frompolymerresearch to io-inkindustry...prof. dr. sandra van vlierberghe scientific advisor head of...
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From Polymer Research ToBio-ink Industrydr. Jasper Van Hoorick
Online 3D Bioprinting Conference, 8th Edition
CHALLENGES
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# Pe
op
le
Year
Waiting List Transplants Donors
20People / Day
https://www.organdonor.gov/statistics-stories/statistics.htmlwww.XPECT-INX.com
CHALLENGES
Replace Regenerate
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CHALLENGES
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CHALLENGES
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CHALLENGES
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CHALLENGES
Material based collaborations during my PhD
Can we make a business out
of this?
Where tostart?
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CHALLENGES
Fundamental Tissue
Engineering
Regenerative Medicine
Drug Screening
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CHALLENGES
Fundamental Tissue
Engineering
Regenerative Medicine
Drug Screening
Biofabrication
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CHALLENGES
Fundamental Tissue
Engineering
Regenerative Medicine
Drug Screening
Biofabrication
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BIOFABRICATION
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BIOFABRICATION
3D Printing
Bio-Inks
Cell Culture
CAD Design
Groll et al. “Biofabrication: Reappraising the definition of an evolving field”; Biofabrication (2016)
Cells
Tissue, bone and organRegeneration
(Personalized) Drug Screening
ReplaceAnimal Testingwww.XPECT-INX.com
OUR SOLUTION4 patents: 1 granted, 3 pending
• First Biodegradable resin
• Highest resolution ever reported for a biodegradable
material (150 nm)
• First High resolution (1µm) hydrogel resin enabling cell
encapsulation
• First hydrogel processable from the melt
• Low temperature processable polyester
XPECT INX Bioink
50 µm XPECT INX Bioprinted
Membrane
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OUR SOLUTION
Digital light processing Multiphoton lithographyDeposition-based 3D printing
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Deposition Based 3D Printing
Deposition-based 3D printing
Resolution: 100’s of µm
Key Bio-ink properties• Rheological properties
• Easy flow during extrusion• Rapid/stable shape retention
after deposition• Cell-compatible
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Deposition Based 3D Printing
Deposition-based 3D printingwww.XPECT-INX.com
Deposition Based 3D Printing
Deposition-based 3D printingwww.XPECT-INX.com
TECHNOLOGY
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TECHNOLOGY
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
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TECHNOLOGY
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
www.XPECT-INX.com
TECHNOLOGYOur patented CURASOL® technology offers photo-crosslinkable solid inks, enabling
solvent-free fabrication of robust hydrogel or biodegradable scaffolds with a well-defined
architecture. This technology provides inks with a faster photo-crosslinking reaction
compared to their analogs that are irradiated in the molten state.
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
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Deposition Based Portfolio
Deposition-based 3D printing
Our portfolio is subdivided in two categories:
• Extra Cellular Matrix (ECM) MIMICS can be applied both
for cell-encapsulation and as a scaffolding material for
cell seeding.
• SCAFFOLD INX: Specifically designed to serve as scaffold
for cell seeding. These inks are characterized by an
incredible robustness
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PORTFOLIO
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BIO-DEGRADABLE
CELL INTERACTIVE
CELL ENCAPSULATION
HYDROGELUV
CURINGSTIFFNESS APPLICATIONS
✔️ ✔️ ✔️ ✔️ ✔️ -
✔️ ✔️ ✔️ ✔️ ✔️ -
- ✔️✔️
✔️ ✔️ ✔️
- ✔️/- - ✔️ ✔️ ✔️
✔️ ✔️ / - - - ✔️ ✔️✔️
PORTFOLIO
OUR SOLUTION
Digital light processing Multiphoton lithographyDeposition-based 3D printing
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Multiphoton Lithography
Multiphoton Lithography
Energy
S0
S1
hνIR1
hνIR2
hνUV
R* P
o
l
y
m
e
r
i
z
a
t
i
o
n
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Multiphoton Lithography
Multiphoton Lithography
Resolution: nm - µm
Key Bio-ink properties• 2-photon-Photocrosslinkable• Fast crosslinking• Cell-compatible• Solid state crosslinkable
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TECHNOLOGY
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TECHNOLOGYOur patented CURADUO® technology allows for unprecedented photo-processing
capabilities both in terms of reactivity and versatility.
By implementing the CURADUO® technology to gelatin-based inks, the photo-crosslinking
occurs 33% faster in comparison to conventional gel-MA based inks while maintaining all
the beneficial mechanical and biological properties.
CU
RA
DU
O®
Co
nve
nti
on
al
GEL
-MA
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
www.XPECT-INX.com
TECHNOLOGYOur patented CURASOL® technology offers photo-crosslinkable solid inks, enabling
solvent-free fabrication of robust hydrogel or biodegradable scaffolds with a well-defined
architecture. This technology provides inks with a faster photo-crosslinking reaction
compared to their analogs that are irradiated in the molten state.
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
www.XPECT-INX.com
PORTFOLIO
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BIO-DEGRADABLE
CELL INTERACTIVE
CELL ENCAPSULATION
HYDROGEL STIFFNESS Resolution Applications
✔️ ✔️ ✔️ ✔️ - µm
- ✔️ - ✔️ ✔️ µm
✔️ ✔️/- - -✔️✔️
nm
PORTFOLIO
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OUR SOLUTION
Digital light processing Multiphoton lithographyDeposition-based 3D printing
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Digital light projection
Digital Light Projection
Resolution: µm
Key Bio-ink properties• Photo crosslinkable• Liquid• Low penetration depth• Cell-interactive
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TECHNOLOGYOur patented CURADUO® technology allows for unprecedented photo-processing
capabilities both in terms of reactivity and versatility.
By implementing the CURADUO® technology to gelatin-based inks, the photo-crosslinking
occurs 33% faster in comparison to conventional gel-MA based inks while maintaining all
the beneficial mechanical and biological properties.
CU
RA
DU
O®
Co
nve
nti
on
al
GEL
-MA
• SHEAR-THINNING HYDROGELS
• CURADUO® TECHNOLOGY
• CURASOL® TECHNOLOGY
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PORTFOLIO
Coming Soon!
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TEAM
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TEAM
Prof. Dr. Sandra Van Vlierberghe
Scientific Advisor
Head of the Polymer Chemistry
and Biomaterials (PBM) group at
Ugent
Dr. Jasper Van Hoorick
Project Lead
PhD in Polymer Chemistry and
Engineering (UGent; VUB)
Co-inventor of the applied IP
platform
Dr. Agnes Dobos
Application Specialist
PhD in Technical Chemistry (TUWIEN)
Extensive experience in polymer
processing for biofabrication
applications
Dr. Aysu Arslan
Material Specialist
PhD in Polymer Chemistry (UGent)
Co-inventor of the applied
IP platform
Coralie Gréant
Operational Support
PhD candidate in Polymer Chemistry (Ugent, BE)
Previous experience: Surgical Application Engineer
@ 3D-Side
Erik Devroe
Technician
Technician experienced
in organic synthesis
Dr. An Van Den Bulcke
Business Developer
Business Developer at ChemTech,
the Chemistry Business and
Valorisation Cluster at UGent
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PARTNERS
40
Multiphoton lithographyDeposition-based 3D printing
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