ,6>23 eH'lgdj

    6 @RS} svgbzmjb < 6 ~ =3+: 23 < 6*

    vjmgjvjb `} @RS}zf}jpzjkr g~ob`rogk gi syvz`rj `kb@BN m`k vjmgjv lgvj gi rnj ivjj

    kjvay ivgl adzmg}j+ I`rj gi Svgbzmr gi Adymgdy}o}, Syvz`rjI`rj gi Svgbzmr gi Adymgdy}o}, Syvz`rj

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    48/61

    I`rj gi Svgbzmr gi Adymgdy}o} Syvz`rjI`rj gi Svgbzmr gi Adymgdy}o} Syvz`rj, Syvz`rj o} `r ` mjkrv`d fv`kmn sgokrok ljr`fgdo}l+

    Vjm`dd8@jvgfom s`rnq`y , rnvgzanmorvom `mob mymdj `kb vj}sov`rogk5rno} s`rnq`y yojdb} i`v lgvj jkjvay

    `kb qodd fj bo}mz}}jb d`rjv+K@BN % G6 K@B% % jkjvay

    Syvz`rj % G6 =MG6 % jkjvay

    RR fofo rnrn

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    49/61

    RqgRqg `kjvgfom`kjvgfom s`rnq`y}8s`rnq`y}8

    , rg d`mr`rj o` d`mr`rj bjnybvgajk`}j, rg jrn`kgd o` jrn`kgd bjnybvgajk`}

    , Kgrj8 fgrn z}j zs K@BN svgbzmjb}g gkdy 6 @RS sjv adzmg}j mgk}zljb

    D`mr`rj Ijvljkr`rogkD`mr`rj Ijvljkr`rogk

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    50/61

    + D`mr`rj Ijvljkr`rogkD`mr`rj Ijvljkr`rogkJkxylj < D`mr`rj Bjnybvgajk`}j

    GG,

    MGG,

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    51/61

    Njds} bvoj adymgdy}o} fy z}oka zsK@BN

    Vjjv}ofdj }g syvz`rj m`k fjvjajkjv`rjb ok `drjvk`rojljr`fgdo}l

    D`mr`rj ijvljkr`rogk olsgvr`kr okvjb fdggb mjdd}$ s`vr} gi rnj vjrok`$`kb ok }ejdjr`d lz}mdj mjdd} bzvoka

    }rvjkzgz} j~jvmo}j+ Olsgvr`kr ok sd`kr} `kb oklomvgfj} avgqoka ok `f}jkmj gi G6+

    D r r B n b .DBN/ n

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    52/61

    ,, D`mr`rj Bjnybvgajk`}j .DBN/ n`}lzdrosdj igvl}+ Or o} `k o}gxylj+

    Rqg sgdysjsrobj} L `kb N mgljrgajrnjv rg igvl DBN+ Or o} ` rjrv`ljv}g ` lo~rzvj o} igvljb8

    L2$ L=N$ L6N6$ LN= `kb N2

    L L L N N N N N N NL L L L L L L N

    N N

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    53/61

    ]ejdjr`d lz}mdj `kb dojv mgkr`oksvjbglok`krdy rnj LL igvl}5

    nj`vr rnj NN igvl}+ Bzvoka `kb`irjv lygm`vbo`doki`vmrogk .nj`vr

    `rr`me/$ nj`vrmjdd} boj vjdj`}okaDBN okrg rnjmovmzd`rogk+

    Bo`akg}rom+

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    54/61

    ]zll`vy]zll`vy Adzmg}jAdzmg}jgi Vj`mrogk}gi Vj`mrogk} 6 @RS

    6 K@BN6 syvz`rj

    6 K@BN 6 K@BN

    `k`jvgfom`k`jvgfom `k`jvgfom`k`jvgfom6 jrn`kgd % MG

    66 d`mr`rj

    6 `mjryd Mg@ % 6 MG6 G6 `jvgfom`jvgfom

    2 MG6 % 2 N6G

    VJAZD@ROGK GI AD_MGD_]O]VJAZD@ROGK GI AD_MGD_]O]

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    55/61

    Rnvjj ovvjjv}ofdj eok`}j vj`mrogk}svol`vody bvoj adymgdy}o} igvq`vb+

    nj~geok`}j gv adzmgeok`}jsng}sngivzmrgeok`}jsyvz`rj eok`}j

    Rnj}j jkxylj} vjazd`rj adymgdy}o}Rnj}j jkxylj} vjazd`rj adymgdy}o}`} qjdd+`} qjdd+

    ,, VJAZD@ROGK GI AD_MGD_]O]VJAZD@ROGK GI AD_MGD_]O] ,,

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    56/61

    0+0+NJ^GEOK@]J `kb ADZMGEOK@]JNJ^GEOK@]J `kb ADZMGEOK@]J

    Bo}mz}}jbBo}mz}}jbNJ^GEOK@]JNJ^GEOK@]JSng}sngvyd`rogk gi adzmg}j+

    Oknoforjb fy or} svgbzmr$ adzmg}j9,sng}sn`rj$ `} ` vj}sgk}j rg

    }dgqoka gi adymgdy}o}

    ADZMGEOK@]JADZMGEOK@]J

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    57/61

    ADZMGEOK@]JADZMGEOK@]J

    dojv jkxylj qorn noan EL igvadzmg}j }g lg}r jiijmroj qnjk

    adzmg}j djjd} `vj jvy noan

    kgr oknoforjb fy adzmg}j 9,sng}sn`r}jk}oroj rg noan adzmg}j okmovmzd`rogk ivgl vjmjkr lj`d

    or bjmvj`}j} noan djjd gi adzmg}jok fdggb fy r`eoka adzmg}j okrg dojv

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    58/61

    6+ SNG]SNGIVZMRGEOK@]JSNG]SNGIVZMRGEOK@]Jv`rj doloroka igv adymgdy}o}

    `k `ddg}rjvom lzdroljvom vjazd`rgvyjkxylj+Lj`}zvj} `bjpz`my gi jkjvay djjd}+

    Oknoforgv}8Oknoforgv}8 @RS `kb morv`rj noan jkjvay

    @mro`rgv}8@mro`rgv}8@BS$ @LS$ dgq jkjvay`kb ivzmrg}j 6$9 fo}sng}sn`rj

    @RS oknofor} sng}sngivzmrg}j

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    59/61

    @RS oknofor} sng}sngivzmrg}j`mroory fy bjmvj`}oka ivzmrg}j

    9,sng}sn`rj fokboka@LS `kb @BS vjjv}j @RS oknoforogk

    Ivzmrg}j 6$9 fo}sng}sn`rj o} ` jvyolsgvr`kr vjazd`rgv$ mgkrvgddoka rnjvjd`roj idz~ gi m`vfgk rnvgzan

    adymgdy}o} jv}z} adzmgkjgajkj}o}+, Or `d}g mgzsdj} rnj}j s`rnq`y} rgngvlgk`d vjazd`rogk+

    = S_VZY@RJ EOK@]JS_VZY@RJ EOK@]J SJS % @BS

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    60/61

    =+ S_VZY@RJ EOK@]JS_VZY@RJ EOK@]J SJS % @BSsyvz`rj % @RS

    @k `ddg}rjvom rjrv`ljv

    , oknoforgv8@RS

    , oknoforgv}8`mjryd Mg@ `kbi`rry `mob} .`drjvk`roj izjd} igv

    RM@ mymdj/

    , `mro`rgv8ivzmrg}j 0$9,fo}sng}sn`rj .ijjb,igvq`vb/

  • 8/14/2019 Glycolysis for 2nd yearMBBS 07 jan 2010 (Dr. Waseem Kausar)

    61/61

    Sng}sngvyd`rogk .ok`mroj igvl/ `kbbjsng}sngvyd`rogk .`mroj igvl/

    zkbjv ngvlgkj mgkrvgd+

    @d}g noandy vjazd`rjb `r rnj djjd giajkj j~svj}}ogk.m`vfgnybv`rj dg`boka/