electrocardiogram a valuable diagnostic tool
TRANSCRIPT
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Electrocardiogram A valuable diagnostic tool
Jean Vorster Netcare Unitas Hospital STEMI Early Reperfusion Initiative 2015
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Overview
1. Arrhythmias
2. Structural heart disease
3. Ischaemia
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Arrhythmias
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Sinus Bradycardia
1. Drugs
2. Well-trained athletes
3. Physiological (Sleep – adolescents, young adults)
4. Myxedema
5. Hypothermia
6. Gram negative sepsis
7. Vomiting
8. Vasovagal syncope
9. Sick sinus syndrome
10.Intracranial tumors
11.Increased intracranial pressure
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Conduction System
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Conduction System
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2nd Degree AV Block
1. Increased vagal tone
2. Athletes
3. Sick sinus syndrome
4. Acute carditis
5. Ischaemic heart disease
6. Hypokalemia
7. Digoxin
8. Beta-blockers
9. Calcium-channel blockers
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3rd Degree AV Block
1. Idiopathic (Conduction tissue fibrosis)
2. Congenital
3. Ischaemic heart disease
4. Associated with aortic valve disease (Stenosis)
5. Cardiac surgery and trauma
6. Digoxin toxicity
7. Bundle branch interruption by tumors, granulomas, injury, etc.
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Atrioventricular Nodal Reentry Pathway (AVNRT)
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Atrioventricular Reentry Pathway (AVRT)
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Incidental finding of an irregular pulse
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Atrial Fibrillation 1. Most common arrhythmia
2. Fivefold increase in risk of stroke
3. Twofold increase in all-cause mortality
4. Etiology / Underlying substrate:
a. Hypertension
b. Ischaemic heart disease
c. Mitral valve diseased.
d.Cardiomyopathy (hypertrophic and dilated)
e. Hyperthyroidism
f. Open heart / thoracic surgery
g. Myocardial infarction
h. Pericarditis
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Atrial Fibrillation - Consequences • Heart Failure:
• Loss of atrial contribution to LV filling:
• Loss of atrial systole – decrease in stroke volume: 15 – 20%
• Accelerated ventricular response:
• Decrease in LV diastolic filling time
• Myocardial ischaemia
• Tachycardia-induced Cardiomyopathy
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Atrial Fibrillation - Consequences
• Systemic Thrombo-embolisation:
• Loss of atrial systole (contraction / transport function)
• Stasis of blood in LA
• Thrombus formation (90% in left atrial appendage)
• Fragmentation / Embolisation
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Atrial Fibrillation - Consequences • Syncope:
• Associated arrhythmias:
• Sick Sinus Syndrome
• AV blocks
• Accelerated ventricular response
• Structural heart disease e.g. Aortic Stenosis (fixed cardiac output)
• Underlying:
• Ischaemia
• LV dysfunction
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Indications for Warfarin in Atrial Fibrillation
1. CHA2DS2-VASc Score:
• C Congestive Heart Failure / LV dysfunction 1
• H Hypertension 1
• A Age ≥ 75 Years 2
• D Diabetes Mellitus 1
• S Stroke / Transient Ischaemic Attack 2
• V Vascular Disease 1
(prior MI / Peripheral Arterial Disease / Aortic plaque)
• A Age 65 – 74 years 1
• Sc Sex Category (Female) 1
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Indications for Warfarin in Atrial Fibrillation CHA2DS2-VASc Score
• ≥ 2
• 1
• 0
Recommended Therapy
Oral Anticoagulation
Oral Anticoagulation preferred
No therapy required
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Atrial Flutter • Less common than atrial fibrillation
• Can occur as a result of atrial dilation from:
• Septal defects
• Pulmonary emboli
• Mitral or tricuspid valve disease (stenosis / regurgitation)
• Heart failure
• Aging
• Can also occur without underlying heart disease:
• Thyrotoxicosis
• Alcoholism
• Pericarditis
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Atrial Flutter - Treatment • Cardioversion:
• Electrical (≈ 50J DCC)
• Chemical – anti-arrhythmic drugs (Class IA, IC or III)
• Ablation: • Highly effective (success rate >90%)
• Preferred approach because of high relapse rate after cardioversion and difficult to control ventricular response with medical therapy (β-blockers, Ca-channel antagonist, digoxin or anti-arrhythmic drugs)
• Risk of thrombo-embolism: • Lower than with atrial fibrillation
• Indications for anticoagulation similar to atrial fibrillation
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Atrial Flutter
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Ventricular Premature Complexes • Occur in association with:
• Aging
• Excessive use of
• Tobacco
• Caffeine
• Alcohol
• Various medications
• Electrolyte imbalances (e.g. hypokalemia)
• Ischemic or inflamed myocardium
• Infections
• Hypoxia
• Autonomic stimulation
• Anesthesia
• Surgery
• Importance depends on clinical setting:
• In the absence of underlying heart disease:
• No impact on longevity or limitation of activity
• Anti-arrhythmic drugs are not indicated
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Ventricular Premature Complexes • In the setting of an acute myocardial infarction:
• Occur in the early phase
• Seldom cause ventricular fibrillation (VF)
• Frequent VPC’s
• Multiform configuration
• Early coupling (“R-on-T”)
• Repetitive patterns (couplets / salvos)
• Check for:
• Recurrent ischemia
• Electrolyte or metabolic disturbances
• Maintain S-K+ > 4.5mmol/l and S-Mg2+ > 2mmol/l
• Β-blocker if sinus tachycardia
• Anti-arrhythmic drugs not indicated, may increase risk for fatal bradycardic and asystolic events
Low sensitivity and specificity for identifying patients at risk for VF
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82 year old man Smoking history:140 to 150 pack years
Severe COPD Severe pulmonary hypertension
Dilated right ventricle
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Chaotic (Multifocal) Atrial Tachycardia • Characteristics:
• Atrial rates between 100 and 130 beats/min
• Marked variation in P-wave morphology (at least 3 P-wave contours)
• Irregular P-P intervals
• Variable PR-intervals
• Etiology / Associations:
• COPD
• Congestive heart failure (elderly patients)
• Digitalis (unusual cause)
• Theophylline
• May develop into atrial fibrillation
• Treatment:
• Avoid β-blockers (COPD)
• Verapamil / Amioderone
• K- / Mg supplementation
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46-year old male Mitral valve prolapse
Infective endocarditis in 2012 – managed medically Rupture of chord with severe mitral regurgitation
Underwent mitral valve repair in April 2014 This arrhythmia documented during routine follow up (asymptomatic)
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Focal Atrial Tachycardia • Characteristics:
• Atrial rates between 150 and 200 beats/min
• P-wave contour different from sinus P-wave
• At the onset there may be some warming up of the rate that results in an increase in heart rate over the initial several complexes
• Frequently occur in short, recurrent burst with spontaneous terminations; may also be incessant
• Etiology / Associations: • Coronary artery disease (with or without myocardial infarction)
• Heart failure
• Digitalis intoxication
• Potassium depletion
• May develop tachycardia-induced cardiomyopathy if incessant
• Treatment: • β-blockers / Calcium channel blocker
• Discontinue digitalis
• K-supplementation
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Accelerated Idioventricular Rhythm
• Characteristics:
• Rate: 55 to 110 beats / min
• Broad QRS complex
• AV dissociation
• Setting:
• Seen in 20% of STEMI patients
• Frequently occurs in first 2 days
• Most episodes are of short duration
• Occurs with about equal frequency in both anterior and inferior infarctions
• Often seen after successful reperfusion
• Not a reliable marker of reperfusion
• Not thought to affect prognosis
• No treatment required
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Ischemic Cardiomyopathy (LV ejection fraction = 39%) Previous inferior myocardial infarction CABG – graft to right coronary artery Recurrent palpitations (no syncope)
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Ventricular Tachycardia (VT) • Etiology:
• Most patients with symptomatic recurrent VT have ischemic heart disease
• Sustained VT displays a circadian variation – peak frequency in the morning
• Next largest group has cardiomyopathy (congestive and hypertrophic)
• Lesser percentages:
• Inherited ion channel abnormalities
• Idiopathic VT
• Congenital heart disease
• Patients with sustained VT are more likely to have:
• Reduced ejection fraction
• ECG abnormalities (e.g., wide QRS)
• Previous myocardial infarction
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Polymorphic VT from hypokalemia
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Ventricular Tachycardia (VT) - Management
• Acute (Termination):
• No hemodynamic decompensation:
• Anti-arrhythmic drug (e.g., Amioderone)
• Hemodynamic compromise / decompensation:
• Synchronized DC cardioversion (10 to 50 J)
• Search for reversible cause:
• Ischemia
• Hypotension
• Hypokalemia
• Prevention of recurrences or sudden death:
• Implantable Cardioverter / Defibrillator (ICD):
• LV ejection fraction < 35%
• Survivors of cardiac arrest
• Structural heart disease
• Sustained VT with hemodynamic decompensation
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ECG and hemodynamic tracing during angiography
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Ventricular Fibrillation • Clinical scenario’s:
• Most commonly in association with coronary artery disease
• As such a terminal event
• Most frequently in the morning
• Anti-arrhythmic drug administration
• Hypoxia
• Ischaemia
• Electrical cardioversion (non-synchronized, faulty)
• Accidental electrical shock (improperly grounded)
• AF with pre-excitation (WPW)
• Severe derangement of cardiac contractility:
• Terminate fatally or produce significant brain damage within 3 to 5 minutes unless corrective measures are undertaken promptly
• Management:
• CPR and non-synchronized DC shock (200 to 400J)
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Structural
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67 year old man Presented with unstable angina due to left main stem disease
(underwent CABG)
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Right Bundle Branch Block - Significance
1. Common finding in general population: a. Many people with RBBB have no structural heart disease b. Fragility of RBBB
2. New onset RBBB predicts a higher rate of: a. Coronary artery disease b. Heart failure c. Cardiovascular mortality
3. In the presence of cardiac disease, coexistence of RBBB suggests: a. Advanced disease b. Extensive multi-vessel disease c. Reduced long-term survival in ischaemic heart disease
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Left Bundle Branch Block 1. Criteria:
• QRS duration >120ms • Broad, notched, or slurred R waves in leads I, aVL, V5 and V6
• Prolonged time to peak R wave (>60msec) in V5 and V6
2. ST-T wave changes • ST-segment and T-wave discordant with QRS complex
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Left Bundle Branch Block - Significance • Usually in patients with underlying heart disease:
a. 30% of patients with CCF have LBBB b. 70% of people developing LBBB have preceding LVH (Only 12% of patients with LBBB have no demonstrable disease)
• Prognostic implications: a. Higher risk of CV mortality from infarction and heart failure b. Higher risk of AV block and cardiac death c. CAD: more extensive disease and LV dysfunction and reduced
survival rates
• Obscuring other ECG patterns:
a. Myocardial infarction (ST-segment elevation –equivalent) / ischaemia b. LV hypertrophy
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Left Anterior Fascicular (Hemi) Block
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Left Posterior Fascicular (Hemi) Block
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Left Ventricular Hypertrophy
1. Criteria: a. Sokolow – Lyon: SV1 + RV5/6 > 35mV
b. Cornell voltage: SV3 + RaVL ≥ 28mV (men)
SV3 + RaVL ≥ 20mV (women)
2. Etiology: a. Hypertension
b. Aortic stenosis
c. LV outflow tract obstruction
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Left Ventricular Hypertrophy
1. Other QRS changes in LVH:
a. Widening of the QRS complex beyond 110ms
b. Delay in the intrinsicoid deflection (ventricular activation)
c. Notching of the QRS complex
2. ST-T wave patterns:
a. Normal
b. Somewhat elevated in leads with tall R-waves
c. ST-segment slopes downward from depressed
J-point and T-wave is asymmetrically inverted
3. Additional abnormalities:
a. Prolongation of QT-interval
b. Left atrial abnormality
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Left Ventricular Hypertrophy - Significance
• Increased risk for cardiovascular morbidity & mortality:
• LIFE study – Losartan antihypertensive therapy:
• A 1 SD decrease in Cornell product associated with:
• 25% decrease in cardiovascular death
• 17% lower rate of myocardial infarction
• Repolarization abnormalities:
• More severe degrees of anatomic LV hypertrophy
• Greater risk of future cardiovascular events:
• LIFE study:
• Significant increases:
• Risk of cardiovascular death (HR, 2.42)
• Myocardial infarction (HR, 1.95)
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74 year old lady Cor Pulmonale with severe pulmonary hypertension secondary to
chronic and multiple pulmonary emboli
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48-year old female Cor Pulmonale
Severe Pulmonary hypertension – PAP = 75 to 95mmHg Dilated RV and main pulmonary artery, paradoxical septal motion
Spontaneous pulmonary embolism in 2007
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Right Ventricular Hypertrophy • Criteria:
• R in V1 ≥ 0.7mV
• R vs. S ratio in V1 >1 with R > 0.5mV
• Right axis deviation (>90°)
• P-pulmonale
• Etiology:
• Pulmonary hypertension
• Respiratory disease – COPD, Interstitial lung disease
• Pulmonary emboli
• Left to right shunting - ASD
• Idiopathic
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Ischaemia
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54 year old man with 3 hour duration central chest discomfort Risk factors: Smoking Dyslipidemia Total occlusion of mid LAD
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After restoring flow to LAD with percutaneous coronary intervention
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47 year old man with an occluded LAD
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38 year old man Ischaemic chestpain
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Don’t be caught between a rock and a hard place!
Thank you!
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