explanation of hinri labs

8/14/2019 Explanation of HINRI Labs

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Translational Labs

A patient-centered approach to:

Turning knowledge into practice totransform lives.

HINRI Labs 2008


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HINRI Translational LabsMission

Build a nationally recognized nexusfor academia, science, medicine,

business, philanthropy, and publicpolicy to advance patient-centered

research, rehabilitation,

restoration, and recovery fromneurological impairments due toinjury, disease, or congenital causes.

HINRI Labs 2008


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HINRI Labs 2008

HINRI Translational Labs Goals

Turn knowledge into practice to transform lives by: Creating the nation's leading translational laboratories for

spinal cord injury, brain trauma, and neurological disorderswith collaboration centers in Atlanta, Palo Alto, and Boston

Linking knowledge, ideas, and innovation from thescientific, medical, philanthropic, public policy, investment,and patient communities

Create and support clinical trials to speed timesbetween innovation and application: Supporting translational and clinical research Promoting promising new technologies and commercial

applications


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HINRI Translational Labs Goals(cont.)

Develop patient-centric coordinated care models: Collaborate with experts on clinical, physical, emotional,

lifestyle, financial, family, friends, community, and faith

for optimum capabilities development

Engage Venture Philanthropy, Foundations, & Payors:

Fostering a pre-competitive environment to evaluate anddistribute critical intellectual property from research

Establishing best practices and a model standard of care forrehabilitation and restoration

Creating economic support and rationalization of care forrecovery

HINRI Labs 2008


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HINRI Labs 2008

HINRI Translational LabThe Problem Statement

Institute of Medicine it takes 18 years for acceptedresearch to become common practice, because of:

Inadequately focused research

Delays in research to trials Delays in trials to specialist providers

Delays in specialist knowledge to common practice

Delays in treatment applications to help patients

Lack of patient-centered treatments traditional focus is onincomplete SCI rather than acute (1st 30 days) or complete SCI

Reimbursement and Treatment Limits


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HINRI Labs 2008

HINRI Translational Lab The Solution

Rapid Dissemination and Translation of Ideas &Best Practices for:

Research coordinate and support new ideas Rehabilitation Test and develop new individualized

patient-centered physical and emotional approaches torehabilitation

Restoration Promote and conduct clinical trial testing inpartnership with researchers, early stage companies andtrauma centers

Recovery Provide clinical, emotional, & lifestyleeducation for individual, family, and friends to optimizerecovery and capabilities


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Translational Research

HINRI Labs 2008

Atlanta*

Boston*Palo

Alto*HINRILABS

Finding Patient Centered Solutions

RestorationRehabilitation

Recovery

* Academia, Science,

Medicine, Business,

Philanthropy, and

Public Policy


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Translational Rehabilitation

HINRI Labs HINRI Labs HINRI Labs

Activity-Based

Electrophysiology

Patients

Payors

Nutrition/Supplements

Mental, Spiritual

Emotional Health

Locomat &

Armin

Manual Therapies

Massage TriggerMedical

Monitoring

PatientCentered

Best Practices

Improved

FunctionalityOptimum

Capabilities

Hyperbaric

Chamber

Collaboration Traditional RehabNon-Traditional Rehab

Assistive

Technology

Clinical Trials

Clinical Practice

Academia,

Business

HINRI Labs 2008


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Translational Restoration

HINRI Labs 2008

Basic

Research

P of P

Research

Clinical

Research

Clinical

Practice

University

Partners

HINRI

Labs

Shepherd

Center

Trauma

Centers

Proof of Principle Research Does the basic science &

new ideas hold true for human patients?

HINRI Translational Labs patient-centered clinical

trial platform will foster collaboration between

universities and clinical research centers.


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Translational Recovery

HINRI Labs 2008

Medication

Therapy

Physical

Health

NutritionSocialization

Readiness for

Employment

Education

Spirituality

Leisure

Activities

Family and

FriendsPatient Centered

Goals

Normality

Functionality

Fulfillment

Independence


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HINRI Labs 2008

Hinri LABSAreas of Focus

Permanent or irreversible

central nervous system disorders

Phase 1 - Complete Spinal Cord Injury (SCI)

Phase 2 - Traumatic Brain Injury (TBI) and Stroke

Phase 3 - Neurological Disorders*

*Disease/Degeneration Multiple Sclerosis, Amyotrophic

Lateral Sclerosis, Parkinsons, and Alzheimers


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HINRI Labs Action Plan

1A Complete SCI Measurement NeuralPlasticity, Functional

Recovery

Electrophysiology and

Robotics

1B Complete SCI Translation Bench toBedside Assistive Technology,Holistic Medicine,Stem Cell Research

2 Brain Injury Measurement andTranslation

Imaging, Surgery,

Pharmaceuticals, Stem

Cells, EmergingTherapies

3 Neuro-

Disease

Neural Injury and

Degeneration - Cell

death, nerve regeneration

and reconnection

Basic Research

Phase Target Focus Method

HINRI Labs 2008


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HINRI Labs Rehabilitation Phase1A and 1B

Provide the scientific insights, new technologies and novel treatments to test, train and measurefunctional recovery (neural activity, muscle pattern activity, spinal reflexes and plasticity) Activity-Based Rehabilitation New Drugs, Electrical Stimulation and Cell Transplantation Therapies Train Reaching and Grasping (to improve upper extremity function)

Electrophysiology and Robotics (Lokomat and Armin) Control experimental conditions Generate standardized training of motor tasks Measure mechanical aspects of functional recovery

Proof of Principle Studies

Focus on underserved areas of investigation in SCI research Translate animal studies research to human SCI studies Neural mechanisms underlying functional recovery and neural connections across the level of injury Measure Brain Motor Control Assay (BMCA) Functional MRI and diffusion tensor imaging


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HINRI Labs Timeline 2009

JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Atlanta 1A

($3 MM)

Atlanta 1B

($5 MM)Palo Alto 1A

($2.5 MM)

Boston 1A

($2.5 MM)

Atlanta 2

($7.5 MM)

Atlanta 3

($5 MM)

Phase

HINRI Labs 2008


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US Military

Wounded Veterans

Patients

Test & Develop

Best Practices

Rehabilitation

Business Model

Promote/Conduct

Clinical Trials

Restoration

Collaborate on

Best Practices

Rehabilitation

Patient Centered

Clinical & Lifestyle

Recovery

Foundations & Charities

Common Mission

Collaborate on

Best Practices

Rehabilitation

Government, VA,

Private Insurance

Capital

Venture Philanthropy

Common Goals

Coordinate & Support

ResearchStrategic Partners

Collaboration

Translational


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Strategic Partners

Location The Shepherd Center has agreed to providethe third floor in their main building for HINRI Labs

University Partners - Emory, Georgia Tech and

Morehouse; Stanford and Harvard/MIT Media CNN (Dr. Sanjay Gupta)

Corporate - Google Health and Microsoft HealthVault

SHARE Initiative a $6MM partnership between

Humana, Major League Baseball, Bernie Marcus andthe McCormick Foundation to assist Wounded Veteransand their Families at Shepherd (68 participants to date)


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Venture Philanthropy

Corporate Partners Dr. Louis Sullivan* 3M; Bristol, Myers, Squibb; CIGNA Bernie Marcus SHARE Initiative, Home Depot ($300 MM) Jeff Arnold WebMD

Bill Ide Former ABA President, East West Institute Bob Bozeman Google Health Ron Bachman - Microsoft HealthVault John Brandon Apple John Moore Morgan Stanley (Former Head of Global HC)

Carter Burton GE Healthcare Financial Services Sanjay Gupta CNN Medical Director Steve Case Former Vice-Chair CECP Anthony Begando Tenon Consulting

* Have agreed to collaborate


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Foundations & CharitiesInitial Prospect List

Foundation Partners:

Woodruff

Hewlett Healthcare Georgia Bill/Melinda Gates Omidyar Network Google

Gordon Moore Henry Kravitz

Advisory Panel:

David Brailer Health Evolution Partners

Kleiner PerkinsDraper Fisher JurvetsonJames Robinson III RRE VenturesPete G. Peterson BlackstoneSilicon Valley Bank Carlyle GroupBono Elevation Partners


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Military Partners Armed Forces Service Organization (AFSO) United Service Organization (USO) Wounded Warrior Project Military Foundations (2) Tenon Consulting Solutions

Advisory Panel Hon. Sam Nunn and/or Max Cleland Hon. John McCain (Orson Swindle) Gen. Norman Schwartzkopf Hon. Jeb Bush and/or Hon. Jay Rockefeller Tom Hanks www.welcomebackveterans.org Congressional Service Academy Representatives Former Head(s) of VA or VA Hospital System Secretary of the Army and/or Joint Chiefs

US MilitaryInitial Prospect List
http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/http://www.welcomebackveterans.org/


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HINRI Labs 2008

CHT Partnership

A CHT Capabilities Project

Ross Mason, Fellow CHT

The Center for Health Transformation (CHT) willpartner with HINRI Translational Labs (Atlanta, Palo

Alto, and Boston) to advise, support, and promote the

creation of a national nexus, collaboration, and model

of a patient-centered standard of care in research,rehabilitation, restoration, and recovery from

permanent central nervous system disorders.

explanation of hinri labs

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