Subsidiary Company in USABloomage Freda Biopharm USA Inc.181 New Road, Suite 308, Parsippany NJ 07054TEL: +1-862-485-8343FAX: +1-973-428-4925

Bloomage Freda Biopharm JapanR. 521 Banchoheim, 1-2 Nibancho, Chiyoda-ku, Tokyo 102-0084TEL: +81-3-6256-9688FAX: +81-3-6256-9687

Shanghai OfficeTEL: +86-21-64480654FAX: +86-21-64480654

Guangzhou OfficeTEL: +86-20-36261514 FAX: +86-20-86253859

Global Distribution

SODIUM HYALURONATE

Add : No.678 Tianchen St., High - Tech Development Zone,Jinan,China 250101Tel：+86 531 82685998 Fax：+86 531 82685988www.bloomagefreda.com E-mail:customer@bloomagefreda.comCopyright Jun. 2018, Bloomage Freda Biopharm

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Sodium Hyaluronate

Sodium Hyaluronate

Gamma Aminobutyric Acid

Molecular Weight

200 kDa ~ 600 kDaCustomized molecular weight for your application

200 kDa ~ 600 kDa1,000 kDa ~1,500 kDa

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Applications

Used as ingredient in food or health food

Injection Grade

Sodium Hyaluronate

Medical Grade

Sodium Hyaluronate

Intrinsic Viscosity m³/kg

Measured Value

1.6~2.2

2.7~3.6

Measured Value

1.2~2.8

2.7~3.6

0.5~1.0

Applications

For parenteral preparations, including intra-articular and intra-ocular preparations, such as OVD，intra-articular injections, intradermal injections for aesthetic correction, anti-adhesive products, etc.

For parenteral preparations or oral preparations not including intra-articular and intra-ocular preparations. It can be used in eye drops,contact lens solutions, topical preparations for wound or burn healing, medical lubricants, etc.

Product Code

HA-EP2

HA-EP1.8 (DMF & CEP & KDMF)

HA-EP3.0 (DMF & CEP & KDMF)

HA-EP1

HA-E2.0 (DMF)

HA-E3.0 (DMF)

HA-P-0.5 (DMF)

Pharmaceutical Grade Products

Food Grade Products

HyatrueTM

Product Name

Product Name

HAPLEX®

HAPLEX®Plus

GabarelaxTM

Product List

Product Name Molecular Weight Benefits

HA-THM

HA-T

HA-TLM

HA-TLM 20-40

HA-TLM 3-5

HA-Oligo

HA-TL

HA-TLLM

Applications

应用

HybloomTM

miniHATM

COMPANY HISTORY

Bloomage Freda Biopharm Co.,Ltd. was established in 1998 by Bloomage International Investment Group Inc.

and it’s national high-tech enterprises.For the past 20 years, the company has focused its efforts on

R&D,production and sales of Sodium Hyaluronate (HA)， and has become one of the world's leading

manufacturers. The applications and specifications of HA vary by product and are divided into Pharmaceutical,

Cosmetic, and Food grades.

Certification

Pharmaceutical Grade Sodium Hyaluronate

Cosmetic Grade Sodium Hyaluronate & Aminobutyric Acid

Food GradeSodium Hyaluronate & Gamma Aminobutyric Acid

China GMP

ECOCERTCOSMOS HALAL KOSHER

DMF CEP

High Molecular Weight Sodium Hyaluronate

Sodium Hyaluronate

Low Molecular Weight Sodium Hyaluronate

Low Molecular Weight Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Oligo Hyaluronic Acid

Sodium Hyaluronate 1% Solution

Low Molecular Weight Sodium Hyaluronate 1% Solution

≥1,800kDa

1,000kDa ~ 1,800kDa

10kDa ~ 1,000kDa

200kDa ~ 400kDa

37 kDa~56 kDa

＜10kDa

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--

＜10kDa

MoisturizingLubricity and film-forming effects Increase emulsion stabilityNutrition deliveryPrevent and repair skin damageAnti-aging

Skin care products: cream, emulsion, essence, lotion, gel, facial mask, etc.

Makeup products:lipstick, eye shadow, foundation, etc.

Cleansing products:facial cleaner, body wash, etc.

Hair care products: shampoo, hair conditioner, styling gel, hair restorer, etc.

Recommended usage:0.1%-0.5%

HA-Oligo Degraded by Hyaluronidase

Transdermal absorptionDeep moisturizingRepair damaged cellsScavenge free radicalsAnti-aging

Product Name Benefits Applications Recommended Usage

1 HA

2 HA Derivatives

3 Other Fermentation Products

HyacrossTM

Hyaluronic Acid Elastomer

HymagicTM-AcHASodium Acetylated Hyaluronate

HymagicTM-4D

HyacolorTM

Oil-dispersed Sodium Hyaluronate

cationHATM

Substantive Sodium Hyaluronate

Excellent protective film with long-lasting moisturizing effect Smooth and not sticky feelingIncrease skin elasticity and reduces roughness

High affinity & adsorption Superb moisturizationRepair skin barrierImprove skin elasticity

Accurately targeting different skin layers, synergistic moisturizing

High content of HAUnique HA microsphere technologyPerfect transdermal absorptionExcellent lip-plumping, repairing, moisturizing

High substantivity Reduce the irritation caused by SAA Improve the barrier function of the skin & scalpGood compatibility

Skin care products

Skin care products

skin care＆hair care product

Specially for lip care products & make-up products

Specially for rinse-off products

1%-5%

0.01%-0.1%

1%~10%

0.1%-2%

0.5%-1%

Product Name Benefits Applications Recommended Usage

GabacareTM BL98TAminobutyric Acid

HyafactorTM-NAGAcetyl Glucosamine

HyafactorTM-PGASodium Polyglutamate

Bioyouth™-BriceBrown Rice Ferment Filtrate

Reduce wrinkles and smooth skinRepair the damaged skinPromote the synthesis of HA and collagen

Promote HA synthesis and scavenge free radicalsNatural exfoliating regulator Whiten and moisturize effects

Promote the accumulation of NMFsReduce the degradation of HAEnhance moisturizing capacity and elasticity of skinInhibition of melanin production

Repairing skin barrierAnti-oxidant and delaying skin agingSignificant whitening

Skin care & Hair care products Make-up products

Skin care products

Skin care products

Skin care ＆ rinse-off product

0.05%-0.3%

0.5%-2%

0.05%-1%

0.5%-4%

Cosmetic Grade Products

1990s

1998

2001

2002

2004

2005

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

Chief Scientist Dr. Guo Xueping initiated the research on producing HA by bio-fermentation technology

�e company Shandong Freda Biochem Co., Ltd. was established and launched the production of Cosmetic Grade HA by fermentation

Bloomage International Investment Group invested in the company�e company passsed ISO 9001 Quality Management System Certi�cation

Dr. Guo received Wu Jieping Medical Research Award & Paul Janssen Pharmaceutical Research Award for his great contributions to the HA industryProduction line of HA for Pharmaceutical Excipient use passed the inspection by China FDA Achieved the National approval license for Eye Drop Grade HA used as a Pharmaceutical Excipient

�e company moved into the new location in the development zone of Jinan City

HAPLEX was approved as a New Dietary Ingredient in ChinaBecame the �rst holder of the production license for HA as a New Dietary Supplement in China

Injection Grade HA new workshop was established and trial production was successful

Company name changed into Shandong Freda Biopharm Co., Ltd.

Achieved the National approval license for Eye Drop Grade HA used as an API Obtained the China GMP certi�cateObtained the CEP and DMF certi�cation for Injection Grade HAminiHATM - the world �rst Oligo HA by enzymatic degradation was successfully launched

Successfully passed the on-site inspection by US FDACompany name changed into Bloomage Freda Biopharm Co., Ltd. Subsidiary company Bloomage Freda Biopharm USA Inc. was established in New Jersey

Achieved the National approval license for Injection Grade HA used as an APIObtained the KDMF registration certi�cate for Injection Grade HAHyacolorTM(Oil-dispersed HA) was successfully launchedObtained the 2013 China Personal Care & Cosmetics Innovation Award for miniHATM

New anti-wrinkle ingredient GabacareTM BL98T(Aminobutyric Acid) was successfully launchedObtained the 2014 China Personal Care & Cosmetics Innovation Award for HyacolorTM

New factory was put into operationObtained the Japan MF registration certi�cate for Medical Grade HA

New food ingredient GabarelaxTM was successfully launchedNew cosmetic ingredients HyacrossTM(Hyaluronic Acid Elastomer) & cationHATM(Substantive Sodium Hyaluronate) were successfully launchedObtained the 2015 China Personal Care & Cosmetics Innovation Award for GabacareTMBL98T and cationHATM

New cosmetic ingredients HyafactorTM-NAG(Acetyl Glucosamine) & HyafactorTM-PGA(Sodium Polyglutamate) were successfully launchedObtained the Russian registration certi�cate for Pharmaceutical Grade HAObtained the CEP registration certi�cate for Medical Grade HAHAPLEX® Plus with clinical e�cacy data was successfully launchedBloomage Freda Biopharm Japan was established in Tokyo

Obtained the COSMOS certi�cation for Cosmetic Grade HA and GabacareTM BL98THymagicTM(Sodium Acetylated Hyaluronate ) was successfully launched