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Membrane Structure and Function
Chapter 8
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• Plasma membrane of cell selectively permeable (allows some substances to cross more easily than others)
• Made mostly of proteins and lipids (phospholipids).
• Phospholipids and proteins create unique physical environment (fluid mosaic model)
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Phospholipid
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• Membrane - bilayer - hydrophilic (water loving) heads pointing outwards, hydrophobic (water fearing) tails pointing inwards.
• Proteins help membrane to stick to water.
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• Fluid because lipids and proteins can move laterally.
• As temperatures drop, liquid membrane can solidify.
• Saturated fatty acid tails - more solid than unsaturated fatty acid tails.
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• Cholesterol found in membrane helps with fluidity of membrane.
• Membranes need to be fluid to work properly - systems in place to help keep it fluid.
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• Two different types of proteins are found in membrane.
• 1Peripheral proteins not in membrane, bound to surface of protein.
• 2Integral proteins in membrane often spanning entire membrane.
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/MembraneProteins.gif
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• Membrane helps keep cell’s shape.
• Also aids in cell-to-cell recognition (ability of a cell to distinguish one type of neighboring cell from another)
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• Some substances move steadily across membrane (sugars, ions, and wastes like CO2)
• Hydrophobic molecules (i.e. hydrocarbons, CO2, and O2) can dissolve in lipid bilayer and cross easily.
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• Charged particles and polar molecules have more difficulty passing.
• Specific ions and polar molecules can cross lipid bilayer by passing through transport proteins that span membrane.
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• Diffusion - tendency for substance to spread out in open area.
• Permeable membrane separating a solution with dye molecules from pure water, dye molecules will cross barrier randomly.
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• No force acting upon it - substance will tend to move down it’s concentration gradient from where it is more concentrated to less concentrated (passive transport).
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• Diffusion of molecules with limited permeability through lipid bilayer may be assisted by transport proteins.
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• Difference in concentration - ions move from one area to other.
• Solution with higher [ ] solutes - hypertonic.
• Solution with lower [ ] solutes -hypotonic.
• [ ] equal - isotonic.
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http://www.biologycorner.com/resources/hypertonic.gif
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• Solution hypertonic - higher solute [ ] but lower H2O [ ].
• H2O moves into solution and solute moves out.
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• Movement of H2O across selectively permeable membrane - osmosis.
• 2 solutions isotonic, H2O molecules move at equal rates from one to the other, (no net osmosis)
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• Cell placed in hypertonic solution – H20 rushes out of cell (cell shrinks).
• Cell placed in hypotonic solution – H2O rushes into cell (cell swells).
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• Organism does not have rigid walls must have ability to osmoregulate and maintain internal environment.
• Plant cells expand when watered causing pressure to be exerted against cell wall.
• Allows plant to stand up against gravity (turgid cell); not watered, plant will begin to wilt (flaccid cell).
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• Plant loses enough water, plasma membrane will pull away from cell (plasmolysis).
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• Charged particles that cannot pass through membrane - proteins to pass through (facilitated diffusion - diffusion of substance down it’s [ ] gradient with help of transport protein)
• Some channel proteins (gated channels) open/close depending on presence/absence of physical or chemical stimulus.
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In this case, the protein actually rotates to dump the materials to the inside of the cell.
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• Sometimes materials need to be moved against [ ] gradient (active transport)
• Active transport requires energy of cell to move substances from an area of low [ ] to an area of high [ ] (i.e. sodium-potassium pump in animal cells)
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• Sodium-potassium pump actively maintains gradient of sodium (Na+) and potassium ions (K+) across membrane.
• Sodium-potassium pump uses energy of 1 ATP to pump 3 Na+ ions out and 2 K+ ions in.
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• Cells maintain voltage across plasma membranes.
• Cytoplasm negative compared to opposite side of membrane (membrane potential - ranges from -50 to -200 millivolts)
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• Membrane potential favors passive transport of cations (positive ions) into cell and anions (negative ions) out of cell.
• Creates an electrochemical gradient across membrane.
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• Some organisms have proton pumps that actively pump H+ out of cell (i.e. plants, bacteria, and fungi)
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• Materials leave membrane through lipid bilayer or through transport proteins.
• Exocytosis - transport vesicle buds from Golgi apparatus - moved by cytoskeleton to plasma membrane.
• When membranes meet - fuse - material is let out to outside of cell.
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• Endocytosis - cell brings in macromolecules and matter by forming new vesicles from plasma membrane.
• Membrane is inwardly pinched off and vesicle carries material to inside of cell.
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• 1Phagocytosis (“cell eating”) - cell engulfs particle by extending pseudopodia around it, packaging it in a large vacuole.
• Contents of vacuole are digested when vacuole fuses with lysosome.
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• 2Pinocytosis (cell drinking) - cell creates vesicle around droplet of extracellular fluid.
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• 3Receptor-mediated endocytosis - specific in transported substances.
• Extracellular materials bind ligands (receptors) - causes vesicle to form.
• Allows materials to be engulfed in bulk (i.e. cholesterol in humans)
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