differential gene expression between han chinese and japanese
DESCRIPTION
Differential Gene Expression between Han Chinese and Japanese. Yuan Yuan Prof . Shuhua Xu’s group Population genomic group PICB. Chinese and Japanese are very similar in phenotype. Expression variation among Chinese and Japanese individuals. - PowerPoint PPT PresentationTRANSCRIPT
Differential Gene Expression between Han Chinese and Japanese
Yuan YuanProf. Shuhua Xu’s group
Population genomic groupPICB
Chinese and Japanese are very similar in phenotype.
Expression variation among Chinese and Japanese individuals
Differentlyexpressed
Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached.
Genome locations of 768 DE genes
Functional enrichment of 768 DE genes
Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference
Population
Cis: # genes(snps)
Trans: # genes(snps)
CHB 39 (306) 271 (4544)
JPT 68 (648) 92 (1216)
Distribution of cis-associations(SNPs) relative to the transcription start site (TSS)
Genetic contributions to total expression variation for 11 cis-genes
Cis-gene vs GWAS trait
CTSS vs cis-SNPs
Acknowledgment
Dr. Shuhua Xu
Yang ling, Lu dongsheng, Shi meng, Lou haiyi
Jin wenfei, Pankaj
All in population genomics group