Inorganic Ion Transport

2

2

2

Ubiquinol

thiL

2

5

Cofactor Biosynthesis

Riboflavin

Molybdenum Synthesis

3

Heme Biosynthesis

4

Lipoate

dead end

2

NAD/NADP Metabolism

Fe-S clusters

ATPSynthase

3

2

CoA

33

dead end

Biotin

Enterochelin

Converted to GLX

8

Vitamin B12

Transhydrogenase

2

Thiamin

2

(see Central Metabolism Map)Menaquinone

methionine synthase

Vitamin B6

2 2

Folate2

33

Isoprenoid

atp

lipoate[e]

adocbip

h[p]

h[p]

h

adp

adp

pi

h2o

pydam

g3p

h

gbbtn[p]

adp

10fthf

h

h

nmn[p]

h[p]

dad-5

h

etoh

nadh

co2

adp

amet

2dhp

dhnpt

atp

rdmbzi

atp

h

nh4

lac-L[e]

ppi

nadph

h

h[p]

o2

nad

h

h

amet

h

adp

pi

dxyl

sufse

crnDcoa

glyclt

h

gtp

h2o2

4fe4s

atp

ahdt

ppi

pi

nadh

atp

6pgc

h2o

nadh

h2o

for

pheme[p]

thmnp

pi

pppi

cys-L

4adcho

adp

mql8

h2o

atp

fe3

ni2

lipopb

pi

iscssh

h2o

h2o

h

ppi

co2

atp

amp

atp

na1

5drib

h2o

23dhb

h

co2

h

h

nadp

g3p

adp

bmoco1gdp

sufbcd

nadph

h

pi

pydxn[p]

bglycogen

bbtcoa

coa

mn2[p]

4hthr

fum[e]

thf

fmnh2

mg2

h

pi

btn[e]

ala-L

h

nadh

h

hcys-L

atp

coa

h2o

glc-D[p]

h

pmeACP

fe2

co2

ppi

mobd[p]

h[p]

ppi

h

h

pyr

pi

nad

h2o

adp

5apru

akg

6hmhptpp

fru[e]

h2o

adp

12ppd-R

h

dhpmp

h2o

for

h

h

h

octa

dhpt

amp

h

atp

h

ac[p]h

pan4p

fe2

ctp

nadp

pi

h

h

na1[p]

nadp

h[p]

for

nadp

h2o

nad

ppi

gcald

ppi

atp

nh4

h[p]

h

h

adp

pi

mptamp

octapb

bwco1gdp

adp

ppi

nadp

fadh2

h2o

nad

adpglc

atp

q8h2

accoa

h

h2o

ichor

4r5au

h

q8

h

dmbzid

co2

pi

co2

nadp

3pg

nadh

co2

atp

h2o

glyclt[p]

co2

glu-L

h

h2[p]

gmp

cmp

h2o

pyr

ade

cobalt2[p]

pi

2tpr3dpcoa

nad

ppi

nadh

adp

cu2

atp

atp

asp-L

k[p]

h2o

h

fum

fe2

h

succ

h

h

h2o

dhgly

xyl-D

h

for

h2o

h2o

pi

h

nad

h

mobd[e]

f6p[p]

nadph

h[p]

h2o

gtp

h2o

h2o

ppi

5mthf

pi

nadp

nac

h[p]

co2

pyr[e]

pi

akg

pi

g1p[e]

h

co2

h2o

adp

ribflv

tyr-L

ahcys

atp

atp

4mhetz

atp

acald

ctbt[p]

h

pydxn

h

h

2dmmql8

atp

g6p

h

h[p]

amet

h2o

ACP

co2

atp

o2

h

atp

frdp

lac-D[p]

adp

pi

iscssh

cpmp

14dhncoa

nad

h

h

pi

pyr

ppi

for[e]

h

crn[e]

glutrna

h

h

h

h

h

adp

h

h

cu2

glyc[e]

h

ppi

mg2[p]

fum

h2o

pi

h2o

nh4

pi[p]

co2

pi

iscssh

h2o

glu-L

cph4

g6p[p]

h

adp

h[p]

atp

prpp

h2o

fadh2

h

ppi

mlthf

h2o

h

h

mg2[e]

r5p

cu2

iscu

fad

atp

h

ala-L

ipdp

nadph

h2o

coa

h2o

2me4p

h

h

adp

opmeACP

gbbtn

lipoate[p]

cobalt2

h

h

pi

moco

h

cpppg3

2oph

h2o

fe2

pi

pdx5p

nad

h

atp

nadph

nadp

sufbcd-2fe2s2

h

coa

2dmmq8

atp

pih2o

gtp

5aop

pi

nadh

h[p]

h

5prdmbz

crn-D

iscu

2fe1s

nadh

mqn8

ncam

na1

crn-D

co2[p]

h

adocbi

nadp

atp

h

nicrnt

ppi

h

h

ppi

nadph

co2

pi

h2o

2sephchc

2mecdp

amp

atp

cbl1[e]

h2o

adp

co2

sufbcd

ppi

cit[p]

nadh

adprib

atp

cu2[e]

h2o

nad

adp

nadp

ppi

h2o

q8h2

nad

2pg

bwco

23ddhb

pi

h

co2

h2o

mpt

atp

cl[p]

nad

h2o

adp

h2o

adp

pi

pi

co2

5fthf

nmn[e]

agdpcbi

h[p]

fe2

iscs

h

nh4

h

2omhmbl

h

cdg

ahcys

h[p]

pnto-R

h2o

adp

q8

cl

pep

adp

coa

akg

h[p]

ahcys

adp

glyc3p[e]

nad

co2

nadp

coa

pi[p]

2fe2s

amet

sufsesh

2fe2s

amp

23dhba

h

h

h[p]

nad

atp

f1p

h2o

dhap

nmn

nadh

h2o

adp

nad

co2

fadh2

h

acald

ppi

o2

h2o

h2o

acon-T

adp

h

h[p]

nadp

nadp

mal-L[e]

pi

ni2[e]

h2o2

nadh

h2o

h2o

h

h2o

mql8

pep

pi

iscu-2fe2s2

pi

h

pi

cu2

ppi

h2o

atp

h

h

h

h

ocACP

glu-L

h2o

adp

g6p[e]

pyr

meoh[e]

h2o

rib-D[e]

h2o

co2

amet

atp

nadh

h

nad

h

gtp

h

ppi

lac-D[e]

mobd

adp

for

nad

co2

h

atp

btn[p]

nadph

glyc

dmpp

h

h

fadh2

f6p

bwcogdp

nad

h

amp

h[p]

h[p]

h2o2

pyr

dhf

h ppi

pydam[p]

nadph

h2oppi

pppi

amp

adp

h

ppi

pi

lipoamp

h

nad

h

adp

amp

h[p]

ctp

h2o

h

h2o

h

icit

h[p]

h2o

pi

atp

nad

cbi[p]

amp

h

ppi

mn2[e]

2fe2s

atp

acald[e]

pydx

pi

amet

h

nh4

lac-D

ac

fe2

h2o

oaa

atp

h

h[p]

h

bmoco

h

4hbz

h[p]

ppi

2ohph

h

fadh2

fe2

h2o

nadph

5aprbu

quln

h

atp

ade

h2o

2dmmql8

ala-B[p]

preq0

mql8

iscu-2fe2s

sufse

h

adp

coa

h2o

o2

cu[e]

malACP

nadh

6hmhpt

ogmeACP

pi

thmmp

nadh

atp

h

h

akg[p]

h

nad

adp

ppi

fad

sufbcd-2fe2s

atp

atp

h

acon-C

h

nadh

moadcoo

k[e]

nadh

cu

pydx5p

ru5p-D

glu1sa

mthgxl

nadph

2fe1s

thm

h[p]

h

adocbl[e]

for

ppi

glyc3p

cbl1[p]

h2o

lald-D

adp

btn

ahcys

h

nad

h

nadh

ca2

ala-D

pyr

adp

h

nad

amp

ac[e]

h

h2o

h

atp

nh4

h2o

h[p]

nadph

h

succ

nadph

uppg3

tungs

h

cbi

h

h2o

nadph

h

nicrnt

pi

co2

h2o

coa

nad

h

h

flxr

atp

h[p]

nadp

pi

h2o

nad

atp

h

co2

nad

h2o[p]

ppi

udcpdp

h[p]

nadph

h

fadh2

wco

akg[e]

s17bp glu-L

o2

iscssh

atp

hgmeACP

h

pi

4crsol

h2o

nadp

fad

co2

h

atp

pap

pi

ppbng

adp

ppi

o2

na1[p]

glyclt[e]

amp

lac-L[p]

adp

adp

h

h2o

amet

h2o

fadh2

accoa

pnto-R[e]

h[p]

h

ctp

lac-L

sufbcd

o2[p]

h

h

h[p]

nadp

nadh

adp

zn2

succ[e]

dmlz

h2o

nadh

h

pi

succ[p]

h

pheme[e]

amp

nadh

h

h

h

adp

h

na1[p]

4ampm

h2o

nadh

h

h

adp

aconm

h[p]

fe2

nadh

for[p]

h

tungs[e]

thmpp

ca2[e]

nadph

nh4

13dpg

nadp

h2o

pi

h2[e]

moadamp

h

h

xyl-D[e]

thm[e]

moadcosh

h

dtbt

nadh

h

crn

adp

na1

fru[p]

atp

mptamp

mqn8

nh4

mal-L[p]

atp

pi

meoh

dhmpt h

ahcys

dhna

h

h

iscs

h2o

adp

ACP

adp

adp

atp

glyc3p[p]

h

h

5drib

ppi

4fe4s

atp

atp

h

o2

h2o

nh4

pi

amp

air

atp

h2o

adp

amp

iscu

h

atp

h2o

h[p]

atp

h

cl[e]

pep

h

23dhbzs

h

fum[p]

amp

iscs

enter

h

pyr

pep

pheme

atp

nad

coa

h

atp

pi

h

adp

nad

12ppd-R[p]

h

ru5p-D

h

atp

nad

h[p]

nadh

s7p

h

etoh[p]

chor

h[p]

nadph

ni2[p]

ala-L

ppi

gtp

prpp

3ophb

amob

h

pyr

nadh

nadh

pydx[e]

sucbz

amp

lgt-S

cbi[e]

gbbtn[e]

h2o

h

btnso

nadph

h

pyr

pyr

gtp

amet

h

e4p

h2o2

atp

pyr

sbzcoa

atp

2mahmp

h

sufbcd-4fe4s

atp

apoACP

cys-L

bmocogdp

mql8

malcoa

3mob

h

8aonn

ctbtcoa

atp

nad

nad

h2o

atp

pi[p]

h[p]

ohpb

dhmptp

h

h[p]h2o

coa

ppi

actp

nadh

nadp

ACP

adp

nadp

atp

no

h2o

sufbcd

h2o

adp

atp

nadp

h

h

scl

pi

pih2o

crn-D[e]

h

4ppcys

dxyl5p

xyl-D[p]

dnad

h

h

nadph

pi

adp

h

fad

atp

adp

h

nadh

adp

pnto-R[p]

na1[e]

gtp

h

iscu-4fe4s

atp

fdp

ACP

pi

2ommbl

h

h

h

h

h

amet

2fe1s

h2o

pep

dhap

coa

fe3

ser-L

q8

gln-L

h

sheme

h

atp

h

pydam[e]

h

h2

ppi

h

4c2me

amp

h

adp

n2o

meoh[p]

co2

h

succ

fmn

h

h2o

ala-B

h

h[p]

h2o

ppp9

pi

h

h2o

ppi

h

h2o

h2o

dad-5

h[p]

atp

adp

h

pi

h2o

succoa

lipoate

atp

glx

2p4c2me

xu5p-D

h2o

cbl1

ppi

h[e]

h2o

h

dad-5

gthrd

asp-L

pi[p]

nac

mocogdp

4mpetz

h2o

octdp

egmeACP

atp

pydxn[e]

dha

ahcys

gly

adocbl

nad

pi

mql8

h[p]

h

dpcoa

seramp

trnaglu

iasp

iscs

pi

nad

h

adp

pi

amet

nadp

o2

zn2[p]

fad

cu2

h ppi

pi

h2o2

2shchc

sufsesh

dscl

co2[e]etoh[e]

h

glycogen

f6p[e]

nad

co2

cu2

pppi

h

25drapp

o2

pyr

atp

q8

6pgl

h2o

atp

iscu

4abz

pimACP

met-L

adp

h

r5p

4per

h

2omph

pyam5p

dann

dxyl5p

nadp

cu2[p]

succ

hmbil

grdp

h[p]

ppi

h2o

h

adp

nadph

adp

nadp

r5p

coa

h[p]ca2[p]

gmeACP

ac

dad-5

ala-B[e]

h

mqn8

tungs[p]

q8h2

mlthf

nad

atp

3fe4s

adocbl[p]

h2o

epmeACP

succ[p]

h

h

nadp

nadh

h

preq1

h

12ppd-R[e]

mn2

h

2ddg6p

ala-L

hemeO

nadh

h[p]

cobalt2[e]

cmp

adp

h

coa

h

zn2[e]

h2o[p]

mococdp

glyc[p]

nadp

nadph

atp

ahcys

g1p[p]

met-L

cit

nadh

h2o

nad

h

h

adp

pi

e4p

amp

athtp

q8h2

pi

h

hpmeACP

met-L

fad

db4p

h

crn[p]

h

h

nadph

atp

amet

adp

glc-D[e]

pi

ade

adp

h2o

methf

h[p]

k

h

amet

nadh

coa

ppi

gtp

fad

pi

nadh

h2o

pi

ppi

nadph

h2o

adp

rbflvrd

h

adp

atp

phthr

h

mal-L

co2

pyr[p]

glc-D

cu[p]

acald[p]

co2

4ppan

h2o

h

pi

pi

pi

pi

flxso

nadh

h2o

crn-D[p]

nadph

atp

adp

pydx[p]

nadp

malcoame

xylu-D

h

thm[p]

atp

atp

adp

fum

h

pi

atp

4ahmmp

pant-R

h

h

h2o

h

malACP

h2o

h2o

g1p

pppg9

atp

h

co2

atp

thf

nadph

nadph

h

adp

cit[e]

h2o

h[p]

atp

met-L

rib-D

mqn8

crn-D[p]

coa

rib-D[p]

atp

2ombzl

atp

ppi

h

h

for

crncoa

h

h

h2mb4p

nad

atp

q8h2

h

h2o

atp

ctbt

GLCtex

ADOCBLtonex

L-LACD2

MECDPDH5

BMOGDS2

XYLK

MALt2_3pp

OPMEACPS

CPH4S

G6PP

DHFS

H2tex

OCTNLL

FBA3

BTNtex

GLCptspp

CO2tex

DXPS

FESR

FADRx2

FORtppi

COBALT2tex

GLYCL

F6Ptex

NADDP

UDCPDPS

CUtex

FADRx

MTHFD

NADS1

CRNDCAL2

GLCP

RPE

ICHORS

MN2tpp

G6Pt6_2pp

AOXSr2

PPCDC

OPHHX3

OPHBDC

2MAHMP

OGMEACPD

CTBTCAL2

12PPDRtpp

NADN

4HTHRS

FBA

NADK

CLt3_2pp

AKGDH

EGMEACPR

EPMEACPR

FLVRx

SHCHCS3

ACKr

GLCP2

OGMEACPR

LDH_D

DHFR

MNt2pp

OAADC

DM_AMOB

PFK_3

OCTDPS

DHNAOT4

MALS

DHBS

PYRtex

FRUptspp

OMPHHX3

FOMETRi

ME2

MG2tpp

DHNPA2r

LCARR

CPPPGO2

E4PD

CRNDt2rpp

ADOCBLabcpp

MALt3pp

UPP3MT

Kabcpp

LIPOt2pp

DPCOAK

HEX1

F6PA

GLUTRS

DB4PS

ADCL

FORt2pp

CBIuabcpp

NI2abcpp

HBZOPT

ACBIPGT

ADOCBIK

S2FE2SS2

DBTS

LIPAMPL

XYLt2pp

SUCCt2_3pp

ACtex

MEPCT

ACONTb

CO2tpp

PYDXtpp

PNTOtex

I2FE2SR

MG2uabcpp

PPCK

CRNDabcpp

NAtex

DHNCOAT

OPMEACPR

ASPO5

MOHMT

CPMPS

I2FE2SS2

GLYC3Ptex

PTAr

BSORy

CBL1abcpp12PPDRtex

G3PD2

DHBSH

ADCS

I4FE4SR

TPRDCOAS

TUNGStex

MTHFR2

ALDD2x

OHPBAT

I2FE2SS

CITt3pp

NI2tex

FCLT

CRNCBCT

OMMBLHX3

ASP1DC

CUt3

CTBTt2rpp

PNTK

OMBZLM

SERASr

IPDPS

HEMEOS

ThDPAT

ALATA_D2

TKT2

MALt2_2pp

MG2tex

ACALD

RZ5PP

GLBRAN2

NMNN

GCALDD

FESD1s

GTPCII2

LALDO2x

DHBD

AMMQLT8

PYK

PYDXNK

AKGt2rpp

MOGDS

G6PDH2r

FHL

ACPS1

GLCptspp

IPDDI

CBLAT

ACALDtex

PYDAMtpp

ZN2t3pp

CRNDtex

MPTS

HMPK1

TALA

DXYLK

FRD3

FORtex

ASPO6

CTBTabcpp

PGK

CU1abcpp

PANTS

NADTRHD

S4FE4ST

MNtex

CITtex

DHPS2

CHRPL

MN2t3pp

L-LACtex

NAt3pp

NMNAT

ETOHtrpp

CBItonex

NNAM

ICHORSi

ADOCBLS

CRNCAR

Kt3pp

CPPPGO

THMabcpp

XYLI1

MG2t3_2pp

D-LACtex

S2FE2SR

FMNRx2

UPP3S

ALCD2x

PYRt2rpp

ZN2abcpp

DHPPDA2

PYDAMK

PERD

DM_5DRIB

GLGC

MPTSS

DNTPPA

CAt6pp

GLCS1

BWCOGDS1

CRNCDH

NAt3_2pp

EDDGLYCtpp

AMAOTr

FRUKFBP

LIPOS

FTHFLi

Kt2pp

CRNtex

XYLtex

TMPK

ASPO4

RIBabcppENTCS

BSORx

SUCBZL

RBK

DMATT

THMtex

LIPOCT

GBBTNtex

PYDXPP

DHAPT

FUMt2_3pp

MALtex

CU2abcpp

FUMt2_2pp

DHMPTR

NNDMBRT

SHCHF

BWCOGDS2

PGM

AMPMS2

GLYC3Pt6pp

G1Ptex

ICYSDS

BMOGDS1

PDX5PO2

PPC

PDX5PS

5DOAN

CRNt7pp

SUCCt3pp

BMOCOS

UPPDC1

FMNRx

LGTHL

SUCCtex

I4FE4ST

OGMEACPS

BALAtex

CRNBTCT

NAt3_1p5pp

CRNCAL2

LIPOtex

MOX

MEOHtex

MECDPS

BWCOS

PPPGO3

ACONTa

GTPCI

CLtex

CITt7pp

DHPTPE

ICL

CCGS

EDA

RBFSb

Zn2tex

ALATA_L2

NNATr

CRNt8pp

NNDPR

CRNt2rpp

D-LACt2pp

COBALT2abcpp

XYLabcpp

CA2t3pp

PYDXK

PYDXtex

DM_4CRSOL

GLYCLTtex

NADPPPS

FRUpts2pp

DPR

I2FE2ST

MOCDS

GLYC3Pabcpp

MGSA

MDH3

G1SAT

OPMEACPD

TUNGSabcpp

SUCCt2_2pp

GLYCLTt4pp

MOBDtex

PYDXNtex

PTPATi

PGL

OMMBLHX

FESD2s

APRAUR

CA2tex

TYRL

MTHFC

THFAT

PGMT

BTS5

ACONMT

MPTAT

HMBS

COBALT2tpp

PDH

GND

AKGtex

GLCt2pp

G3PT

CBIAT

G1PPpp

ICDHyr

TMK

MALCOAMT

SEPHCHCS

CS

PHEMEtiex

PMPK

MDH

CU1Opp

PPPGO

ENO

Ktex

TDP

CU2tex

TKT1

PPNCL2

PGI

GLYK

MOADSUx

PNTOt4pp

ACALDtpp

ZNabcpp

OPHHX

H2tpp

DNMPPA

ASPO3

RBFSa

DHNPTE

NMNtex

GRTT

FRUtex

ZN2tpp

HPPK2

L-LACt2rpp

NI2tpp

SCYSDS

CDGS

NMNDA

FUMtex

DMQMT

ATPS4rpp

PHEMEabcpp

HETZK

ALDD2y

PMEACPE

L-LACD3

F6Pt6_2pp

SUCBZS

NMNt7pp

PFK

CU2tpp

CITL

NAMNPP

S2FE2SS

PYDAMtex

PDXPP

RPIRIBtex

COBALT2t3pp

MOCOS

LIPATPT

FUM

MDH2

THD2pp

CDGR

FRD2

G6Ptex

RBFK

S2FE2ST

QULNS

GLYCLTt2rpp

HYPOE

GAPD

GLDBRAN2

DXPRIi

MOBDabcpp

ETOHtex

TMPPP

CDPMEK

BTNt2ipp

5DOAN

ACONIs

CBL1tonex

DHNCOAS

SUCOAS

CRNabcpp

PYDXNtpp

PDX5POi

NI2t3pp

ACS

NMNPtpp

WCOS

OHPHM

PMDPHT

ICHORT

TPI

GLYCtex

FTHFD

BALAt2pp

DMPPS

ACt2rpp

ME1

FLVR

PYAM5PO

GLYOX

OMPHHX

SHCHD2

S4FE4SR

SUCDi

PPBNGS

FMNAT

MEOHtrpp

GLUTRR

THZPSN3

PPS

NI2uabcpp

PFL

GLYCDx

Central Metabolism

Figure S4