dr_awa_aidara-kane
DESCRIPTION
http://www.cddep.org/sites/cddep.org/files/dr_awa_aidara-kane.pdfTRANSCRIPT
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Public Health Consequences of Use of Antibiotics in Agriculture
How is WHO addressing the issue Globally
Dr Awa Aidara-Kane, Department of Food Safety and Zoonoses
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Foodborne Antimicrobial resistance: a public Health concern
• Antimicrobials are essential drugs for treatment of infectious diseases in Human and Animals
• Discovery of antibiotics has been one of the most important achievements of the 20th century
• Resistance has developed soon after and new drugs has been developed to replace older ones as resistance emerged…
• BUT today, Resistance is emerging and spreading faster than new drugs are being developed;
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Source: The antibiotic resistance: the nexus of chemical and genetic diversity. Gerard D. Wright. Nature Reviews Microbiology 5, 175-186 (March 2007)
Discovery of antibiotics: a faltering pipeline
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
How does antibiotic resistance develop?
l Some bacteria are naturally resistant; new resistances also arise spontaneously by chance mutations and these resistant strains then multiply.
l Some resistances can be passed from one bacterium to another, spreading resistance between species. Loops of DNA (called plasmids) carry the resistance genes from one bacterium to another.
l When an antibiotic is given, it kills the sensitive bacteria, but any resistant ones can survive and multiply.
l The more antibiotics are used (in animals and agriculture as well as in man) the greater will be the "selective pressure", favoring resistant strains. This is an example of Darwin's Theory of evolution, operating the "survival of the fittest".
l Antibiotics don't 'cause' resistance; rather, they create an environment which favors the growth of resistant variants which already exist in nature or arise by chance.
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
AMR and Animal Husbandry
l Widespread use of antimicrobials in livestock production ….not only from therapeutic purposes
l Same classes of antimicrobials are used both in humans and food-producing animals…
l Food is generally considered to be the most important vector for spread of resistance between humans and animals
l Globalization of food trade, need for international action
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
More than 50% of all antimicrobials are used non-therapeutically in animal husbandry
Antibiotics…"the more you use them, the faster you lose them"
l In industrial production, antibiotics are added to drinking water to decrease diseases of crowding and as growth promoters
– When microbes are exposed to antibiotics, the bacteria resistant to these drugs survive and multiply which results in Antimicrobial Resistance
Use of antimicrobials in food animals can lead to Antimicrobial Resistance (AMR) in human pathogen.
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Ceftiofur in ovo use and prevalence of ceftiofur resistance among retail chicken Escherichia coli, and retail chicken and human clinical Salmonella enterica
serovar Heidelberg isolates during 2003–2008 in Québec, Canada
Lucie Dutil, Rebecca Irwin, Rita Finlay et al. Emeg. Infect. Dis. Vol. 16, No. 1, January 2010
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Summary on the importance of the animal reservoir
l Larger selective pressure
l Most important reservoir for antimicrobial resistant Salmonella and Campylobacter.
l An increasingly important reservoir for MRSA
l Important, but not quantified reservoir for E. coli
l Transferable genes
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
AMR and the Food Chain = AMU in the Food Chain
l In Terrestrial animals
l In Aquaculture
l In Horticulture – Plant production
Others : Environment, Waste management….One Health!
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Resistance is consequence of selective pressure created by use
l Any kind of antimicrobial use, can select for emergence of
resistance and further promote the dissemination of resistant bacteria and resistance genes
l AMR does not respect phylogenetical, geographical or ecological borders Ø Antimicrobial use in one ecological compartment can have
consequences for the resistance situation in another ecological compartment, need for an integrated inter-sectoral approach
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
One Health it all goes around, and around, and around
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Antibiotic Resistance in people
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Are Food-Producing Animals involved?
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Addressing the public health impact of use of antimicrobials in food-producing animals- WHO Achievements 1990-2011 l International collaboration established
– Codex, FAO, OIE, WHO
l 18+ expert meetings and consultations
l Codex Ad Hoc Intergovernmental task Force on Antimicrobial resistance (2007-2010)
l WHO list of Critically Important Antimicrobials for Human Heath developed
l Establishment of an Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR)
l WHD 2011 : Joint WHO and OIE Call for reduction of use of AMU in Animal Husbandry
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Berlin 1997. Assessing the Medical Impact
l In 1997 WHO convened an expert meeting on “The Medical Impact of the Use of Antimicrobials in Food Animals”
l The experts acknowledged that antimicrobial use can select resistant forms of bacteria in the ecosystem and resistant bacteria and resistance genes can be exchanged between human, animal and other ecosystems. The following adverse consequences of selecting resistant bacteria in animals were identified:
– 1. Transfer of resistant pathogens to humans via direct contact with animals or through the consumption of contaminated food or water.
– 2. Transfer of resistance genes to human bacteria. – 3. Increased incidence of human infections caused by resistant pathogens. – 4. Potential therapeutic failures.
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
September 2001
Preserving effectiveness of anti-microbial therapy: globally
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
The five key areas: global strategy for containment of antimicrobial
resistance
Rational drug use and regulation
Research and development
Agriculture/ Animal husbandry Surveillance
Infection prevention
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
WHO Global Principles for the Containment of AMR in food-animals
To minimise the public health impact of the use of antimicrobial agents in food animals and provide recommendations for their safe and effective use in veterinary medicine. Large consultation incl. stakeholders As chapter in the publication on WHO Global strategy on Containment of Antimicrobial Resistance - 2001
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
WHO Global strategy for Prevention and Control of Foodborne Antimicrobial Resistance
l National and international interdisciplinary cooperation for a fully integrated surveillance system
l Prudent use of antimicrobial agents in all sectors – Phasing out use of antimicrobial agents for growth promotion
• EU banned all growth promoters as of January 1, 2006 – A good regulatory system for approval and licensing – Prescription-only – Practitioners not having economic profit from prescription – Routine prophylactic use of antimicrobials should never be used as a substitute
for health management – Accurate diagnosis and antimicrobial susceptibility testing – Appropriate antimicrobial product and administration route
l Infection control – Successful disease control relies on a holistic approach encompassing hygiene,
animal husbandry and management, nutrition, animal welfare, and vaccination
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Integrating Surveillance Systems AGISAR
A group of experts working in veterinary, food and public health disciplines advising WHO on ensuring globally containment of foodborne antimicrobial resistance trough integrated surveillance of antimicrobial usage and antimicrobial resistance in the animal, food and human sectors
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Outputs of AGISAR Meetings - Annual Meeting Report
- WHO List of Critically Important Antimicrobials for Human Medicine (revised version every 2 years)
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
World Health
Organization
Secretariat
Usage Monitoring
Subcommittee
Cap.Building &
Country Pilot Projects
Subcommittee
AMR Monitoring
Subcommittee
Steering Committee
(Chairs &Co-Chairs of
Subcommittees)
Data Management
&Software Dev.
Subcommittee
Governance of AGISAR
Organizations
Networks
Institutes
Universities
Individuals
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
Global Foodborne Infections Network (GFN)
A network of professionals working in veterinary, food and public health disciplines committed to enhancing capacity of countries to conduct integrated surveillance of foodborne and other enteric infections, incl. antimicrobial resistance
GFN Steering Committee
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
(Inter)national Training Courses
Microbiology training – Global/Region-specific pathogens
(e.g. Salmonella, Campylobacter, E. coli, V. cholerae, S. Typhi, Brucella, Shigella, Listeria, C. botulinum)
– Quality assurance – Biosafety – Antimicrobial Susceptibility Testing
Epidemiology training – Outbreak detection and response – Evaluation of surveillance systems – Study design – Source attribution – Burden of disease
Joint Epidemiology and Laboratory – Joint case studies – Integrated surveillance – Risk assessment – Country Plans of Action – Advocacy and communication – Information sharing networks
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
GFN training activities
St. Petersburg, Russian Federation
Papua New Guinea
Moscow, Russian Federation
Guam
Fiji
Argentina
Poland
ThailandCameroon
EgyptChina
Kenya
Brazil
Guatemala
Madagascar
Costa Rica Trinidad & Tobago
South Africa
TunisiaIndia
St. Petersburg, Russian Federation
Papua New Guinea
Moscow, Russian Federation
Guam
Fiji
Argentina
Poland
ThailandCameroon
EgyptChina
Kenya
Brazil
Guatemala
Madagascar
Costa Rica Trinidad & Tobago
South Africa
TunisiaIndia
v 20 Active Sites
v > 1 300 Trained
v > 130 MS
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
1. Thailand-Level 1-December 1999 2. Argentina-Level I-June 2000 3. Middle East-Level I-July 2000 4. China-Level I-April 2001 5. Thailand-Level II-June 2001 6. Argentina-Level II-Sept 2001 7. Mexico-Level I-July 2001 8. Thailand-Level III-Jan 2002 9. Poland-Level I-April 2002 10. Middle East-Level II-June 2002 11. Caribbean-Level I-Sept 2002 12. Cameroon-Level I-Nov 2002 13. China-Level II-Nov 2002 14. Mexico-Level II-March 2003 15. Moscow-Level I, Part I-May 2003 16. Argentina-Level III-May 2003 17. Poland-Level II-June 2003 18. Middle East-preLevel III-July 2003 19. Kazakhstan-Level I-July 2003 20. Thailand-Advanced Wksp I-Aug 2003 21. Cameroon-Level II-Dec 2003 22. Middle East-Level III-Feb 2004 23. Caribbean-Level II-March 2004 24. Poland-Level III-April 2004 25. China-Level III- May 2004 26. Mexico-Level III-Sept 2004 27. Russia-St. Pete-Level I-Oct 2004 28. Cameroon-Level III-Dec 2004 29. Caribbean-Level III- May 2005 30. Russia-St. Pete-Level II-June 2005 31. Brazil-Level I,Part I-Sept 2005 32. China Advanced Wksp I- Dec 2005 33. Cameroon-Level IV-Dec 2005 34. Poland-Adv Wksp-I-Feb 2006 35. Russia-St. Pete-Level III-May 2006 36. Argentina-Adv Wksp I-May 2006 37. Brazil-Level I-Part II-Sept 2006 38. Pacific-Level I-Oct 2006 39. Antisera Training Course-Nov 2006 40. China-Adv Wksp II-Nov 2006 41. Thailand-Adv Wksp II-Jan 2007 42. Madagascar-Level I-Jan 2007 43. Guatemala-Level III-March 2007 44. Egypt-Adv Wksp I-March 2007 45. Russian Fed./St. Pete-Adv Wksp I-Sept 2007 46. Caribbean-Adv Wksp I-Sept 2007 47. Kenya-Level I-Oct 2007 48. Brazil-Level II-Nov 2007 49. China-Adv Wksp III-Nov 2007 50. Poland-Adv Wksp-II-Feb 2008 51. Cameroon-Adv Wksp I-March 2008 52. Russian Fed./Moscow-Level I-March 2008 53. Argentina-Adv Wksp II-May 2008 54. Papua New Guinea-Level I-June 2008 55. Brazil-Level III-Sept 2008 56. China-Adv Wksp IV-Oct 2008 57. Kenya-Level II-Jan 2009 58. Guam-Level I-Feb 2009 59. Thailand-Adv Wksp III-March 2009 60. Costa Rica-Adv Wksp I-April 2009 61. Madagascar-Level II-April 2009 62. China-Focussed Wksp-May 2009 63. Poland-Adv Wksp-May 2009 64. Thailand - Nat. course-July 2009 65. China-Nat. course-Sept 2009 66. Brazil-Adv Wksp I-Oct 2009 67. Caribbean-Adv Wksp II-Nov 2009 68. United Arab Emirates – Nat. course-Feb 2010 69. Russian Fed./Moscow-Level II-May 2010 70. Argentina-Adv Wksp III-May 2010 71. Thailand GFN/ASIA Foodnet Wksp-July 2010 72. China-Adv Wksp V-Sept 2010 73. Tunisia-Level I-Nov 2010 74. Kenya-Level III-Nov 2010 75. Cameroon-Adv Wksp II-January 2011 76. United Arab Emirates – Nat. course-March 2011 77. India – Level I Nat. course I – March 2011 78. India – Level I Nat. course II – March 2011 79. South Africa – Level I – May 2011 80. Costa Rica – Level II – May 2011
GFN Training activities 2000 - 2011
Global Foodborne Infections Network (GFN) 14 November 2011
1st Global Forum on Bacterial Infections, New Delhi, 3-5 October 2011
More information at :
http://www.who.int/foodborne_disease/resistance
:: General information :: Codex ad hoc Intergovernmental Task Force of Antimicrobial Resistance :: List of Critically Important Antimicrobials :: WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR) :: Publications :: Meetings