dvh-based analysis of pre- treatment verification for vmat...
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DVH-based analysis of pre-treatment verification for VMAT
delivery
Amy Comrie, Andiappa Sankar, Gillian Cooke, Paul Drewell
Edinburgh Cancer Centre
RapidArc QA
• Performed with ArcCHECK phantom & PTW pinpoint chamber for central axis dose measurement
• Gamma passing rates used to compare 2 dose distributions
• 3%/3mm and 2%/2mm Dose Difference (DD) and Distance to agreement (DTA) criterion used for relative and absolute 2D gamma analysis
• Provides no information about size/location of dose errors
Sun Nuclear 3DVH v2.1• Compares two dose matrices using a Planned Dose
Perturbation (PDP) algorithm• Perturbs the planned patient dose matrix to account for
discrepancies between planned and measured dose• Generates 3D local (per structure) and global (per
patient) gamma passing rates, DVH-curves and dose statistics
Software input includes:• DICOM RT Plan, Dose, Structure set & planning CT data
set• Comparison dose file (.acml from ArcCHECK)
3DVH Software output
3DVH Analysis
• 15 RapidArc patients (11 H&N and 4 Prostate)
• 2%/2mm and 3%/3mm gamma analysis, 10% threshold (local and global)
• Comparison of ArcCHECK and 3DVH gamma analyses
• Comparison of 3DVH and Eclipse DVH curves
• Comparison of Eclipse and 3DVH volumes
• Dmean, Dmax, D90% & D95% for PTVs
Results (1)
ArcCHECK and 3DVH Gamma Analyses (1)
ArcCHECK and 3DVH Gamma Analyses (2)
3DVH and Eclipse DVH differences
3DVH and Eclipse volume differences
Differences in Dmax
Potential Errors/Issues
• ArcCHECK setup and temperature dependence• Differences between Eclipse and 3DVH
volumes• Possible differences between AAA and Planned
Dose Perturbation algorithms• Comparison of measured dose to a phantom
with planned dose to a patient
How effective is 3DVH?
• Successfully generated DVH data using 3DVH and compared to Eclipse DVH curves
• All patients passed our ArcCHECK pre-treatment QA• 13 out of 15 patients passed 3DVH analysis, no
obvious reason for 2 failures• No relationships between volume or Dmax differences
for individual structures and gamma passing rates were found
• Future work includes analysing overall benefits of using 3DVH and the clinical significance of errors (PTV coverage, OAR overdose etc.)
References
• Carrasco, P. et al. (2012) 3D DVH-based metric analysis versus per-beam planar analysis in IMRT pretreatment verification, Medical Physics, 39(8) pp.5040-5049
• Zhen, H., Nelms, B.E. & Tome, W.A (2011) Moving from gamma passing rate to patient DVH-based QA metrics in pretreatment dose QA, Medical Physics, 38 (10) pp.5477-5489
• Nelms, B.E., Zhen, H. & Tome, W.A. (2011) Per-beam, planar IMRT QA passing rates do not clinically predict clinically relevant patient dose errors, Medical Physics, 38(2) pp.1037-1044