emma food on workshop allergy_eg
TRANSCRIPT
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FoodON Use Cases: Food Allergy
Emma Griffiths, PhDBrinkman Lab
Department of Molecular Biology and BiochemistrySimon Fraser University
International Conference on Biological Ontologies, Corvallis, OR Aug 4 2016
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Definition of a Food Allergy• Food allergies: body’s immune response to food antigen• Allergy (IgE-mediated) vs intolerance (non-IgE response)
Issues:• Describing Common & Hidden food allergens• Cross-contact concerns
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The Big 8!
• Food intolerance
Lots of Things!
The Problem: Lack of a Standardized Food Vocabulary Impacts Allergy Risk Assessment and Research
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Synonyms• Arachide• Cacahouète• Goober peas• Kernels• Mandelonas • Nut meats• Valencias
Possible Food Sources • Marzipan• Asian cuisine • Baked goods • Candies• Cereals and granola• Chili• Chipotle sauce • Salad dressings • Snack foods • Vegetarian meat substitutes
Non-Food Sources • Pest bait • Cosmetics• Craft materials• Medications & vitamins• Pet foods • Sunscreen • Stuffing in children’s toys
Peanuts: An Ontology Case Study[NCBITaxon] Taxonomy: Arachis hypogaea[DOID] Peanut Allergy Definition: A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms.
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1. Identify hazards (synonyms/sources)
2. Identify control points (handling & storage, HACCP)
3. Standardized labeling4. Comparing data across studies5. Implementing results in policy
Why Do We Need A Food Ontology for Food Allergy?
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The Mission of The CHILD StudyTo determine the causal factors of asthma and allergy
during childhood development
http://www.canadianchildstudy.ca/
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Infant Food Types• Breast milk• Formula• VitaminsParenting Guidelines• Breastfeeding Practices• Introduction of Adult Food
Processing/Preservation• Pasteurization
Storage• Contact Concerns• Chemical Exposure e.g. phthalates
Biochemical Factors of Food & Allergy• Immune Response• Diet• Microbiomes• Genetics & Predisposition
How FOODON Would be Useful for CHILD and Allergy Research
1. Compare food descriptors across child cohorts2. Correlate food facets with biological causes
3. Create guidelines for parents
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Who Should Shape the Food Allergy Domain?
• Food Advocates
• Clinicians
• Allergy Researchers
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…And The FoodON Consortium Founding
Members!
AcknowledgementsSFU Fiona BrinkmanGeoff Winsor Gemma Hoad Thea Van Rossum
BC Centre for Disease ControlWill HsiaoDamion Dooley
CHILD InvestigatorsMalcolm SearsDiana LefebvreDavid DaiPJ SubbaraoTim TakaroStuart TurveyAnita KozyrskyjDiana RoyceMeghan AzadDean BeafusJeff BrookScott TebbuttDenise DaleyMichael KoborJudah Denburg….
Email: [email protected]
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Activity – Identify the Common Allergens
• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
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• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Activity – Identify the Common Allergens
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
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• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Activity – Identify the Possible Hidden Allergens
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
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• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Activity – Identify the Possible Hidden Allergens
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
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• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Activity – Identify the Cross Contact Concerns
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
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• Fresh large eggs• Frozen whole-kernel
corn• Low fat 1% milk• Fresh green peppers,
diced• Fresh onions, diced
• Fresh tomatoes, diced• Yellow mustard• Hot pepper sauce• Salt• Reduced fat cheddar
cheese• Flour tortillas
Breakfast Burrito
Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis
Activity – Identify the Cross Contact Concerns