fungi 3 lecture 26 summer, 2006 demosthenes pappagianis, md, phd mmi 480b
TRANSCRIPT
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Fungi 3Lecture 26
Summer, 2006
Demosthenes Pappagianis, MD, PhDMMI 480B
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The scope of medically important
fungi
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Select Agents for Bioterrorism….
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Domingo Escurra first patient with
Coccidioidomycosis
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Domingo Escurra
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Alejandro Posadas
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D.P and D. Stevens with Domingo Escurra
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Joao Silveira
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Spherule of Coccidioides immitis
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Sputum culture Coccidioides immitis
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Hyphae/arthroconidiaCoccidioides immitis
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Life CycleCoccidioides
immitis
in vivo - 48-72 hours
in vitro - 32-96 hours
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Coccidioidomycosis -Spectrum of Disease
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Primary Pulmonary Coccidioidomycosis
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CoccidioidalErythema Nodosum
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Palmar coccidioidalmacules/urticarial - thighs
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Coccidioidomycosis - patella
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Spherule of Coccidioides immitis
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DNA Probe
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Serologic Sequence of Antibody Coccidioidomycosis
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Aardvark1 (Orycteropus aferi)Armadillo, nine banded 2 (Dasypus
novemcinctus)Baboon1 (Papio sp), mandrill
Mandrillus sp.)Badger1 (Taxidea taxus)Bear, Malayan sun1 (Ursus malayanus)Binturong1 - a civet (Arctitis binturong)Burro (Equus assinus)*Cat, domest. (Felis catus)Cattle, domest. (Bos taurus)Cheetah1 (Acinonyx jubatus)Chimpanzee1 (Pan troglodytes)Chinchilla1 (Chinchilla lanigera)Coyote1, 2 (Canis latrans)Deer, white-lipped 1 (Cervus albirostris)Dog (Canis familiaris)Dog, Cape or African hunting1 (Lycaon pictus)Dolphin, Pacific bottle-nosed 2 (Tursiops gilli)Ferret1, (Mustela sp. Mustela putoris furo)Gazelle (Gazella thomsonii)Genet1, 3(Genetta felina)Gorilla, mtn.1 (Gorilla gorilla beringeri); lowland1 (Gorilla gorilla gorilla)Horse, domestic (Equus caballus)*Horse1, Przewalski (Equus przewalski)* Human (Homo sapiens)Impala1 (Aepyceros melampus)Jackrabbit2 (Lepus californicus)Kangaroo1 (Macropus rufus); wallaroo1 (Macropus robustus or erubescens)Kiang1 (Equus hemionus kiang)* Kit fox2 (Vulpes velox)Lemur, ringtail1 (Lemur catta); red ruffed1
(Varecia variegata v. suber) Lion, mountain1 (Felis concolor)
Lion, transvaal1 (Panthera leo krugeri )Llama1 (Lama glama)Makhor, turkomen (Capra megaceros or falconeri)Monkey1 - tropical American (Cebus hypoleucus);spider 3 (Ateles sp.)wooley 3 (Lagothrix sp.)colobus (Colobus guereza) sooty mangabey (Cerocebus atys)guenon DeBrazza (Cercopithecus neglectus)bonnet macaque (Macaca radiata)Celebes macaque (Macaca maurus)lion tail macaque (Macaca silenus) rhesus (Macaca mulatta)Okapi1, (Okapia johnstoni)Onager1 (Equus hemionus onager)*Otter, river1 (Lutra canadensis); sea2 (Enhydra lutris) Rhinoceros, Northern White1 (Ceratotherium
simum cottoni); black (Diceros bicornis)Rodents2 - pocket mouse (Perognathus baileyii, P. penicillatus, P. intermedius); grasshopper mouse (Onchyomys torridus); kangaroo rat (Dipodomys merriami); ground squirrel (Citellus harrisi);Sea lion1,2 (Zalophus californianus)Sheep (Ovis aries); Barbary (Ammotragus lervia); bighorn (Ovis
canadensis nelsoni)2
Skunk, hog-nose1,3 (Mephitis sp.)Snake, Sonoran Gopher2 (Piticophis melanoleucus affinis)Swine (Sus scrofa)Tapir1 (Tapirus terrestris)Tiger1, Bengal and Sumatran (Panthera tigris)Wild ass (Equus africanus somaliensis)*Wisent (Bison bonasur)Zebra1, Grevy's (Equus grevyi)*
*Equids1 Zoo or captive animals, 2 In the wild ,3 Species name uncertainThis compilation includes cases detected by Raymond Reed, DVM and Kathryn Orr, DVM, andvarious publications.
Animal species with naturally acquired coccidioidomycosis
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Endemic Areas
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Coalinga
Soledad
Paso Robles
Avenal
Calif. Men’s Colony
Dye Creek
Corcoran
OtayTecate
California Endemic Areas
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Simi Valley Northridge earthquake 1994
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Histoplasma capsulatumin macrophage
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Histoplasma capsulatum intracellular-adrenal macrophages
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H. capsulatum hyphae, tuberculate macroconidia
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Acute histoplasmosis
3 months laterhealed
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Acute histoplasmosis
healed, calcified
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Ulcerative histoplasmosis - mouth
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H. capsulatum adrenal
H&E Methenaminesilver
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Serologic reaction histoplasmosis
HAg - histoplasmal antigen
HAb - histoplasmal antibody
CAg - coccidioidal antigen
CAb - coccidioidal antibody
Bubbles indicate catalase
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Histoplasmosis - world
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Histoplasmosis endemic Western
hemisphere
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Blastomyces dermatitidisyeast phase
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B. dermatitidis yeast phasepus/KOH
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B. dermatitidis mold, hyphae, conidia
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Blastomycosis – facial lesion
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Blastomycosis – crustedpyogranulomatous lesions - extremities
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Endemic AreasBlastomycosis
in USAand Canada
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Paracoccidioides brasiliensisyeast phase
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Paracoccidioides brasiliensismixed inflammation
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Paracoccidioides brasiliensishyphae/conidia
Paracoccidioides brasiliensishyphae/conidia
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Paracoccidioides brasiliensismorphogenesis
Paracoccidioides brasiliensismorphogenesis
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Paracoccidioidermycosismucocutaneous
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Paracoccidioides brasiliensis -
geographic distribution