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Edema
Brad Anawalt, MDVA Puget Sound
University of Washington
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Types of edema
• Dependent bilateral edema (usually“pitting”)
• Lymphedema
• Localized edema
• Myxedema
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Pitting dependent edema: causes
• Decreased serum protein
• Increased systemic venous pressure
• Capillary edema (increased permeability)
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Edema due to hypoalbuminemia: common causes
• Impaired protein synthesis– Decreased protein intake: starvation, kwashiokor– Decreased absorption of proteins: malabsorption– Impaired hepatic synthesis due to liver disease
• Increased loss of protein– Skin loss: burns, weeping skin diseases – Urinary loss: nephrotic syndrome – Fecal loss: bowel disease
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Edema due to venous pressure: common causes
• Systemic venous hypertension– Congestive heart failure– Pericardial diseases, tricuspid valve disease
• Regional venous hypertension– Inferior vena cava syndrome– Venous thrombosis– Lower extremity venous insufficiency
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Edema due to capillary permeability
• Vasculitis
• Idiopathic cyclic edema of women– Varies with menstrual cycle
• Post-anoxic encephalopathy
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Pitting recovery time
• Technique:– Press firmly to bone– Shine light and determine time to resolution of
shadow
• Interpretation– Acute edema (< 3 months)– < 40 seconds associated with low serum albumin
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Rapid pitting recovery: < 40 seconds• protein synthesis
– protein intake: dietary history– absorption of proteins: diarrhea– hepatic synthesis due to liver disease:
• History: alcohol, other hepatotoxins, hepatitis• Physical findings: spider angiomata
• loss of protein– Skin loss: skin lesions such as burns, ulcers– Urinary loss: foamy urine with high protein– Fecal loss: diarrhea, sticky, oily stools
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Edema with rapid pitting recovery:evaluation of etiology
• Impaired protein synthesis– protein intake: starvation, kwashiokor – absorption of proteins: malabsorption– hepatic synthesis due to liver disease
• Increased loss of protein– Skin loss: burns, weeping skin diseases – Urinary loss: nephrotic syndrome – Fecal loss: bowel disease
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Slow pitting time (> 40 seconds)normoalbuminemic edema
• Systemic venous hypertension– Congestive heart failure– Pericardial diseases, tricuspid valve disease
• Regional venous hypertension– Inferior vena cava syndrome– Venous thrombosis– Lower extremity venous insufficiency
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Venous hypertension & edema:systemic vs regional
• Systemic venous hypertension– Elevated neck veins– Abdominojugular reflux and third heart sound
in heart failure
• Regional venous hypertension– Neck veins not elevated– No abdominal reflux, third heart sound
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Regional venous hypertension: Venous insufficiency vs obstruction
• Venous insufficiency– Common– Bilateral– Chronic
• Associated with hemosiderin deposition
• Venous obstruction– Often unilateral:
• Baker’s cyst, venous thrombosis– Acute (< 3 months)
• Not associated with hemosiderosis
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Characteristics of venous insufficiency
• Dependent edema: lower extremities, perineum– May be asymmetric– Often tender– Usually chronic or recurrent
• Associated with hemosiderin deposition– Ulceration often occurs
• Treatment– Elevation– Exercise to improve venous return– Diuretics– Compression +/- topical corticosteroids
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Signs of systemic venous hypertension
• Elevated neck veins– More than 3 cm above the angle of Lewis
• Angle of Lewis = sternal angle
– Abdominojugular reflux• Suggests congestive heart failure• Press for 10 seconds firmly on abdomen• If neck veins fall after relief of pressure, then
suggests congestive heart failure
– Third heart sound• Listen with bell of stethoscope• Suggests congestive heart failure
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normoalbuminemiahypoalbuminemia
Overview of pitting edemaPitting edema
< 40 sec > 40 sec
Decreased protein synthesis Increased protein loss
Venous hypertension
Elevated neck veins
Systemic: cardiac disease
Venous insufficiency or obstruction
no yes
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Treatment of fast-recoveringpitting edema
• hypoalbuminemic (<40 seconds)– Treat malnutrition– Treat underlying cause of malabsorption– Treatment of edema due to cirrhosis
• Judicious use of diuretics and aldosterone antagonist can alleviate edema
– Treat protein loss• Skin or fecal loss: treat underlying disease• Urinary loss: angiotensin-converting enzyme
inhibitor
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Treatment of slow-recoveringpitting edema
• normoalbuminemic ( > 40 seconds)– Treat congestive heart failure
• Bed rest and elevation of legs useful for acute edema
• Loop diuretics, digoxin, angiotensin-converting enzyme inhibitor, beta blocker if tolerated
– Treat venous insufficiency• Diuretics, compression, leg-elevating exercises
– Treat underlying obstruction of veins• Anticoagulants, leg elevation for thrombosis
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Lymphedema: nonpitting edema
• Protein-rich edema due to abnormality of lymphatic drainage
• Characteristics– Nontender, painless– Does not vary much during the day– Ulceration rare– Hyperkeratosis, thickening of skin
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Lymphedema: causes• Upper extremity
– breast cancer or surgery/radiation for breast cancer
– Newborn baby, Turner’s syndrome (X0)• Lower extremity
– Idiopathic: aplasia/dysplasia of lymphatics• 3 types: congenital, praecox, form tarde• Associated with yellow nails, pleural effusions
– Secondary• Inflammatory• Obstructive
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Lymphedema: secondary causes• Inflammatory
– Tropical: filariasis + recurrent strep infection– Nontropical: recurrent streptococcal cellulitis
• Obstructive– Unilateral in 95%– Usually due to malignancy– Prostate cancer most common in men– Lymphoma most common in women– Any pelvic tumor or major pelvic surgery
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Lymphedema: complications• Infection
– Recurrent cellulitis, lymphangitis– Lymphangiosarcoma
• Starts as nonhealing bruise
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Lymphedema: treatment • Fluid mobilization
– Diuretics– Elevation– Exercise– Compressive, elastic stockings– Massage
• Control of infection– Treatment of dermatophytes– Prophylaxis against streptococcal infections
• Amoxicillin, amoxicillin/clavulanate
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Lymphedema: treatment #2• Other therapies
– Coumadin• Stimulates cutaneous macrophages and local
proteolysis• Might be effective with topical administration• Reduces edema ~55%
– Flavenoids• Water soluble vitamin
– Surgery• liposuction
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Miscellaneous causes of edema• Hot days: bilateral edema due to venous pooling +
compensatory salt and water retention (aldosterone)• Localized edema
– Facial edema• Trichinosis, hypothyroidism, allergies, nephrotic
syndrome• Pretibial myxedema from Graves’ thyrotoxicosis
• Neurogenic edema• Lipedema
– adiposity of the legs• Pseudothrombophlebitis
– A form of unilateral edema with elevated venous pressure due to a popliteal cyst
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Summary of lower extremity edema• Key questions:
• Are both legs edematous?
• Is it pitting edema?
• Is the edematous area tender or painful?
• Are the neck veins elevated?
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normoalbuminemiahypoalbuminemia
Overview of bilateral pitting edemaPitting edema
< 40 sec > 40 sec
Decreased protein synthesis Increased protein loss
Venous hypertension
Elevated neck veins
Systemic venous hypertension:
cardiac disease
Venous insufficiency or obstruction
no yes
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Unilateral lower extremity edemaUnilateral
Edema
Nonpitting Nontender
Lymphedema: obstruction due to filariasis, recurrent strep infection, malignancy
Pitting Tender
Thrombosis Baker’s cyst
Acute cellulitis
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Bilateral lower extremity edemaBilateral Edema
Pitting Tender
Cardiac edema
Low protein
state
Venous insufficiency or occlusion
Nonpitting Nontender
Lymphedema Venous hypertension
Elevated neck veins?
YES NOsynthesis
loss
FastSlow
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Case #1
A 55 year old man with a history of heavy alcohol use complains of unilateral edema for one week. On exam he has pitting edema of his left leg below the knee. His left leg is tender. The skin of legs is not hyperpigmented.
The likely diagnosis is a. Cirrhosisb. Filariasisc. Deep venous thrombosisd. Prostate cancere. Congestive heart failure
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Case #1 answer
A 45 year old man with a history of heavy alcohol use complains of unilateral edema for one week. On exam he has pitting edema of his left leg below the knee. His leg is tende. The skin of legs is not hyperpigmented.
The diagnosis is likely to be deep venous thrombosis (c) or cellulitis. The edema is unilateral (congestive heart failure and cirrhosis are unlikely) and tender (lymphedema from malignancy or filariasis is unlikely).
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Case #2
A 45 year old man with a history of heavy alcohol use and hepatitis complains of bilateral edema for two months. On exam he has pitting edema of his legs below the knee. Pitting resolves in 1 minute. His neck veins are elevated.
The likely diagnosis is a. Cirrhosisb. Filariasisc. Inferior vena cava obstructiond. Prostate cancere. Congestive heart failure
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Bilateral lower extremity edemaBilateral Edema
Pitting Tender
Cardiac edema
Low protein
state
Venous insufficiency or occlusion
Nonpitting Nontender
Lymphedema Venous hypertension
Elevated neck veins?
YES NOsynthesis
loss
FastSlow
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Bilateral lower extremity edemaBilateral Edema
Pitting Tender
Cardiac edema
Low protein
state
Venous insufficiency or occlusion
Nonpitting Nontender
Lymphedema Venous hypertension
Elevated neck veins?
YES NOsynthesis
loss
FastSlow
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Case #2 answer
A 45 year old man with a history of heavy alcohol use and hepatitis complains of bilateral edema for two months. On exam he has pitting edema of his legs below the knee. Pitting resolves in 1 minute. His neck veins are elevated.
The likely diagnosis is congestive heart failure (e). He has bilateral edema with slow pitting (> 40 seconds) and neck veins are elevated.
Bonus: What additional physical findings would be useful to elicit?
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Case #3
A 55 year old woman complains of right lower extremity edema for one month. The leg was previously normal. On exam she has nonpitting edema of the right leg. It is nontender, and there is no hyperpigmentation.
The most likely diagnosis isa. Baker’s cystb. Inferior vena cava obstructionc. Chronic venous insufficiencyd. Lymphomae. Congestive heart failure
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Case #3 answer
A 55 year old woman complains of right lower extremity edema for one month. The leg was previously normal. On exam she has nonpitting edema of the right leg. It is nontender, and there is no hyperpigmentation.
The most likely diagnosis is lymphedema due to lymphoma (d). She has nontender unilateral edema. Therefore, causes of bilateral edema (congestive heart failure and inferior vena cava obstruction) are unlikely. A Baker’s cyst will cause tenderness and pitting edema. Chronic venous insufficiency is unlikely given the acute presentation and is usually associated with hyperpigmentation.
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Unilateral lower extremity edemaUnilateral
Edema
Nonpitting Nontender
Lymphedema: obstruction due to filariasis, recurrent strep infection, malignancy
Pitting Tender
Thrombosis Baker’s cyst
Acute cellulitis
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Unilateral lower extremity edemaUnilateral
Edema
Nonpitting Nontender
Lymphedema: obstruction due to filariasis, recurrent strep infection, malignancy
(lymphoma in woman)
Pitting Tender
Thrombosis Baker’s cyst
Acute cellulitis
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Edema references
Sapira JD. The Art & Science of Bedside Diagnosis. Williams & Wilkins, Baltimore, 1990.
Rockson SG. Lymphedema. Am J Med. 2001;110:288-295.Wiese J. The abdominojugular reflux sign. Am J Med.
2000;109:59-61.McGee SR. Physical examination of venous pressure: a
critical review. Am Heart J. 1998;136:10-18.Henry JA, et al. Assessment of hypoproteinaemic oedema: a
simple physical sign. Br Med J 1978;890.