digital light innovations...life sciences economic impact on austin • dean of dell medical school...
TRANSCRIPT
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Digital Light Hyperspectral Imaging for the Medical Arena
Brian Crowell
May 6, 2014
A Texas Technology Story 9 Years in the Making
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Digital Light Hyperspectral Imaging for the Medical Arena
Chronicling the journey of commercializing innovative imaging technology for
A Texas Technology Story 9 Years in the Making
surgical & medical applications
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A Joint Texas Entrepreneurial Venture
TX Industry Military
Federal & TX Government
Austin
San Antonio
Plano
Dallas Arlington
Houston
Fort Worth
& Academic Institutions TX Medical Centers
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The DLHsi Commercialization Stages
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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Stage I. The Science & Technology
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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Stage I. The Science & Technology
Video: Intro to Hyperspectral Imaging
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Dr. Karel Zuzak, P.h.D. – DLHsi Inventor
• Developed Hyperspectral Imaging, Hsi, at the University of Texas Arlington
• Translated Hsi to the surgical and clinical bedside at UT Southwestern Medical Center
• Founded The Laboratory of Biomedical Imaging (LBI) at UTA
Arlington
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• By measuring the spectrum of reflected light, the biochemical composition of the tissue can be evaluated
• DLP ® technology has the unique ability to conform light to any desired spectral illumination scheme - Active Illumination
• Real-time mapping & visualization of tissue oxygen levels of a patient 10
20
30
40
50
60 Relative HbO2
DLHsi for Medical & Surgical Utilities
Arlington
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DLHsi for Medical & Surgical Utilities
• As expected the tissue oxygenation falls below normal with a tourniquet restricting blood flow to a finger and above normal after removing the tourniquet
Tourniquet In-Place:
58 % HbO2
Tourniquet Removed:
83 % HbO2
Arlington
10
20
30
40
50
60
70
80
90
Percentage HbO
2
82%HbO2
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DLHsi Prototype Setup
Texas Instruments DLP® Chip
Arlington
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Stage II: Early Research & Support
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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University of Texas at Arlington
Engineering Laboratory Building
Arlington
UTA Chemistry & Science Building
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The Laboratory of Biomedical Imaging (LBI)
The Laboratory of Biomedical Imaging
Mission
Bringing Better Health To Everyone by Developing Hyperspectral Imaging for Surgical and Clinical Utilities
Arlington
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Texas Congressman Joe Barton
Representative Joe Barton
R-Texas, 6th District
Fort Worth
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Texas Congressman Joe Barton
Demonstrating DLHsi to Congressman Joe Barton
• Provided funding to support the translation of medical imaging technology from the research laboratories at UT Arlington to the clinics and surgeries at UT Southwestern Medical Center
• Resulted in building the Advanced Medical Imaging Laboratory on the UT Southwestern campus
• Created a complete team of specialists from the research & developers, to the clinicians that will use the technology
Congressman Joe Barton giving Funding Check
Fort Worth
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Texas Instruments
Plano
Texas Instruments, Plano, TX
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Platform Technology Patent
• Research resulted in a Platform Technology Patent application being issued in 2012
• UT system as the IP Assignee
Arlington
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Stage III. Clinical Exercises
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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UT Southwestern Medical Center
• The premier location for the Biomedical Industry to interact with clinical, surgical, academic, sciences, engineering, and technology.
UT Southwestern Medical Center, Dallas, TX
UT Southwestern Medical Center, Dallas, TX
Dallas
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Clinical Collaborators – Endocrinology
Dr. Edward Livingston, M.D.
• Chairman of GI Endocrine Surgery • Southwestern Medical Center • Clinical & Surgical collaborator • Early Clinical Advocate • Helped acquire TI funding • Used own endowment to fund preliminary data collection
Dallas
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Clinical Collaborators – Plastic Surgery
Dr. Michel Saint-Cyr, M.D.
Skin Flaps
Dr. Lawrence Lavery, D.P.M.
Lower Limb Amputation
Dr. Javier La Fontaine, D.P.M.
Lower Limb Wounds/Wound Debridement
Dallas
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Clinical Collaborators - Endoscopy
Dr. Jeffrey Cadeddu, M.D.
• Director of the UT Southwestern Clinical Center for Minimally Invasive Treatment of Urologic Cancer
• Endoscopy
Dallas
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Dallas Veterans Affairs Medical Center
Dallas
Dallas VA Medical Center, Dallas, TX
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United States Army – Fort Sam Houston
Brooke Army Medical Center (BAMC) - San Antonio, TX Fort Sam Houston - San Antonio, TX
San Antonio
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Clinical Collaborators – Combat Medicine / Burns
Leopoldo C. Cancio, M.D., FACS
• Colonel, MC, US Army
• Brooke Army Medical Center
• Critical Care Fellow
• Combat Medicine & Burns
San Antonio
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Stage IV: Entrepreneurship / Engineering / Standards
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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Digital Light Innovations (DLi)
DLP ® Design House
Austin
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Digital Light Innovations (DLi)
DLP ® Design House
Austin
Video: Intro to DLP ® Technology
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Digital Light Innovations (DLi)
• Authorized Design House for DLP® embedded products
• DLi TI DLP® Symposium
• Recognized Zuzak & HSi at research state
• Hired Dr. Zuzak from UTA
• Began licensing negotiations for UTA IP
• Zuzak & DLi engineers quickly added synergistic IP applications
• Implemented ISO 13485 & FDA 21 CFR 820 Design Controls
Austin
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Digital Light Innovations (DLi)
• Licensing Contracted with large medical device channel owner for development, sales & support of DLHsi device
• Other, clinically proven, fields of use
• Opportunity to broaden technology within medical market, additional biomarkers
• Ability to add complementary technology (non-contact, 3D measurement, vein location) to DLHsi device
• Researching extending technology into adjacent markets, i.e. food safety (preliminary)
Austin
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TIETRONIX Software
• Software development partner
• ISO 13485 and 21 CFR 820 Compliant
• Strategic initiative to penetrate Austin medical development market
• Deliver complex, mission-critical systems to NASA’s space flight operations
• Augmented Reality
Houston
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ISO Certification
• ISO 13485 Compliant Processes
• Represents the requirements for a comprehensive quality management system for the design and manufacture of medical devices
• EMERGO GROUP consulted on our implementation
• Building Design History File
•Third-Party Audit in Q4 2014
Austin
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FDA Certification
• Food & Drug Administration
• Compliance for Medical Devices
• 21 CFR 820 Certification
• Code of Federal Regulations Title 21
Austin
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Stage V. Commercialization
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
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The Client – Texas Medical Device Company
• Headquartered in Texas
• Worldwide footprint
• Clinic & hospital environments
• Multi-billion dollar revenue
• Focusing on improving standard of care while reducing direct & indirect costs of healthcare within field of use
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Economic Spend
I. The Science & Technology $1M UTA < 2005
II. Early Research & Support $1M Gov/TI 2006/2010
III. Clinical Exercises $0.5M UTSWMC 2009/2010
IV. Entrepreneurship/Eng/Dev > $0.5M DLi 2011
V. Pre-sales Commercialization > $6M Client 2014
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Life Sciences Economic Impact on Austin
• Dean of Dell Medical School at University of Texas Austin
• Dr. Clay Johnston
• Digital Healthcare Initiative
• Austin-Round Rock-San Marcos Metropolitan Area (MSA)
* The Life Sciences sector in Austin MSA represents:
• > $1 billion in value added to the regional economy
• 206 companies
• Approximately 6,052 jobs
• Five industries contributed > $100 million
Dr. Clay Johnston, M.D., Ph.D. Dean of Dell Medical School, UT Austin
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Digital Light Hyperspectral Imaging for the Medical Arena
Thank You
A Texas Technology Story 9 Years in the Making