Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of Neurology

University of PittsburghUniversity of PittsburghSchool of MedicineSchool of MedicineSchool of MedicineSchool of MedicineSeptember 8, 2008September 8, 2008

Departmental OrganizationDepartmental Organizationp gp g

Lawrence R. Wechsler, MDLawrence R. Wechsler, MDInterim ChairInterim ChairInterim ChairInterim Chair

Department of NeurologyDepartment of Neurology

Patrick ConwayPatrick Conway Leslie Dunn, MPHLeslie Dunn, MPH

Lawrence Wechsler, MDLawrence Wechsler, MDVice ChairVice Chair Clinical AffairsClinical Affairs

Steven Graham, MD PhD.Steven Graham, MD PhD.Vice ChairVice Chair ResearchResearch

Paula Clemens, MDPaula Clemens, MDVice ChairVice Chair VA AffairsVA Affairs

yyExecutive AdministratorExecutive Administrator Academic AdministratorAcademic Administrator

Tim Greenamyre, MD PhDTim Greenamyre, MD PhDVice ChairVice Chair Academic AffairsAcademic AffairsVice Chair Vice Chair –– Clinical AffairsClinical Affairs Vice Chair Vice Chair -- ResearchResearch Vice Chair Vice Chair ––VA AffairsVA AffairsVice Chair Vice Chair –– Academic AffairsAcademic Affairs

Division ChiefsDivision Chiefs

Division ChiefsDivision ChiefsLawrence Wechsler, MDLawrence Wechsler, MD Interim Chairman of NeurologyInterim Chairman of Neurology

Chief, Stroke DivisionChief, Stroke DivisionDirector, UPMC Stroke InstituteDirector, UPMC Stroke Institute

Anto Bagic, MD, MScAnto Bagic, MD, MSc Chief, Division of EEG and Epilepsy Chief, Division of EEG and Epilepsy Director, Center for Advanced Brain Magnetic Source Director, Center for Advanced Brain Magnetic Source ImagingImaging

Paula Clemens, MDPaula Clemens, MD Chief, VA NeurologyChief, VA Neurology

John Doyle, MDJohn Doyle, MD Chief, General NeurologyChief, General NeurologyDirector, Residency Training ProgramDirector, Residency Training Program

Tim Greenamyre MD PhDTim Greenamyre MD PhD Chief Division of Movement DisordersChief Division of Movement DisordersTim Greenamyre, MD PhDTim Greenamyre, MD PhD Chief, Division of Movement Disorders Chief, Division of Movement Disorders Director, Pittsburgh Institute of Neurodegenerative Director, Pittsburgh Institute of Neurodegenerative Diseases (PIND)Diseases (PIND)

Rock Heyman MDRock Heyman MD Chief Division of Neuroimmunology & MultipleChief Division of Neuroimmunology & MultipleRock Heyman, MDRock Heyman, MD Chief, Division of Neuroimmunology & Multiple Chief, Division of Neuroimmunology & Multiple SclerosisSclerosis

Robert Kaniecki, MDRobert Kaniecki, MD Chief, Headache DivisionChief, Headache Division

D id L i MDD id L i MD Chi f Di i i f N l DiChi f Di i i f N l DiDavid Lacomis, MDDavid Lacomis, MD Chief, Division of Neuromuscular DiseasesChief, Division of Neuromuscular Diseases

Oscar Lopez, MDOscar Lopez, MD Chief, Cognitive and Behavioral NeurologyChief, Cognitive and Behavioral Neurology

Fac lt Dist ib tionFac lt Dist ib tionFaculty DistributionFaculty Distribution

Professors 10Associate Professors 6Associate Professors 6Assistant Professors 25R h A i t P f 12Research Assist Profs 12

Department of NeurologyDepartment of NeurologyRecent Faculty AdditionsRecent Faculty Additions

Gena Ghearing, MDGena Ghearing, MD Mayo Clinic; Epilepsy and EEGMayo Clinic; Epilepsy and EEG

Eric Hoffmann, PhDEric Hoffmann, PhD Pitt; Molecular genetics of degenerative diseasePitt; Molecular genetics of degenerative disease

Samay Jain, MDSamay Jain, MD Columbia; Movement Disorders and early diagnosis Columbia; Movement Disorders and early diagnosis techniquestechniques

Angela Lu, MDAngela Lu, MD Pitt; Neuromuscular DiseasesPitt; Neuromuscular Diseases

Chith j R MDChith j R MD W St t N l DiW St t N l DiChitharanjan Rao, MDChitharanjan Rao, MD Wayne State; Neuromuscular DiseasesWayne State; Neuromuscular Diseases

Asim Roy, MDAsim Roy, MD Tufts University; Neurophysiology and Sleep MedicineTufts University; Neurophysiology and Sleep Medicine

M Fi Si fi MDM Fi Si fi MD Pi G l N lPi G l N lM. Firas Sioufi, MDM. Firas Sioufi, MD Pitt; General NeurologyPitt; General Neurology

Valerie Suski, DOValerie Suski, DO Duke; Movement Disorders and deep brain stimulationDuke; Movement Disorders and deep brain stimulation

Olga Vergun, PhDOlga Vergun, PhD Pitt; The role of mitochondria in regulation & deregulation of Pitt; The role of mitochondria in regulation & deregulation of neuronal ionic homeostasisneuronal ionic homeostasis

Barbara Vogler, MDBarbara Vogler, MD Thomas Jefferson; Headache and clinical research trials Thomas Jefferson; Headache and clinical research trials

David Wolk, MDDavid Wolk, MD Harvard; Cognitive and Behavioral NeurologyHarvard; Cognitive and Behavioral Neurology

Syed Zaidi, MDSyed Zaidi, MD Pitt; Vascular NeurologyPitt; Vascular Neurology

Clinical and Research TraineesClinical and Research TraineesClinical and Research TraineesClinical and Research Trainees

Neurology ResidentsNeurology Residents 1515Clinical FellowsClinical Fellows 55

Stroke, Epilepsy, NeuromuscularStroke, Epilepsy, NeuromuscularMovement DisordersMovement Disorders

Research AssociateResearch Associate 1717Post Doc AssocPost Doc Assoc 1212Post Doc ScholarPost Doc Scholar 22Graduate StudentsGraduate Students 1111

National RankingsNational RankingsggNIH RankingsDepartments of Neurology

U.S. News and World ReportNeurology and Neurosurgery

2001 26th

2002 19th2002 unranked2003 39th2002 19

2003 14th

2004 17th

2003 392004 39th

2005 17th

2005 10th

2006 8th

2007 6th

2006 19th

2007 12th

2008 14th2007 6th 2008 14th

Research ThemesResearch ThemesResearch ThemesResearch Themes

Neurodegenerative DisordersNeurodegenerative DisordersDiagnosis and Therapeutic Interventions in Diagnosis and Therapeutic Interventions in DementiaDementiaDementiaDementiaMechanisms and interventions in Parkinson’s Mechanisms and interventions in Parkinson’s diseasediseasediseasediseaseBrain Trauma in humans and animal modelsBrain Trauma in humans and animal modelsStroke and ischemiaStroke and ischemia--induced mechanisms ofinduced mechanisms ofStroke and ischemiaStroke and ischemia induced mechanisms of induced mechanisms of neuronal deathneuronal death

Depa tment DetailsDepa tment DetailsDepartment DetailsDepartment Details

Wet laboratory space: BSTWet laboratory space: BST--S; BSTS; BST--3; VA3; VAClinical research space in KaufmannClinical research space in KaufmannClinical research space in Kaufmann Clinical research space in Kaufmann Building, UPMC Montefiore, and at the Building, UPMC Montefiore, and at the VAMCVAMCVAMCVAMCLed the initiative to launch Pittsburgh Led the initiative to launch Pittsburgh Institute for Neurodegenerative DiseasesInstitute for Neurodegenerative DiseasesInstitute for Neurodegenerative DiseasesInstitute for Neurodegenerative Diseases

Department of NeurologyDepartment of NeurologyDepartment of Neurology Department of Neurology Research Funding SourcesResearch Funding Sources

$16 000 000$18,000,000$20,000,000

g

$8 000 000$10,000,000$12,000,000$14,000,000$16,000,000

al F

undi

ng

OTHERSTATEVA

$$2,000,000$4,000,000$6,000,000$8,000,000

Ann

u VANIH

$-FY 02 FY 03 FY 04 FY 05 FY 06 FY 07 FY 08

Fiscal Year

Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyExtramural FundingExtramural Funding

State, 2%R Awards, 20%Industry, 4%Foundation, 9%

Fellowships, 3%

K Awards, 5%VA/Other Federal, 2%

DoD, 3%

Training, 1%

Center, 24%Program Projects,

27%

Department of NeurologyDepartment of NeurologyFunding by NIH InstitutesFunding by NIH InstitutesFunding by NIH InstitutesFunding by NIH Institutes

Fogarty International Center (FIC), 0.8%National Institute of

N ti l I tit t f ChildEnvironmental Health Sciences (NIEHS), 0.1%

National Institute of Child Health & Human

Development (NICHD), 0.1%

National Center for Complementary &

Alt ti M di i

National Institute of Mental Health (NIMH), 2%

Alternative Medicine (NCCAM), 27%

National Institute of Aging (NIA), 38%

National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS),

2%

National Institute of Neurological Disorders &

Stroke (NINDS), 30%

Centers & Program Project GrantsCenters & Program Project GrantsCenters & Program Project GrantsCenters & Program Project Grants

Alzheimer’s Disease Research CenterAlzheimer’s Disease Research Center(P50; O. Lopez, PI; $10,438,440 over 5 years)(P50; O. Lopez, PI; $10,438,440 over 5 years)

Morris K. Udall Center of Excellence: Morris K. Udall Center of Excellence: Neuroprotection and Early Detection in PDNeuroprotection and Early Detection in PD(P01; M. Zigmond, PI; $6,453,809 over 5 years )(P01; M. Zigmond, PI; $6,453,809 over 5 years )

GRECC (G i t i R h Ed ti dGRECC (G i t i R h Ed ti dGRECC (Geriatric Research, Education, and GRECC (Geriatric Research, Education, and Clinical Center) Clinical Center) (S. Graham, Director)(S. Graham, Director)(S. Graham, Director)(S. Graham, Director)

State Tobacco G antState Tobacco G antState Tobacco GrantState Tobacco GrantThis grant focuses on This grant focuses on s g a t ocuses os g a t ocuses o

computer screening techniques for cognitive computer screening techniques for cognitive impairment in the communityimpairment in the communityp yp y

the use of PET imaging with the amyloid ligand the use of PET imaging with the amyloid ligand PIB and computer analysis of MR images to aid in PIB and computer analysis of MR images to aid in p y gp y gdiagnosisdiagnosis

the examination of biological specimens for the examination of biological specimens for g pg pbiomarkers of diagnosis and disease severity using biomarkers of diagnosis and disease severity using cuttingcutting--edge techniques to do drug discovery in edge techniques to do drug discovery in novel cellnovel cell--based systems to identify newbased systems to identify newnovel cellnovel cell--based systems to identify new based systems to identify new treatments for dementia. treatments for dementia.

Center on Excellence in Detection, Diagnosis andCenter on Excellence in Detection, Diagnosis and

Commonwealth Tobacco Settlement Fund 5/05Commonwealth Tobacco Settlement Fund 5/05--5/09:5/09:Center of Excellence on Research In Neurodegenerative Diseases Center of Excellence on Research In Neurodegenerative Diseases

Center on Excellence in Detection, Diagnosis and Center on Excellence in Detection, Diagnosis and Intervention in Dementia Intervention in Dementia

DDIDDDID Administrative

Core

Clinical/Health Basic ResearchServices Research Basic Research

Computerized Screening for

Dementia DetectionJ Saxton,

Project LeaderPitt ADRC, SWPA-AAA,

PIB-PET for Diagnosis of

DementiaW Klunk/D Wolk,Project Leaders

University of

MRI Diagnostic AnalysisJ Becker,

Project LeaderUniversity of PittsburghADRC/Penn State/CMU

Tau MetabolismL Taylor,

Project LeaderUniversity of Pittsburgh

ADRC and Cellumen

High-ThroughputDrug Screening

J Lazo, Project Leader

University of Pittsburgh

Oxidized NeurolipidsV Kagan,

Project LeaderUniversity of Pittsburgh

ADRC PST, Theiss Health

Center

University of Pittsburgh ADRC

ADRC/Penn State/CMU ADRC and Cellumen ADRC and Penn State and Univ Pgh GSPH

Clinical Trials: NIH and PharmaClinical Trials: NIH and Pharma

Ginkgo Biloba Prevention Trial in Older Individuals Ginkgo Biloba Prevention Trial in Older Individuals G go oba e e t o a O de d dua sG go oba e e t o a O de d dua s(NCCAM and NIA; S. DeKosky, PI; O. Lopez, Co(NCCAM and NIA; S. DeKosky, PI; O. Lopez, Co--PI) PI) 3000 normal elderly in 4 clinical sites around the USA: 3000 normal elderly in 4 clinical sites around the USA: yyPittsburgh, Hopkins, Wake Forest, UC Davis; Data Pittsburgh, Hopkins, Wake Forest, UC Davis; Data Mgt/Statistics at Univ. Washington, Lab at U. Vermont, Mgt/Statistics at Univ. Washington, Lab at U. Vermont, Cognitive Diagnostic Center and Imaging Center at U. Pgh.Cognitive Diagnostic Center and Imaging Center at U. Pgh.g g g g gg g g g gLargest grant ever given by NCCAMLargest grant ever given by NCCAMFunded the continuation of the GEM clinical trial for Funded the continuation of the GEM clinical trial for $16 632 639 h h J l 2009$16 632 639 h h J l 2009$16,632,639 through July 2009$16,632,639 through July 2009

Other clinical trials are sponsored by NINDS, NIA and Other clinical trials are sponsored by NINDS, NIA and Pharma in Alzheimer’s Parkinson’s Stroke ALSPharma in Alzheimer’s Parkinson’s Stroke ALSPharma in Alzheimer s, Parkinson s, Stroke, ALS, Pharma in Alzheimer s, Parkinson s, Stroke, ALS, Huntington’s, Multiple SclerosisHuntington’s, Multiple Sclerosis

Foundation SupportFoundation SupportppppPicower Foundation Picower Foundation

JT Greenamyre MD PhDJT Greenamyre MD PhD $750 000 per year for 3 years$750 000 per year for 3 yearsJT Greenamyre, MD, PhDJT Greenamyre, MD, PhD, $750,000 per year for 3 years, $750,000 per year for 3 years

Pathogenic mechanisms as therapeutic targets in PD Pathogenic mechanisms as therapeutic targets in PD

Emmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh FoundationEdward Burton, MD, DPhilEdward Burton, MD, DPhil, a two year grant totaling , a two year grant totaling $138,646. $138,646.

Development of a biochemical model of Parkinson’s disease in Development of a biochemical model of Parkinson’s disease in zebrafish to enable identification of pathogenic pathways and zebrafish to enable identification of pathogenic pathways and neuroprotective drugs.neuroprotective drugs.p gp g

Emmerling Fund of the Pittsburgh Foundation Emmerling Fund of the Pittsburgh Foundation David Hinkle, MD, PhDDavid Hinkle, MD, PhD 3 year grant totaling $166,7603 year grant totaling $166,760, ,, , y g g $ ,y g g $ ,

The research project will target astrocytes for neuroprotective The research project will target astrocytes for neuroprotective therapies in stroke therapies in stroke

Current Career Development AwardsCurrent Career Development AwardsSarah Berman, MD, PhD: K08 Award (NINDS)Sarah Berman, MD, PhD: K08 Award (NINDS)

Mitochondrial dynamics in neurodegenerationMitochondrial dynamics in neurodegeneration

David Hinkle, MD, PhD: K08 Award (NINDS) David Hinkle, MD, PhD: K08 Award (NINDS) The Potential Role of DJThe Potential Role of DJ--1 in Astrocyte1 in Astrocyte--Mediated Neuroprotection Mediated Neuroprotection

Samay Jain, MD: K12 Award (NIH)Samay Jain, MD: K12 Award (NIH)Improving diagnosis and treatment of Parkinson disease with assessments of Improving diagnosis and treatment of Parkinson disease with assessments of nonnon--motor features by clinical and physiologic measures motor features by clinical and physiologic measures

Deric Park, MD: K02 award (NINDS)Deric Park, MD: K02 award (NINDS)Determination of growth and differentiation pathways in glioblastoma multiforme Determination of growth and differentiation pathways in glioblastoma multiforme

Amanda Smith, PhD: K01 award (NINDS)Amanda Smith, PhD: K01 award (NINDS)Endogenous neuroprotective agents in Parkinson’s DiseaseEndogenous neuroprotective agents in Parkinson’s Disease

David Wolk MD: K23 award (NIA)David Wolk MD: K23 award (NIA)David Wolk, MD: K23 award (NIA)David Wolk, MD: K23 award (NIA)Recollection and Familiarity in AmnesticRecollection and Familiarity in Amnestic--Mild Cognitive Impairment Mild Cognitive Impairment

Training Grants Training Grants T32 MH18273 Training in the Neurobiology of T32 MH18273 Training in the Neurobiology of Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI)

U13 NS060553 Training Faculty to Teach Survival Skills U13 NS060553 Training Faculty to Teach Survival Skills and Ethics (M. Zigmond , PI)and Ethics (M. Zigmond , PI)

R25 NS39805 Survival Skills and Ethics Workshops for R25 NS39805 Survival Skills and Ethics Workshops for Neuroscientists (M. Zigmond , PI)Neuroscientists (M. Zigmond , PI)

Numerous Neurology faculty serve on other training Numerous Neurology faculty serve on other training grants in several basic and clinical departments.grants in several basic and clinical departments.

C t f th PINDConcept of the PIND

Robert Y. Moore, MD, PhD and Michael Zigmond, PhD conceptualized an Institute for the study of p f y fNeurodegenerative Diseases, that would build on the significant strengths in research at the university of PittsburghgCentral idea was a dual focus on translational research (to translate ideas from the lab to the clinic) clinic)

Laboratories that were open and interactiveClinical translational by clinician researchers AND clinicians who both ran laboratories and did clinical researchwho both ran laboratories and did clinical researchClose proximity of laboratories and clinics

1997-2000Drs. Moore and Zigmond, working with Joanne Beyer, d l d l f th PIND t t t th developed a proposal for the PIND to present to the Scaife FoundationBob Moore met with Jeff Romoff CEO of UPMC and Bob Moore met with Jeff Romoff, CEO of UPMC and secured a promise to match a Scaife Foundation Gift of $10 million with $10 million from UPMC - a promise made goodmade goodDrs Moore, Zigmond, and DeKosky met with the Scaife Foundation Board with a proposal to support h PIND l i h P ki ’ Di the PIND, leveraging the Parkinson’s Disease

expertise, Alzheimer’s disease research, emerging ALS research in the Division of Neuropathology, and

h d d hother neurodegenerative disease research

Th t tThe targets…Dual theme reflected in the unique aspects of the neurodegenerative diseases, and also their common featurestheir common features

Neuronal death in specific brain regionsAbnormal processing of brain proteinsn rma pr c ng f ra n pr t nLoss of cell-to-cell communicationInflammationO id i Oxidative stress

Th S if C it t t f ldThe Scaife Commitment: two-fold

The PIND gift was $10,800,000$10 million for the building$800 000 for recruiting equipment seminars education and $800,000 for recruiting, equipment, seminars, education and related activities in the interim before the building was completed

Used for PIND symposiums, organizing lectures, recruitment and equipment utilized in labs before the move to the new laboratoriesmove to the new laboratories

Allowed PIND to develop its “Center without Walls” presence

2000-2004Moore took sabbatical in London to study neuroimaging in Parkinson’s disease and then returned to start a new research programDeKosky took Chair of Neurology in 2000; was appointed Director of DeKosky took Chair of Neurology in 2000; was appointed Director of the PINDLeslie Dunn, MPH, appointed Executive Director of PIND, overseeing PIND activities, grants, seminarsPIND act v t es, grants, sem narsRecruiting for researchers from inside and outside University of Pittsburgh beganZigmond NIH-funded Program Project Grant designated a Morris K. Zigmond NIH funded Program Project Grant designated a Morris K. Udall Parkinson's Disease Research Center of Excellence

One of very few to have both basic and clinical research

Ed Burton, MD, PhD (movement disorders), David Hinkle, MD, PhD , , ( ), , ,(movement disorders) recruited from Queen’s Square and University of PennsylvaniaGroundbreaking for the building was held March 6, 2003

2004-presentTim Greenamyre, MD, PhD, recruited from Emory University as Professor and UPMC Chair in Movement University as Professor and UPMC Chair in Movement Disorders, Chief of the Division of Movement Disorders, Department of Neurology, and Director of the PINDthe PINDAdditional recruitments in Parkinson’s disease, Alzheimer’s disease, ALS, animal models of m , L , m m fneurodegenerationDesignated as an Advanced Center for Parkinson’s Di R h b th A i P ki Di Disease Research by the American Parkinson Disease Association

The Pittsburgh Institute for Neurodegenerative DiseasesThe Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative DiseasesMission Statement:

ByBy virtuevirtue ofof bothboth philosophyphilosophy andand architecture,architecture,thethe PINDPIND isis aa centercenter wherewhere therethere areare nono wallswallsbetweenbetween individualindividual scientists,scientists, andand wherewhere therethereareare nono barriersbarriers betweenbetween basicbasic scientificscientific inquiryinquiryandand translationtranslation ofof thethe latestlatest findingsfindings intointo newnewandand translationtranslation ofof thethe latestlatest findingsfindings intointo newnewtreatmentstreatments.. AsAs such,such, thethe missionmission ofof thethe PINDPIND isistoto transformtransform cuttingcutting--edgeedge sciencescience intointo novelnovelhh dd dd hh d ld l b fb ftherapiestherapies andand diagnosticsdiagnostics thatthat directlydirectly benefitbenefit

individualsindividuals affectedaffected byby neurodegenerativeneurodegenerativediseasesdiseases..diseasesdiseases..

The Pittsburgh Institute for Neurodegenerative DiseasesThe Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative Diseases

Administ ti St uctuAdministrative Structure

Director:Tim Greenamyre, MD, PhD

Executive Committee:Executive Committee:Bob Bowser, PhD

Jun Chen, MDSt G h MD PhDSteve Graham, MD, PhD

Terri Hastings, PhDPeter Strick, PhD

Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND?

• The 7th floor of BST3

Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND?

• The 7th floor of BST3Th i ti t th 7th fl • The investigators on the 7th floor of BST3

The Pittsburgh Institute for Neurodegenerative DiseasesThe Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative Diseases

The PeopleThe PeopleThe PeopleThe PeopleNeurology:Neurology: Sarah Berman, MD, PhDSarah Berman, MD, PhD Dave Hinkle, MD, PhDDave Hinkle, MD, PhD

Ed Burton, MD, PhDEd Burton, MD, PhD Ruth Perez, PhDRuth Perez, PhD h h h l hh l hTim Greenamyre, MD, PhD Tim Greenamyre, MD, PhD Michael Zigmond, PhDMichael Zigmond, PhD

Terri Hastings, PhD Terri Hastings, PhD

Pharmacology:Pharmacology: Don DeFranco PhDDon DeFranco PhD Michael Palladino PhD Michael Palladino PhD Pharmacology:Pharmacology: Don DeFranco, PhDDon DeFranco, PhD Michael Palladino, PhD Michael Palladino, PhD

Geriatrics:Geriatrics: Al Fisher, MD, PhDAl Fisher, MD, PhD

StructuralStructural Ron Wetzel PhDRon Wetzel PhDStructuralStructuralBiology:Biology:

Ron Wetzel, PhDRon Wetzel, PhD

Sarah Berman, MD, PhD

Assistant Professor

Sarah Berman, MD, PhD

Assistant ProfessorAssistant Professor

Neurology

Assistant Professor

Neurology

Mitofusin

FUSION

OPA

Drp1Fis1 FISSIONFISSION

Ed Burton, MD, PhD

Assistant Professor

Ed Burton, MD, PhD

Assistant Professor

Genetically tractable models in Zebrafish

Assistant Professor

Neurology

Assistant Professor

Neurologyin Zebrafish

Don DeFranco, PhD

Professor

Don DeFranco, PhD

ProfessorProfessor

Pharmacology

Professor

Pharmacology

Oxidative StressOxidative Stress

Al Fisher, MD, PhD

Assistant Professor

Al Fisher, MD, PhD

Assistant Professor

Geriatric MedicineGeriatric Medicine

Tim Greenamyre, MD, PhD

Professor

Tim Greenamyre, MD, PhD

ProfessorProfessor

Neurology

Professor

Neurology

Terri Hastings, PhD

Associate Professor

Terri Hastings, PhD

Associate ProfessorAssociate Professor

Neurology

Associate Professor

Neurology

David Hinkle, MD, PhD

Assistant Professor

David Hinkle, MD, PhD

Assistant ProfessorAssistant Professor

Neurology

Assistant Professor

Neurology

Michael Palladino, PhD

Assistant Professor

Michael Palladino, PhD

Assistant ProfessorAssistant Professor

Pharmacology

Assistant Professor

Pharmacology

Ruth Perez, PhD

Assistant Professor

Ruth Perez, PhD

Assistant ProfessorAssistant Professor

Neurology

Assistant Professor

Neurology

Ron Wetzel, PhD

Professor

Ron Wetzel, PhD

ProfessorProfessor

Structural Biology

Professor

Structural Biology

Michael Zigmond, PhD

Professor

Michael Zigmond, PhD

ProfessorProfessor

Neurology

Professor

Neurology

Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND?

• The 7th floor of BST3Th i ti t th 7th fl • The investigators on the 7th floor of BST3

• An inclusive center without walls -b i & li i l i ti t basic & clinical investigators throughout Pitt g

How is PIND research funded?How is PIND research funded?Extramural Funding FY-'07

Individual NIH Research Awards

53%

Foundations/Associations21%

NIH Program Project or Center Awards

25%

$6 031 129 direct$6 031 129 direct$6,031,129 direct

$1,476,041 indirect

$6,031,129 direct

$1,476,041 indirect

K-Awards

• Sarah Berman, MD, PhD - K08

• Al Fisher, MD, PhD - K08 (Beeson Award) -Division of Geriatrics

• Dave Hinkle, MD, PhD - K08

P M b d PhD K99• Pier Mastroberardino, PhD - K99

• Samay Jain, MD - K12y

Graduate students

• 12 Pitt PhD students (4 MD-PhD)

• CNUP Pharmacology MBSB• CNUP, Pharmacology, MBSB

• Visiting students from University of Padova, U i it f I b iUniversity of Insubria

• Formal exchange agreements with University of Insubria & Mondino Neurological Institute

Postdocs

• 26 postdocs

• PhDs from Pitt Michigan Michigan State • PhDs from Pitt, Michigan, Michigan State, Rome, Padova, Insubria, Navarra

2 RiMED f ll (J i t UPMC Si il ) • 2 RiMED fellows - (Joint UPMC-Sicily program)

Journal Editors

• Molecular Endocrinology, Don DeFranco, editor (IF 5.4) ( )

• Neurobiology of Disease, Tim Greenamyre, editor (IF 4.4)(IF 4.4)

• Progress in Neurobiology, Michael Zigmond, editor (IF 10 5)(IF 10.5)