FINAL PROGRAMME

XVI NIBIT MEETINGMilan, October 11-13, 2018San Raffaele Congress Centre, Milan

Under the auspices of

XVI NIBIT MEETINGAlberto Amadori, PadovaMatteo Bellone, MilanoMarco Bregni, Busto Arsizio | VALuana Calabrò, SienaMario Paolo Colombo, Milano

Massimo Di Nicola, MilanoPier Francesco Ferrucci, MilanoEnrico Proietti, RomaVincenzo Russo, Milano

Scientific Committee

Alberto AmadoriUniversità degli Studi di Padova, Padova (Italy)

Sebastian AmigorenaUniversité Paris Descartes, Paris (France)

Matteo BelloneIRCCS Ospedale San Raffaele, Milano (Italy)

Andrea BotticelliOspedale Sant’Andrea,Roma (Italy)

Marco BregniAzienda Ospedaliera Ospedale di Circolo, Busto Arsizio | VA (Italy)

Vincenzo BronteUniversità degli Studi di Verona, Verona (Italy)

Luigi BuonaguroIstituto Nazionale Tumori IRCCS “Fondazione G. Pascale”Napoli (Italy)

Luana CalabròAzienda Ospedaliera Universitaria Senese, Siena (Italy)

Arianna CalcinottoInstitute of Oncology Research IOR, Bellinzona (Switzerland)

Monica CasucciIRCCS Ospedale San Raffaele, Milano (Italy)

Mario Paolo ColomboIRCCS Istituto Nazionale dei Tumori, Milano (Italy)

Mark S. CraggUniversity of Southampton, Southampton (UK)

Michele De PalmaÉcole Polytechnique Fédérale de Lausanne,Lausanne (Switzerland)

Anna Maria Di GiacomoAzienda Ospedaliera Universitaria Senese, Siena (Italy)

Massimo Di NicolaIRCCS Istituto Nazionale dei Tumori, Milano (Italy)

Gianpietro DottiUNC School of Medicine,Chapel Hill | NC (USA)

Faculty

Faculty

Matteo Bellone, MilanoVincenzo Russo, Milano

Local Scientific Organisers

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XVI NIBIT MEETINGSoldano FerroneMassachusetts General Hospital, Boston | MA (USA)

Pier Francesco FerrucciIstituto Europeo di Oncologia IEO, Milano (Italy)

Wolf Herman FridmanUniversité Paris Descartes,Paris (France)

Niels HalamaUniversitätsklinikums Heidelberg, Heidelberg (Germany)

Alexandre HarariCHUV centre hospitalier universitaire vaudois,Lausanne (Switzerland)

Guido KroemerUniversité Paris Descartes, Paris (France)

Franco LocatelliIRCCS Ospedale Pediatrico Bambino Gesù, Roma (Italy)

Enrico LugliIstituto Clinico Humanitas, Rozzano | MI (Italy)

Chiara MagnaniUniversità degli Studi di Milano Bicocca, Milano (Italy)

Susanna MandruzzatoUniversità degli Studi di Padova, Padova (Italy)

Massimo MassaiaAzienda Ospedaliera Citta’ della Salute e della Scienza,Torino (Italy)

Federica MoschellaIstituto Superiore di Sanità, Roma (Italy)

Antonio MoschettaUniversità degli Studi di Bari Aldo Moro, Bari (Italy)

Massimiliano PaganiUniversità degli Studi di Milano,Milano (Italy)

Anna PastòIstituto Oncologico Veneto IOV, Padova (Italy)

Giuseppe ProcopioIRCCS Istituto Nazionale dei Tumori, Milano (Italy)

Enrico ProiettiIstituto Superiore di Sanità, Roma (Italy)

Maria Pia ProttiIRCCS Ospedale San Raffaele, Milano (Italy)

Rahul RoychoudhuriBabraham Institute,Cambridge (UK)

Marco RuellaPenn Medicine Hospital of the University of Pennsylvania,Pennsylvania | PA (USA)

Vincenzo RussoIRCCS Ospedale San Raffaele,Milano (Italy)

Dario SangioloUniversità degli Studi di Torino, Torino (Italy)

Antonio SicaIstituto Clinico Humanitas, Rozzano | MI (Italy)

Francesco SpagnoloIRCCS Ospedale San Martino, Genova (Italy)

Sjoerd van der BurgLeiden University Medical Centre, Leiden (The Netherlands)

Laurence ZitvogelUniversité Paris-Sud,Paris (France)

Faculty

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XVI NIBIT MEETINGSCIENTIFIC PROGRAMME THURSDAY - OCTOBER 1112.30 Light lunch and registration14.00 Welcome addresses

Session 1 - Tumor Microenvironment I Chairs: Massimo Di Nicola, Maria Pia Protti

14.15 Immune and tumor cell cooperations in shaping the tumor microenvironment Wolf Herman Fridman (Paris, France)

14.40 In silico modeling of immunotherapy and stroma-targeting therapies in human colorectal cancer

Niels Halama (Heidelberg, Germany)

15.05 Deep interrogation and profiling of tumor-infiltrating T lymphocytes Alexandre Harari (Lausanne, Switzerland)

SELECTED ABSTRACTS15.30 IL23 secreted by myeloid cells drives castration resistant prostate cancer Arianna Calcinotto - Institute of Oncology Research IOR, (Bellinzona, Switzerland)

15.45 Breast cancer-adipocytes crosstalk as promoter of cancer progression Tiziana Triulzi - Fondazione IRCCS Istituto Nazionale dei Tumori (Milano, Italy)

16.00 Coffee break

Session 2 - Tumor Microenvironment II Chairs: Alberto Amadori, Arianna Calcinotto

16.20 Myelopoiesis in cancer: “Flipping” over monocytes into immune regulatory cells

Vincenzo Bronte (Verona, Italy)

16.45 Single cell transcriptome analysis of human tumor-infiltrating lymphocytes Massimiliano Pagani (Milano, Italy)

17.10 Chemotherapy, innate immunity and tumor metastasis Michele De Palma (Lausanne, Switzerland)

SELECTED ABSTRACTS17.35 Myeloid Derived Suppressor Cells-Mast Cells Cross-Talk Via CD40-CD40L

Mediates Tumor Specific Immunosuppression in Prostate Cancer Elena Jachetti - Fondazione IRCCS Istituto Nazionale dei Tumori (Milano, Italy)

17.50 Role of anti-PD-1 antibody-Fc/FcR Interaction on Macrophages in inducing hyperprogressive disease in non-small cell lung cancer

Michele Sommariva - Università degli Studi di Milano (Milano, Italy)

18.15 General Assembly of the NIBIT

19.30 POSTER SESSION

20.00 Welcome Wine & Cheese and Poster Viewing

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XVI NIBIT MEETINGSCIENTIFIC PROGRAMME

FRIDAY, OCTOBER 12 Session 3 - Adoptive Immunotherapy Chairs: Marco Bregni, Monica Casucci

09.00 CAR-T cells in pediatric hematologic malignancies Franco Locatelli (Roma, Italy)

09.25 Mechanisms of resistance to CAR-T cell therapy Marco Ruella (Philadelphia, USA)

09.50 Chimeric antigen receptor for acute lymphoblastic leukemia: challenges and opportunities

Chiara Magnani (Milano, Italy)

10.15 CAR-T cells in brain tumors Gianpietro Dotti (Chapel Hill, USA)

SELECTED ABSTRACTS10.40 Safety and efficacy of Anti-Leukemia CTL infusions for prevention/Treatment

of Leukemia relapse in high risk patients given Haploidentical HSCT Daniela Montagna - Fondazione IRCCS Policlinico San Matteo (Pavia, Italy)

10.55 Monocyte-derived IL-1 and IL-6 are differentially required for cytokine release syndrome and neurotoxicity by CAR-T cells

Margherita Norelli - Università Vita-Salute San Raffaele (Milano, Italy)

11.10 Generation of memory stem T cells specific for tumor antigens and resistant to inhibitory signals by genome editing

Beatrice Claudia Cianciotti – IRCCS Ospedale San Raffaele (Milano, Italy)

11.25 Coffee break

Session 4 - Microbiota and Metabolism Chairs: Matteo Bellone, Anna Pastò

11.40 Gut-liver axis in hepatocarcinoma Antonio Moschetta (Bari, Italy)

12.05 Gut oncomicrobiome fingerprints in cancer Laurence Zitvogel (Paris, France)

12.30 Metabolic reprogramming and myeloid cell heterogeneity in cancer Antonio Sica (Milano, Italy)

SELECTED ABSTRACTS12.55 Antioxidant metabolism regulates CD8+ T memory stem cell formation

and anti-tumor immunity Karolina Pilipow - Istituto Clinico Humanitas (Rozzano - MI, Italy)

13.10 Harnessing the gut microbiome for personalized tumor prevention and treatment

Luigi Nezi - Istituto Europeo di Oncologia IEO (Milano, Italy)

13.25 Lunch

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XVI NIBIT MEETINGSCIENTIFIC PROGRAMME Session 5 - Tumor and T cell Interactions Chairs: Mario Paolo Colombo, Federica Moschella

14.25 Neoantigen landscape dynamics during human melanoma-T cell interactions Sjoerd van der Burg (Leiden, The Netherlands)

14.50 Understanding agonism: rules and exceptions for TNF receptors Mark S. Cragg (Southampton, UK)

15.15 Tumor-intrinsic PD1 expression: biological role and potential therapeutic relevance Dario Sangiolo (Torino, Italy)

SELECTED ABSTRACTS15.40 Identification of chemotherapy-induced self antigens suitable for DNA

vaccination in pancreatic cancer Sara Bulfamante - Università degli Studi Torino (Torino, Italy)

15.55 Neoantigens released by Salmonella-infected tumor cells as a novel vaccine platform

Alessia Melacarne - Istituto Clinico Humanitas (Rozzano - MI, Italy)

16.10 Analysis of potential immunological markers associated with the PD-1 checkpoint inhibitor Nivolumab in non- small cell lung cancer patients

Selene Ottonello - Center of Excellence for Biomedical Research - CEBR (Genova, Italy)

16.25 Coffee break

16.40 Soldano Ferrone (Boston, USA) introduces the Keynote Lecture

Keynote Lecture: Guido Kroemer (Paris, France) Therapeutic manipulation of oncometabolism

and immunometabolism

17.40 POSTER SESSION

20.00 Social Dinner at Terrazza Aperol

SATURDAY, OCTOBER 13 Session 6 - Biology of T Cells in Cancer Chairs: Susanna Mandruzzato, Enrico Proietti

09.00 Control of signal-driven transcriptional programmes in T cells Rahul Roychoudhuri (Cambridge, UK)

09.25 Anti-tumor T cell immunity at single cell resolution Enrico Lugli (Milano, Italy)

09.50 Epigenetic control of anti-tumor immune responses Sebastian Amigorena (Paris, France)

10.15 Vγ9Vδ2 T cells activation by phosphoantigens released by antigen-presenting cells Massimo Massaia (Torino, Italy)

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XVI NIBIT MEETINGSCIENTIFIC PROGRAMME

SELECTED ABSTRACTS10.40 Neoantigen landscape in low mutational load tumors in immunotherapy naive

and treated patients Sara Bobisse - Ludwig Institute for Cancer Research (Lausanne, Switzerland)

15.55 Tetanus toxoid preconditioning and absence of temozolomide induce a strong effector response associated to memory generation in patients with recurrent GBM treated with dendritic cell (DC) - immunotherapy

Cristina Corbetta - Fondazione IRCCS Istituto Neurologico Carlo Besta (Milano, Italy)

11.10 Neutrophils driving unconventional T cells are essential for resistance to sarcomas

Andrea Ponzetta – Istituto Clinico Humanitas (Rozzano – MI, Italy)

11.25 Coffee break

Session 7 - Clinical and Research Highlights Around NIBIT Chairs: Luana Calabrò, Pier Francesco Ferrucci

11.40 Tyrosine Kinase Inhibitors and antitumor immune responses Andrea Botticelli (Roma, Italy)

12.00 Progress in development of cancer vaccine for liver cancer: the HEPAVAC clinical trial and beyond

Luigi Buonaguro (Napoli, Italy)

12.20 Immunotherapy in the treatment of urogenital cancer Giuseppe Procopio (Milano, Italy)

12.40 Targeted therapies in the treatment of metastatic melanoma Francesco Spagnolo (Genova, Italy)

13.00 The NIBIT Foundation Clinical Trials Anna Maria Di Giacomo (Siena, Italy)

13.20 NIBIT Awards Nominations

13.35 Lunch

14.30 Adjourn

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Acknowledgments

http://www.nibi t .org/meet ing/index.php

San Raffaele Congress CentreVia Olgettina, 5820132 Milano, IT

Congress Venue

AcheloísProfessional Congress OrganiserVia Olgettina 58 - Milano, ITPhone: +39 02 2643 6227e-mail: linda.isella@achelois.eu

ACHELOÍS - Professional Congress Organiser

Organising Secretariat