Slide #2

LASIK & Cataract Surgery Technology Have Never Been Better

Slide #3

Ocular Surface is a Rate Limiting Step for Surgical Outcomes

The ocular surface affects:•IOL calculations•Topographic and wavefront ablations•Postoperative healing •Quality of vision and patient satisfaction

Slide #4

Sometimes it’s obvious. Sometimes it’s not.

Diagnosing the severe dry eye patient is easy.

The mild-moderate dry eye patient may look similar to normals

Slide #5

Using Diagnostics to ‘See’ Before We See

Kam W, et al. Invest Opthalmol Vis Sci. 2016; 57:E-abstract 6181.

Abnormal osmolarity can reveal a compromised ocular surface earlier

Slide #6

Effect of Hyperosmolarity on Keratometry Readings

Epitropoulos AT et al. J Cataract Refract Surg 2015 Aug;41(8)1672–7.

• 17% of hyperosmolar eyes had more than 1 D of change in keratometry cylinder values (Kcyl) between two visits

Slide #7

Future of Tear Biomarker Analysis

Osmolarity is important, but it’s not the only biomarker•Inflammatory markers•Allergic markers•DED subtyping markers

IL1-raIgE

Lactoferrin

Slide #8

Leading the Future of Diagnostics

TearLab Next Generation Platform•Quantitative•Rapid testing (< 2 minutes)•Multiplexed biomarkers•EHR Integration

Clinical Application•Normalization using osmolarity•Customized chips with designed sensitivity & specificity

Slide #9

• CE Mark by end of 2016• 510k submission in early 2017

– First test will have osmolarity + 1 or 2 additional markers– Likely to be focused on inflammation– New iterations possible every 6 months

When?