efficacy and potency of drug
TRANSCRIPT
Department of Pharmaceutical Department of Pharmaceutical sciencessciences
33rdrd Semester Semester
Group membersGroup members
Mohammad AsadMohammad AsadHafiz JunaidHafiz JunaidAmir Sohail KhanAmir Sohail KhanSana MushtaqSana Mushtaq
What is Pharmacodynamics Drug response curve EC50 Potency Efficacy Refrences
Pharmacodynacmics describes the action of drug on body and influence of drug concentration on magnitude of response
Most of drugs exerts effect by ineracting with receptor
An agent that can bind to recepor and produces iological rsponse is called as agonist
The interaction between drug and its receptor can be described by a curve called as drug response curve
on Vertical axix there is response of drug
On horizontal axix there is concentration of dose
The magnitude of drug effect depends on drug concentration at receptor site and this availbilty and concentration of drug at receptor is determined by both dose of drug administered and by drug pharmacokinetics(ADME)
When no drug is added then no effect is produced
When some drug is added then we get response
By adding more drug we get maximum response
A time will reach on which adding more drug will not cause increase in response because we have reached to maximum effect
EC50EC50Is concentration of drug needed to get half
of the maximum effect
Two important properties of drug can be found by dose reponse curve
Efficacy Potency
PotencyPotency amount of drug necessary to
produce maximum effect is the potecncy of drug
Candesartan and ibesartan are angiotensin receptor blocker
Candesartan is more potent then Ibesartan because the dose range for candesartan is 4 to 32 mg as compared to dose range of ibesartan whose dose range is 25 to 300 mg
Ability of a drug to elicit a response when it interacts with a receptorEfficacy is dependent on;
the number of drug-receptor complexes formedefficiency of the coupling of receptor activation to
cellular responses. Maximal efficacy of a drug assumes that all
receptors are occupied by the drug and if more drugs are added, no additive response will be observed.
Maximal response (efficacy) is more important than drug potency.
A drug with greater efficacy is more therapeutically beneficial than the one that is more potent.
Lipincott pharmacology
Rang and dales pharmacology