UGent contribution to PolExGene(WP 3)

PolExGene Midterm meetingGhent 17-18/12/2007

PBM-GGentent

UU

Polymer Chemistry & Biomaterials GroupPolymer Chemistry & Biomaterials Group

S. Van Vlierberghe, V. Vermeersch, P. Dubruel & E. Schacht

Overview

• Workpackage content

• Work Performed

• Ongoing & future plans

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 2

Workpackage Content

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 3

Workpackage 3:Development of CIP containing polymer membranes

Development of polymer membranes by solvent-casting and electrospinning

Characterisation through AFM, SEM, XPS, ATR-FTIR, TOF-SIMS

Polyimide modification (1st approach)

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 4

O

O

N

O

O

N

n

O

NH

H2N+

O

O

HN

O

O

NH

n

NH

HNO

HN

HNO

Gel NH2 + H2C C

CH3

C

O

O C

O

C

CH3

CH2 Gel NH C

O

C

CH2

CH3

+ Gel Gel

Gel

Gel+ Irgacure + UV

PI

aminopropylmethacrylamide

gel-MOD

MeOH, 21°C

5 w/v%

gel

ATR-IR spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 5

20

30

40

50

60

70

80

90

100

110

120

5001000150020002500300035004000

Wavenumber (cm-1)

%T

ran

smit

tan

ce

PIPI + gel-MODgel-MOD

Imide C=O asymmetric stretch at 1771 cm-1

Imide C=O symmetric stretch at 1703 cm-1

Imide C-N stretch at 1353 cm-1

• Characteristic peaks of gel-MOD: 1556 cm-1

1665 cm-1

3274 cm-1

ATR-IR spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 6

1556 cm-1 1664 cm-1 3274 cm-1

gel-MOD is grafted on the PI membrane

PI + // + gel-MOD

Atomic Force Microscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 7

PI, 0.54 nm PI + //, 3.52 nm

PI + gel-MOD, 0.92 nm PI + gel-MOD, 0.92 nm

X-ray Photoelectron Spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 8

PI PI + //

C 79% 74%

N 5% 7%

O 16% 19%O

O

HN

O

O

NH

n

NH

HNO

HN

HNO

PI

PI + //

Polyimide modification (2nd approach)

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 9

succinimidyl ester of 4-azido-2,3,5,6-tetrafluorobenzoic acid (AFB) (5 mg/ml, in ethyl acetate)

N3

FF

FF

C

O

O

N

O

O+F

F

F

F

C

OON

O

O

F

F

F

F

C

OON

O

O

(5 w/v%, pH 8)

ATR-IR spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 10

1556 cm-1 1664 cm-1

gelatin is grafted on the PI membrane

PI + AFB + gel

Atomic Force Microscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 11

PI, 0.54 nm PI + AFB, 3.26 nm

PI + AFB + gel, 1.93 nm PI + AFB + gel, 1.93 nm

X-ray Photoelectron Spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 12

PI PI + AFB PI + AFB + gel

C 79% 71% 69%

N 5% 6% 11%

O 16% 21% 19%

F 0% 1% 1%

F

F

F

F

C

OON

O

O

F

F

F

F

C

OON

O

O

PI

X-ray Photoelectron Spectroscopy

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 13

PI PI + AFB PI + AFB + gel

C 79% 71% 69%

N 5% 6% 11%

O 16% 21% 19%

F 0% 1% 1%

F

F

F

F

C

OON

O

O

F

F

F

F

C

OON

O

O

PI

Static Contact Angle Measurements

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 14

0

10

20

30

40

50

60

70

80

PI PI + // PI + // + gel-MOD

PI + N3 PI + N3 + gel

Co

nta

ct a

ng

le (

°)

SCA

hydrophilicity

• Preparation of polymer membranes based on gelatin type A (IEP = 8) (IEPgelatin B = 5).

• Preparation of polymer membranes based on gel-MOD + HA-MOD (1 – 5 w/v%) gel-MOD + CS-MOD (1 – 5 w/v%)

• PBM products sent out:Gelatin coated polyimide membranes (sent to Tübingen)

Ongoing and future plans

S. Van Vlierberghe – PolExGene Ghent - 18/12/2007 pag. 15