A Walk Around the Intuvo
Simon JonesGC Application Scientist
February 13, 2019
February 13, 20191
• Easier
• Faster
• Smaller
• Smarter
• Greener
2
Innovating a New Path to GC Productivity
A whole new way to GC
3
Direct
heating
Innovating a New Path to GC Productivity
A whole new way to GC
4
No-trim
column
Direct
heating
Innovating a New Path to GC Productivity
A whole new way to GC
Innovating a New Path to GC Productivity
A whole new way to GC
5
No-trim
column
Direct
heating
Ferrule-free click-and-run
connections
6
Disposable
Intuvo
Guard Chip
No-trim
column
Direct
heating
Ferrule-free click-and-run
connections
Innovating a New Path to GC Productivity
A whole new way to GC
7
Disposable
Intuvo
Guard Chip
No-trim
column
Direct
heating
Modular
Intuvo Flow Chips
Ferrule-free click-and-run
connections
Innovating a New Path to GC Productivity
A whole new way to GC
A New Portfolio of GC Consumables
UI inlet linersGuard Chip
No-trim
column
Flow
Chips
Smart keys
Tools and
accessories
Intuvo Smart KeysSelf aware
• Flow Chips and columns
• Smart: informs how Intuvo is configured
• Easy: sets method context and parameter defaults – no complex calculators needed
9
Flexible Compatible DesignConfigurable to many applications
• SSL, MMI, GSV, LSV inlets
• FID, TCD, ECD, NPD, FPD, NCD, SCD detectors
• SQ and TQ mass spectrometers
• Headspace, thermal desorption, purge and trap samplers
• 16-, 50-, 150-position autoinjectors and trays
• Software: Agilent OpenLab and MassHunter
10
Comparing the Agilent 7890 GC with the Intuvo 9000 GC
7890 Intuvo
Footprint (H × W × D) in
Inches
19.2 × 22.9 × 20.2 20 × 10.7 × 27.2
Power Consumption 2,250 VA standard (2,950 VA /220) 1,296 VA standard (1,548 VA / 220)
Oven Ramp Rate Temperature
Range (°C)
120 V
Oven
Fast Oven Fast oven
with Pillow Maximum achievable temperature
ramp rate: 250 °C/min50 to 70 75 120 120
70 to 115 45 95 120
115 to 175 40 65 110
175 to 300 30 45 80
300 to 450 20 35 65
Oven Cooling Rate
Oven cool down (22 °C ambient) 450 to 50
°C in 4 minutes (3.5 minutes with oven
insert accessory)
Oven cool down (22 °C ambient)
450 to 50 °C in less than 3 minutes
Heat Dissipation
Standard oven ramp
7,681 BTU / hour
maximum 120 V
4,424 BTU /
hour maximum
Fast oven ramp 10,071 BTU / hour
maximum 200 to 240 V 5,285 BTU /
hour maximum
11
Smaller Footprint
12
10.7” 22.9”
New Heated Zones
13
Guard Chip
Bus
Intuvo with MSD, FID, and Postcolumn Backflush
14
Mini-Bus
What ‘Can’ it Do?
One inlet (SSL or MMI)
Two detectors
can split 1:1 between detectors – including MSD
Column limitation of 60 m total, max ID of 0.32 mm
Midcolumn backflush
Postcolumn backflush
15
Innovating the GC Flowpath
16
To detector
Conventional
flowpath
Inlet
Gold seal
Nuts and ferrules
Classic capillary
column
Innovating the GC Flowpath
17
To detector
Conventional
flowpath
Intuvo
flowpath
Inlet Inlet
Guard Chip
Gold seal
Nuts and ferrules
Classic capillary
column
Innovating the GC Flowpath
18
Click-and-run
direct
connections
To detector
To detector
Conventional
flowpath
Intuvo
flowpath
Inlet Inlet
Guard Chip
Intuvo planar
column
Gold seal
Nuts and ferrules
Classic capillary
column
Flow
Chip
Modular Intuvo Flow ChipsHigh-purity inert silica flowpath
• Inert
• Modular, configurable
• Click-and-run connections
19
Intuvo Flow Chip
cross section
Thermally conductive
proprietary alloy
High-purity
silica channel
Intuvo Ultra Inert
treatment
Carrier
gas
Guard/Jumper Chips
20
Roughly 0.75 m × 0.53 mm ID
Click-and-Run Direct ConnectionsEliminating connection uncertainty
• No more ferrules
• Direct face seal connections
• Audible and tactile click lets you know connection is made
• Easier to train
• Less unplanned downtime
• Fewer batch reruns and precious samples lost
22
Intuvo Flow Chips – Installation Distance Always Perfect
No more:
- measuring
- overtightening
- trimming
Intuvo Inert FlowpathOptimized for active compounds
25
5 ppb injection of pesticide mix
TQ MRM transitionsChrysene-d12
EPN
Pyroclostrobin
Perylene-d12
Phosalone
Coumaphos
Agilent 7000 triple
quadrupole GC/MS
Intuvo Graphical User Interface
• System status
26
Intuvo Graphical User Interface
• System status
• Real time chromatograms
27
min.0.6 0.8 1.0 1.2 1.4 1.6 1.8
pA
0
500
1000
1500
2000
2500
3000
Intuvo Graphical User Interface
• System status
• Real time chromatograms
• Finding parts fast
28
ReplaceInletLiner
FindInletParts
InletLinerPartNumber8001-
0101
Intuvo Graphical User Interface
• System status
• Real time chromatograms
• Finding parts fast
• Step-by-step user maintenance and troubleshooting
29
Autonomous Leak CheckingAvoiding unplanned downtime
Microfluidic-enabled sixth generation EPC modules allow hands-free leak checking to confirm and document leak-free operation autonomously.
30
Intuvo Graphical User InterfaceInteractive maintenance
31
Remove lock nut and septum
Replace liner
Step 1: Remove lock nut
Maintenance?!
32
You lose the screen as
soon as you open the
door to do the
maintenance!
Remote Access to Intuvo Screen
Access the Onscreen Tools Remotely
Counters Give you Quick System Information
35
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance
Column Maintenance – Automatic Leak Checks!
Column Maintenance – Automatic Leak Checks!
Column Installation
47
It is much easier to
install the column, but
there are still some
‘Gotchas’!
Tips to Ensure a Good Column Installation
1. Finger tighten until only one thread on each of the two nuts is showing.
If more than one thread is showing, wiggle or reposition the column into place to further finger-tighten the nuts to one thread.
Tips to Ensure a Good Column Installation
2. Check that the small integrated column nuts on the column are in form-fitted place on the heater in the instrument.
3. Click and run!
Intuvo Guard Chip and No-Trim ColumnsNo retention time shifts after maintenance
50
0.5 min
Shifts beyond
retention time
window
Pesticide mix injected before and
after 300 mm column trim
0.5 min
Maintaining
retention times
Pesticide mix injected before and
after Guard Chip change
Conventional Column Intuvo Column
February 13, 2019 Title Confidentiality label Regulatory statement (if applicable)51
6x10
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
2
2.2
2.4
2.6
2.8
3
3.2
3.4
3.6
Counts vs. Acquisition Time (min)
27 27.5 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 33 33.5 34 34.5 35 35.5 36 36.5 37 37.5
1
81
4
1
31
0
1
7
1
1
1
2
1
5 1
6
4x10
00.20.40.60.8
11.21.41.61.8
22.22.42.62.8
33.23.43.63.8
44.24.44.64.8
5
Counts vs. Acquisition Time (min)26.5 27 27.5 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 33 33.5 34 34.5 35 35.5 36 36.5 37 37.5
1
8
1
7
1
51
6
1
41
31
0
1
1
1
2
7890
Intuvo
Guard Chip Versus Column Trimming
1x10
-0.1
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
2
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9
3
3.1
3.2
3.3
3.4
3.5
3.6
3.7
3.8
3.9
4
4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
4.9
5
5.1
5.2
5.3
5.4
5.5
5.6
+ TIC Scan 12 Cal-10 (Dec 10) 20000 ppb .D
Counts (%) vs. Acquisition Time (min)
4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5 18 18.5 19 19.5 20 20.5 21 21.5 22 22.5 23 23.5 24
1x10
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
2
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9
3
3.1
3.2
3.3
3.4
3.5
3.6
3.7
+ TIC Scan 12 CAL 10 (20000 ppb) - Apr 30.d
Counts (%) vs. Acquisition Time (min)
4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5 18 18.5 19 19.5 20 20.5 21 21.5 22 22.5 23 23.5 24
Seamless Method Migration to IntuvoNo business disruption
52
Intuvo
7890
83 SVOC by US EPA 8270
February 13, 2019 Title Confidentiality label Regulatory statement (if applicable)53
7890 GC
Intuvo GC
42
Acquisition Time (min)3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66
1 35 6
7
9
8
10
12
11
13
1814
15, 16, 17
21
19
20
22 2523 24
PAHs
How Does it Line Up?
Fast Direct Heating and CoolingEvery single minute counts
• Fast, efficient heating
• Ballistic cooling
• Smaller footprint
“We are the police – we need answers fast. Even a 1 minute faster cool-down
would be valuable…”
54
Ultra Fast GCIt’s all about how well you do GC, fast
55
min0 0.5 1 1.5 2 2.5
pA
0
500
1000
1500
2000
2500
3000
C5
C6
C7C8 C9
C10
C11
C12
C14
C15
C16
C17
C18
C20 C24 C28 C32 C36 C40 C44
Five replicate overlay of ASTM D7798 SimDist standard mix
Recovery
C5 0.9
C6 0.9
C7 1.0
C8 1.0
C9 1.0
C10 1.0
C11 1.0
C12 1.0
C14 1.0
C15 1.0
C16 1.0
C17 1.0
C18 1.0
C20 1.0
C24 1.0
C28 1.0
C32 1.0
C36 1.0
C40 1.0
C44 0.9
• Excellent retention time and
area count reproducibility
• No concern for cold spots
Efficient, Even, Direct Heating
56
0.00
0.50
1.00
1.50
2.00
2.50
0 10 20 30 40 50 60 70 80
Rela
tive
Resp
on
se
Compound Number
7890Intuvo
Benzo[b]fluouranthene
Benzo[k]fluoranthene
Benzo[a]pyrene
Perylene-d12(ISTD)
Indeno[1,2,3-cd]pyrene
Dibenz[a,h]anthracene
Benzo[ghi]perylene
0
20
40
60
80
100
120
17 18 19 20 21 22 23
PAHs0.098ug/mL9000/5977A(scan)
High molecular
weight PAH
compounds also
have largely identical
response factors
Even high molecular
weight compounds such
as Benzo(ghi)perylene
(molecular weight 276
amu) have excellent
peak shape
Optimizing Lab SpaceSupporting lean laboratory thinking
Less than half:
• Power consumption
• Heat output into laboratory
• Laboratory bench footprint
• Lower operating costs
• Higher efficiency
• Greener
57
Accessing the Power of InnovationTransforming the user experience
New mobilized generation
• Expectations of remote mobile connection
• Technology accessed through interactive graphic SW and apps
Make technology accessible
• Interface meeting today’s expectations
58
Internet of ThingsA full suite of customer support
• Intuvo serves up a web homepage
• User help for maintenance, troubleshooting, and diagnostics
• Accessible through any approved PC or mobile device securely on internal network
59
Keep ConnectedTablet or phone connectivity
60
Go Mobile
Check instrument and batch
status remotely
Confirm laboratory operations
while out of the laboratory
Connect to any instrument with
a single mobile device
A Gateway of Information at Your FingertipsWhenever and wherever you are
• Online resources
• Agilent University
• YouTube
• Agilent.com
• Agilent GC community
61
Agilent CrossLab Services for IntuvoA streamlined service experience
Intuvo 9000 GC Health Report
Installation and familiarization
Compliance services
Education
62
An Ideal Partner for Mass Spectrometry
• Guard Chip protection of column and MS ion source
• Retention time stability after changing Guard Chip
• Easy and reliable backflush
• Leak-free click-and-run connections
• Fast direct heating and cooling
63
Intuvo 9000 GC Videos
The Agilent Intuvo 9000 GC System – Environmental Science Corporation (ESC)
Discover higher GC productivity with the Agilent Intuvo 9000 GC system.
Playing Time: 4:00
The Agilent Intuvo 9000 GC System Story
Learn more about the Agilent Intuvo 9000 GC System
Playing Time: 2:21
The Agilent Intuvo 9000 GC System: Return on Investment. Return on Innovation
A testimonial regarding the return on investment on the Agilent Intuvo 9000 GC System
Playing Time: 4:17
August 2016 AGILENT CONFIDENTIAL65
Questions
66
Contact Agilent Chemistries and Supplies Technical Support
1-800-227-9770 Option 3, Option 3:
• Option 1 for GC/GCMS Columns and Supplies
• Option 2 for LC/LCMS Columns and Supplies
• Option 3 for Sample Preparation, Filtration, and QuEChERS
• Option 4 for Spectroscopy Supplies