Dr Patrick Dixon Chairman Global Change Ltdhttp://www.globalchange.com

Take Hold of the FutureOpportunities for pharma to meet needs of older people

1 billion children à cities

1 billion children alive today

300 million à cities in China by 2020Real Estate over-supplyCommodity pressures

� IMF - adjusted for Purchasing Power Parity

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>40% WDP Asia by 2015

1 billion over 60s in 10 years

• most are women

Europe Dying

4 couples needed to produce just

one great-grandchild

65% health spend on those over 65

The future is about

EMOTION

Search: know more than your

doctor

Future in developed markets is about performance not wellness

People Want to Look Better• 51% growth in botox treatment• 31% growth laser hair removal• 31% growth in cosmetic surgery enquiries

Brain Faster – and better?

may be

BrandTrustedNatural

Obesity Epidemic

�1 in 3 newborn babies in New York will develop diabetes

�Obesity costs US $100bn a year

Interesting Neutraceuticals

�Resveratol�Broccoli (sulforaphane)

�Flavonoids�Beta-carotene�Anthocyanins

�Alpha-linoleic acid�Glucosamine�Chondroitin�Ginseng�Garlic oil

Global Sales Nutraceutical Ingredients $24 Billion by 2015China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group)

�Click to edit Master text styles

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$100 for 1.7-ounces

Alzheimers: Souvenaid

�Souvenaid clinical trial�Multi-nutrient drink �MIT collaboration

Worn out Mitochondria – Energy Boost

R-alpha-lipoic acidAcetyl-L-carnitine

Computer-aidedClinical Decisions:

Safer - Less lawsuits

•Ottawa Hospital, Ontario, Canada - 3,000 iPads.

•Mayo Clinic - 10,000 iPhones and 2,000 iPads

Virtual Medicine

90% in US want to view test

results before their doctor

Mayo Clinic

2 million visitsevery month

Read Human Genome in an Hour • Fluidics• Biochemistry• Semiconductors• Genetics• Mathematics• Immunology• Robotics

Home Tele-Monitoring

Home Tele-Monitoring Ecosystem

• Diabetes, congestive heart failure, obstructive pulmonary

• 2.2 million at home

• > $22bn by 2015

• Mobile telephony

• swallow smart pill

• relays info about gut

• sensor-enabled tablets

• check if medication taken

Smart Tablet Startups

EU 8bn in UK alone

Independent Living

MobilityComfortSupportSafety

Faster healing

Can we stop ageing ?

Treatment which restores and maintains the youthful elasticity of

hardened arteries – and helps

Monkeys on diet live longer• After 20 years - 80% alive v 50% on normal calories• Less cancer, diabetes, heart disease, strokes, brain decay

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Slow or no ageing is a reality

• Rockfish, Turtles, some Whales

• No signs of getting old

IrrationalRationing

Rationing all government budgets Health competes with ....Specialties competeDiseases / Patient groupsTreatment methods

Individuals also rationhealth v food v heat vholidays v clothes

Competition

Summary - Pharma and Ageing�Many new opportunities�See through older eyes�Connect with emotion�Timing is everything�Events + decisions

�Performance - wellness

�Diagnostics �Home monitoring�Neutraceuticals�Save treatment costs�Improve mobility�Prolong independence

Ageing remedies with real evidence will be tomorrow’s blockbusters

Dr Patrick Dixon Chairman Global Change Ltdhttp://www.globalchange.com

Take Hold of the FutureOpportunities for pharma to meet needs of older people