Download - Atherosclerosis
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maryam al-qahtani Group: 6Case 1 A
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Introduction
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Learning Objective
Risk factor of atherosclerosis ? How
are they regulate ?
How do they risk factor contribute
to the pathogenesis of
atherosclerosis? (Summarize)
Clinic manifestations of
atherosclerosis .
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Risk factor:
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Permanent factors
Co-existing conditions
Lifestyle, social and environmental
factors
Risk factor:
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Age:
1
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Gender:
MaleFemale
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Family history
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High blood pressure
Diabetes
Hyperlipidaemia
2
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Cigarette smoking
Overweight or obesity
3
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Sedentary lifestyle:low physical exercise
High stress
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Control (regulate)
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Risk Factors
UncontrollableUncontrollable
•Sex
•Hereditary
•Race
•Age
ControllableControllable
•High blood pressure
•High blood cholesterol
•Smoking
•Physical activity
•Obesity
•Diabetes
•Stress and anger
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pathogenesis
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4 main stages :
1. Chronic endothelial injury
2. Accumulation of lipoproteins
3. Resultant Inflammation & Factor release
4. Smooth muscle cell recruitment, proliferation and
ECM production.
pathogenesis
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Chronic endothelial injury1
increased endothelial permeability
enhanced leukocyte (monocyte and T lymphocyte ) and platelet adhesion
Monocyte migrationlesions
Endothelial dysfunction
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Smooth muscle cell recruitment, proliferation and ECM production.
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Finally
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Summary
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Clinical manifestations
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Pain and severe cramp in the right calf on exercise
Absent pulses of the right arterioles of the right foot and ankle.
Bruits over arteries
Dry skin
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Low skin temperature of the right foot.
Atrophy
lack of hair on right lower leg and foot
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Summary
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Reference
• Clinic medicine book• Merck Manual book• http://sphweb.bumc.bu.edu/otlt/MPH-Modules/PH/PH709_H
eart/PH709_Heart3.html• http://www.slideshare.net/slideshow/embed_code/11843653• http://www.merckmanuals.com/home/heart_and_blood_ves
sel_disorders/atherosclerosis/atherosclerosis.html#v1652416• http://www.nhlbi.nih.gov/health//dci/Diseases/Atheroscleros
is/atherosclerosis_risk.html
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Good lifestyleHealthy life
Thank
you…