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Atul Butte, MD, PhD
Principal Investigator, CIAPM
www.ciapm.org
#CIAPM16
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• Launched by Governor Edmund G. Brown Jr. in April 2015
• California-wide initiative, hosted by UCSF & UC Health
• $3 million initial investment from California government
• $10 million appropriated in FY 2016 / 17 budget
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Population Individual characteristicsand circumstances
- Diseases affect individuals differently- People have different responses to
same treatment- Some people get conditions such as
diabetes or heart disease despite a healthy life style
Precision Medicine: toward tailored approaches to health and disease
Stratified population
More precise - Prevention- Diagnoses- Treatments
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• Building a California precision medicine asset inventory– We want to know what you are doing to advance precision medicine and if
you have resources to share!– Contact us at [email protected]
• Two funded demonstration projects– Started 10 months ago
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Demonstration ProjectCalifornia Kids Cancer Comparison
David Haussler, PhD, UC Santa Cruz
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Demonstration ProjectCalifornia Kids Cancer Comparison
David Haussler, PhD, UC Santa Cruz
Data of more than 80 kids with cancer have been analyzed under CKCC – to date… this will double by the end of the project
These kids’ data against a compendium of over 10,000 tumors
Project indicators are highly encouraging: in all cases presented to live Tumor Boards, CKCC has identified new therapeutic options
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Academic PartnersIndustry and
Nonprofit Partners Advocacy Partners
Demonstration Project: California Kids Cancer ComparisonProject Partners
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Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases
Charles Chiu, MD, PhD, UC San Francisco
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Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases
Charles Chiu, MD, PhD, UC San Francisco
Validation in UCSF CLIA-certified clinical microbiology laboratory (ended May 2016)
Clinical trial (began June 2016)300 CSF samples for acute meningitis / encephalitis dx35 patients enrolled to dateComparison with conventional testingOutcomes and cost-effectiveness measures
Clinical Microbial Sequencing Board (CMSB)Weekly online case discussion w/ multiple specialties
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Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases
Project Partners
Academic PartnersNonprofit / Government
Partners Industry Partners
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• Building a California precision medicine asset inventory– We want to know what you are doing to advance precision medicine and
if you have resources to share!– Contact us at [email protected]
• Two funded demonstration projects– Started 10 months ago
• Six additional demonstration projects– 29 proposals under review right now
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Selection Committee Institution ExpertiseNancy Cox - Chair Vanderbilt University Genomics / StatisticsElaine Mardis Washington University Genomics / CancerMarylyn Ritchie Geisinger Health System Genomics / BioinformaticsIsaac Kohane Harvard University Statistics / ComputationEric Hekler Arizona State University Digital HealthStanley Shaw Harvard University Digital HealthShawneequa Callier George Washington University Health Disparities / EthicsAkinlolu Ojo University of Arizona Health Disparities / Global HealthRachel Ceballos Fred Hutchinson Cancer Research Ctr Health Disparities / Behavioral HealthJeffrey Kahn Johns Hopkins University EthicsYa Chen Tina Shih MD Anderson Cancer Center Health EconomicsTimothy Coetzee National Multiple Sclerosis Society Patient EngagementMargaret Anderson Faster Cures Patient Engagement
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Agenda
9:45 Panel Discussion: NGS-Based Molecular Diagnostics11:15 Break/Networking11:45 Panel Discussion: Big Data Progress and Challenges1:00 Lunch Break/Networking2:00 RFP 2 Applications: Speed Presentations
• Centennial Hall A• Centennial Hall C/D
4:00 Elevator Pitches/Reception • Centennial Hall C/D
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Steven DubinettEsther FlattoDan GeschwindUta GrieshammerDeborah HermanIndia Hook-Barnard
Iman HussainTheresa O’BrienAnne SkinnerLinda TabaKeith Yamamoto
Thanks
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Thank you to UCLA!
Uta Grieshammer, PhD, Program Director
www.ciapm.org
#CIAPM16