For more information please visit

www.elekta.com/perfexion

Why Leksell Gamma Knife®?Inspired to develop an e!ective yet gentler alternative to intracranial neurosurgery, Professor Lars Leksell conceived the idea of replacing the surgical precision of a scalpel with simultaneous beams of ionizing radiation. Able to deliver a highly accurate therapeutic dose of radiation to the brain with little or no harm to the patient, Leksell Gamma Knife de"ned the "eld of stereotactic radiosurgery (SRS). Over forty years, hundreds of studies, and several evolutions later, Leksell Gamma Knife® Perfexion™ is "ne-tuned to treat the most challenging targets of the head faster and more e#ciently than ever before. The new benchmark upon which all other SRS options are measured, Leksell Gamma Knife Perfexion is rede"ning excellence in stereotactic radiosurgery. Leksell Gamma Knife is manufactured solely by Elekta, the 2nd largest radiation therapy company in the world.

Leksell Gamma Knife uses simultaneously focused radiation to replace the

neurosurgeon’s knife, enable the physician to destroy tumors, and other brain

GLVRUGHUV�ZLWKRXW�RSHQLQJ�XS�WKH�VNXOO��7KH�LPDJH�RQ�SDJH�ÀYH�LOOXVWUDWHV� the principle of Leksell Gamma Knife.

Latest Technology6LQFH�������WKHUH�KDYH�EHHQ�IRXU�QHZ�JHQHUDWLRQV�RI�*DPPD�.QLIH�V\VWHPV�introduced by Elekta, as well as software and hardware upgrades. Today there

DUH�WZR�*DPPD�.QLIH�V\VWHPV�DYDLODEOH��/HNVHOO�*DPPD�.QLIH��&�DQG�/HNVHOO�*DPPD�.QLIH�3HUIH[LRQ��%RWK�PRGHOV�KDYH�D�JXDUDQWHHG�SUHFLVLRQ�IRU�WKH�lifetime of the equipment. The main difference between the models is in

DXWRPDWLRQ��PDNLQJ�WKH�ORZHU�SULFH�PRGHO�PRUH�VXLWHG�IRU�ORZHU�YROXPHV�RU�ORZHU�UHLPEXUVHPHQW�OHYHOV�

Extend™ SystemLeksell Gamma Knife Perfexion is also prepared for fractionated treatment

with a re-locatable frame allowing for a broader range of cases - the Extend

System.

Why Gamma Knife Radiosurgery?

Fully integrated system

Unrivalled accuracy

ShrinkWrap dose conformity

Unparalleled clinical track record

Gamma Knife® Radiosurgery Facts in Short

0

100,000

200,000

300,000

400,000

500,000

600,000

9192

9394

9596

97 9998 00

0102

03 0504

07 0908 1006

Cumulative Number of Patients Treated

2

Leksell GammaPlan - an intuitive treatment planning system with a surgical approach.

900

800

700

600

500

400

300

200

100

0Gamma

Knife

778

AdaptedLinacs

225

Cyberknife

26

Novalis

Note: Across the following indications: acoustic neuroma, meningioma,brain metastases, trigeminal neuralgia, arteriovenous malformation

Source: Elekta Database based on PubMed, 29 February 2012

13

Peer-Reviewed Papers ReportingMore Than 30 Patients Treated With SRS

Patients Treated$V�RI�WRGD\��PRUH�WKDQ���������SDWLHQWV�KDYH�EHHQ� treated with Gamma Knife radiosurgery. The growth is

illustrated below.

The reason for this growth is:1. 3URYHQ�FOLQLFDO�UHVXOWV�²�PRUH�WKDQ�������SXEOLFDWLRQV�

documenting the results.

2. *DPPD�.QLIH�UDGLRVXUJHU\�LV�D�QRQ�LQYDVLYH�technique. This means the patient can usually return

to normal lifestyle the day after treatment.

3. *DPPD�.QLIH�UDGLRVXUJHU\�LV�GHYHORSLQJ�²�QHZ�indications are being researched, and the excellent

UHVXOWV�KDYH�OHG�WR�LQFUHDVLQJ�DFFHSWDQFH�DV�EHWWHU�treated with Leksell Gamma Knife. This leads to

more treatments, and a greater need for Gamma Knife

systems.

��� ,PDJLQJ�LV�JHWWLQJ�EHWWHU�²�05,�LV�ZLGHVSUHDG��DQG�����RI�*DPPD�.QLIH�SURFHGXUHV�DUH�EDVHG�RQ�05,��7KXV��DV�05,�JHWV�EHWWHU��VR�GRHV�*DPPD�.QLIH�radiosurgery.

5. 3DWLHQW�DZDUHQHVV�²�SDWLHQWV�DQG�WKHLU�IDPLOLHV�DUH�PRUH�DZDUH�RI�WKH�EHQHÀWV�RI�*DPPD�.QLIH�radiosurgery compared to other techniques, and more

patients are referred to Gamma Knife treatment. This

includes both doctor and self referrals.

Clinical Evidence7KH�FOLQLFDO�UHVXOWV�RI�*DPPD�.QLIH�UDGLRVXUJHU\�DUH�YHU\�well documented. There are more than 3,000 published

papers on Gamma Knife radiosurgery. The chart shows

the number of published papers document treatments of

30 or more patients, for Leksell Gamma Knife and

VRPH�RWKHU�UDGLRVXUJHU\�WHFKQRORJLHV��5HYLHZLQJ�papers reporting on more than 30 patients, the superior

GRFXPHQWDWLRQ�RI�HYLGHQFH�IRU�*DPPD�.QLIH�UDGLRVXUJHU\�is striking. No other technology can present such rigid

HYLGHQFH�DV�LV�VKRZQ�LQ�WKH�JUDSK�WR�WKH�ULJKW��

Gamma Knife ReliabilityLeksell Gamma Knife® systems

are completely unique in their

design. They are designed to

WUHDW�KLJK�YROXPHV�RI�SDWLHQWV��PRUH�WKDQ�����SHU�\HDU�LV�YHU\�common), with guaranteed

precision and extremely high

reliability. The reliability today is

more than 99% uptime for Leksell

Gamma Knife. Other radiosurgery

WHFKQRORJLHV�KDYH�ORZHU�RU��VLJQLÀFDQWO\�ORZHU�XSWLPH� than a Gamma Knife system.

The reason for this is that Leksell

Gamma Knife is designed with

multiple simultaneous radiation

VRXUFHV�WKDW�GR�QRW�PRYH�GXULQJ�treatment. Thus mechanical

errors and failures from rotating

or translating radiation sources

during treatment are eliminated.

The radiation source for Leksell

*DPPD�.QLIH�LV�WKH�&REDOW����LVRWRSH��SURYLGLQJ�D�UHOLDEOH�DQG�well known intensity, energy and

focus. Elekta is strictly following

the international regulations

regarding transportation and

GLVSRVDO�RI�&REDOW����

Highest Accuracy - 0.15 mmLeksell Gamma Knife® Perfexion™ combines a patented collimator design with a revolutionary new positioning system to e!ectively wrap dose around the most complex shapes while limiting dose to surrounding tissue and critical structures. Dose delivered by each individual beam falls from 80% to 20% in about 1 mm, creating a penumbra that dramatically illustrates how Leksell Gamma Knife Perfexion is able to deliver highly e!ective treatments. "e average accuracy of a Leksell Gamma Knife is 0.15 mm during its lifetime.*

3

Leksell Gamma Knife has the market’s best radiation protection for patients and sta!.

Neurosurgery, volume 61, Sept 07, Christer Lindquist MD and Ian Paddick, MSc, Cromwell Hospital, London, UK.

ShrinkWrap dose conformity. Leksell Gamma Knife has the steepest dose fall o! rate of all radiosurgery devices.

* Based on measurements of 189 individual systems

Cost of Operation and ServiceLeksell Gamma Knife is unique in that it does not require

H[WHQVLYH�VWDIÀQJ��8VXDOO\�RQH�RU�WZR�SK\VLFLDQV��D�physicist and a nurse (all part time) are all the needed

VWDII��6HUYLFH�LV�XVXDOO\�SUHYHQWDWLYH��WKXV�UHGXFLQJ�RU�eliminated any down time or missed patient treatments.

(OHNWD�RIIHUV�D�UDQJH�RI�VHUYLFH�FRQWUDFWV��LQFOXGLQJ�FRPSOHWH�FRYHUDJH��HPHUJHQF\�VHUYLFH�DQG�UHPRWH�GLDJQRVWLFV��6HUYLFH�VWDII�LV�ORFDO�LQ�WKH�UHJLRQ�

Building RequirementsLeksell Gamma Knife is self-shielding, so room

requirements are usually simple. A linac bunker, or other

UDGLDWLRQ�VKLHOGHG�URRP��LV�XVXDOO\�PRUH�WKDQ�VXIÀFLHQW��5DGLDWLRQ�VKLHOGLQJ�OHYHOV�DUH�WKH�PDUNHWV�EHVW��XS�WR�����WLPHV�EHWWHU�WKDQ�DOWHUQDWLYH�WHFKQRORJLHV��VHH�JUDSK�RQ�SDJH�IRXU���+RZHYHU��WKH�*DPPD�.QLIH�XQLW�ZHLJKV��������NJ��VR�WKH�ÁRRU�PXVW�EH�DEOH�WR�ZLWKVWDQG�D�KHDY\�ZHLJKW��JURXQG�ÁRRU�RU�EDVHPHQW�LV�UHFRPPHQGHG��(OHNWD�assists customers with drawings and site planning as part

RI�WKH�VHUYLFH�LQFOXGH�ZKHQ�D�*DPPD�.QLIH�V\VWHP�LV�purchased.

4

Long Lifetime*DPPD�.QLIH�V\VWHPV�KDYH�D�GRFXPHQWHG�OLIHWLPH�RI� at least 10 years. Elekta protects customers with upgrade

and trade in allowances, to ensure those that want the

latest Gamma Knife technology are able to make cost

HIIHFWLYH�LPSURYHPHQWV�WR�WKHLU�V\VWHP��(OHNWD�KDV�D�ORQJ�tradition of rewarding customers for their membership in

WKH�(OHNWD�IDPLO\��7KLV�LV�ZK\�QHDUO\�HYHU\�*DPPD�.QLIH�program started during the last 25 years is still using

Leksell Gamma Knife.

What Else Does Gamma Knife® Bring to a Hospital?Prestige and recognition are two common results of

acquiring Leksell Gamma Knife. Leksell Gamma Knife

is the Gold Standard in radiosurgery, and hospitals that

DFTXLUH�D�*DPPD�.QLIH�V\VWHP�VHH�WKH�EHQHÀW�ERWK�ÀQDQFLDOO\�DQG�LQ�WKHLU�SUHVWLJH�DQG�VWDQGLQJ�LQ�WKH�healthcare and academic community.

In addition, a Gamma Knife program also increases

SDWLHQW�YROXPHV�LQ�RWKHU�GHSDUWPHQWV��$V�DQ�H[DPSOH��ZKHQHYHU�D�SDWLHQW�LV�WUHDWHG�RQ�/HNVHOO�*DPPD�.QLIH��pre-treatment imaging, as well as follow up images at

VL[���������DQG����PRQWKV�DUH�RIWHQ�QHHGHG��GHSHQGLQJ� on the indication treated. All Gamma Knife treatments

DUH�IROORZHG�XS�ZLWK�VRPH�IRUP�RI�LPDJLQJ��7KLV�SURYLGHV�DGGLWLRQDO�VHUYLFHV�IURP�5DGLRORJ\��$QRWKHU�H[DPSOH�LV�the patient who is self-referred, or physician-referred for

Gamma Knife radiosurgery. On occasion, the tumor or

disease is not appropriate for Gamma Knife radiosurgery,

but the hospital is able to offer radiotherapy or surgery as

DQ�DOWHUQDWLYH��,Q�WKLV�PDQQHU��/HNVHOO�*DPPD�.QLIH�KDV�EHHQ�VKRZQ�WR�LQFUHDVH�SDWLHQW�YROXPHV�LQ�WUDGLWLRQDO�RSHQ�neurosurgery, as well as in radiation oncology.

3.13.3

1.3

3.7

1.61.0

0.30.80.8

0,0

0,5

1,0

1,5

2,0

2,5

3,0

3,5

4,0

5,0

5,5

6,0

6,5

7,0

7,5

8,0

8,5

9,0

Average incidents Overall satisfaction

AccurayCyberKnife

ElektaInfinity

ElektaLeksell

Gamma KnifePerfexion

SiemensARTISTE*

TomoTherapyHi-Art

VarianClinac iX

VarianNovalis

Tx*

VarianTrilogy

VarianTrueBeam*

User Satisfaction: Leksell Gamma Knife® Perfexion™ had the highest overall rankings by a 10 point margin. The 2011 KLAS Radiation Oncology and TPS report.

80.3

80.7

84.0

84.3

84.4

94.4Leksell Gamma Knife® Perfexion™

Elekta Infinity™

Accuray CyberKnife® System

TomoTherapy® Hi-Art®

Varian Trilogy®

Varian Clinic iX®

Radiation Therapy Vendor / Product Performance Score 1-year trend

1

2

3

4

5

6

Leksell Gamma Knife® PERFEXION™

PERFEXION

Elekta

Leksell Gamma Knife® Perfexion™

Treats brain disorders with a high dose of radiation delivered with surgical precision.

Radiation unit

20ton

With the treatment planning software, Leksell GammaPlan, the shape and amount of radiation is decided to give an optimal treatment.

Leksell Gamma Knife Perfexion is fully automated. The radiation unit is housed inside of the machine itself. The radiation beams are shaped exactly around the tumor. Several tumors can be treated in one session.

The patient can communicate via video camera and an intercom at all times. The treatment time varies between 20 minutes and several hours depending on the complexity of the treatment.

Perfexion is designed to treat patients with di!erent types of brain disorders.

A stereotactic frame is attached to the patients

head and interlocked to the Gamma Knife unit. This to ensure maximum precision.

Ionizing gamma radiation is emitted from

192 cobalt-60 sources whose beams converge on a precise selected area of the brain. The accuracy is about 0.5 mm. There is minimal e!ect on the surrounding healthy tissue.

1

2

21

5

Corporate Head O#ce:

www.elekta.com Human Care Makes the Future Possible

Regional Sales, Marketing and Service:

Asia Paci"c

Tel +852 2891 2208 Fax +852 2575 7133info.asia@elekta.com

Europe, Middle East, Africa, Eastern Europe, Latin AmericaTel +46 8 587 254 00 Fax +46 8 587 255 00info.europe@elekta.com

North America

Tel +1 770 300 9725 Fax +1 770 448 6338info.america@elekta.com

Elekta AB (publ) Box 7593, SE-103 93 Stockholm, Sweden Tel +46 8 587 254 00 Fax +46 8 587 255 00info@elekta.com

Doc

No.

102

8438

.00

MAY

201

2 ©

2012

Ele

kta

AB (p

ubl).

All

men

tione

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adem

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and

regi

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ed tr

adem

arks

are

the

prop

erty

of t

he E

lekt

a Gr

oup.

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ts re

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ed. N

o pa

rt o

f thi

s do

cum

ent m

ay b

e re

prod

uced

in a

ny fo

rm w

ithou

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from

the

copy

righ

t hol

der.

Available Patients(OHNWD�DQG�*DPPD�.QLIH�XVHUV�KDYH�ORRNHG�LQ�GHSWK�DW�WKH�number of cases suitable for Gamma Knife surgery. From

a population of 1,000,000 people, you would expect 376

suitable Gamma Knife cases per year. From this, the number

of cases per year for any population can be easily calculated.

LGK applicable treatable diagnosis

Annual incidence per million

Treatable with LGK

Treatable patients per million

Arteriovenous Malformations 19 70% 13

Meningioma 41 50% 20

Acoustic Neuroma 15 75% 11

Brain metastases: solitary/multiple 621 47% 292

Trigeminal Neuralgia 51 50% 26

Other indications 96 25% 14

Total 376

Table 1. Incidence for the most common Gamma Knife indications.