Duke NIRL Hosted MIRIAD Datahttp://nirlarc.duhs.duke.edu

Both XNAT and HID

Multispectral Segmentation 1.5T and 3T

1.5T Segmentation 3T Segmentation

Source scans: proton density, T1-w, T2-w, FLAIRAutomated segmentation of gray, white matter, csf and lesion (red). Shown overlaid on proton density image (showing just skull, surface tissues and reference tube outside skull)

500

550

600

650

700

750

gm 3

500 550 600 650 700 750

gm 1.5

0

5

10

15

20

25

30

35

les

3

0 5 10 15 20 25 30 35

les 1.5

Lesion SimulationFractional Contrast for Lesion to White Matter, 3T data

PD-weighted

T1 weighted T2-weighted FLAIR

Mean 0.299168 -0.12935 0.88210114 0.356158

Standard Deviation (SD) of Mean 0.041301 0.020395 0.13435156 0.097343

SD/Mean 0.138053 -0.15767 0.152308567 0.273315

VSL=volume of segmented lesion inside of true lesion (True positives) VNSL=volume of nonsegmented lesion inside of true lesion (False negatives)

VNL=volume of non-lesion outside of true lesion (True negatives) VLOL=volume of segmented lesion outside of true lesion (False positives)

sensitivity=VSL/(VSL+VNSL) specificity=VNL/(VNL+VLOL) accuracy=VSL/(VSL+VLOL)

For this example we have sensitivity = 0.73, specificity = 0.89 and accuracy=0.46.

SENSE DTI Image Distortion Correction

B0 and eddycurrent maps

distortedSENSE DTI

images

correctedSENSE DTI

imagesdifference

AVID software for fMRI-guided fiber tracking

Toward Quantitative Fiber Volume Measurement

Left Column: Conventional Euler’s methodRight Column: Improved streamline tracking method with RK4 algorithm.

a b

c d

a b

c d

Unit Hausdorff Distance vs NEX

= FA>0.3

FA vs NEX

FA=0.32

FA=0.31

Deviation Angle vs NEX

FA=0.30FA=0.27

= FA>0.3