enhanced facilities for marcus research imaging...used in advanced nuclear medicine research have...

Enhanced Facilities

for Marcus Research ImagingPROGRAM PLAN

January 22, 2020

University of Colorado Anschutz Medical Campus


Enhanced Facilities for Marcus Research Imaging Program Plan | 1/22/2020

Table of ConTenTs

I. exeCuTIve summmary .........................................................................1

II. Goals and objeCTIves .......................................................................2

III. ProGram InformaTIon ......................................................................3

A. Units ......................................................................................................... 3

A.1 School of Medicine 3A.2 Department of Radiology 3A.3 Colorado Translational Research Imaging Center (C-TRIC) 3A.4 Marcus Institute for Brain Health 3

B. Existing Facilities .................................................................................... 4

C. Economic Impact .................................................................................... 4

D. Consistency ............................................................................................. 6

D.1 Mission 6D.2 Strategic Plan 6D.3 Facilities Master Plan 6

Iv. ProPosed ProjeCT ...........................................................................8

A. Background and Assumptions .............................................................. 8

B. Project Description ................................................................................. 8

B.1 Alternatives 8

Iv. ImPlemenTaTIon ...............................................................................10

A. Budget .................................................................................................... 10

B. Funding Sources ................................................................................... 10

C. Schedule ................................................................................................ 10

D. Third Party Review ................................................................................ 10


lIsT of fIGuresFigure III-1: Existing Facility and Project Location ................................................................................... 5Figure IV-1: Project Plan .......................................................................................................................... 9Figure V-1: Project Budget ....................................................................................................................... 9

aPPendICes

Appendix A: Acronym ListAppendix B: Third Party Review


1Enhanced Facilities for Marcus Research Imaging Program Plan | 1/22/2020

I. exeCuTIve summaryThe University of Colorado Anschutz Medical Campus (CU Anschutz) is seeking spending authority from the University of Colorado Board of Regents (CU BOR) to proceed with the buildout of 5,402 gross square feet (GSF) in the Bioscience 3 building. Biosciences 3 is a new 117,000 GSF facility constructed by the Fitzsimons Redevelopment Authority (FRA).

The Authority was established in 1995 by the City of Aurora and the University of Colorado as a quasi-governmental entity to develop the portion of the former Fitzsimons Army Medical Center (FAMC) north of Montview Boulevard into a functioning community that directly supports the health and well-being of life science companies. The FRA’s mission is to imagine and govern the evolution of a historic Army Medical Center into one of the world’s most forward-looking bioscience communities.

University of Colorado School of Medicine (SOM) will lease the bioscience space for use by the Marcus Research Imaging Center and the Department of Radiology to conduct research using state-of-the-art nuclear medicine and diagnostic imaging technologies. The Marcus Research Imaging Center will be an expansion of the existing Colorado Translational Research Imaging Center (C-TRIC) that will create a larger facility to provide more resources that support multi-disciplinary research by CU Anschutz researchers. This state-of-the-art research imaging center at CU Anschutz will drive world-class research in Traumatic Brain Injury (TBI) and multiple other diseases.

Sponsored research at CU Anschutz is robust with over $550 million awarded in fiscal year 2018-2019 covering grants from the Schools of Medicine, Dental Medicine, Pharmacy and Pharmaceutical Sciences, Engineering (Department of Bioengineering), Graduate School, Public Health, and College of Nursing. A grant from the Marcus Foundation will allow the C-TRIC, which will further Marcus Research Imaging, to purchase a positron emission tomography/magnetic resonance (PET/MR) scanner that will enhance the care and research of veterans suffering from TBI among other areas of research. The space will accommodate the new PET/MR, a relocated positron emission tomography/computed tomography (PET/CT) and a new large bore 7Tesla magnet.

The total project budget is $3,332,494 and will be supported through the use of the Marcus Foundation grant and School of Medicine cash funds.


2 Enhanced Facilities for Marcus Research Imaging Program Plan | 1/22/2020

II. Goals and objeCTIves

The project is being driven by the desire to continue to offer a state-of-the-art research imaging center on the Anschutz Campus that will drive world-class research in TBI and multiple other diseases. This effort will enhance the existing comprehensive, collaborative imaging resources of C-TRIC to maximize creative translational discovery.

Radiology is a medical specialty that diagnoses and treats injuries and diseases using medical imaging procedures (exams/tests) such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine, positron emission tomography (PET) and ultrasound . Engineers have combined imaging techniques, such as PET/CT and PET/MR, into single pieces of equipment to enable simultaneous acquisition of anatomical and functional imaging information to aid in the detection, evaluation and treatment of disease.

PET, CT, and MRI are well-established standard non-invasive imaging tools that allow researchers and physicians the ability to visualize and render the body in three dimensions to pinpoint the location of disease or abnormalities. PET scans capture images of miniscule changes to the body’s metabolism caused by abnormal cells. CT scans pinpoint the exact location, size, and shape of diseased tissue. MRI uses a powerful magnetic field, radio waves and a computer to produce detailed pictures of the body’s internal structures that are clearer, more detailed and more likely in some instances to identify and accurately characterize disease than other imaging methods.

Combined scanning is well suited to determining extent of disease, determining disease location for subsequent procedures, assessing response to and effectiveness of treatments, detecting residual or recurrent disease, and may replace an alternate invasive research approach. The integration of PET and MRI modalities is relatively recent and offers the ability to perform both scans in one session, reduced exposure to ionizing radiation compared to PET/CT, and often shorter sessions. The purchase of a PET/MR machine, through a grant from the Marcus Foundation, will allow Anschutz Medical Campus researchers to utilize the most current technology to remain at the forefront of imaging research and practices.

These machines often make use of radiopharmaceuticals that are produced by a cyclotron. Many of the radiopharmaceuticals used in advanced nuclear medicine research have extremely short half-lives and there is benefit in having a cyclotron and imaging equipment in proximity to each other to maximize the use of these products. However, these large and heavy imaging machines require radiation and magnetic shielding for their proper operation to ensure scans are accurate and not influenced by conditions outside the rooms where they are located.



III. ProGram InformaTIon

This project will be undertaken by the University of Colorado, Anschutz Medical Campus to provide space for the future Marcus Research Imaging Center, a multi-disciplinary center managed by the School of Medicine’s Department of Radiology that expands the capacities of the existing C-TRIC to reach a broader portion of the campus research community.

A. UnitsA brief description of the units involved in this effort is provided below.

A.1 School of Medicine

The School of Medicine is the largest School or College on the Anschutz Medical Campus. It is comprised of 17 clinical departments that focus on specific medical specialties, 6 basic science departments, and 16 centers and institutes with 3,429 full-time faculty as of July 1, 2018. Its mission is to provide Colorado, the nation and the world with programs of excellence in:

• Education - through the provision of educational programs tomedical students, allied health students, graduate students,practicing health professionals and the public at large;

• Research - through the development of new knowledge inthe basic and clinical sciences, as well as in health policy andhealth care education;

• Patient Care - through state-of-the-art clinical programswhich reflect the unique educational environment of theUniversity, as well as the needs of the patients it serves; and,

• Community Service - through sharing the School’sexpertise and knowledge to enhance the broader community,including our affiliated institutions, other healthcareprofessionals, alumni and other colleagues, and citizens ofthe state.

A.2 Department of Radiology

The Department of Radiology is one of the SOM’s 17 clinical departments. It provides dynamic clinical, educational and research initiatives ensuring that it continues to offer cutting-edge diagnostic imaging techniques and advanced interventional/neuro-interventional radiological therapies.

The Department’s primary clinical partner is the University of Colorado Hospital and they work closely with other affiliated

hospitals: Denver Health Medical Center, Denver Veterans Affairs Medical Center, National Jewish Medical Center and Children’s Hospital Colorado. They serve patients from the greater Denver-Metro community as well as the entire Rocky Mountain region. These collaborations have created an exceptionally enriched environment for the training of Medical Students, Residents and Fellows in Radiology. The Department is committed to a collaborative and interdisciplinary approach to research.

A.3 Colorado Translational Research Imaging Center(C-TRIC )

C-TRIC is a comprehensive research imaging center on theUniversity of Colorado Anschutz Medical Campus managedby the Department of Radiology. Established in 2010 fromStrategic Infrastructure for Research Committee (SIRC) fundsand the support of CU departments, the goal of C-TRIC isto create for the campus a collaborative, research imagingenvironment by bringing together researchers from differentdisciplines with imaging scientists, and providing theorganizational structure and a state-of-the art imaging facilitythat maximizes creative translational discovery. It will becomethe Marcus Research Imaging Center.

A.4 Marcus Institute for Brain Health (MIBH)

The MIBH provides specialty care for military Veterans and retired athletes struggling with mild to moderate traumatic brain injuries (including concussion) and changes in psychological health. Patients at the MIBH are treated as a person first. They welcome Veterans of any discharge status. The MIBH offers comprehensive care for the physical, emotional, and cognitive changes that can accompany trauma to the head. Their emphasis is on detailed evaluation and treatment that works to relieve symptoms by addressing their root causes.



B. Existing FacilitiesThe Colorado Translational Research Imaging Center (C-TRIC) is currently split between two locations on the Anschutz Medical Campus: Building 400 and in leased space within the University of Colorado Hospital.

The existing C-TRIC space in Building 400 was renovated and expanded to house a PET/CT machine in 2011. Building 400 is one of five temporary “400 series” structures built as part of the Fitzsimons Army Medical Center (FAMC) in 1944 and has a Facility Condition Index (FCI) of 70%. While initially envisioned as a modular building, due to site conditions and the need to provide adequate radiological and magnetic shielding, the expansion was constructed as an addition to B400. The expansion included a 461 net square feet (NSF) space for the PET/CT machine and 224 NSF for additional imaging. Four other rooms totaling 711 NSF are used for office workstations, patient consultations, and procedure robing. No patient waiting area is provided in this 1,396 NSF.

In addition to this space, the Department of Radiology utilizes 1,413 NSF in the Anschutz Outpatient Pavilion (AOP) that is leased from UCHealth. This space that houses equipment, including a cyclotron, that can produce some of the radiopharmaceuticals that are required for its research and supporting devices. The remainder of the required radiopharmaceuticals are produced by other providers.

C. Economic ImpactAccess to a PET/MR machine will significantly advance biomedical research by combining sophisticated MR imaging technology with the expanding capabilities of molecular imaging provided by PET into a single instrument. Providing access to both a PET/MR and PET/CT scanner will improve the ability of the campus to predict, follow, and treat disease across a range of disciplines including neuroscience, cardiology, oncology, and metabolism. This project will have a major impact on job retention and creation in the Colorado region by fueling infrastructure, generating grants, stimulating biotechnology, fostering partnerships and expanding educational opportunity. This dynamic, interdisciplinary field relies on the expertise and collaboration of biologists, chemists, biochemists, medical doctors, engineers and others striving to solve age-old and emerging human health challenges.

Bioscience 3

Anschutz Health and Wellness Center

Building 400

UC HealthAnschutz Outpatient Pavilion (AOH)

Bioscience 1Bioscience 2

HendersonParking Garage

AnschutzHealth

SciencesBuilding

Research 2 Research 1North

Research 1South

AcademicOffice 1

LeprinoGarage

LeprinoBuilding

UC HealthUniversity of Colorado

Hospital

Montview Boulevard

Racine Street

Quentin Street

E. 19th Avenue

E. 17th Place

E. 17th Avenue

Artwalk

ResearchQuad

Legend

Non-CU Building

CU Anschutz Building



Figure III-1: Existing Facilties and Project Location



Under this priority, Goal 6.1 is to: Promote partnerships and active engagement with business, industry, nonprofits, government, schools, and venture capitalists to optimize intellectual and cultural capital for societal use. By accessing the products created by an adjacent business and proximity to other health services, this project will incubate partnerships to advance nuclear medicine and imaging technologies.

D.3 Facilities Master Plan

This project supports a goal and a project in the Anschutz Medical Campus 2012 Facilities Master Plan. The plan included the following principle under its innovation goal:

create hybrid multiuse facilities that enable inter-disciplinary, interprofessional, and interinstitutional teamwork, cooperation, and advancement.

As noted earlier, this project will help support the inter-disciplinary, interprofessional and interinstitutional work of the C-TRIC, and the future Marcus Research Imaging Center. It will support cooperation and collaborations with the Marcus Institute for Brain Health and with private companies.

This effort was also included as Project A3 in the plan to provide space for the C-TRIC. Provision of 48,000 GSF was anticipated in 2018 dependent on the availability of funding. Funding has been procured which will allow CU Anschutz to start the development of a center for imaging research that may eventually grow to include research that is currently spread across campus in various locations.

D. ConsistencyD.1 Mission

The 2008-2020 Strategic Plan for the University of Colorado Denver (the plan covers both CU Denver and CU Anschutz) states that the campus:

is a diverse teaching and learning community that creates, discovers and applies knowledge to improve the health and well-being of Colorado and the world.

The mission for the Anschutz Medical Campus has been further refined to state that:

the University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative education, science, medicine and healthcare.

As this project will provide C-TRIC space to house new advanced imaging machines and technologies it will allow CU Anschutz to maintain its position as a world-class health sciences campus that advances medical breakthroughs .

D.2 Strategic Plan

This project ties into many of the priorities, goal and objectives for the university as outlined in the University of Colorado Denver Strategic Plan for 2008-2020. Most specifically, the plan’s third Strategic Priority is to “Conduct Outstanding Research and Creative Work for the Public Good” Goal 3.1 under this priority is to “Be a global leader in the translation and application of discovery, innovation, and creativity for the societal good.” Under this goal, Objective 3.1.2 is to “Implement fully the Colorado Clinical and Translational Science Institute.”

Establishing a center for advanced imaging also aligns with University Strategic Priority 4 to

Enhance the university’s world-class health care programs to achieve recognition as one of the best academic health centers in the nation

Finally, as the proposed project is adjacent to other private businesses, it supports University Strategic Priority 6 to:

Grow strong, mutually beneficial partnerships that engage our local, national and global communities



Iv. ProPosed ProjeCT

A. Background and AssumptionsC-TRIC, and the future Marcus Research Imaging Center, must have access to multiple imaging machines and nuclear medical technologies to remain a world-class imagingand nuclear medicine center. A PET/MR scanner is being purchased through a grant from the Marcus Foundation to enhance the care and research of veterans suffering from Traumatic Brain Injury (TBI). As TBI patients are treated at the Marcus Institute for Brain Health (MIBH) located in the Anschutz Health and Wellness Center (AHWC), the project should be located close to the AHWC.

PharmaLogic, a nationwide radiopharmaceutical and mobile PET/CT operations company, is constructing a new PET radiopharmaceutical production laboratory that will house a radio-pharmacy, cyclotron, and associated manufacturing equipment, adjacent to the proposed space, in Bioscience 3. They will produce existing radiopharmaceuticals and also use their technology to create new ones for use in nuclear medicine and imaging. Many of the newer products will have extremely short half-lives, specifically Oxygen 15 (O-15, with its 2.5 minute half-life). Proximity to the cyclotron will enhance Marcus Research Imaging’s PET and CT research capabilities as their researchers will be able to utilize these newer products to develop innovative therapeutic, diagnostic, and imaging programs.

The PET/MR will be delivered in summer 2020 and space must be provided for it and the PET/CT well in advance of delivery. This will allow the necessary shielding and support infrastructure to be put in place to allow them to be quickly installed, certified, and operational.

B. Project DescriptionAll existing C-TRIC equipment and functions will be moved from Building 400 and the AOP into the new space to consolidate and expand imaging resources.

4,991 NSF of space will be used for Marcus Research Imaging’s research activities. Of this amount, 1,667 NSF will be dedicated to the MRI, PET/CT and PET/MR imaging devices. An additional 223 NSF will be provided to provide control rooms that have visibility into the imaging rooms for operators of the equipment. Two rooms that provide 433 NSF will house equipment required to support the operations of the imaging machines. Therefore, slightly more than 46% of the total available NSF will be dedicated to the imaging equipment and its direct operation or support.

Before entering these imaging and procedure rooms patients will enter into a waiting room that has been sized to accommodate anticipated use of all three imaging rooms at once. After leaving the waiting area, patients will enter one of two consultation rooms where medical providers can prepare them for and discuss procedures. After consultation, a patient will enter one of two rooms where they will change into gowns or other clothing for their procedure. These rooms will provide lockers for patients to store their clothing, cell phones and other personal effects. The 506 NSF of these patient pre-procedure spaces are extremely important as they improve the patient’s experience in the clinic and are generally lacking in B400.

After they exit these rooms, patients will be led to the appropriate procedure room, a third consultation room where additional procedure preparation will occur, or to one of three uptake rooms where samples may be drawn. A toilet will also be provided for convenience or to collect urine samples. After procedures are completed, patients will be led to an uptake room for sample collection or to the dressing rooms to change out of any gowns to leave the imaging center. A hematology lab and a “hot lab” to analyze samples with radiopharmaceuticals presents will be provided adjacent to the imaging rooms. These diagnostic, collection, and procedure spaces total 737 NSF.

597 NSF will be dedicated to the administration of the imaging center. This space includes an imaging room that will allow clinicians to review images and a dedicated room holding patient records. Five workstations will also be provided within four rooms to allow clinicians to perform administrative duties or to conduct private phone calls. These spaces will be used by the Director of the imaging center, image technologists that operate the scanners, research PhDs and image analysis experts when they are not operating the machines or working in associated clinical spaces.

The remaining 828 NSF of the space is dedicated to hallways and circulation spaces. Many of these have been designed to accommodate movements of stretchers or cots between the imaging machines, changing areas, and adjacent lab areas.

Location in Bioscience 3

Main BuildingEntrance

1347.0T MRI799 SF

133Control70 SF

131Hematology

80 SF

126Equipment

271 SF

129Code Team Area

278 SF

128Linen Area/19 SF

118PET/MRI436 SF

125Hall

131 SF

127Hot Lab105 SF

135IT/Telecom

105 SF

124Uptake40 SF

123Uptake37 SF

122Uptake40 SF

119Hot Toilet

55 SF

121Nurse

141 SF

113Code Team Area

172 SF

117Control Room

153 SF

116PET/CT432 SF

115AStorage46 SF

115Consult/Prep

104 SF

111Hall

106 SF

101Hall

141 SF

109Dress45 SF

107Dress45 SF

110Storage46 SF

103Consult58 SF

105Consult56 SF

114Equipment

162 SF

102Imaging258 SF

100Waiting302 SF

112Office

128 SF

104Office55 SF

106Office55 SF

108Office55 SF

Legend

Imaging Equipment/Support Space

Patient Pre-procedure Space

Procedure Support Space

Administration



Figure IV-1: Project Plan



ImPlemenTaTIon

BudgetBased upon detailed projections and utilizing cost data from similar projects, the build-out of the Marcus Research Imaging Center will have a total project cost of $3,332,494.

A 12-year lease for 6,266 rentable square feet (RSF) will accommodate the imaging center and associated support areas outside the improved area. A $65/RSF tenant improvement (TI) allowance is included within the lease to allow a portion of the imaging center buildout to be financed over the lease term. The budget for this effort includes all costs to prepare the Marcus Research Imaging Center above this $407,290 allowance.

As the project was designed, its scope was consistently reviewed to identify cost savings that could be realized without adverse impact to the operation of the center. During a meeting on November 20, 2019 the program was finalized as no further significant scope reductions could be identified. The budget was then finalized over the 1st week of December, immediately after the Thanksgiving holiday.

Funding SourcesThis effort will be funded through the Marcus Foundation grant and School of Medicine cash funds.

AlternativesGiven the limited space available within and adjacent to Building 400, further expansion to accommodate additional imagery equipment within Building 400 is not possible. As part of the temporary “400 series” structures constructed in 1944, B400 is an outdated, inefficient facility that currently is in a state of general disrepair with a FCI of 70%. It restrains collaboration and is financially unsustainable. Mold remediation has also been an ongoing issue in all of the 400 series buildings.

The Marcus Foundation grant will allow Marcus Research Imaging to purchase a new PET/MR image machine. Solely replacing the existing PET/CT with the PET/MR within B400 is not acceptable as use of both machines is required.

ScheduleProject design was initiated in the summer of 2019. No tenant improvements have been initiated for this effort as of December 17, 2019.

The Enhanced Facilities for Marcus Research Imaging Project would begin once CU BOR spending authority is approved. Final design documentation, procurement and construction is expected to take approximately seven months.

If spending authority is granted as requested, the schedule would be as follows:

Item Start CompletionProgram Plan Submission December 2019 N/A

Design and Permits July 2019 March 2020

Procurement January 2020 May 2020

Construction March 2020 August 2020

PET/MR, PET/CT Install May 2020 September 2020

The PET/CT machine in B400 will be moved into Bioscience 3 between May and September 2020. The appropriate equipment from the AOP will be moved during this time as well.

Third Party ReviewTo ensure the validity of the cost estimate for the Enhanced Facilities for Marcus Research Imaging project, the Facilities Projects Division at the university, and the Fitzsimons Innovation Community, enlisted the services of Mortenson to review the proposed program and associated costs. Mortenson is a leading provider of construction management services both regionally and nationally. They have reviewed the concept drawings of the proposed facility and referenced historical cost data for similar structures. Upon their professional reviews and independent estimates of cost, it was determined that the cost estimate provided within this program plan is in alignment with the expert opinions of the renowned owners representatives and builders.

Total Cost 2019 Unit Cost of SF Cost Description

Square Footage - Finished 6,266 rental able SFSquare Footage - Total 6,266 B PROFESSIONAL SERVICES

$0 0.00Included in the $65/rsf tenant improvement allowance

$0 0.00Included in the $65/rsf tenant improvement allowance

$59,403 9.482% of work above the $65/rsf allowance. FRA PM cost are included in the $65/rsf TI Allowance

$59,403 9.48C CONSTRUCTION - BUILDING

$2,620,084 418.14

$2,620,084 418.14D EQUIPMENT AND FURNISHINGS

$21,953 3.50 Number from CU Security$50,000 7.98 Provided by CCi and CU Imaging

Furniture not from CCi $7,000 Blood draw chairs, exam tables$86,100 13.74 Number from CU OIT

$0 0.00 Included in the $65/rsf tenant improvement

$165,053 26.34E MISCELLANEOUS

$25,000 3.99Number from CU Move Management team plus the Hot Lab move

$160,000 Number from CU Imaging and Philips

$185,000 29.52SUBTOTAL - B THROUGH E $3,029,540 483.49PROGRAM CONTINGENCY $302,954 48.35 10% on the items above the $65/rsf allowance

TOTAL PROGRAM BUDGET $3,332,494 531.84

Move Philips PET CT Scanner form Bldg. 400

Subtotal C

Electronic security

Subtotal D

Relocation/moving

Subtotal E

Mortenson has indicated that CU Imaging is paying $588,000 for Shared Services, emergency power service, GE Humidification, GE Dehumidification, Lead shielding, Permits, GCs (this equates to $94/rsf)

Does not include the scope of work to decommission and remove the Cyclotron (~$500,000.00 to decommission and remove).

Assumptions:Numbers are based on accepted value engineering and Mortenson Const numbers dated 11-30-19The design is 65 to 70% complete. Core and Shell construction will complete in Nov 2019. TI finish for late May 2020.

Furnishings new Bldg. from CCI

Telecom/IS- new

Telecom/IS- Outside plant service to building

University of Colorado Anschutz Medical Campus Project Cost Estimate Marcus Research Imaging Space in FRA BS3 Cost above the $65/RSF Tenant Improvement Allowance

17-Dec-19

Design and construction above the $65/rsf tenant improvement allowance

Provide imaging rooms, hot lab, hot toilet, and office space

PROJECTSUMMARY

A/E Service

Code Review Permits

CU Program Management

Subtotal B



Figure V-1: Project Budget

APPENDIX A: ACRONYMS

C-TRIC Colorado Translational Research Imaging Center CT Computed Tomography CU University of Colorado CU Anschutz University of Colorado Anschutz Medical Campus CU BOR University of Colorado Board of Regents

FAMC Fitzsimons Army Medical Center FRA Fitzsimons Redevelopment Authority

GSF Gross Square Feet

MIBH Marcus Institute for Brain Health MRI Magnetic Resonance Imagery

NSF Net Square Feet

PET Positron Emission Tomography PET/CT Positron Emission Tomography/Computed Tomography PET/MR Positron Emission Tomography/Magnetic Resonance

RSF Rentable Square Feet

SIRC Strategic Infrastructure for Research Committee SOM University of Colorado School of Medicine

T Tesla TBI Traumatic Brain Injury

December 5, 2019

University of Colorado Denver I Anschutz Medical Campus Director Facilities Projects Attn: Mike Barden 1945 N. Wheeling St Aurora, Colorado 80045

Re: Imaging Suite in Bioscience 3 Building

Dear Mike,

-■.Mortenson

M.A. Mortenson Company

1621 18111 Street. Suite 400

Denver, Colorado 80202

main 303.295.2511

fax 303.297 .8055

www.mortenson.com

Mortenson and MOA Architecture have worked with the Radiology Department, GE Medical and the School of Medicine to design and plan the program fitting into a leasable space on the first floor of the newly finished Bioscience 3 Building adjacent to the Anschutz Medical Campus. In the process of finalizing the program for the space and the current needs versus future needs of the space we have completed an estimate of cost for the work to achieve code and the program requirements of the Imaging tenant. As a part of the process we explored various options for mechanical and electrical system as well as the shielding program.

In review of the square footage costs for the space they do fall in the lower range of costs for similar space built across the metro area for various entities. With the trade partner input we received for the cost estimate we are confident the project can be built for these costs.

Sincerely,

�;}� MORTENSON

Sean Wennerstrom Senior Estimator [email protected] 303.917-7670

Appendix B

enhanced facilities for marcus research imaging...used in advanced nuclear medicine research have...

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