Invited Faculty (Tentative List)

Industry Support & ExhibitionThe Industry is invited to contribute and to support this important event. Affordable table top exhibits and sponsorship opportunities are available to expose and enhance your organization’s visibility. Interested Com-panies, please contact Valentina Zigrino (valentina.zigrino@cartilage.org)

Registration & FeesRegistration is accepted online only through www.cartilage.org

Fee Category Sept. 10 Sept. 11– Nov. 30 From Dec. 01 Early Fee Regular Fee Onsite Fee

Residents/Students& Physiotherapists EUR 190.00* EUR 290.00* EUR 450.00*

ICRS Members EUR 290.00 EUR 390.00 EUR 450.00

Non Members EUR 390.00 EUR 490.00 EUR 550.00

Industry Reps EUR 490.00 EUR 590.00 EUR 650.00

Friday Afternoon Workshop EUR 80.00 EUR 80.00 EUR 80.00

* To be accompanied by a certifi cate signed by the head of department.

Included in the Registration Fee• Access To All Sessions• Welcome Reception• Coffee Breaks & Refreshments• Access to Industry Exhibition• Main Programme, Registration Material

Course Directors• Elizaveta Kon, IT• Maurilio Marcacci, IT• Alberto Gobbi, IT

Scientifi c Programme Committee• Elizaveta Kon, IT• Massimo Berruto, IT• Giuseppe Filardo, IT• Peter Verdonk, BE• Giuseppe Peretti, IT• Vincenzo Condello, IT• Berardo Di Matteo, IT

Course VenueHumanitas UniversityVia Rita Levi Montalcini 4, 20089 Rozzano (Milan)

Course LanguageEnglish, no simultaneous translation will be available.

Updated InformationPlease note that this is a preliminary programme. For updated information (topics, faculty, registration fees, etc.), please visit frequently our website www.cartilage.org

AccommodationOffi cial Course HotelsRoyal Garden HotelVia Giuseppe di Vittorio 420090 Assago (MI)www.royalgardenhotelmilano.comE-Mail: garden@monrifhotels.comTel. +39 02 457811Reservation: www.royalgardenhotelmilano.com/en/reservations/?promo_code=ICRSMILANGroup-Code: ICRSMILAN

Special ICRS Rates incl. Breakfast, excl. taxesSGL 125.00 Euros / DBL 145.00 Euros

NH HotelStrada 1 Milanofi ori20090 Assago (MI)www.nh-hotels.it/hotel/nh-milano-congress-centreE-Mail: nhmilanocongresscentre@nh-hotels.comTel. +41 31 5208011Reservation: www.nh-hotels.com/event/icrs-focus-meeting

Special ICRS Rates incl. Breakfast, excl. taxesSGL 139.00 Euros / DBL 159.00 Euros

Course Organizing Offi ce Cartilage Executive Offi ce (CEO) GmbH Spitalstrasse 190, House 38623 Wetzikon, SwitzerlandPhone: +41 44 503 73 70Fax: +41 44 503 73 72E-Mail: valentina.zigrino@cartilage.org

Important Dates:Deadline Early Bird Registration Sept. 10, 201880% Refund for Cancellations until Sept. 10, 2018Deadline for Hotel Reservation Oct. 15, 201850% Refund for Cancellation until Oct. 30, 2018No Refund for Cancellations after Oct. 30, 2018Deadline Course Registration (Normal Fee) Nov. 30, 2018

Sponsors & Exhibitors

Diamond Sponsors

Platinum Sponsors

Gold Sponsor

Cells, Scaffolds & Co.

I'm NOT ready for metal

Preliminary ProgrammeICRS Focus Meeting

MILAN-ITALYDecember 13–14, 2018

#ICRSFOCUS

In collaboration with:

ICRS Getting Social – Join us

We are pleased to announce that the ICRS has been establishing its Social Media presence on the major platforms during last few months. For those of you who are active on these platforms, we strongly encourage you to CONNECT, ENGAGE & SHARE - Be the ICRS Digital Ambassadors Worldwide!

We all are looking forward to welcoming you at upcoming the ICRS 11th World Congress. Don’t forget to use hash tag: #ICRS2013 on these Social Media sites if you are talking about this meeting (Twitter, Facebook, LinkedIn and Google+ all support hash# tagging to help categorizing and organize topics).

The ICRS aims to leverage the rapidly advancing digital technologies continuously to help the society stay engaged, transparent and informative for all of our stakeholders. By the way, we will launch ICRS Blog and maybe ICRS Chatter app. Stay tuned.

Best regards,

Your ICRS Cartilage Executive Office Team

Scan the QR* (Quick Response) code with your QR reader or Click the icon (Digital Copy), you will be taking to the corresponding ICRS Social Media site directly.

Video: Social Media 2013

ICRS Getting Social – Join us

We are pleased to announce that the ICRS has been establishing its Social Media presence on the major platforms during last few months. For those of you who are active on these platforms, we strongly encourage you to CONNECT, ENGAGE & SHARE - Be the ICRS Digital Ambassadors Worldwide!

We all are looking forward to welcoming you at upcoming the ICRS 11th World Congress. Don’t forget to use hash tag: #ICRS2013 on these Social Media sites if you are talking about this meeting (Twitter, Facebook, LinkedIn and Google+ all support hash# tagging to help categorizing and organize topics).

The ICRS aims to leverage the rapidly advancing digital technologies continuously to help the society stay engaged, transparent and informative for all of our stakeholders. By the way, we will launch ICRS Blog and maybe ICRS Chatter app. Stay tuned.

Best regards,

Your ICRS Cartilage Executive Office Team

Scan the QR* (Quick Response) code with your QR reader or Click the icon (Digital Copy), you will be taking to the corresponding ICRS Social Media site directly.

Video: Social Media 2013

ICRS Getting Social – Join us

We are pleased to announce that the ICRS has been establishing its Social Media presence on the major platforms during last few months. For those of you who are active on these platforms, we strongly encourage you to CONNECT, ENGAGE & SHARE - Be the ICRS Digital Ambassadors Worldwide!

We all are looking forward to welcoming you at upcoming the ICRS 11th World Congress. Don’t forget to use hash tag: #ICRS2013 on these Social Media sites if you are talking about this meeting (Twitter, Facebook, LinkedIn and Google+ all support hash# tagging to help categorizing and organize topics).

The ICRS aims to leverage the rapidly advancing digital technologies continuously to help the society stay engaged, transparent and informative for all of our stakeholders. By the way, we will launch ICRS Blog and maybe ICRS Chatter app. Stay tuned.

Best regards,

Your ICRS Cartilage Executive Office Team

Scan the QR* (Quick Response) code with your QR reader or Click the icon (Digital Copy), you will be taking to the corresponding ICRS Social Media site directly.

Video: Social Media 2013

ICRS Getting Social – Join us

We are pleased to announce that the ICRS has been establishing its Social Media presence on the major platforms during last few months. For those of you who are active on these platforms, we strongly encourage you to CONNECT, ENGAGE & SHARE - Be the ICRS Digital Ambassadors Worldwide!

We all are looking forward to welcoming you at upcoming the ICRS 11th World Congress. Don’t forget to use hash tag: #ICRS2013 on these Social Media sites if you are talking about this meeting (Twitter, Facebook, LinkedIn and Google+ all support hash# tagging to help categorizing and organize topics).

The ICRS aims to leverage the rapidly advancing digital technologies continuously to help the society stay engaged, transparent and informative for all of our stakeholders. By the way, we will launch ICRS Blog and maybe ICRS Chatter app. Stay tuned.

Best regards,

Your ICRS Cartilage Executive Office Team

Scan the QR* (Quick Response) code with your QR reader or Click the icon (Digital Copy), you will be taking to the corresponding ICRS Social Media site directly.

Video: Social Media 2013

Social Media – Follow us on:

Adaravanti Paolo (IT) Angele Peter (DE) Bait CorradoBerruto Massimo (IT)Boldrini Lorenzo (IT) Bonanzinga Tommaso (IT)Brittberg Mats (SE)Capato Simone (IT) Caplan Arnold (US)Castagna Alex (IT) Chubinskaya Susan (US) Condello Vincenzo (IT)Cugat Ramon (ES) Chul-won Ha (ROK) D’Agostino Maria Cristina (IT)Di Girolamo Laura (IT) Della Villa Stefano (IT) Di Matteo Bernardo Filardo Giuseppe (IT) Ferrua Paolo (IT) Gatti Roberto (IT)Gobbi Alberto (IT)

Grappiolo Guido (IT) Iacono Francesco (IT)Ichiro Sekiya (JPN) Jorgensen Christian (FR) Kon Elizaveta (IT)Lattermann Christian (US) Loppini Mattia (IT) Madonna Vincenzo (IT)Mantovani Alberto (IT) Marcacci Maurilio (IT) Marmotti Antonio (IT)Massazza Giuseppe (IT) Melegati Gianluca (IT) Menetrey Jacques (CH)Milano Guiseppe (IT) Minas Tom (US) Montorsi Marco (IT)Murrel William (UAE) Nakamura Norimasa (JP) Papalia Rocco (IT)Pereira Maria Teresa (IT) Peretti Giuseppe (IT)

Pisoni Davide (IT)Randelli Filippo Randelli Pietro (IT) Respizzi Stefano (IT)Robinson Dror (IL) Ronga Mario (IT) Rosa Donato (IT)Sacchi Andrea (IT) Seil Romain (LU) Selmi Carlo (IT)Shabshin Nogah (IL) Slynarsky Conrad (ES) Tencone Fabrizio (IT)Vadalà Gianluca (IT) Vannini Francesca (IT) Verdonk Peter (BE)Volpi Piero (IT) Zaffagnini Stefano (IT) Zanon Giacomo (IT)Zaslav Kenneth (US)

International Cartilage Regeneration& Joint Preservation Society&INTERNATIONAL CARTILAGE

REGENERATIONJOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION&

JOINT PRESERVATION SOCIETY

INTERNATIONAL CARTILAGE REGENERATION& JOINT PRESERVATION SOCIETY

International Cartilage Regeneration&

Joint Preservation Society

WelcomeThe ICRS is happy and proud to present another Focus Meeting that will take place in Hu-manitas University, Milan, Italy in December 2018. The focus of this meeting is quite provo -cative: “I am not ready for metal!” and it is on a cutting-edge field regarding current state of art in growth factors, scaffolds, cells and other joint preservation techniques for OA. A topic that everybody will be more and more interested in the near future. The course is dedicated to both basic scientists and orthopaedic practitioners. During the meeting, participants will get a deep overview on joint preservation techniques, and also exposed to practical tips and tricks on their application.

International renowned specialists and opinion leaders (clinicians and basic scientist) will give insights about what is coming from the bench, such as GFs and MSC application, biomarkers, unloading approaches, bone marrow edema, novel MR imaging methods and injectable biologic products.

This Focus meeting will be enriched by RE-LIVE SURGERY SESSIONS, where innovative osteochondral and meniscal scaffolds, stem cells/bone marrow/adipose tissue concentrate techniques will be displayed.

Milan is not only the capital of fashion and design, but it is also home to some of the most acclaimed art pieces in the world, from its Gothic Duomo to the elegant La Scala opera house, from Renaissance masterpieces to avant-garde design. Milan is filled with museums, art galleries, churches and beautiful palazzi. Hidden away, on the walls of the Basilica di Santa Maria delle Grazie’s refectory, you will find Leonardo da Vinci’s most famous fresco, the Last Supper. Both inside and out, the extravagant Duomo Gothic cathedral is a wonder to behold, with the largest stained-glass windows in the world. One of Italy’s oldest and most prestigious art schools, the Accademia delle Belle Arti, houses an impressive collections of Old Masters, including works by the Bellin-Italians, such as Goya and Rubens. Christmas in Milan is truly a magical experience. The weather may be gloomy, but Milan is not, as the city is bedecked with Christmas trees, colored lights and sparkles, and there is a warm welcome to all!

The Christmas period in Milan isn’t just beautiful – it’s the perfect place and season to get some shopping done! One of the world’s most renowned shopping destinations, Milan lights up during the holidays with miles of designer stores, unique boutiques and outdoor markets, making it the perfect destination for getting through your Christmas list.

Hope to see you in Milan in December

Elizaveta Kon, Maurilio Marcacci, Alberto Gobbi, Course Directors

Thursday, December 13, 201811.00 – 12.30 Registration

11.30 – 12.15 Welcome Reception

12.15 – 12.30 Opening HUMANITAS: Alberto Mantovani (IT), Marco Montorsi (IT), Maurilio Marcacci (IT) ICRS: Alberto Gobbi (IT), Kenneth Zaslav (US) SIGASCOT: Pietro Randelli (IT), Massimo Berruto (IT) ESSKA: Jacques Menetrey (CH)

12.30 – 13.00 Introduction Lectures Cells, Scaffold & Co: I Am Not Ready for Metal – Maurilio Marcacci (IT) Post-Traumatic OA – Susan Chubinskaya (US

13.00 – 16.00 Session I: Cells Chair: Susan Chubinskaya (US), Alberto Gobbi (IT)13.00 – 13.30 Opinion Leader Confrontation: Arnold Caplan (US) vs Daniel Saris (US) Open Questions: - Adipose Derived vs Bone Marrow? - Concentrate or Expanded? - Autologous or Allogenic? - Inject or Implant? - Injection Alone or Combined with Surgery?13.30 – 13.45 Synovial Stem Cell-Based Therapy in Cartilage Repair – From Autologous to Allogenic Clinical Trial – Norimasa Nakamura (JPN)13.45 – 14.00 Cord-Blood Stem Cell-Based Therapy in OA – Chul-won Ha (ROK)14.00 – 14.15 Stem Cell-Based Meniscal Regeneration – Ichiro Sekiya (JPN)14.15 – 14.45 “Nose to Knee” – Giuseppe Peretti (IT)14.45 – 15.00 Adipose-Derived Stem Cells: ADIPOA Project – Christian Jorgensen (FR)15.00 – 15.15 Secretoma – Next Generation of Stem Cell Therapy? Antonio Marmotti, Laura Di Girolamo (IT)

15.15 – 15.50 Technical session – Stem cells: How to Do it? Relive & Relevant Results BioCue – Berardo Di Matteo (IT) Lipogems – Konrad Slynarsky (PL) Marrow Cellution – Maurilio Marcacci (IT), Laura De Girolamo (IT) Isto Biologics – Rocco Papalia (IT) SVF – TBD

15.50 –16.00 Discussion

16.00 – 16.30 Coffee Break & Industry Workshops: Watch & Try

16.30 – 18.10 Session II: PRP & GF Chair: Ken Zaslav (US), Rocco Papalia (IT)16.30 – 17.00 PRP – Opinion Leader Confrontation: Giuseppe Filardo (IT) vs Ramon Cugat Open questions: - Platelet Rich vs Platelet Poor? - Leucocytes Rich vs Leucocyte Poor? - PRP vs HA? - Combined with HA or Cortisone? - New Frontiers?

17.00 – 17.30 Technical Session - Prp: How to do it Relive & Relevant Result PRGF – Ramon Cugat (IT) APS – Elizaveta Kon (IT) ACP & Angel – Laura di Girolamo (IT) Gold induced Cytokine (GOLDIC) – William Murrel (UAE)

17.30 – 17.40 Discussion17.40 – 17.55 Can this Work in Rheumatic Disease? – Carlo Selmi (IT)17.55 – 18.10 Regulatory on Biologics: AAOS – ICRS Initiative – Ken Zaslav (US)

Friday, December 14, 201809.00 – 10.45 Session III: Scaffolds Chair: Donato Rosa (IT), Angele Peter (DE)09.00 – 09.15 Scaffolds: Where are we Today – Mats Brittberg (SE)09.15 – 09.30 Role of Subchondral Bone Reconstruction: From Cartilage Defects to OA – Dror Robinson (IL)

09.30 – 11.00 Technical Session – Scaffolds: How to do it Relive Surgery & Relevant Results Cartiheal – Elizaveta Kon (IT) MaioRegen – Maurilio Marcacci (IT), Giuseppe Filardo (IT) Hyalofast – Alberto Gobbi (IT) Geistlich AMIC Chondro-Gide – Massimo Berruto (IT) Cartgel – TBD Joint Rep – Simone Capato (IT)

10.45 – 11.00 Discussion

11.00 – 11.30 Coffee Break & Industry Workshop: Watch & Try

11.30 – 13.00 Session IV: Unloading Procedures Chair: Giuseppe Milano (IT), Paolo Adaravanti (IT)11.30 – 11.45 Post-Meniscectomy Syndrome – Jacques Menetrey (CH)

11.45 – 12.45 Meniscal Transplantation: Where are We Today – Peter Verdonk (BE) Relive Surgery & Relevant Results Meniscal Root Repair – Roman Seil (LU) Meniscal Allografts – Vincenzo Condello (IT) NuSurface – Peter Verdonk (BE) Osteotomy – Peter Angele (DE) Atlas – Vincenzo Madonna (IT)

12.45 – 13.00 Discussion

13.00 – 14.00 Lunch Session – Round Table: “Biotech & Sport” by Gazzetta Chair: Massimo Berruto (IT) Participants: Ramon Cugat (SP), Tom Minas (US), Peter Verdonk (BE), Piero Volpi (IT), Gianluca Melegati (IT), Stefano Della Villa (IT), Stefano Respizzi (IT), Maurilio Marcacci (IT), Alex Castagna (IT)

14.00 – 15.00 Session V: Bone Marrow Edema Chair: Pietro Randelli (IT), Mario Ronga (IT)14.00 – 14.15 Definition & Diagnosis – Nogah Shabshin (IL)14.15 – 14.30 Conservative Treatment – Massimo Berruto (IT)

14.30 – 14.45 Relive Surgery & Results: Subchondroplasty – Pietro Randelli (IT)14.45 – 15.00 Relive Surgery & Results: Cell Implantation – Elizaveta Kon (IT)

15.00 –15.30 Discussion

15.30 – 16.00 Coffee Break & Industry Workshops: Watch & Try

16.00 – 16.30 Session VI: Patient Profiling – A New Graal Chair: William Murrel (AE), Carlo Selmi (IT)16.00 – 16.15 Biomarkers – Christian Lattermann (USA)16.15 – 16.30 Morphologic Profiling – Peter Verdonk (BE)

16.30 – 18.00 Session VII: The Final Countdown Before Meta Chair: Corrado Bait (IT), Randelli Filippo (IT)16.30 – 16.45 Joint Preservation, How Far We Can Go Today? – Tom Minas (US)16.45 – 17.00 I Am Not Ready For Metal in Patello-Femoral – Stefano Zaffagnini (IT)17.00 – 17.15 I Am Not Ready For Metal in Shoulder – Alex Castagna (IT)17.15 – 17.30 I Am Not Ready For Metal in Hip – Guido Grappiolo, Mattia Loppini (IT)17.30 – 17.45 I Am Not Ready For Metal in Ankle – Francesca Vannini (IT)

17.45 – 18.00 Discussion

Optional: Workshop Rehabilitation (EUR 80.00)14.00 – 18:00 Parallel Session (in English & Italian) Focus on Knee Rehabilitation: From Aging Athlete to Housewife Chair: Stefano Respizzi (IT), Giuseppe Massazza (IT), Roberto Gatti (IT)

Introduction14.00 – 14.15 Knee Preservation Surgery: From Aging Athlete to Housewife Maurilio Marcacci (IT), Francesco Iacono (IT)14.15 – 14.30 Physiopathology & Rehabilitation of Arthrogenous Muscle Inhibition – Roberto Gatti (IT)14.30 – 14.45 Movement Analysis Test: Evaluating Impairments & Planning Correct Neuromotor Training Lorenzo Boldrini (IT)

Non Operative Treatment-Indications & Role of:14.45 – 15.00 Knee Rehabilitation – Gianluca Melegati (IT) 15.00 – 15.15 PRP – Maria Teresa Pereira (IT)15.15 – 15.25 Acido Ialuronico – TBD15.25 – 15.35 PEMF – Giacomo Zanon (IT)15.35 – 15.45 Shock Wave Therapy – Maria Cristina D‘Agostino (IT)

15.45 – 16.15 Discussion

Post-Surgical Recovery16.15 – 16.30 Rehabilitation Protocols After Cartilage Surgery – Fabrizio Tencone (IT)16.30 – 16.45 New frontiers: Gym, Green Room & on Field Rehabilitation – Davide Pisoni (IT), Andrea Sacchi (IT)16.45 – 17.00 Return to Sports After Surgery in Ageing Athlete. Where Are We Today, & Where We Are Going Stefano della Villa (IT)

17.00 – 17.30 Clinical cases: Tommaso Bonanzinga (IT), Paolo Ferrua (IT), Gianluca Vadalà (IT)

17.30 – 18.00 Discussion

Preliminary Programme Preliminary Programme Preliminary Programme