department of chemistry, dr. h. s. gour university, sagar ... · 5 ph.d. course work semester – i...

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Department of Chemistry, Dr. H. S. Gour University, Sagar (M.P.)

Ph.D. Programme

Semester - I

Course Code Course Title Credits

CHE- C- 141 Research Methodology and Spectroscopy 3

CHE- C- 142 Solid State and Material Chemistry 3

CHE- C- 143 Recent Developments in Chemistry of Natural Products 3

CHE- C- 144 Advanced Nano-Materials and Technology 3

CHE- C- 145 Laboratory Course in Research Methodology and Spectroscopy 1

CHE- C- 146 Laboratory Course in Solid state chemistry 1

CHE- C- 147 Laboratory course in Recent Developments on Chemistry of

Natural Products 1

CHE- C- 148 Laboratory course in Advance Nano-Materials and Technology 1

CHE-C- 149 Project work : Research Methodology and Survey Literature 4

CHE-C-1410 Seminar presentation on contents of CHE-C-149 4

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Ph.D. Course Work, Semester I

CHE-C- 141

Research Methodology in Chemistry

Credits-3 45 Hours

1. Research Methodology : Research: Objectives - types, Approaches, Methodology and

Process of Rsearch : Problem Identification and survey design, collecting evidences and

notion based correlation, survey literature and design, scope for the hypothetical problem

and its formulation, preparation of synopses, work plan and data collection, data

processing using qualitative and quantitative analytical / statistical approaches.

Writing of- abstracts; research projects; reports; papers; dissertations; thesis General idea

about: Seminars; Symposia; Workshops; Conferences. Making deliberations; General idea

about impact factors of journals, IPR and patents.

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3

2. Quantitative approaches in research methodology: Statistical tools and approaches-

accuracy and precision, testing confidence limits, method of least square and successive

approximation, correlation and regression – Linear and non linear; multiple variable matrix

and its analysis, drawing of good fit lines, slopes, correlation coefficients and their

significance.

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3. Methods in Molecular Modelling: ab-initio: HF approximation, MO combinations,

Rothman Hall equation, ab-initio methods HF definitions, introductio to post-SCF, Cl, MP2,

MP3, Working with SCF-HF; density functional theory : what is functional, DFT process,

variation approach, difference between SCF-HF and DFT; semi-empirical models :

Simplified HF, simplification, some semi empirical methods; molecular dynamics :

Molecular mechanics – Force fields, their parameters, Geometry optimisation,

minimisation-methods, conformational search - methods, electro density, electrostatic

potential, Molecular topology : Types and their determination, General idea about using

material studio and molecular modeling software’s. Applications : SAR and in

Combinatorial Spectral analysis.

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4

4. Basic Instrumentation:, Detectors: sensor and transducers, types – pressure, optical, flow

meter, acclrometers and inclinometers, temperature sensors, chemical sensors etc; sensor

networking, Instruments- conventional, microprocessor based systems and Computer

Aided (CAA) instruments – brief introduction of spectrophotometers- UV,Vis., ir,

Microwave, NMR, AAS-E, chromatographic – detectors, brief introduction of packages,

tailoring of plots.

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2

5. Using Computers: Importing and exporting of computer data – a knowledge of .pdf and

.html formats, using notepad / word pad , log, semi log and log-log plots using computers,

Using Excel and Origin for graphical representations and computation, using SPSS and Mat

lab , using internet and search engines, using power-point / flash / video for making

deliberations

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Course Coordinator : Prof. S.N.Limaye

.

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Ph.D. Course Work Semester – I

CHE-C-142

Solid State and Material Chemistry

Credits-3 45 Hours

1. Preparative Methods: Introduction, High temperature ceramic methods, Microwave

synthesis, Combustion synthesis, High pressure methods, Chemical vapour deposition,

preparing single crystals, Intercalation.

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2. Physical Methods for characterizing solids:

a. X-ray diffraction: Powder diffraction, Single crystal X-ray diffraction, X-ray

absorption spectroscopy; Neutron diffraction; Electron Microscopy: SEM, TEM,

STM, AFM; Solid state-NMR;

b. Thermal analysis: TGA, DTG, DTA, DSC, Non-Isothermal & Isothermal degradation

kinetics, various applications;

c. Vibrational: IR, RAMAN; Electronic: UV-visible.

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3

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3. Phase Transitions: Classifications, Magnetic and dielectric properties.

Super conductivity: Conventional super conductors, high temperature super conductors,

BCS theory

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4. Ionic conductivity and solid electrolytes: Typical ionic crystals, solid electrolytes (fast ion

conductors, super ionic conductors), Conductivity measurements, Applications of solid

electrolytes

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5. Nano chemistry: Metal nanoclusters, Chemical synthesis, Self assembly processes,

stabilization; Spectral and microscopic characterization, physical properties. Application in

catalysis, and material sciences. Nano hazards.

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Course Coordinator Dr. Vijay Verma

Books: CHE-C-142

1. Solid state chemistry: An Introduction, Third edition, Lesley E. Smart, Elaine A. Moore, Taylor &

Francis

2. Solid State Chemistry and its Applications, Anthony R. West, John Wiley & Sons

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CHE-C-143

Recent Developments in Chemistry of Natural Products

Credits-3 45 Hours

1. Prospects of Natural Products research in the 21st Century: - Introduction, use of natural

products in traditional medicines, potential of natural products, Natural products in drug

discovery and development.

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2. Recent development in the research on naturally occurring flavonoids: - Introduction,

Recently reported flavonoids, Biological and Pharmacological activities of flavonoids

(Antioxidant activity, cyto-toxic activity, anticancer and anti-turmeric activities, cardio

protective effect, anti-microbial activity).

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3. Glycodrugs: - A new window for chemo-diversity and drug discovery from natural

products- Introduction, Antibiotics, Anti-cancers and Anesthetics.

Alkaloids: - Recent developments in pharmacological, biological and medicinal aspects-

Introduction, Antimicrobial activity, antioxidant and anti-inflammatory activities of

alkaloids.

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4. Terpenoids: - Old secondary metabolites with new therapeutic properties- Introduction,

general biosynthesis of flavonoids and Ecological role of terpenoids and terpenoids in

herbal medicines.

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5. Essential Oils:- Introduction, manufacturing process, processing of essential oils, uses of

essential oils and composition of essential oils.

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Course Coordinator: Prof. R. N. Yadav

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Ph.D. Course Work Semester – I CHE-C-144

Advanced Nano-Materials and Technology Credits-3 45 Hours

1. Carbon Nanomaterials

History of nanomaterials, Carbon nanotubes: Single and multiwall carbon nanotubes.

Fullerenes, Nanowire, nanorods, nanocone, nanofibre. Simple synthesis, and

characterization. Applications.

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2. Nano-chemistry of Photonic Crystals

Photonic band gap, periodic dielectric, nature photonic crystals, Bragg reflector, Butterfly-

wings, Different applications.

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3. Nanocomposite Hydrogels and Technology

Nanocomposite chemistry by polysaccharide hydrogels, Ionotropic gelation, difference

between ordinary gels and ionotropic gels, Rayleigh – Bennard convection, Poly anions

and poly cations, structure of alginate, method of fabrication of ionotropic gels by

dissipative convective process.

Cross-linking phenomenon, Cold bath and unidirectional freezing. Encapsulation of

different nanoparticles and cells in ionotropic gels. Mechanical strength, its determination,

Applications of ionotropic gels.

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4. Fuel Cells Technology

Fuel Cell, History and background, Principle of fuel cells, difference between fuel cell and

Carnot cycle technologies, William Grove fuel Cell, anode, cathode, electrolyte and

interconnect of fuel cells. Stack of fuel cells, Solid oxide fuel cell (SOFCs), different

materials used. Sketch designs of different SOFCs. Applications of Fuel cells.

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5. Superconductivity

History and background of superconductivity, Superconducting phenomenon, low

temperature Superconductors, Bardeen – Cooper and Schrieffer Theory (BCS), Cooper

pair, High temperature Superconductivity. Applications of Superconductors.

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Course Coordinator Prof. Farid Khan

Books Suggested : CHE-C-144

• Nanomaterials Chemistry: Recent Developments and New Directions by C. N. R. Rao, A. Muller and

A. K. Cheetam, Willey- VCH Gmbh & Co.

• Nanostructures and Nanomaterials: Synthesis, Properties and applications, by Guozhong Cao,

Imperial College Press, London.

• Nanomaterials (Architecture & Design) by Leydecker Sylvia, Springer Verlag

• Nanomaterials and Nanochemistry by Catherine Brechignac, Philippe Houdy and Marcel

Lathmani, Springer Verlag, Berlin

• Solid State Chemistry and its Applications by A. R. West, John Wiley & Sons, NewYork

• New Directions in Solid State Chemistry by C. N. R. Rao and G. Krishnan, Cambridge University

Press, Cambridge, London


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CHE-C-145

Laboratory Course in Research Methodology and Spectroscopy

Credits : 1 15 Hours

• Perform a quantitative analysis of two component mixture using spectrophotometric (or any other

analytical method) and evaluate the statistical equation for the simultaneous determination.

• Perform a quantitative analysis of three component mixture using spectrophotometric (or any other

analytical method) and evaluate the statistical equation for the simultaneous determination.

• Take a suitable complex of any one of the 3d- or 4d- transition metal and discuss its UV-visible spectra for

cfse, magnetic properties and infra red spectra for elucidation of the complex structure.

• Take a suitable molecule (preferably aliphatic or cyclic hetero atomic of more than 20 atoms) and use their

UV-Visible spectra, IR, Mass spectra, 1H, 13C spectra in order to evaluate its 3D structure. Verify the same

using PC model structure.

• Evaluate PC model parameters for a known organic molecule or a coordinate compounds (with minimum

coordination number of six or eight) and theoretically calculate pc model parameters.

• Take a standard organic molecule and evaluate structural parameters using pc model. Predict the possible

1H, 13C, spectra, fragmentation parts and m/e ratio in order to evaluate its 3D structure. Predict its tR in

standard Hexane medium.

• Isolate given component of two or more than two components of cations using suitable complexone by

means column chromatographic method

Course In charge Prof. S. N. Limaye


Laboratory Course in Solid state chemistry Credits : 1 15 Hours

1. Co- precipitation as a precursor to solid state reaction.

2. Synthesis of Zeolites from solns and gels.

3. Synthesis of LiNbO3by sol-gel method.

4. Synthesis of calcium silicate hydrate by hydrothermal method.

5. Synthesis of BaTiO3 perovskite by solid state reaction method and its characterization by powder

X-ray method.

6. Determination of dielectric constant of BaTiO3 material.

7. To verify the Arrhinius equation and determination of energy of activation for ionic conductors.

8. To study the relaxor behaviour of BaTiO3 material by impedance spectroscopy.

9. To calculate the molecular weight of polymers by Viscometry method.

10. To determine the symmetry and lattice parameters by CRYSFIRE software.

11. Fabrication of a solid state battery and estimating its cell performance.

12. Microwave assisted solid state synthesis of materials.

13. Evalution of Non isothermal degradation based solid state kinetic parameters.

14. Vibrational spectroscopy of solids.

Course In charge Dr. Vijay Verma

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CHE-C-147

Laboratory course in Recent Developments on Chemistry of Natural Products


1. Isolation and purification (by PC, TLC and CC) of the flavonoids, alkaloids, terpenoids, glycodrugs

and essential oils from medicinal plants.

2. Charaterisation of the compounds by spectral analysis viz. UV, IR, 1H-NMR, 13C-NMR and Mass etc

Course In charge Prof. R.N.Yadav

Books suggested:

1. K.Paech, M.V. Tracey, Modern Methods of Plant Analysis, vol-3rd, Springer-Berlag, 1955.

2. J.B.Harborn and T.J.Mabry, The Flavonoids Advances in Research, Chapman and Hall Limited,

London, 1985.

3. G. Brahmchari, Chemistry of Natural Products, “Recent Trends and Developments Research

Signpost, Trivendrum”, 2006.

4. G. Brahmchari, Natural Products: Chemistry, Biochemistry and Pharmacology, Narosa

Publishing House, New Delhi, 2009.

5. Modern Technology of Perfumes, Flavors and Essential Oils, National Institute of Industrial

Research, Delhi.


Laboratory course in Advance Nano-Materials and Technology Credits : 1 15 Hours

1. Synthesis of nanoparticles using suitable reducing agents.

2. Interpretation of compounds by FT-IR spectra.

3. Face identification by Powder X–Ray Diffractometer.

4. Interpretation of porous materials by Thermogravimetric analysis.

5. Fabrication of simple fuel cells.

6. Rheological study and determination of molecular weight of polysaccharide/polymers.

Course In charge Prof. Farid Khan

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Department of Chemistry, Dr. H. S. Gour University, Sagar (M.P.)

Ph.D. Programme

Semester – II

S.No. Course Code Course Title Credits

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

CHE-C-241

CHE-C-242

CHE-C-243

CHE-C-244

CHE-C-245

CHE-C-246

CHE-C-247

CHE-C-248

CHE-C-249

CHE-C-2410

Structural Inorganic Chemistry and Radio-chemistry

Advanced heterocyclic synthesis and its applications

Kinetics and Mechanism of Chemical Transformation

Applied Electrochemistry

Laboratory Course in Structural Inorganic Chemistry and Radio-chemistry

Laboratory Course in Advanced heterocyclic synthesis and its applications

Laboratory Course in Kinetics and Mechanism of Chemical Transformation

Laboratory Course in Applied Electrochemistry

Project work on proposed research topic and synopsis of the thesis

Seminar and viva-voce examination on above CHE-C-249

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1

1

4

4

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Ph.D. Course Semester - II CHE-C-241

Structural Inorganic Chemistry and Radio-chemistry

Credits: 03 45 Hours:

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Part- A

Preparative Inorganic Chemistry: Kinetics and thermodynamic aspect of synthesis; Basic Techniques (Low temp., High temp., High pressure, Vacuum line, Inert atm., etc. devices). Electrolytic, electrostatic discharge, Photochemical & Microwave assisted synthesis; Role of solvents in synthesis & crystallization; Uses of Chromatographic techniques in synthesis; Some selected Inorganic synthesis; Growing Crystals from Solutions.

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2 Structure/ Characterization from Chemical data: Microanalysis, magnetic measurements, mass spectrometry, electronic spectra, optical activity, i.r., Raman, esr, nmr, X-ray (diffraction & single crystal), electron diffraction,

Photoelectron spectroscopy, probing surface & size using SEM , TEM & XRD; application of electrometric and thermal techniques.

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3 Application of Inorganic compounds in: (a) Homogeneous & Heterogeneous catalysis, (b) Bioinorganic Chemistry, (c) Other Industrial Applications.

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4

Part- B

Coordination and stereochemistry of Actinide elements: Chemistry of Ac, Th and U, Identification and uses of elements beyond Uranium; Super heavy elements. Nuclear synthesis of Trans-uranium elements; Nuclear power reactors; Safety features of reactors.

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5 Processing of spent nuclear fuel: Radio-active waste management- Sources, Processing, Causes and Effects; Treatment, Storage and Disposal; Hazards and Safety measures

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6 Radiation Chemistry and Radiation Biology: Primary radiation effect, Radiation dosimetry, radiolysis, Intermediates (ions, excited molecules, free radicals), Radiation chemistry in different media, Radiation in chemical processes, Industrial applications of Radiation and Health processes.

Nuclear medicines and diagnostics.

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Course Coordinator: Prof A.P.Mishra

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Ph.D. Course Semester II

CHE-C-242

Advanced Heterocyclic Synthesis and its Applications


1. General Introduction

I.1. Organic synthesis by conventional, microwave, ultrasonic, electro-organic and PTC

based synthesis and relation to green chemistry.

I.2. General idea of main heterocyclic molecules with chemistry and biochemistry of

present functional groups.

I.3. Comparative study and advantages of these techniques.

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2. Synthesis of azetidinones (ββββ-lactams ring)

II.1a. Introduction ; II.1b. Nomenclature of azetidinones and interaction with other

molecules ; II.1c. Thermodynamic aspects ; II.1d. Stereochemical aspects ;

II2a Reactivity and ; mechanisms on heteroatom ; II.2b. Thermal and Photochemical

reactions ; II.2c. Electrophilic substitution ; II.2d.Nucleophilic substitution ; II.2e.

Cycloaddition reactions ;

II.3a. Synthetic procedures ; II.3b.Synthesis by condensation ; II.3c. Synthesis by

cycloaddition ; II.3d.Various bond formation ; II.3e. Cyclization and ring transformation ;

II.4a.Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC

etc.) ; II.4b. Pharmaceutical and clinical applications of various β-lactams.

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3. III. Synthesis of Thiadiazoles

III.1a. Introduction of various thiadiazoles ; III.1b. Nomenclature of thiadiazoles ; III.1c.

Physical aspects of thiadiazoles ; III.1d. Stereochemical aspects of

thiadiazoles ;

III.2a. Reactivity and mechanisms ; III.2b. Thermal and Photochemical reactions ;

III.2c.Electrophilic reaction ; III.2d.Nucleophilic reaction ; III.2e. Reactions with radicals

and electron-deficient species. ; III.2f. Cycloaddition reactions ; III. 2g. Reactions of

substituents on methylene group ;

III. 3a. Synthetic procedures ; III. 3b. Formation of one bond, two and three bond with

cyclizations and dipolar cycloadditions. ; III. 3c. Formation by ring

transformations

III.4a. Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC

etc.);4b. Pharmaceutical and clinical applications of various Thiadiazole nucleus.

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4. IV. Synthesis of thiazolidenes and their 5-arylidene derivatives

IV .1a. Introduction of thiazolidenes ; 1b. Nomenclature of thiazolidenes ; 1c. Physical

aspects of thiazolidenes ; 1d. Stereochemical aspects of thiazolidenes ;

IV .2a. Reactivity and chemistry ; 2b. Electrophilic substitution ; 2c. Nucleophilic

substitution ; 2d. Knovenzal reaction ;

IV .3a. Synthetic procedures ; 3b.Cyclization procedures – formation of 3,4-bond and 2,

3-bond ; IV .3c. 5-substitution ;

IV .4a. Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC,

etc.) IV .4b. Pharmaceutical and clinical applications of various thiazolidenes and

their 5-arylidenes

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Course Coordinator Prof. S.K. Shrivastava

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Books Suggested

1. Goodman and Gillman. The Pharmacological basis of therapeutics, McGraw Hill, 1996.

2. Katritzky, A.R. and Rees, C.W., Comprehensive Heterocyclic Chemistry Pergamon Press, N. York.

3. Katritzky, A.R. and Pozharskil H. and Book of Heterocyclic Chemistry, 2nd

Ed. Pergamon Press,

2000, New York.

4. Gupta, R.R., Vol. I and II, Heterocyclic Chemistry Sprinzer Verlap.

5. Comprehensive Heterocyclic Chemistry Vol. 6 by Katritzky and Rees.

6. George R. Newkome and Asutosh Nayak.

7. Heterocyclic Chemistry and Introduction, A. Albert, 2nd

Ed., Athlone Press, London.

8. Physical Methods in Heterocyclic Chemistry, Vol. III and IV, Academic Press, New York.

9. The Structure and Reactions and Heterocyclic Compounds M.H. Palmer Edward Arnold London.

10. Dehmlow, E.V., Dehmlow S.S., PTC Third revised and enlarged Edition.

11. Burger’s Medicinal Chemistry, Vol. I-V.

Ph.D.Course Semester II

CHE-C-243

Kinetics and Mechanism of Chemical Transformation


1. Solution Kinetics

Frank – Robinowitch effect, Bronsted – Bjerrum equation, linear free energy relationship,

Thermodynamics implications of linear free energy relationship. Hammett's equation, Taft

equation. Effect of solvent on reaction rate.

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2. Catalytic reactions

Function of catalyst in terms of Gibbs's free energy of activation in chemical reactions,

Effect of pH on reaction rate. Bronsted catalysis law and its equation. Acidity function,

Heterogeneous catalysis, Langmuir-Hinshelwood mechanism, Kinetics of Heterogeneous

reactions.

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3. Drug Release Kinetics

The blood level curve, volume of distribution, types of drug release, reservoir type and a

matrix type system.

Polymeric microspheres- Gelation Microspheres, Albumin Microspheres, Dextran

Microspheres, Poly Lactide and Poly Glycolide Microspheres etc.

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4. Modeling of Drug Release

Korsmeyer –Peppas model, Moyes- Whitney theory, Nernst and Brunner Film Theory.

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5. Release Kinetic Modelling

Statistical Methods- Explanotory data analysis method, repeated measures design,

multivariate approach [ MANOVA, multivariate analysis of variance],Model dependent

methods – zero order, first order, Higuchi Square root model, Korsmeyer Peppas model,

Hixon Crowell model, Baker Lonsdale, Weibull model. Model independent methods-

difference factor, similarity factor, LOQ & LOD ( Limit of quaification and Limit of detection)

Hopfenberg model, Gompertz model.

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6. Regression model for drug Release Kinetics

Linear or first order regression model, Quadratic or Second order regression model, Non

Linear regression model.

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Course Coordinator Prof Archana Pandey

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Ph.D. Course, Semester II

CHE-C-244

Applied Electrochemistry


1. Carbon based Electrode Materials: Material synthesis, fabrication and application of

Carbon based electrode, Carbon paste electrode, Carbon nanotube (Single and Multi

walled), Glassy Carbon electrode, glassy carbon fiber electrode etc.

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2. Some Modern Electroanalytical Techniques : Principle and application of Anodic and

Cathodic stripping voltammetry, Pseudo-polarography for speciation studies, Spectro-

electrochemistry, Cyclic voltammetry.

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3. Electrochemistry in Materials Science: Corrosion of Metals. Corrosion rate expression.

Electrochemical aspect of polorization, Passivity. Forms of corrosion (Eight forms of

Corrosion).

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4. Corrosion Kinetics : Corrosion testing. Materials and specimens, Surface propagation,

Gravimetric method, measuring and weighing, exposure techniques. Planned interval tests.

Corrosion rate determination at short time intervals.

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5. Corrosion of Metals and Alloys in different media. High Silicon Cast steel, other alloy cast

steel. Carbon steel and iron, Low alloy steels. Corrosion of Al, Ni, Ph, Cu etc. and their

alloys.

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6. (i) Electrode modification: Fabrication and application of modified electrodes

(Biomolecular modified, DNA, drugs, inorganic compounds etc modified) for analytical

purposes and also for the study of mechanism of action of biomolecules, Types of electrode

modification.

(ii) Enzyme Electrode: Electrodes carrying enzymes, The electrochemical enzyme

catalysed oxidation of some organic compounds (styrene). Application of Enzyme modified

electrode for the study of mechanism of action of drugs (Anticancer and other drugs).

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7. Biosensor: Typical functions of biosensor. Electrochemical biosensor, Amperometric

biopsensors. Potentiometric biosensors and impedimetric / conductometric biosensors,

Electrochemical biosensors in chemotherapy

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Course Coordinator Prof. S.N.Limaye

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CHE-C-245

Laboratory Course in Structural Inorganic Chemistry and Radio-chemistry Credits ; 1 15 Hrs

1. Syntheses and characterization of some selected Inorganic Complexes.

2. Physico-chemical studies of Complexes of Th, U and some selected lanthanides.

3. Separation/estimation of some Lanthanide and Actinide ions (Two ion mixture) by solvent

extraction/ion exchange/gravimetric methods.

4. Uses and application of available techniques /Instrumentation.

5. Interpretation of Spectra/Thermograms/Voltammograms/Chemical data

Course-in-charge: Prof A.P.Mishra


CHE-C-246

Laboratory Course in Advanced Heterocyclic Synthesis and its Applications Credits : 1 15 Hours

I.a. Synthesis of azetidinones, thiadiazole, and thiazolidene and their 5-arylidene heterocyclic

molecules by applying conventional, microwave, ultrasonic, phase transfer catalysis, electroorganic

based synthesis.

I.b. Using one or more heterocyclic moiety

II.a. Purification of products by chromatographic techniques.

II.b. Characterization of the products by spectroscopic and chemical techniques.

III.a. Determination of various physical parameters of the synthesized molecules

III.b. Study their various possible stereoisomers of the synthesized molecules.

IV.a. Biological significance of the compounds.

IV.b. SAR Study of the synthesized compounds.

Course Coordinator: Prof S. K. Shrivastava

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Ph.D. ourse, Semester II

CHE-C-247

Laboratory course in Kinetic of Mechanism of Chemical Transformation

Credits 1 15 Hours

1. Determination of rate constant:

(a) Determination of velocity constant and order of the reaction catalyzed by surfactants, oxides and

sulfides.

(b) Study the influence of medium i.e. dielectric constant, ionic strength.

2. Solubility of drugs:

Study the solubility of hydrophobic drugs in different solvents viz. distilled water, SLS, CTAB, PEG 400,

and PVP 44000 by spectrophotometry, Turbidimetry, Nephelometry.

3. Drug Release

(a) Study the drug dissolution as reported in pharmacopaea; (b) Study the drug dissolution in

different media i.e. at different pH, buffers and polymeric surfactants.

4. Physico-chemical characterization of Drugs

The following chemical and physical properties of the drug will be studied by using computer software

(a) Surface area; (b) Dipole ; (c) Molar volume ; (d) Minimization energy ; (e) Bond angle ; (f) Bond

Length ; (g) Partial charge on active sites ; (h) lipophilicity ; (i) Drug release profile

Course Coordinatror: Prof Mrs. A. Pandey

Ph.D. ourse, Semester II CHE-C-248

Laboratory course in Applied Electrochemistry

Credits ; 1 15 Hrs 1. Use of following modern analytical techniques for the analysis of electroactive species (organic

and inorganic), in synthetic samples and samples of natural, biological/ industrial origin.

2. Techniques:-

Differential pulse polarography / voltammetry

Differential pulse anodic stripping / voltammetry

Differential pulse cathodic stripping / voltammetry

Pseudo polarography for specification studies on sea water (synthetic samples) for its Pb

content.

3. Gravimetric method for corrosion rate determination (brass in acidic and basic medium).

4. Corrosion rate determination at short intervals using DPP/DPASV methods.

5. Preparation of conducting polymers as polymer electrolytes and material for electrodes.

6. Fabrication of DNA and anticancer drug modified electrodes as biosensors for analytical

purposes.

Course Coordinator: Prof S.N.Limaye

department of chemistry, dr. h. s. gour university, sagar ... · 5 ph.d. course work semester – i...

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