do oligomers damage membranes?. oligomers bind to vesicle membranes (in vitro incubation with...
Post on 19-Dec-2015
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Do oligomers damage membranes?
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Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids)
Brain derived lipids
Phosphatidylglycerol
![Page 3: Do oligomers damage membranes?. Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids) Brain derived lipids Phosphatidylglycerol](https://reader035.vdocuments.us/reader035/viewer/2022062407/56649d3a5503460f94a14950/html5/thumbnails/3.jpg)
E57K mutant promotes the formation of ring-like structures (in vitro incubation with lipid monolayer)
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Disrupting the organization between -helix and -sheet strands improves the formation of oligomers versus fibrils, making the -synuclein more toxic
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Can -synuclein oligomers cause mitochondrial damage in PD?
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Overexpression of -syn induces mitochondrial fragmentation
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-syn dependent mitochondrial fragmentation precedes mitochondrial dysfunction…
![Page 8: Do oligomers damage membranes?. Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids) Brain derived lipids Phosphatidylglycerol](https://reader035.vdocuments.us/reader035/viewer/2022062407/56649d3a5503460f94a14950/html5/thumbnails/8.jpg)
…and neuronal death
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-syn disrupts intramitochondrial structure in vitro and…