HINRI Labs © 2009

Healthcare Institute for Neuro-Recovery and Innovation

“Turning knowledge into practice to transform lives.”

Translational

Translational Labs

A patient-centered approach to:

“Turning knowledge into practice to transform lives.”

HINRI Labs © 2009

HINRI Translational Labs Mission

Build a nationally recognized nexus for academia, science, medicine, business, philanthropy, and public policy to advance patient-centered

research, rehabilitation, restoration, and recovery from neurological impairments due to

injury, disease, or congenital causes.

HINRI Labs © 2009

HINRI Labs © 2008

HINRI Translational Labs Goals

• Turn knowledge into practice to transform lives by:– Creating the nation's leading translational laboratories for

spinal cord injury, brain trauma, and neurological disorders with collaboration centers in Atlanta, Palo Alto, and Boston

– Linking knowledge, ideas, and innovation from the scientific, medical, philanthropic, public policy, investment, and patient communities

• Create and support clinical trials to speed times between innovation and application: – Supporting translational and clinical research – Promoting promising new technologies and commercial

applications

HINRI Translational Labs Goals (cont.)

• Develop patient-centric coordinated care models:– Collaborate with experts on clinical, physical, emotional,

lifestyle, financial, family, friends, community, and faith for optimum capabilities development

• Engage Venture Philanthropy, Foundations, & Payors: – Fostering a pre-competitive environment to evaluate and

distribute critical intellectual property from research – Establishing best practices and a model standard of care for

rehabilitation and restoration– Creating economic support and rationalization of care for

recovery HINRI Labs © 2008

HINRI Labs © 2008

HINRI Translational Lab The Problem Statement

Institute of Medicine – “it takes 18 years for accepted research to become common practice”, because of:

• Inadequately focused research • Delays in research to trials• Delays in trials to specialist providers• Delays in specialist knowledge to common practice • Delays in treatment applications to help patients• Lack of patient-centered treatments – traditional focus is on

incomplete SCI rather than acute (1st 30 days) or complete SCI • Reimbursement and Treatment Limits

HINRI Labs © 2008

HINRI Translational Lab The Solution

Rapid Dissemination and Translation of Ideas & Best Practices for:

• Research – coordinate and support new ideas• Rehabilitation – Test and develop new individualized

patient-centered physical and emotional approaches to rehabilitation

• Restoration – Promote and conduct clinical trial testing in partnership with researchers, early stage companies and trauma centers

• Recovery – Provide clinical, emotional, & lifestyle education for individual, family, and friends to optimize recovery and capabilities

Translational Research

HINRI Labs © 2008

Atlanta*

Boston*Palo

Alto*HINRI LABS

Finding Patient Centered Solutions

RestorationRehabilitation

Recovery

* Academia, Science, Medicine, Business, Philanthropy, and

Public Policy

Translational Rehabilitation

HINRI Labs HINRI Labs HINRI Labs

Activity-Based

Electrophysiology

Patients

Payors

Nutrition/Supplements

Mental, SpiritualEmotional Health

Locomat & Armin

Tissue Regeneration

Manual TherapyMedical

Monitoring

Patient Centered

Best Practices

Improved Functionality

Optimum Capabilities

Hyperbaric Chamber

Collaboration Traditional RehabNon-Traditional Rehab

Assistive Technology

Clinical Trials

Clinical Practice

Academia, Business

HINRI Labs © 2008

Translational Restoration

HINRI Labs © 2008

Basic Research

“P of P” Research

Clinical Research

Clinical Practice

University Partners

HINRI Labs

Shepherd Center

Trauma Centers

“Proof of Principle” Research – Does the basic science & new ideas hold true for human patients?

HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between

universities and clinical research centers.

Translational Recovery

HINRI Labs © 2008

Medication

Therapy

Physical Health

NutritionSocialization

Readiness for Employment

Education

Spirituality

Leisure Activities

Family and Friends

Patient CenteredGoals

Normality

Functionality

Fulfillment

Independence

HINRI Labs © 2008

Hinri LABS Areas of Focus

Permanent or irreversible

central nervous system disorders

• Phase 1 - “Complete” Spinal Cord Injury (SCI)

• Phase 2 - Traumatic Brain Injury (TBI) and Stroke

• Phase 3 - Neurological Disorders*

*Disease/Degeneration – Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s, and Alzheimer’s

HINRI Labs – Action Plan

1A Complete SCI Measurement – Neural Plasticity, Functional

Recovery

Electrophysiology and Robotics

1B Complete SCI Translation – Bench to Bedside

Assistive Technology, Holistic Medicine, Stem Cell Research

2 Brain Injury Measurement and Translation

Imaging, Surgery, Pharmaceuticals, Stem

Cells, Emerging Therapies

3 Neuro-Disease

Neural Injury and Degeneration - Cell

death, nerve regeneration and reconnection

Basic Research

Phase Target Focus Method

HINRI Labs © 2008

HINRI Labs Timeline 2009

JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Atlanta – 1A

($3 MM)

Atlanta – 1B

($5 MM)

Palo Alto – 1A*

($10 MM)

Boston – 1A

($2.5 MM)

Atlanta – 2

($7.5 MM)

Atlanta – 3

($5 MM)

Phase

HINRI Labs © 2008*10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford

US Military Wounded Veterans

Patients

Test & DevelopBest Practices

Rehabilitation

Business Model

Promote/Conduct Clinical Trials

Restoration

Collaborate onBest Practices

Rehabilitation

Patient Centered Clinical & Lifestyle

Recovery

Foundations & CharitiesCommon Mission

Collaborate onBest Practices

Rehabilitation

Government, VA, Private Insurance

Capital

Venture PhilanthropyCommon Goals

Coordinate & Support Research

Strategic PartnersCollaboration

Translational

Strategic Partners

• Location – The Shepherd Center has agreed to provide space on the third floor in their main building

• University Partners - Emory, Stanford and Harvard/MIT

• Media – CNN (Dr. Sanjay Gupta)• Corporate - Google Health and Microsoft HealthVault• SHARE Initiative – a $6MM partnership between

Humana, Major League Baseball, Bernie Marcus and the McCormick Foundation to assist Wounded Veterans and their Families at Shepherd (100 participants to date)

Venture Philanthropy

Corporate Partners• Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA• Bernie Marcus – SHARE Initiative, Home Depot ($300 MM)• Jeff Arnold – WebMD• Bill Ide – Former ABA President, East West Institute• Bob Bozeman – Google Health• Ron Bachman - Microsoft HealthVault• John Brandon – Apple • John Moore – Morgan Stanley (Former Head of Global HC)• Carter Burton – GE Healthcare Financial Services• Sanjay Gupta – CNN Medical Director• Steve Case – Former Vice-Chair CECP• Anthony Begando – Tenon Consulting

* Have agreed to collaborate

Foundations & CharitiesInitial Prospect List

Foundation Partners:

• Woodruff• Hewlett• Bill/Melinda Gates • Omidyar Network • Google• Gordon Moore• Henry Kravitz

Advisory Panel:

•David Brailer – Health Evolution Partners•Kleiner Perkins - Brooke Buyers •Draper Fisher Jurvetson - Steve Jurvetson and Tim Draper•James Robinson III – RRE Ventures•Pete G. Peterson – Blackstone•Silicon Valley Bank – Carlyle Group•Bono – Elevation Partners

Military Partners• Armed Forces Service Organization (AFSO)• United Service Organization (USO)• Wounded Warrior Project • Military Foundations (2) – Tenon Consulting Solutions

Advisory Panel• Hon. Max Cleland• Hon. John McCain (Orson Swindle)• Gen. Norman Schwarzkopf• Hon. Jeb Bush and/or Hon. Jay Rockefeller• Tom Hanks – www.welcomebackveterans.org • Robin Williams - Christopher and Dana Reeve Foundation• Congressional Service Academy Representatives• Former Head(s) of VA or VA Hospital System• Secretary of the Army and/or Joint Chiefs

US MilitaryInitial Prospect List

HINRI Labs © 2008

CHT Partnership

A CHT “Capabilities” Project

– Ross Mason, Fellow CHT

The Center for Health Transformation (CHT) will partner with HINRI Translational Labs (Atlanta, Palo Alto, and Boston) to advise, support, and promote the creation of a national nexus, collaboration, and model of a patient-centered standard of care in research, rehabilitation, restoration, and recovery from “permanent” central nervous system disorders.