Imagining Lean Biotech

Experimenting on ExperimentsBringing Lean to Scientific ResearchBrian M. FrezzaEmerald TherapeuticsLean Startup 2013

v0.92 (16:9)Learn, Build, Measure in Life ScienceMEASUREProductBUILDIdeasLEARNDataLAB WORKExperimentDESIGNHypothesesANALYSISLAB WORKLAB WORKLAB WORKNature Rev. Drug Discovery(2012) 11,191-200.Intel and Dataquest reports (2002) Gordon E. Moore, Our Revolution

Moores Law

Erooms LawLate 1960: Regulations tighten post thalidomide Early 1990s: First wave of Biologics research beginsLate 1990s: PDUFA regulations clears a backlog at the FDA3Cost of InnovationThe Impact of Innovation and the Role of Intellectual Property Rights on U.S. Productivity, Competitiveness, Jobs, Wages, and Exports N.D. Pham, (2010) NDP Consulting, Washington DC

Mean R&D Expenditures per Employee by Industry Sector $ (USD) Employee-1 Year-1Self report survey, n=130 Scientists (2013)Costs of Instrumentation per LabSingle PurposeMinimalComplete$500k-$1M$1-3M>$10M

Startup Financing

Dow Jones VentureSource, PWH Coopers / National Venture Capital Association, Thomson Reuters4

Modern Laboratory Research

Alexander Fleming 1928Staphylococcus

Connect to large corporations vs startups.Founders solving their own problems with their own two hands.5Scientific Research Product CycleDesign ExperimentConduct ExperimentAnalyze DataOnboard ExperimentTroubleshoot ExperimentAcquire Equipment

NoYesEquipment Access ProblemsPersonal Favor (73%)Most popular workaround:Average Experiment Onboarding Time

Troubleshooting TimeGahh!

Most Time Consuming Activity: Conducting ExperimentsSelf report survey, n=130 Scientists (2013)Slowed Research: No (17%) Yes (83%)Prevented Research: No (27%) Yes (73%06Imagining Lean ResearchLower Barriers to EntryAmortize the fixed costsDemocratize access

Faster IterationMinimize experiment onboarding timesMitigate troubleshooting SNAFUs

INNOVATE ON THE PROCESSRETIREOR DIEI think we should consciously look with great dedication for those things that made Moores law work. God didnt give us Moores law. Even Gordon Moore didnt give us Moores law. Your predecessors in the labs worked hard for it. Andy Grove7Traditional Laboratory Research

Alexander Fleming 1928Staphylococcus

Connect to large corporations vs startups. Founders solving their own problems head on.8

Symbolic Laboratory Research

frezza@emeraldtherapeutics.comFounding Start-upsTech Founders:OutsidersAggressive visionariesSingular dedication

Biotech Founders:Insiders Legendary wisdomHedged approach

Hardware and ICs:Noyes & MooreHewlett & PackardRussell & Sigurd VarianSheldon Roberts, Jay Last, Jean HeorniAmelco -> Teledyne

Biotech:Genentech: Swanson & BoyerVC (KP)UCSF ProfessorAmgen: William Bowes & George RathmannVC (US Venture Partners)Executive from AbbotGilead:DuBose Montgomery & Michael RiordanVCs (Menlo Ventures)Biogen Idec: Ivor Royston, Howard BirndorfVCs (Forward Ventures) and former prof.Walter Gilbert, Phil Sharp, Charles Weissmann, Kenneth MurrayProfessors (Harvard, MIT, University of Zurich, University of Edinburgh)11Supplier EcosystemsTech World:Startup drivenOpen accessInterconnecting

Biotech World:Legacy corporationsHandshake businessSiloed technology stacks

Frankenstein Corps12